Articles tagged with Cancer Risk
A study found that maintaining moderate physical activity over three decades can significantly reduce digestive system cancer risk. The optimal level of physical activity was around 17 metabolic equivalent task-hours/week, equivalent to 5 hours of brisk walking or 2 hours of running per week.
Up to 17 million people in the US, approximately 5%, carry genetic mutations associated with cancer risk. The study highlights the importance of routine cancer screenings and suggests expanding genetic testing beyond high-risk groups.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
BH3 mimetics demonstrate potent anti-cancer activity by targeting pro-survival BCL-2 proteins, effectively eradicating leukaemia cells with complex mutations. The review highlights several important findings about BH3 mimetics and their role in treating acute myeloid leukaemia.
Researchers will investigate the effects of Y chromosome loss on bladder cancer development and progression. The goal is to understand how this genetic change affects cancer cells and immune systems, with potential implications for prevention, early detection, and treatment approaches.
Researchers found that smoking and biological sex shape how normal cells evolve in healthy bladder tissue, with certain mutations gaining an advantage to expand into clones. This study offers new insights into cancer risk and prevention by providing a way to understand tissue evolution and identify early warning signs.
The NCCN Guidelines Navigator now covers treatment for over a dozen cancer types, including hereditary risk assessment, providing seamless navigation and search capabilities. The new format aims to improve treatment decision-making based on the latest evidence and expert-consensus.
The 2025 NFCR Global Summit will convene world-renowned experts in cancer research, entrepreneurship, and patient care. Keynote speakers include Monica Bertagnolli, Webster K. Cavenee, Lisa Coussens, Ronald DePinho, and Tony Hunter.
Researchers found that rectal bleeding increases the odds of a colorectal cancer diagnosis by 8.5 times in patients under 50, highlighting the need for symptom-driven care and lifestyle modifications to reduce the risk. The study analyzed 443 patients and identified no family history as a factor in early-onset colorectal cancers.
A recent study found a small-but-significant link between exposure to radiation from medical imaging and blood cancers in children and adolescents. The study concludes that while ionizing radiation is a carcinogen, the benefit-to-risk ratio favors CT imaging of children when justified and technique minimizes adverse effects.
A large-scale population study found that oxaliplatin benefits only younger stage III patients, with no added survival benefit for those over 70. The study suggests using an age threshold to make evidence-based choices about chemotherapy.
Researchers discovered a mutation in the POT1 gene that prevents telomeres from repairing, leading to pulmonary fibrosis. This study highlights the importance of personalising treatments for diseases caused by dysfunctional telomeres.
Research from Huntsman Cancer Institute found that people with two or more tattoo sessions had a decreased risk of both invasive and in situ melanoma. However, participants with only one tattoo session were more likely to develop melanoma, especially in situ.
A $1.7M Department of Defense grant funds the Convergent Science Virtual Cancer Center, strengthening expertise in cancer risks faced by military personnel and their families. The center provides personalized mentorship, immersive workshops, and non-traditional educational opportunities to improve patient outcomes across various cancers.
A new study finds that women who have overcome cervical cancer are nearly twice as likely to develop anal cancer compared to the general population. The study highlights the need for updated screening guidelines for these patients.
Researchers discovered a specific cell that responds to environmental toxins found in cigarettes, leading to aggressive tumor growth in mice with pancreatic cancer. The study also identified a type of immune cell that fuels this response while stopping the immune system from fighting tumor growth.
A new study in The American Journal of Pathology reveals that perilipin 2 protein modulates aggressive cancer progression in advanced lung adenocarcinoma by regulating lipid droplet accumulation. High perilipin 2 expression is associated with more aggressive disease progression and shorter recurrence-free survival times.
A recent study by researchers at University of California San Diego School found that individuals with cannabis use disorder are more than three times more likely to develop oral cancer within five years. The study highlights the potential long-term health risks associated with problematic cannabis use and emphasizes the need for furth...
A new analysis suggests that preventive mastectomy is a cost-effective way to reduce the likelihood of developing breast cancer compared to breast screening and medication. Women aged 30 or above with a lifetime breast cancer risk of 35% or more may benefit from this treatment option.
Researchers analyzed US cancer registration systems and found disparities in racial minorities' representation, despite revisions to the established standards. The study revealed significantly lower rates for American Indian or Alaskan Native populations under the 1997 standards compared to the previous 1977 standards.
Researchers have identified a hidden molecular mechanism involving two proteins that allows tumors to resist treatment. A new gelatin-based nanoparticle has been developed to shut down both proteins simultaneously, showing promising results in early studies with mice.
A study published in The International Journal of Cancer found that children born by planned C-section have a higher risk of developing acute lymphoblastic leukaemia (ALL) later in life. The risk was 21% higher in children born by planned C-section compared to those born vaginally.
A whole-genome sequencing study found fine-particulate air pollution to cause more cancer-related changes than secondhand smoke. Researchers analyzed lung tumors from 871 never-smoker patients across 28 geographic locations worldwide and linked air pollution exposure to increased genomic changes.
A new study by the NIH found that hormone therapy may alter breast cancer risk in women under 55. Women treated with unopposed estrogen hormone therapy were less likely to develop breast cancer, while those using estrogen plus progestin hormone therapy were more likely to develop the disease.
A cohort study found a strong association between cancer incidence rates and both environmental burden and racial composition. The findings suggest the need for targeted community interventions in areas with high environmental burden and minority populations.
A new study found a sharp increase in appendix cancer incidence rates for those born after 1945, particularly among Generation X and Millennials. The researchers estimated age-specific incidence rates of appendiceal adenocarcinoma per 100,000 persons between 1975 and 2019.
Researchers found that it took 13 years for cervical cancer screenings to halve among women over 65, and even longer for prostate cancer screenings to decrease significantly. The study emphasizes the need for more effective tracking mechanisms to identify and reduce inappropriate screening practices.
A revolutionary AI model has been developed to diagnose lung cancer without relying on costly GPU servers or massive datasets. The ultra-lightweight model achieved a discrimination performance corresponding to an AUC value of 0.92, outperforming state-of-the-art large-scale AI systems.
The ESMO Gynaecological Cancers Congress 2025 will convene in Vienna, Austria, from June 19-21, featuring novel data on immunotherapy combinations and emerging treatment strategies for rare gynaecological cancers. The congress will also explore innovative approaches using antibody-drug conjugates.
Researchers identified C5aR1 as a novel prognostic biomarker and potential therapeutic target for treating metastatic skin cancer. Elevated C5aR1 presence suggests increased metastasis risk and poor survival in patients with cutaneous squamous cell carcinoma.
Researchers have identified FAM111B as a promising candidate for glioma treatment. The study found that FAM111B overexpression enhances glioma malignancy through the PI3K/AKT pathway, providing a novel avenue for therapeutic intervention.
A study found that rising temperatures in the Middle East and North Africa are associated with higher rates of these cancers. The prevalence of the different cancers rose by 173 to 280 cases per 100,000 people for every additional degree Celsius.
A large-scale study published in eClinicalMedicine found that transmasculine and gender-diverse individuals who use testosterone for an average of five years do not have an increased risk of gynecological cancer. The research, which followed 1955 participants, suggests that hormone therapy may be safe for this group.
The NCCN Policy Summit brought together experts to discuss ways to strengthen collaborative cancer care, from early detection to survivorship. Key findings include the need for better communication and coordination between primary care and oncology providers.
A study published in The Lancet Regional Health – Europe found that patients with low household income were more likely to be diagnosed late and receive less effective treatment for liver cancer. This highlights the need for targeted screening in deprived areas to improve early diagnosis and survival rates.
Pennington Biomedical welcomes Dr. Adithya Hari, MD, with expertise in nuclear oncology and translational science, strengthening cancer research and patient-centered innovation in Louisiana. He will establish a research program focused on nuclear medicine and dedicate time to direct patient care through a clinical partnership.
A new review advocates for building confidence in AI applications by implementing robust data governance frameworks, enhancing transparency, and involving stakeholders. The authors emphasize the importance of addressing ethical implications and ensuring equitable access to AI-driven innovations in clinical oncology.
Researchers develop mathematical modeling to predict aflatoxin outbreaks in Texas using remote sensing satellites and soil properties. The model has the potential to save farmers billions of dollars in losses by providing early risk prediction and targeted prevention strategies.
A combination of bazedoxifene and conjugated estrogens reduces obesity-related changes in rats, including fat cell accumulation and insulin resistance. The treatment also increases beneficial gut microbes and improves metabolic health, making it a promising alternative to tamoxifen for women at high breast cancer risk.
Research found that bad habits like smoking, heavy drinking, and lack of exercise can lead to declines in health as young as 36, with effects more pronounced over the long-term. The study tracked hundreds of people for 30 years and found that three unhealthy behaviors were linked to poorer mental and physical health.
Researchers identify colibactin, a bacterial toxin that alters DNA, as a potential trigger for early-onset colorectal cancer. Exposure to colibactin in childhood may imprint a distinct genetic signature on colon cells, increasing the risk of developing cancer before age 50.
Researchers at Nagoya University found that patients with high-risk stigmata and invasive nodules in their pancreatic cysts had a significant impact on their survival. The presence of invasive nodules led to improved survival rates after surgery, while those without invasive nodules had favorable outcomes even without surgery.
Researchers found that adults under 50 with migraine headaches and certain heart defects are at increased risk of stroke. The study highlights the importance of assessing both traditional and nontraditional risk factors in younger people to prevent strokes.
Researchers from the UCLA Health Jonsson Comprehensive Cancer Center are presenting new findings on combination therapies for liver and pancreatic cancers, including a new organoid model for personalized head and neck cancer treatment. Additionally, they are discussing the potential of liquid biopsies for cancer detection and monitoring.
A new study published in The Journal of Internal Medicine found that having an unhealthy metabolic profile increases the risk of breast cancer recurrence by 69% and subsequent breast cancer mortality by 83% among survivors. This association was consistent across Europe, North America, and Asia.
Researchers developed a saliva test that uses AI to identify genetic mutations in the DPYD gene, which can affect how well cancer patients respond to chemotherapy. The study found several new mutations that could lead to severe side effects from 5-fluorouracil, a widely used chemotherapy drug.
A new study finds that a specific genetic variation in the PTGS2 gene is associated with an increased risk of benign prostate hyperplasia (BPH) in Lebanese men. Men carrying the C version of this gene were more than twice as likely to have BPH compared to those without it.
A new study suggests that CT scans could account for 5% of all cancer cases each year, primarily due to radiation exposure. The largest risk is among infants, followed by children and adolescents. To mitigate this risk, reducing the number of scans and doses per scan can help save lives.
Researchers analyzed inherited genomes of 1,000 cancer patients to understand how germline variants impact protein function and physiological activities. The study identified rare and common cancer-causing genetic variants associated with increased cancer risk and disease severity.
Current computed tomography (CT) imaging may lead to up to 103,000 future cancers over a patient's lifetime. If practices persist, CT-associated cancer could account for 5% of all new diagnoses annually.
Researchers found that Schistosoma haematobium parasitic infection triggers cancer-related gene activity in cervical lining, with treatment causing further changes. This study sheds light on how the parasite may contribute to cervical cancer risk at a molecular level.
Researchers at George Mason University have developed AI models that can predict cancer risk with accuracy rates of up to 90% for certain types of cancer. These models can enable risk-based screening recommendations, increasing access to life-saving cancer detection for high-risk patients.
A new American Cancer Society study reveals that adopting healthy lifestyles, as recommended by the organization's guidelines, can significantly lower cancer mortality risk among survivors. Researchers found that those who maintained a healthy lifestyle before and after diagnosis had a lower mortality risk compared to those with poor a...
New research published in the Journal of the American Heart Association suggests that even sporadic physical activity can have lasting health benefits, making it easier for people to prioritize their well-being amid busy schedules. The study found that completing 150 minutes of moderate to vigorous physical activity per week, regardles...
Researchers discovered that a high-fat diet activates mechanisms facilitating breast cancer metastasis by promoting platelet activation and fibronectin expression, creating a fertile breeding ground for tumor cells to take root. This study provides new insights into the relationship between obesity and breast cancer spread.
A survey by the Annenberg Public Policy Center found that over half of Americans believe drinking alcohol increases their chances of developing cancer. The Surgeon General's advisory on alcohol and cancer risk also contributed to increased public awareness, with nearly 3 in 10 respondents saying they would be less likely to accept a dr...
A study found that patient navigators significantly improved one-year follow-up colonoscopy completion rates by 12% and reduced time to follow-up by 27 days. The researchers emphasize the importance of timely follow-up colonoscopies for patients with abnormal stool test results.
A new study has found that a lower dose of the blood-thinning medication apixaban is as effective as the full dose in preventing recurring blood clots in patients with active cancer. Patients who received the lower dose experienced fewer bleeding complications and similar VTE recurrence rates compared to those on the standard dose.
A recent study by Edith Cowan University found that a combination of resistance exercise and aerobic exercise can significantly reduce pro-inflammatory biomarkers in women with non-metastatic breast cancer. The research suggests that moderate to high-intensity aerobic exercises twice weekly, combined with resistance training, may help ...
A growing body of evidence suggests a significant link between human papillomavirus (HPV) and heart disease. Researchers pooled data from nearly 250,000 patients in seven studies, finding HPV-positive individuals had a 40% higher likelihood of developing cardiovascular disease.