Articles tagged with Cancer Patients
Dr. Von Hoff, TGen's Physician-in-Chief, has been recognized with the David A. Karnofsky Memorial Award and Lecture at ASCO's Annual Meeting. He is a renowned physician-scientist who has contributed to developing numerous anticancer agents.
A new study found that ghrelin improved appetite and food intake in gastric cancer patients who had part or all of their stomach removed. Body weight loss was significantly lower in the ghrelin group compared to the placebo group, indicating a potential benefit for these patients.
People with diabetes undergoing cancer surgery are at a higher risk of death in the month following their operations. The study, led by Johns Hopkins researchers, found that newly diagnosed cancer patients with Type 2 diabetes have a 50% greater risk of mortality after surgery, particularly for colorectal and esophageal tumors.
A $3.8 million grant aims to address cultural barriers and biases limiting minority participation in cancer clinical trials. A patient navigation model is being established to provide assistance and support to patients considering or enrolled in trials.
Canadian researchers have identified a previously hidden channel in humans that allows anti-cancer agents like Bleomycin to target leukemia cells. This discovery may revolutionize treatment for acute myeloid leukemia, a cancer affecting white blood cells.
Research suggests locoregional recurrence after long disease-free interval is associated with distant disease rather than cause. Patients with recurrence have four times higher risk of metastases and eight times higher risk of dying compared to those without recurrence.
A randomized trial found that octreotide acetate did not reduce the incidence or severity of diarrhea in patients with anorectal cancer. The study included 215 patients who received either a placebo or long-acting octreotide before and during radiation therapy, but no significant differences were observed between groups.
A new study by Dartmouth researchers found that patients treated at similar, specialized cancer care institutions experienced equal mortality rates regardless of race. This study suggests a substantial decrease in death rates among African Americans when treated at these institutions.
African American patients with similar treatment settings as white counterparts show reduced mortality rates, highlighting the impact of institutional factors on cancer outcomes. The study suggests that where patients receive care may partly explain observed racial disparities.
UAB researchers emphasize the need for community-driven approaches to reduce cancer disparities, citing limited access to care and differences in healthy behaviors as contributing factors. They highlight successful programs that have eliminated disparities in screenings for certain cancers and advocate for engaging diverse populations ...
A nurse researcher has settled a common cancer concern by discovering that routine advice on skin care was rooted in myth instead of scientific evidence. Her findings, published in the Clinical Journal of Oncology Nursing, found no evidence to support a four-hour restriction on lotions before radiation therapy.
A study by University of Texas M.D. Anderson Cancer Center reveals that US cancer centers have varying levels of palliative care programs and services, with NCI-designated centers having more comprehensive programs. Despite the differences, there is strong support for integrating palliative care into oncology care.
A study found significant disparities in palliative care services across US cancer centers, with NCI-designated centers offering more comprehensive programs. The researchers identified barriers such as poor reimbursement and limited institutional resources hindering the delivery of high-quality palliative care.
A content analysis found that media reports tend to focus on aggressive treatments and survival rates, neglecting discussions of death, palliative care, and adverse events. This study highlights the need for a more balanced approach in cancer news coverage.
A RAND-UCLA study found that patients with stage III colon cancer receive chemotherapy at a lower rate than recommended, with older patients being less likely to receive the strongest treatment. Despite this, older patients do not experience more adverse outcomes compared to younger patients.
Peter K. Vogt's groundbreaking discovery of src, the first cancer-causing gene, has profoundly changed biology and medicine. His research has yielded several important targets in cancer therapy.
Two studies reveal a significant increase in non-melanoma skin cancers in the US, with over 13 million Americans affected by 2007. The disease is associated with substantial illness and cost, and continues to be a major public health concern.
A study found that nearly half of dying cancer patients visit the emergency department in the last two weeks of life, often due to uncontrolled symptoms. Effective palliative care can help manage these symptoms and reduce visits to the emergency department.
A new clinical trial at the Virginia G. Piper Cancer Center uses molecular profiling to identify specific treatments for refractory breast cancer. The trial aims to keep cancer under control for longer periods and potentially shrink tumors.
A new study published in the Lancet finds that apixaban is more effective and convenient than enoxaparin in preventing thromboembolism after knee replacement surgery. The anticoagulant also poses less risk of bleeding, a concern with current treatments. This could lead to better patient outcomes and quality of life.
Researchers found that adding tests to cystoscopy increases costs and false positives, while cystoscopy alone is the most effective in detecting tumors. The study suggests that clinicians can make judicious use of urinary markers to reduce costs and anxiety for bladder cancer patients.
A review of over three decades of studies suggests that insulin therapy may increase cancer risk, particularly in those with type 2 diabetes. The study's findings also highlight the potential benefits of metformin treatment in reducing cancer incidence.
Only 25 US states have enacted legislation covering cancer clinical trial costs, with varying requirements for scientific and ethical review. The study highlights the need for closer communication between lawmakers and oncology experts to improve research and patient care.
Researchers found that GP referrals for gynaecological investigation were delayed for older women with suspected ovarian cancer. Women over 70 years old had a 20-week wait for referral, while those aged 75-79 years had a peak wait of 24 weeks. The discrepancy may be due to differences in data recording and GPs' motivation.
A combination of Herceptin and Tykerb significantly inhibits tumor growth in gastric cancers with HER2 amplification, providing a new treatment option for tens of thousands of patients worldwide.
Aspiration is a fast and first approach for evaluating breast lumps without cancerous features. The procedure determines the type of lesion by removing fluid with a needle, which can be done in a doctor's office on women who do not have breast implants or are not on anticoagulants.
Proton beam radiation therapy has been shown to provide encouraging results for patients with locally advanced sinonasal malignancies, with high local control rates at five and eight years after treatment. The study found no significant difference in local control rates based on histological subtype, T stage, or prior surgery.
A large population-based study found that contralateral prophylactic mastectomy (CPM) offers a survival benefit to a select group of breast cancer patients, primarily those under 50 years old and ER-negative. The procedure was associated with a 4.8% increased survival rate at five years for these patients.
A study found that contralateral prophylactic mastectomy is associated with improved 5-year breast cancer-specific survival rates for younger women with early-stage, estrogen-receptor negative tumors. However, the benefit is small and does not apply to most women with breast cancer.
A new study published in The Lancet found that removing both pelvic and para-aortic lymph nodes significantly improves survival rates for patients with endometrial cancer who are at intermediate or high risk of cancer recurrence. The researchers concluded that this complete procedure should be recommended to these patients.
A study by Collinge & Associates found that 14-minute massage sessions by family members significantly reduced stress and anxiety scores in advanced cancer patients. The research also showed improvements in fatigue, depression, and nausea, with effects comparable to professional massage therapy.
Researchers have found a new oncogenic signaling pathway by which arsenic may lead to adverse health effects, including bladder cancer. High levels of arsenic exposure are associated with high levels of Hedgehog activity, supporting the link between arsenic and increased cancer risk.
Researchers developed a new approach to track cancer by identifying personalized biomarkers from tumor DNA, using next-generation sequencing technology. The findings show that this method can provide accurate and specific monitoring of tumors, allowing for better assessment of treatment effectiveness.
Researchers at Johns Hopkins have developed a new approach to detect cancer using whole genome sequencing, identifying rearrangements of DNA that can be found in tumor cells. This approach, called Personalized Analysis of Rearranged Ends (PARE), may help clinicians tailor treatments and monitor tumor levels after therapy.
Researchers have identified a distinct type of mutation in acute myeloid leukemia patients that could account for half of the remaining cases. The mutations lead to increased production of a molecule called 2HG, which may block the ability of leukemic cells to differentiate into normal blood cells.
Researchers developed a standard checklist to facilitate safe administration of sedation at home, finding that PS does not hasten death and is used more frequently in hospitals. The study's findings aim to ease concerns about using palliative sedation in home care settings.
ATM senses DNA damage, ordering repairs or cell death, while also responding to oxidative harm outside the nucleus. This discovery reveals a potential way to activate tumor-suppressors without damaging DNA.
Certain patients with inflammatory bowel disease have an increased risk of developing colorectal cancer. The AGA recommends individualized surveillance plans based on each patient's unique situation, taking into account disease duration, primary sclerosing cholangitis, and family history.
The COMICE study found that adding MRI to conventional triple assessment for breast cancer diagnosis had no impact on reoperation rates. Despite this, the study suggests that routine use of MRI in this population may not reduce health outcomes or costs, but rather increase them. The results have implications for healthcare providers an...
Research suggests that atypical intestinal metaplasia (AIM) may be a precancerous lesion, indicating a higher risk of gastric cancer. The study proposes a new classification system for intestinal metaplasia, distinguishing between simple and atypical subtypes.
A new study by Northwestern University's Feinberg School of Medicine and the American College of Surgeons found that community hospitals can offer safe surgical options for certain types of cancer surgeries. Younger patients with few pre-existing illnesses have similar survival rates at both community hospitals and specialized cancer c...
A study of cancer survivors found that they become advocates for others but not themselves, suggesting a transition from passive to active care. They advise peers with cancer to seek second opinions, check doctors' credentials, and stay positive.
Researchers developed a mathematical model to predict cervical cancer treatment outcomes, allowing for quicker identification of non-responding tumors. The model uses MRI scans and can provide a prediction accuracy of 90 percent for local tumor control and recurrence.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have performed the first complete genomic sequencing of a brain cancer cell line, revealing a unique biological signature that may lead to new therapies. The study also holds promise for developing patient-specific diagnostics to monitor for cancer recurrence.
A combined chemotherapy regimen of capecitabine and oxaliplatin given before chemoradiotherapy and surgery is well tolerated and shows promising anti-tumour activity in patients with poor-risk rectal cancer. The treatment improves overall survival rates, with 68% of patients progression-free after 3 years.
The Cancer Genome Atlas reveals four molecular subtypes of glioblastoma multiforme (GBM), the most common form of malignant brain cancer in adults. Researchers found that response to chemotherapy and radiation differed by subtype, with some subtypes experiencing a 50% slower disease progression.
A study of young age gastric cancer patients in Korea found that epidemiologic characteristics, risk factors, and treatment approaches differ by age and gender. Hormonal factors were more common in females, while environmental factors were more common in males, particularly in the older age group.
Two studies by University of Pittsburgh researchers found that surveillance colonoscopy is being overused in low-risk patients and underused in high-risk patients. The studies suggest that colonoscopy use should be aligned with patient risk to improve healthcare spending.
Researchers at TGen Clinical Research Services have discovered three microRNAs that can predict patients with small-cell lung cancer who will be resistant to first-line chemotherapy. These biomarkers, miR-92a-2*, miR-147, and miR-574-5p, were identified through a study of 34 patients with varying stages of SCLC.
Researchers identified three microRNAs linked to chemoresistance in small cell lung cancer, affecting up to 15-30% of patients who are resistant to first-line therapy. The study provides new insights into predicting patient response to treatment and designing targeted therapies.
A University of Leeds research project aims to develop new treatments for multiple myeloma patients, using techniques such as injecting cements into the spine. The study seeks to improve quality of life for patients suffering from this incurable bone marrow cancer.
Researchers have discovered genetic differences in pediatric brain tumors that can help explain tumor development and potentially lead to targeted treatments. The study identified a subset of malignant astrocytomas with specific genetic alterations, which may enable more individualized care for children with brain cancer.
Phase II study results of ASA404 showed improved overall survival in patients with squamous and non-squamous NSCLC compared to chemotherapy alone. The drug's unique mechanism of action inhibits tumor blood flow, providing a potential new treatment option for limited options.
A recent study suggests that retreating patients with non-small cell lung cancer who initially responded to gefitinib treatment could lead to additional partial responses and stable disease. The overall disease control rate was 66.7 percent in the retreatment group, offering hope for patients who have failed initial chemotherapy.
A new study published in the Journal of the National Cancer Institute found that having multiple family members with pancreatic cancer significantly increases an individual's risk of developing the disease. Relatives with a relative diagnosed under 50 years old are at a ninefold higher risk than the general population.
A study found that erlotinib dosing in lung cancer patients depends on their smoking status, with smokers requiring lower doses than non-smokers. Non-smokers were able to tolerate higher doses without developing grade 2 or 3 toxicity, while smokers reached a maximum tolerated dose of 300mg daily.
A new blood test has been developed to aid in lung cancer diagnosis and potentially reduce unnecessary invasive procedures. The test uses a 40-biomarker panel that correctly identified patients with lung cancer 88% of the time and those without it 79% of the time.
A combined PET-CT scan can accurately detect cancer in patients with neurologic symptoms more effectively than other tests. The study found that PET-CT detected abnormalities suggestive of cancer in 39% of patients, leading to early treatment and improved outcomes for 12 patients.
Researchers found that nine cases of colorectal cancer were diagnosed over 7,626 person-years of observation, with most cancers detected at early stages. The study highlights the importance of close follow-up for patients with a history of advanced adenoma.
A Phase II study found celecoxib effective in reducing basal cell carcinoma development in patients with Gorlin syndrome, a rare genetic disorder. The drug showed promise as a chemoprevention therapy for this population.