Articles tagged with Cancer Risk
Researchers at The Jackson Laboratory have created an atlas of how healthy breast tissue ages, revealing key cellular and molecular changes that may contribute to breast cancer development. The study found that epithelial cells lose their job descriptions, becoming more prone to malignancy, while stromal cells lose their specialized id...
The study reveals that certain DNA regions are more prone to damage but also better repaired by cells. Transcription factors can either help or harm DNA, highlighting the importance of efficient repair in determining mutation formation.
A preclinical study reveals that tumors drive clot formation by releasing chemokines, prompting immune cells to release small vesicles that attach to cell fragments, forming life-threatening clots. The findings may lead to diagnostic tests and safer therapies to target the root of blood clotting risk.
A large study found pregnant women with cervical cancer face higher health risks during pregnancy and childbirth, including premature birth and cesarean sections. However, the babies' health is largely unaffected, with no significant differences in birth defects or stillbirths.
Researchers found that women who had used the oral contraceptive pill had a lower risk of ovarian cancer, with a 39% reduced risk for those who had given birth to two or more children. The study also identified certain biomarkers and lifestyle factors associated with a lower risk of ovarian cancer, including lower body weight and short...
A mathematical modeling study suggests that removing fallopian tubes during other abdominal surgeries can lower ovarian cancer incidence by five percent. The approach could also reduce total healthcare costs in Germany, with estimated annual savings of over €10 million.
A recent study suggests that prolonged exposure to low-dose traffic-derived PM2.5 particles can cause fatty liver disorder in mice. The study found changes in liver function, inflammation, and scar tissue formation, highlighting the potential health risks of air pollution on the liver.
Researchers found two distinct epigenetic states linked to cancer risk, one associated with a lower lifetime risk and the other with a higher lifetime risk. The study's findings suggest that developmental epigenetic risk may be common across cancers.
A recent study found that young individuals with cancer living in previously redlined neighborhoods have a 32% higher risk of dying compared to those in other neighborhoods. The study also shows lower survival rates at both 5 and 10 years after diagnosis.
The RSClin Tool N+ provides more accurate estimates of recurrence risk and individual chemotherapy benefit in node-positive breast cancer. The tool combines clinical and pathologic factors with the 21-gene Oncotype DX Breast Recurrence Score to predict patient-level prognosis and treatment benefit.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
A systematic review found that genomic classifier tests can influence risk classifications and treatment decisions for patients with localized prostate cancer, but more research is needed to understand their cost-effectiveness and impact on racial groups. The tests may lead to more conservative management options, such as active survei...
A meta-analysis found a dose-dependent relationship between alcohol consumption and the risks of cirrhosis and HCC in HBV patients, with daily alcohol consumption exceeding 12g increasing risk by 6.2% and 11.5% respectively.
The new NCCN Guidelines for Patients: Genetic Testing for Hereditary Breast, Ovarian, Pancreatic, and Prostate Cancer provide evidence-based recommendations for assessing and testing for inherited genetic mutations. The resource aims to inform individuals about their cancer risks based on personal or family history.
The FDA has revoked authorization for the use of Red Dye 3 in food and ingested drugs, citing studies linking it to cancer in laboratory male rats. This decision is an important step forward in addressing modifiable risk factors that have the potential to reduce cancer risk.
A recent study found that U.S. soldiers are 10 times more likely to use nicotine pouches, which can cause serious health issues, compared to the general population. The study analyzed anonymous responses from 1,957 soldiers and found that 23.8% reported using nicotine pouches in the previous 30 days.
Researchers from the Keck School of Medicine of USC found an association between levels of manmade “forever chemicals” in drinking water and certain digestive, endocrine, respiratory, and mouth and throat cancers. The study estimated that PFAS contamination contributes to 6,864 cancer cases per year.
Researchers have identified a 177-gene signature common to metastasis across cancers, allowing for personalized risk assessment and potential therapies. The discovery could lead to broader treatment options, faster drug access, and improved patient outcomes.
A nationwide cohort study in Korea found that postdiagnosis weight gain is associated with an increased risk of heart failure after breast cancer development. Effective weight intervention can protect cardiovascular health, particularly within the first few years after diagnosis.
A new test called ORACLE can predict lung cancer survival at the point of diagnosis better than currently used clinical risk factors. This could help doctors make more informed treatment decisions for people with stage 1 lung cancer, potentially improving patient outcomes.
A new study found that while lung cancer deaths decreased globally from 1990 to 2019, mortality linked to tobacco use and air pollution increased. Tobacco remains the leading cause of death, accounting for 66% of TBL cancer deaths in 2019, while particulate matter pollution is a growing concern.
A large international study of GLP1-RA users and dipeptidyl peptidase-4 inhibitors (DPP-4i) found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer. The study, published in the Thyroid journal, analyzed data from 92,497 GLP1-RA users and 2,484,408 DPP-4i users.
A multi-institutional study led by Mayo Clinic researchers has improved the accuracy of genetic testing for BRCA2 variants, enabling precise risk assessments and personalized treatment plans. The findings will aid in identifying patients who may benefit from targeted therapies such as PARP inhibitors.
Research suggests that engaging in low to moderate levels of physical activity before a cancer diagnosis can significantly lower the risk of disease progression and death. The study analyzed data from over 28,000 participants with stage 1 cancers and found that rates of cancer progression and death were lower among those who were physi...
A genetic fault long believed to drive oesophageal cancer development may actually play a protective role early in the disease, according to new research. The study found that defects in CDKN2A were more common in people with Barrett's oesophagus who never progressed to cancer.
Most study participants struggled to understand standard prostate cancer pathology reports, but found patient-centered reports easier to comprehend. PCPRs reduced perceived worry in low-risk conditions compared to traditional reports, suggesting their inclusion could enhance patient care.
A big-data study from HKUMed found a very low association between clozapine and blood cancer, contradicting previous Western studies. The study's comprehensive data monitoring measures suggest that clozapine can be safely used for treatment-resistant schizophrenia.
Genetic testing for cancer risk should always include healthcare providers and genetic counseling to ensure users fully understand their results and receive proper guidance. The authors call on the FDA to provide clear rules for using these tests, particularly for minors.
A pooled analysis of over a dozen studies found that drinking caffeinated coffee daily was associated with a 17% lower risk of head and neck cancer overall. Drinking decaffeinated coffee and tea also showed protective effects, with tea linked to a 29% lower risk of hypopharyngeal cancer.
Sylvester Comprehensive Cancer Center offers expert advice on coping with holiday loss and grief. Biological age can predict early colorectal cancer risk, while research advances may lead to a cure for multiple myeloma. Blood cancer experts share insights into new treatments.
Researchers at UW-Madison found two microbial bile acids that affect colon cancer risk in opposite ways, with one slowing growth and the other fueling tumors. The study provides a roadmap for new cancer detection methods and treatments.
The European Society of Cardiology emphasizes the importance of including heart and cardiovascular health in cancer treatment plans. Recent studies estimate that approximately one-third of patients experience mild toxicities, while 3% develop moderate toxicity. The ESC is launching a new conference to address this growing epidemic.
Researchers at Osaka Metropolitan University developed a new technique for head and neck reconstruction that achieves 100% success rate in high-risk patients. The pedicled latissimus dorsi flap technique provides a reliable, fast, and minimally invasive option for complex tissue defects.
A new study from Karolinska Institutet and Queen Mary University of London has developed a method to divide HPV-positive women into three risk groups, based on the variant of the HPV virus and the amount of virus present in the self-test. This method could enhance cervical cancer screening for high-risk women.
A new study reveals that social risks like food insecurity and housing instability impede patients' ability to receive routine cancer screenings, even when they have access to healthcare. The research highlights the need for health providers to take a more holistic approach to patient care to address these challenges.
Artificial intelligence is enhancing breast cancer risk prediction through mammographic analysis, uncovering key features that predict breast cancer risk. These AI-generated features may inform personalized screening strategies, such as more frequent or less frequent screenings for women at high or low risk of breast cancer.
The AstroRad vest employs high-density polymers to shield vital organs from radiation exposure, addressing cancer and radiation sickness risks. The wearable technology has undergone extensive testing through the ISS National Lab, leading to significant enhancements in its design and functionality.
A new study finds that a blood test using phosphatidylethanol (PEth) can detect liver disease caused by excessive drinking, offering a more reliable alternative to self-reported measures. The test has shown strong correlation with Fibrosis 4, an indicator of liver risk, and could be included in routine blood tests.
Researchers at UCLA Health presented several breakthroughs at the San Antonio Breast Cancer Symposium, including improved survival rates for advanced breast cancer patients who receive trastuzumab deruxtecan (T-DXd), a novel ADC. Additionally, new genomic testing and circulating tumor DNA analysis may help identify high-risk patients a...
A new study finds that not attaining a high school degree is associated with higher cancer mortality, while high allostatic load, a marker of chronic stress, also increases the risk. The researchers emphasize the need for educational attainment promotion and addressing social determinants of health to reduce cancer disparities.
A new study suggests that a person's biological age can predict their risk of developing colon polyps and early colorectal cancer. Accelerated aging, which is higher than chronological age, may be linked to a greater risk of developing the disease, highlighting the importance of early screening.
Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
A new study improves breast cancer risk prediction by analyzing up to three years of previous mammograms, identifying individuals at high risk 2.3 times more accurately than the standard method. The AI method considers subtle changes in mammogram images and holds up well across diverse settings.
Researchers identify two strains of bacteria producing colibactin as a potential link to colorectal, bladder, and prostate cancers. Targeting these strains with vaccines or probiotics could reduce cancer risk and infection burden.
The global lifetime risk of lung cancer is 3.49%, with high-risk countries like French New Caledonia and Canada, while low-HDI countries have lower risks due to shorter lifespans and limited resources. After 40, the risk drastically increases, but residual risk decreases with age.
A study found that postmenopausal women with low-risk tumors experience a long-term benefit from anti-hormonal treatment of at least 20 years, while younger women do not. The researchers highlight the need for new markers to predict long-term risk and benefit in younger patients.
A new study finds that urban communities, lower-income areas, and those with higher proportions of racial minorities have higher estimated cancer risks from air pollution. Despite this, the disparity is decreasing over time, suggesting improvements in air pollution control measures.
The study analyzed DNA from over 100,000 participants and found that nearly 2,000 carried at least one genetic variant linked to these diseases. The findings have led to life-changing discoveries and new insights into personalized medicine.
Researchers found that tumor cell secreted DNA in extracellular vesicles acts as a 'danger' signal to activate an anti-tumor response in the liver, reducing liver metastasis risk. The discovery improves understanding of cancer progression and anticancer immunity.
A new study reveals that lung cancer screening CTs can detect coronary artery disease in 83% of cases, with high levels found in 30%. This finding highlights the potential benefits of lung cancer screening for identifying and managing cardiovascular risk factors.
Researchers urge people to improve their eating habits to reduce the risk of bowel cancer, citing evidence that high-fibre foods promote healthy gut bacteria. Studies found a link between poor diet choices and digestive cancers, highlighting the importance of diets rich in whole grains, vegetables, fruits, and legumes.
A new study suggests that addressing plastic pollution could play a critical role in lowering breast cancer rates. Researchers identified nearly half of the chemicals linked to breast cancer risk as being used in plastics, including 175 potential carcinogens that should be prioritized for regulatory action.
A new study shows that mailing at-home fecal immunochemical testing kits and providing coordinated follow-up led to a tripling of screening completion rates compared to usual care. The intervention increased screening rates by 30% within six months and 34.6% by 12 months.
Less than half of Americans know that drinking alcohol raises cancer risk, despite the CDC's claim that reducing alcohol intake lowers cancer risk. The Annenberg Public Policy Center survey found that 40% were unaware or misinformed about the link between alcohol consumption and cancer.
A new study from the University of Texas M. D. Anderson Cancer Center found that at least 3% of normal breast tissue cells in healthy women contain chromosome abnormalities associated with invasive breast cancer, which may guide future approaches to early detection.
Achalasia is associated with an increased risk of esophageal squamous cell carcinoma, highlighting the need for close surveillance in high-risk patients. Chronic inflammation and food stasis can lead to malignant transformation, emphasizing the importance of timely intervention.
Researchers from Universidad Miguel Hernandez de Elche found that bisphenol analogs BPF and BPS, marketed as safer alternatives to BPA, accumulate in biological membranes and disrupt endocrine function. The study suggests these compounds pose health risks similar to those of BPA.
Researchers found that sacubitril-valsartan, a commonly prescribed heart failure medication, can help prevent heart damage related to chemotherapy treatment among high-risk cancer patients. The study highlights the importance of identifying patients at high risk for heart damage and suggests strategies for early intervention.
A new study by Silent Spring Institute has identified multiple chemical exposures in firefighters that increase their risk of developing breast cancer. The research found 12 hazardous substances, including benzene and flame retardants, that put female firefighters at increased risk for the disease.
A new study in Addiction Biology suggests that cannabis use can cause chromosomal damage, leading to increased cancer risk and birth defects. This genotoxicity may be transmitted to offspring via damaged sperm or eggs.