Cancer Risk
Articles tagged with Cancer Risk
National study examines genetic testing to inform follow-up care for cancer survivors
ERASur colorectal cancer trial reaches one-third patient accrual milestone
The ERASur clinical trial is investigating whether total ablative therapy can improve overall survival in patients with newly diagnosed, limited metastatic colorectal cancer. The study has reached one-third patient accrual milestone, signaling strong momentum.
Trial now enrolling seeks to answer key question: Does adding chemotherapy to hormone therapy improve survival for metastatic prostate cancer?
The ASPIRE trial aims to enroll 1,200 participants with advanced prostate cancer and assess the impact of chemotherapy on overall survival and disease progression. Genetic profiling is included to identify patients who benefit most from intensified treatment.
Blood stem cells evade immunity in aplastic anemia by similar genetic mutations arising independently
Researchers at St. Jude Children's Research Hospital discovered that blood stem cells with aplastic anemia escape the immune system by acquiring different gene mutations independently. These mutations, such as HLA loss and CHIP gene changes, allow cells to hide from the immune system and provide long-term remission.
The benefits of prostate cancer screening outweigh the harms, according to new patient guidelines from NCCN
The new NCCN Guidelines for Patients: Prostate Cancer Screening provide a comprehensive guide to evidence-based recommendations for age-specific screening. The guidelines aim to balance the benefits of early detection with the risks of unnecessary procedures, emphasizing the importance of personalized care and monitoring.
Age, sex, and cancer type influence risk of subsequent cancers among survivors
A study published in PLOS Medicine found that age at initial diagnosis, sex, and type of first cancer significantly affect the risk of developing a subsequent primary cancer. Older age and male sex were associated with a higher risk, while survivors of lung, bladder, and skin melanoma were also at increased risk.
Mail-in test for colorectal cancer could help community health centers increase screening
Researchers found that a newer stool-based screening test, FIT-DNA, increased completion rates among participants from community health centers. However, follow-up colonoscopy tests remained low, highlighting the need for continued support and access to diagnostic services.
Primary breast tumors already harbor cells with metastatic potential
Researchers have identified the Prrx1 gene as a key regulator of metastatic potential in breast cancer tumors. This discovery helps explain why highly invasive cells do not always give rise to metastases, and how cells combine invasiveness and proliferation to become the most dangerous from a clinical perspective.
Alliance for Clinical Trials in Oncology supports April Head and Neck Awareness Month
The Alliance for Clinical Trials in Oncology has several active trials specifically designed to help people with head and neck cancers. Trials include testing high-dose prophylactic gabapentin to prevent opioid use during treatment, as well as immunotherapy with nivolumab and cabozantinib for mucosal melanoma and nasopharyngeal carcino...
Link between male infertility and increased risk of cancer
Research from Lund University found a link between male infertility and an increased risk of developing colorectal and thyroid cancer. Men who underwent assisted reproduction techniques, such as ICSI, were more likely to develop these cancers.
City of Hope scientists to share new findings on cancer risk, immune resistance and AI‑driven discovery at AACR 2026
Researchers at City of Hope present findings on early-onset colorectal cancer, highlighting the role of gut microbiome differences and a new molecular pathway in immune resistance. The study uses AI tools to analyze complex relationships between data types, shedding light on potential strategies for earlier detection and treatment.
BRCA gene mutations now implicated in thyroid, bladder, skin, and head and neck cancer
Researchers found associations between BRCA1/2 pathogenic variants and four types of cancer: thyroid, bladder, skin, and head and neck. Pathogenic variants in BRCA1 increase thyroid cancer risk, while BRCA2 increases risk for bladder, head and neck, and skin cancers.
EMBARGOED: Cancer risk is significantly higher for adults who never married, large study finds
A large U.S. study found that adults who never married have substantially higher rates of developing cancer compared to those who are or have been married. The association is strongest for cancers related to infection, smoking, and alcohol use, with women facing a significantly higher risk than men.
JMIR Publications showcases precision oncology success: individualized multi-drug therapy outperforms standard care
A new article in JMIR Publications showcases precision oncology's success, where individualized multi-drug regimens improve treatment responses and survival rates for patients with advanced cancers. The study found that closely matching drug therapies to tumor mutations leads to better outcomes, while also offering a safer profile.
UCLA researchers develop low-cost blood test to detect multiple cancers and other diseases from a single sample
A new, cost-effective blood test detects liver, lung, ovarian, stomach cancers, and various non-cancer conditions by analyzing DNA fragments in the bloodstream. The test achieved high accuracy rates for multi-cancer detection and tissue-of-origin identification.
Vaping likely to cause cancer: New findings
A new study by UNSW Sydney and published in Carcinogenesis suggests that nicotine-based vapes are likely to cause cancers of the lung and oral cavity. The research, led by Adjunct Professor Bernard Stewart AM, analyzed global research and found consistent findings across multiple disciplines.
Early results from a trial of active surveillance for low-risk DCIS are ‘reassuring’
Researchers have reported early, reassuring results from the LORD trial on active surveillance for low-risk DCIS. The study found that patients with active surveillance did not experience worse early outcomes compared to those who underwent immediate surgery, and that many chose active surveillance over surgery.
Do psychosocial factors affect cancer risk?
A large-scale study of over 421,000 individuals found no link between psychosocial factors and cancer incidence. However, some psychosocial factors were associated with a higher risk of lung cancer, which decreased after adjusting for known risk factors.
New alliance clinical trial aims to improve outcomes in brain tumors
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
Timely scan could save lives of A&E patients with blood in urine
A new study found that A&E patients with visible blood in their urine who receive a scan within 48 hours are 2.5% less likely to die within three months. The study also showed that patients with cancer are diagnosed significantly faster when they receive prompt investigation.
The cost of survival: Women more likely to survive cancer but suffer more severe side effects
A recent study found that women have a 21% lower risk of death compared to men, but a 12% higher risk of severe side effects from cancer treatment. The research, conducted in partnership with international collaborators, analyzed data from over 20,000 cancer patients and identified sex-based differences in survival and treatment toxicity.
Personalized support program improves smoking cessation for cervical cancer survivors
A new study by UCLA researchers shows that a personalized counseling program, called Motivation and Problem-Solving (MAPS), can help cervical cancer survivors quit smoking, with twice as many women quitting compared to standard support. The program's cost-effectiveness is also demonstrated, with the probability of being cost-effective ...
Scan that makes prostate cancer cells glow could cut need for biopsies
A new imaging test, PSMA PET/CT scan, has been shown to safely reduce the number of biopsies needed for suspected prostate cancer, with no harm to patients. The PRIMARY2 trial found that the scan could identify low-risk patients who did not need a biopsy, while targeting suspicious areas for those who did.
How do rapid socio-environmental transitions reshape cancer risk?
A study found North Korean defectors had higher risks of infection-related cancers but lower risks of breast, colon, and prostate cancers compared to South Korean residents. Over time, their cancer profile changed, suggesting adaptation to South Korean society.
Research presented at international urology conference in London shows how far prostate cancer screening has come
Research presented at EAU26 confirms that prostate cancer screening leads to a reduction in mortality, but also detects cancers that would otherwise remain undetected. The study's findings suggest that using MRI in prostate cancer screening can reduce overdiagnosis and unnecessary biopsies.
Severe COVID-19, flu facilitate lung cancer months or years later, new research shows
Severe COVID-19 and influenza infections can prime the lungs for cancer development, according to new research. Vaccination, however, largely prevents these changes, suggesting a reduced risk of lung cancer.
Singapore sees increase in breast cancer cases but fewer deaths
Singapore's breast cancer incidence is rising, but mortality rates are falling, mirroring global trends. The country's strong healthcare system and high-screening participation have contributed to improved survival rates.
New trial seeks to improve sharing of genetic colorectal cancer risks
A new clinical study aims to improve communication between patients and families about genetic risks of colorectal cancer. The trial will compare two methods of sharing genetic test results with close relatives, with the goal of learning which approach helps more family members get necessary genetic testing.
$10 million gift establishes the King Center for Lynch Syndrome at Penn Medicine
The King Center for Lynch Syndrome will advance research, outreach, education, and patient care for Lynch syndrome, a hereditary condition affecting 1 in 279 individuals. The center will provide cutting-edge research, life-long comprehensive care, and increased awareness for patients and families affected by Lynch syndrome.
Researchers create world’s largest dog and cat tumour database
The team has created a unified resource to explore patterns previously hidden by fragmented reporting. Early analyses have raised questions about the influence of neutering practices on cancer risks in pets.
Renowned cancer physician and researcher Dr. Daniela Matei to lead Houston Methodist Neal Cancer Center
Renowned cancer clinician Dr. Daniela Matei will lead the Houston Methodist Dr. Mary and Ron Neal Cancer Center, bringing expertise in ovarian cancer treatment and therapeutics. She aims to bridge laboratory science to the clinic, advancing new concepts from bench to bedside.
Screening improves early detection of colorectal cancer
Researchers found that both screening methods lead to more cases of early-stage cancer being detected, especially in the first two years. The study suggests that screening may have a preventive effect by removing precursors to cancer.
How bacteria may promote breast cancer
Pathogenic bacteria in gut and breast tissue can promote breast cancer development by increasing SMOX activity, leading to DNA damage and tumor growth. Targeting SMOX with inhibitors could be a viable strategy to counteract the cancer-promoting effects of microbial dysbiosis.
Call for action on understudied lung cancer in never-smokers
A new review highlights the growing burden of lung cancer in never-smokers, emphasizing the need for dedicated research, screening, and clinical trials. The study argues that LCINS has distinct causes and biology requiring a different approach to diagnosis and treatment.
Does a past abortion or miscarriage affect a woman’s risk of developing breast cancer?
A nationwide Finnish registry-based study found no increased risk of pre- or postmenopausal breast cancer among women with a history of induced abortion or miscarriage. Breast cancer risks were similar regardless of the number of abortions or miscarriages, as well as the time of first abortion or miscarriage.
Have associations between historical redlining and breast cancer survival changed over time?
A study found that historical redlining has a lasting impact on breast cancer survival, with disparities narrowing from 1995-2014 but increasing in 2015-2019. Redlining-associated mortality disparities were mostly seen in patients with less advanced tumors.
Study in US veterans identifies agent orange exposure as a risk factor for rare skin cancer
A study of US veterans has identified a possible link between exposure to Agent Orange and acral melanoma, a rare form of skin cancer. The researchers found that veterans exposed to the herbicide had a 30% higher odds of developing this type of melanoma.
Updated guidelines standardize how tumor response is measured after surgery
The updated guidelines provide a unified framework for evaluating residual viable tumor, necrosis, and regression after presurgical treatment. The new criteria demonstrate high reproducibility across different tumor types and pathologists, providing a foundation for standardized data collection and improved patient care.
How does lifetime alcohol consumption affect colorectal cancer risk?
Research reveals that higher lifetime alcohol consumption is associated with a higher risk of colorectal cancer, especially for rectal cancer. Quitting drinking can lower a person’s risk, according to the findings published in CANCER, a peer-reviewed journal.
New model improves prediction of prostate cancer death risk
A new long-term prediction tool estimates the risk of dying from prostate cancer by combining PSA levels with factors like family history, race, age, and other health conditions. The tool showed higher accuracy in predicting prostate cancer death over decades compared to existing models.
A study by CNIO identifies new genes that predispose an individual to pancreatic cancer
A new study by CNIO has identified two genes in the complement system that increase the risk of pancreatic ductal adenocarcinoma. These genes, FCN1 and PLAT, may serve as biomarkers for screening high-risk populations.
New research decodes the bacterial “zip code” of colorectal cancer for prediction and survival
Researchers identified specific microbial patterns associated with tumor location, genetic features, and patient outcomes. A new Microbial Risk Score (MRS) offers a practical way to translate complex microbiome data into prognostic insight.
New prostate cancer trial seeks to reduce toxicity without sacrificing efficacy
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Study: Simple wipe test finds invisible cancer-linked PFAs on firefighter gear
A new study has validated a non-destructive method to detect 'forever chemicals' on protective equipment, reducing the risk of cancer to firefighters. Researchers found PFAS in every set of firefighter gear examined, including breathing masks, with concentrations reaching hundreds of nanograms per gram.
Clostridioides difficile: A suspected pro-carcinogenic bacterium for gastrointestinal tumors
A recent review suggests that Clostridioides difficile infection may promote the development of gastrointestinal tumors, including colorectal cancer. The bacterium's toxins can cause damage to the epithelial cytoskeleton and induce inflammation, leading to chronic colitis and increased risk of CRC.
Potentially toxic elements in bananas grown in the Mariana disaster region exceed FAO limits
The study found that consuming bananas grown in soil impacted by iron mining waste poses a possible health risk to children aged six years or younger. The team correlated the risk to human health with the transfer of toxic elements from the soil to the plant, revealing high concentrations of cadmium, chromium, and other metals.
Blood test may help identify which colon cancer patients benefit from NSAIDs
A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.
$4.2M CDC grant to increase colorectal cancer screening in Pennsylvania
The grant aims to increase individual screenings and change how health systems embed evidence-based screening practices into everyday operations. PA-CARES will work with trusted organizations in 28 counties with the lowest screening rates to implement effective screening options and facilitate timely linkage to care.
Cell-free DNA Could Detect Adverse Events from Immunotherapy
Researchers developed a non-invasive blood test to detect genetic material shed by tumors, which can identify adverse events related to immune checkpoint inhibitor therapy. The test found evidence of multi-organ injury in patients with immune-related adverse events, suggesting that the clinical syndromes may represent only a small frac...
GLP-1 receptor agonists likely have little or no effect on obesity-related cancer risk
A systematic review and meta-analysis found that GLP-1 receptor agonists probably have little or no effect on the risk of thyroid, pancreatic, breast, or kidney cancer in patients with type 2 diabetes or overweight/obesity. However, longer-term studies are needed to clarify potential risks or benefits for other obesity-related cancers.
Much-needed new drug approved for deadliest blood cancer
Researchers at the University of Virginia Health System have developed a new treatment for acute myeloid leukemia, a deadly form of blood cancer. The FDA-approved medication works by disrupting cellular protein interactions that drive leukemia cell growth and survival, offering patients a potential cure.
Queens Cancer Center Oncology nurse receives Alliance CRP RISE Award for Advancing Cancer Research
Linda Bulone, a Queens Cancer Center Oncology nurse, received the 2025 Alliance Clinical Research Professionals Research Integrity Service Excellence (CRP RISE) Award. She has significantly increased clinical trial participation, expanded early screening efforts, and supported reductions in late-stage diagnoses.
Scientists move closer to better pancreatic cancer treatments
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
Veteran suicide rates are declining, but remain high for those with brain injuries, research shows
New research from the University of Utah shows a significant decline in veteran suicide rates since 2020, but rates remain high for those with traumatic brain injuries (TBI). The study's findings highlight the importance of safe gun use and various suicide prevention measures.
Chinese Neurosurgical Journal study explores AI tool to predict medulloblastoma subtypes and genetic risks with high accuracy
A new study published in the Chinese Neurosurgical Journal explores an AI tool that identifies medulloblastoma subgroups based on magnetic resonance imaging scans. The model achieved impressive accuracy in predicting molecular subtypes and genetic risk factors, with 91% accuracy for TP53 mutations and 87% accuracy for chromosome 11 loss.
New USC study identifies key genes linked to aggressive prostate cancer in people of African descent
A new USC study identified five genes linked to aggressive prostate cancer in people of African descent, including ATM, BRCA2, CHEK2, HOXB13 and PALB2. The researchers developed a method combining genetic risk scores with family history and specific variant presence for personalized monitoring and treatment strategies.
Extensive LA-area fires altered blood proteins in firefighters, raising health concerns
A new study found that extensive wildfires in the LA area caused changes in firefighters' immune systems and inflammatory response pathways. The research identified 60 changes in serum proteome, affecting various bodily functions.
Consistent adherence to physical activity guidelines and digestive system cancer risk and mortality
A study found that maintaining moderate physical activity over three decades can significantly reduce digestive system cancer risk. The optimal level of physical activity was around 17 metabolic equivalent task-hours/week, equivalent to 5 hours of brisk walking or 2 hours of running per week.
MD Anderson shares latest research breakthroughs
Researchers at MD Anderson Cancer Center identified distinct cellular microenvironments in diffuse large B-cell lymphoma tumors, providing a framework to develop therapies that engage the patient's immune system. Additionally, a study found widespread misbeliefs about the cancer risks of alcohol among Americans, highlighting the need f...