Articles tagged with Cancer Patients
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A new study published in the Lancet finds that apixaban is more effective and convenient than enoxaparin in preventing thromboembolism after knee replacement surgery. The anticoagulant also poses less risk of bleeding, a concern with current treatments. This could lead to better patient outcomes and quality of life.
Researchers found that adding tests to cystoscopy increases costs and false positives, while cystoscopy alone is the most effective in detecting tumors. The study suggests that clinicians can make judicious use of urinary markers to reduce costs and anxiety for bladder cancer patients.
A review of over three decades of studies suggests that insulin therapy may increase cancer risk, particularly in those with type 2 diabetes. The study's findings also highlight the potential benefits of metformin treatment in reducing cancer incidence.
Only 25 US states have enacted legislation covering cancer clinical trial costs, with varying requirements for scientific and ethical review. The study highlights the need for closer communication between lawmakers and oncology experts to improve research and patient care.
Researchers found that GP referrals for gynaecological investigation were delayed for older women with suspected ovarian cancer. Women over 70 years old had a 20-week wait for referral, while those aged 75-79 years had a peak wait of 24 weeks. The discrepancy may be due to differences in data recording and GPs' motivation.
A combination of Herceptin and Tykerb significantly inhibits tumor growth in gastric cancers with HER2 amplification, providing a new treatment option for tens of thousands of patients worldwide.
Aspiration is a fast and first approach for evaluating breast lumps without cancerous features. The procedure determines the type of lesion by removing fluid with a needle, which can be done in a doctor's office on women who do not have breast implants or are not on anticoagulants.
Proton beam radiation therapy has been shown to provide encouraging results for patients with locally advanced sinonasal malignancies, with high local control rates at five and eight years after treatment. The study found no significant difference in local control rates based on histological subtype, T stage, or prior surgery.
A large population-based study found that contralateral prophylactic mastectomy (CPM) offers a survival benefit to a select group of breast cancer patients, primarily those under 50 years old and ER-negative. The procedure was associated with a 4.8% increased survival rate at five years for these patients.
A study found that contralateral prophylactic mastectomy is associated with improved 5-year breast cancer-specific survival rates for younger women with early-stage, estrogen-receptor negative tumors. However, the benefit is small and does not apply to most women with breast cancer.
A new study published in The Lancet found that removing both pelvic and para-aortic lymph nodes significantly improves survival rates for patients with endometrial cancer who are at intermediate or high risk of cancer recurrence. The researchers concluded that this complete procedure should be recommended to these patients.
A study by Collinge & Associates found that 14-minute massage sessions by family members significantly reduced stress and anxiety scores in advanced cancer patients. The research also showed improvements in fatigue, depression, and nausea, with effects comparable to professional massage therapy.
Researchers have found a new oncogenic signaling pathway by which arsenic may lead to adverse health effects, including bladder cancer. High levels of arsenic exposure are associated with high levels of Hedgehog activity, supporting the link between arsenic and increased cancer risk.
Researchers developed a new approach to track cancer by identifying personalized biomarkers from tumor DNA, using next-generation sequencing technology. The findings show that this method can provide accurate and specific monitoring of tumors, allowing for better assessment of treatment effectiveness.
Researchers at Johns Hopkins have developed a new approach to detect cancer using whole genome sequencing, identifying rearrangements of DNA that can be found in tumor cells. This approach, called Personalized Analysis of Rearranged Ends (PARE), may help clinicians tailor treatments and monitor tumor levels after therapy.
Researchers have identified a distinct type of mutation in acute myeloid leukemia patients that could account for half of the remaining cases. The mutations lead to increased production of a molecule called 2HG, which may block the ability of leukemic cells to differentiate into normal blood cells.
Researchers developed a standard checklist to facilitate safe administration of sedation at home, finding that PS does not hasten death and is used more frequently in hospitals. The study's findings aim to ease concerns about using palliative sedation in home care settings.
ATM senses DNA damage, ordering repairs or cell death, while also responding to oxidative harm outside the nucleus. This discovery reveals a potential way to activate tumor-suppressors without damaging DNA.
Certain patients with inflammatory bowel disease have an increased risk of developing colorectal cancer. The AGA recommends individualized surveillance plans based on each patient's unique situation, taking into account disease duration, primary sclerosing cholangitis, and family history.
The COMICE study found that adding MRI to conventional triple assessment for breast cancer diagnosis had no impact on reoperation rates. Despite this, the study suggests that routine use of MRI in this population may not reduce health outcomes or costs, but rather increase them. The results have implications for healthcare providers an...
Research suggests that atypical intestinal metaplasia (AIM) may be a precancerous lesion, indicating a higher risk of gastric cancer. The study proposes a new classification system for intestinal metaplasia, distinguishing between simple and atypical subtypes.
A new study by Northwestern University's Feinberg School of Medicine and the American College of Surgeons found that community hospitals can offer safe surgical options for certain types of cancer surgeries. Younger patients with few pre-existing illnesses have similar survival rates at both community hospitals and specialized cancer c...
A study of cancer survivors found that they become advocates for others but not themselves, suggesting a transition from passive to active care. They advise peers with cancer to seek second opinions, check doctors' credentials, and stay positive.
Researchers developed a mathematical model to predict cervical cancer treatment outcomes, allowing for quicker identification of non-responding tumors. The model uses MRI scans and can provide a prediction accuracy of 90 percent for local tumor control and recurrence.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have performed the first complete genomic sequencing of a brain cancer cell line, revealing a unique biological signature that may lead to new therapies. The study also holds promise for developing patient-specific diagnostics to monitor for cancer recurrence.
A combined chemotherapy regimen of capecitabine and oxaliplatin given before chemoradiotherapy and surgery is well tolerated and shows promising anti-tumour activity in patients with poor-risk rectal cancer. The treatment improves overall survival rates, with 68% of patients progression-free after 3 years.
The Cancer Genome Atlas reveals four molecular subtypes of glioblastoma multiforme (GBM), the most common form of malignant brain cancer in adults. Researchers found that response to chemotherapy and radiation differed by subtype, with some subtypes experiencing a 50% slower disease progression.
A study of young age gastric cancer patients in Korea found that epidemiologic characteristics, risk factors, and treatment approaches differ by age and gender. Hormonal factors were more common in females, while environmental factors were more common in males, particularly in the older age group.
Two studies by University of Pittsburgh researchers found that surveillance colonoscopy is being overused in low-risk patients and underused in high-risk patients. The studies suggest that colonoscopy use should be aligned with patient risk to improve healthcare spending.
Researchers at TGen Clinical Research Services have discovered three microRNAs that can predict patients with small-cell lung cancer who will be resistant to first-line chemotherapy. These biomarkers, miR-92a-2*, miR-147, and miR-574-5p, were identified through a study of 34 patients with varying stages of SCLC.
Researchers identified three microRNAs linked to chemoresistance in small cell lung cancer, affecting up to 15-30% of patients who are resistant to first-line therapy. The study provides new insights into predicting patient response to treatment and designing targeted therapies.
A University of Leeds research project aims to develop new treatments for multiple myeloma patients, using techniques such as injecting cements into the spine. The study seeks to improve quality of life for patients suffering from this incurable bone marrow cancer.
Researchers have discovered genetic differences in pediatric brain tumors that can help explain tumor development and potentially lead to targeted treatments. The study identified a subset of malignant astrocytomas with specific genetic alterations, which may enable more individualized care for children with brain cancer.
Phase II study results of ASA404 showed improved overall survival in patients with squamous and non-squamous NSCLC compared to chemotherapy alone. The drug's unique mechanism of action inhibits tumor blood flow, providing a potential new treatment option for limited options.
A recent study suggests that retreating patients with non-small cell lung cancer who initially responded to gefitinib treatment could lead to additional partial responses and stable disease. The overall disease control rate was 66.7 percent in the retreatment group, offering hope for patients who have failed initial chemotherapy.
A new study published in the Journal of the National Cancer Institute found that having multiple family members with pancreatic cancer significantly increases an individual's risk of developing the disease. Relatives with a relative diagnosed under 50 years old are at a ninefold higher risk than the general population.
A study found that erlotinib dosing in lung cancer patients depends on their smoking status, with smokers requiring lower doses than non-smokers. Non-smokers were able to tolerate higher doses without developing grade 2 or 3 toxicity, while smokers reached a maximum tolerated dose of 300mg daily.
A new blood test has been developed to aid in lung cancer diagnosis and potentially reduce unnecessary invasive procedures. The test uses a 40-biomarker panel that correctly identified patients with lung cancer 88% of the time and those without it 79% of the time.
A combined PET-CT scan can accurately detect cancer in patients with neurologic symptoms more effectively than other tests. The study found that PET-CT detected abnormalities suggestive of cancer in 39% of patients, leading to early treatment and improved outcomes for 12 patients.
Researchers found that nine cases of colorectal cancer were diagnosed over 7,626 person-years of observation, with most cancers detected at early stages. The study highlights the importance of close follow-up for patients with a history of advanced adenoma.
A Phase II study found celecoxib effective in reducing basal cell carcinoma development in patients with Gorlin syndrome, a rare genetic disorder. The drug showed promise as a chemoprevention therapy for this population.
A study published in the journal Cancer found that radiofrequency ablation (RFA) significantly reduced pain from bone metastases in patients. RFA is a minimally invasive cancer treatment that uses heat to kill tumor cells, eliminating the need for strong narcotic pain management.
Researchers at Georgetown Lombardi Comprehensive Cancer Center report a significant advance in personalized medicine using a new chip that examines hundreds of genetic mutations. The chip, called DMET, could replace highly-specialized and labor-intensive genotyping tools, accelerating cancer research and treatment.
A study published in the Journal of the National Cancer Institute found that urinary tract cancer is associated with the use of Chinese herbal products containing aristolochic acid. The risk increased with higher doses and was independent of arsenic exposure. The authors recommend continued surveillance and monitoring of patients who h...
Researchers used DNA sequencing technology to analyze genetic mutations in small-cell lung cancer cells and compared them to normal DNA. They found over 23,000 mutations and identified a new gene, CHD7, involved in lung cancer.
A comprehensive infection control program at the Seattle Cancer Care Alliance successfully suppressed H1N1 cases among immunocompromised cancer patients, despite a high-risk environment. The program's rigorous screening measures, isolation protocols, and staff vaccination policies significantly minimized transmission and acquisition.
Research teams analyzed cancer genomes, uncovering over 30,000 mutations in lung cancer and 33,000 in melanoma, which carried records of when and how they occurred. The studies revealed the impact of environmental mutagens, such as cigarette smoke and sunlight, on DNA.
Researchers at Dana-Farber Cancer Institute found that support of patients' spiritual needs by medical teams is associated with greater use of hospice care, less aggressive treatment, and better quality of life near death. Patients whose spiritual needs were largely or completely supported had scores on average 28% higher in well-being.
A new study reveals significant variation in radiation doses for CT procedures, with some patients receiving up to 13-fold more exposure than others. The research highlights the need for standardization to reduce the risk of cancer associated with CT scans.
A new study found that cancer patients with dementia have a lower survival rate than those without dementia, even after controlling for age, tumor type, and stage. Patients with mild cognitive impairment can still live independently for nearly four and a half years, while those with moderate to severe dementia have an average survival ...
Studies quantify radiation doses and cancer risks from CT scans, revealing wide variations in doses and estimated lifetime cancer risks. The studies estimate that tens of thousands of future cancer cases may be related to CT scans performed annually.
Researchers at M. D. Anderson Cancer Center identified an association between mucinous carcinoma and multiple undetected tumors, contrary to its long-considered favorable prognosis. The study suggests that these patients may need more treatment and additional screening.
A new review emphasizes the need for cardio-oncology to address cardiovascular side effects of cancer treatments. The authors suggest identifying high-risk patients with biomarkers and imaging techniques to reduce morbidity and mortality.
Researchers found that genetic variations in the Sonic Hedgehog pathway increase the likelihood of bladder cancer recurrence, reduce survival time, and limit response to immunotherapy. Patients with certain variations had a significantly shorter recurrence-free survival time compared to those without.
A new study found that cancer patients treated with epidermal growth factor receptor inhibitors (EGFRIs) have a high prevalence of skin and nail infections. The researchers discovered that 38% of patients developed these infections, including bacterial infections resistant to common antibiotics.
A study found that people living in poorer neighborhoods are at a higher risk for death and have worse health outcomes, regardless of their dietary and lifestyle habits. The research controlled for various risk factors but still showed a significant association between neighborhood deprivation and increased mortality.
Researchers identified 18 single-point genetic variations linked to recurrence and secondary cancer in early-stage head and neck cancer patients. Genetic variations in miRNA biogenesis genes and binding sites were associated with an increased risk of recurrence or secondary primary tumors.
Researchers found that vitamin D levels in patients with diffuse large B-cell lymphoma were strongly associated with cancer progression and overall survival. Patients with deficient vitamin D levels had a 1.5-fold greater risk of disease progression.
A new three-drug combination has shown a highly effective regimen in treating newly diagnosed patients with multiple myeloma, with partial responses or better seen in all 66 patients. The treatment also resulted in encouraging complete or near-complete responses at 54 percent.
A new study published in the Journal of the National Cancer Institute found that late recurrence is a risk for some pediatric cancers, particularly Ewing sarcomas and tumors of the central nervous system. The study analyzed data from over 12,000 childhood cancer survivors and found varying rates of late recurrence depending on the type...