Articles tagged with Cancer Risk
The National Comprehensive Cancer Network has updated its guidelines for genetic/familial high-risk assessment, incorporating the latest scientific research and expert recommendations to enhance screening practices and treatment options. The expanded guidelines cover various cancer types and provide guidance on genetic testing, heredit...
A study by Texas A&M University has revealed high levels of lead, barium, and chromium in soil samples from the Greater Fifth Ward neighborhood. The findings highlight the need for environmental protection programs to address health risks associated with heavy metal exposure.
A geospatial analysis found that areas with more tanning bed facilities experience higher rates of melanoma. The study identified six high-risk clusters and seven low-risk clusters, suggesting a significant association between access to tanning beds and increased melanoma incidence.
Researchers have found that specific E. coli bacteria in the gut promote colon cancer by binding to intestinal cells and releasing a DNA-damaging toxin called colibactin. This binding is made possible by bacterial pili and adhesins, which can be targeted to prevent tumor development.
A new survey by Ohio State University shows that most people believe pancreatic disease affects only the elderly and that there is nothing they can do to reduce their risk. However, obesity increases lifetime risk for pancreatic cancer by 20%.
Researchers identified six novel genes associated with a significant increase in cancer risk, including BIK for prostate cancer, ATG12 for colorectal cancer, and CMTR2 for lung and melanoma. Loss of AURKB was found to protect against any cancer type, while loss of PPP1R15A was linked to a 53% lower risk of breast cancer.
Researchers developed an AI model that can identify and measure aggressive prostate cancer lesions with high accuracy. The model's estimates of tumor size were associated with the likelihood of cancer recurrence or metastasis.
A systematic review and meta-analysis found a significant association between Helicobacter pylori infection and the risk of cardia gastric cancer in Asian countries, with stronger associations observed in East Asia. The study suggests that H. pylori infection is a major risk factor for CGC in this region.
A comprehensive study examining over 16,000 necropsy records from 292 vertebrate species found significant differences in cancer prevalence. Cancer rates increase with body size and cellular mutation rates but decrease with longer gestation periods.
Researchers found a link between non-functional p53 genes and the regenerative cell state in ulcerative colitis, leading to cancer progression. A new diagnostic test could identify aberrant cells earlier using molecular tools.
A national report reveals nearly 18% of Canadian homes have radon levels above 200 Bq/m³, increasing lung cancer risk. Canadians are among the most highly exposed to radon, highlighting the need for urgent action to address this public health concern.
A new study by H. Lee Moffitt Cancer Center researchers has uncovered crucial information about the incidence and risk factors of oral human papillomavirus (HPV) infections among men in the US, Mexico, and Brazil. The study found that the risk of acquiring oral HPV was notably higher in the US compared to Brazil and Mexico.
Researchers developed an AI model that uses machine learning and combination theory to predict suspicious skin lesions. The new C4C Risk Score has an accuracy of 69% and significantly outperformed existing methods, including 7PCL and Williams score.
A new study suggests that a healthy diet may help keep low-grade prostate cancer from progressing to more aggressive states in men undergoing active surveillance. The research team led by Johns Hopkins Medicine found that a reduced risk of prostate cancer progression is associated with a healthy diet.
A Danish nationwide study found an association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and increased breast cancer risk in females ages 15 to 49. The absolute breast cancer risk is low, but the study revealed an excess risk of 14 per 10,000 females, which did not increase with duration of use.
Researchers identified three genetic regions strongly associated with increased prostate incidence in a diverse group of African men. The study, the largest of its kind in Africa, may lead to new treatment possibilities and refined screening methods.
A systematic review and meta-analysis found that weight-loss surgery reduces pancreatic cancer risk among individuals with obesity by 44%, and among those with both obesity and type 2 diabetes by 79%. The study suggests that metabolic-bariatric surgery may play a crucial role in reducing the risk of pancreatic cancer.
A new study found an association between some types of cancer and multiple sclerosis (MS), with people with MS having a 6% increased risk of developing any type of cancer. The study identified higher risks for bladder, brain, and cervical cancers, but lower risks for prostate, colorectal, and breast cancers.
A retrospective cohort study found that AI algorithms can identify women at high risk of developing breast cancer 4-6 years before detection. The results suggest using commercial AI algorithms as a pathway to personalized screening approaches, leading to earlier cancer diagnosis.
A recent study published in Liver Cancer found that patients with diabetes mellitus and comorbid obesity are at a higher risk of liver cancer recurrence after resection. The risk is significantly higher for those with comorbid obesity, increasing by approximately 3.8 times over five years postoperatively.
A new study aims to increase follow-up care for patients who receive abnormal stool-based fecal immunochemical tests, focusing on improving coordination between primary and specialty clinics. The goal is to improve colorectal cancer screening processes in underserved populations, increasing survival and reducing mortality.
A large proportion of gene variants previously classified as 'variants of uncertain significance' (VUS) have been reclassified as benign, according to a study published in the American Journal of Human Genetics. This reduces the total number of VUS by 37%, providing relief for carriers worldwide.
A new study found that the IOTA ADNEX ultrasound model can detect up to 96% of ovarian cancers in postmenopausal women, outperforming the current standard test. The research team recommends replacing the risk of malignancy (RMI1) test with the IOTA ADNEX model.
Early-stage HR+ breast cancer survivors experience weight gain, particularly those with healthy BMI or overweight at diagnosis. Black women have higher rates of obesity and related comorbidities compared to White women, leading to a 40% higher breast cancer mortality rate.
Researchers have developed an AI technology that can analyze mammary tissue biopsies to identify signs of damaged cells, a key indicator of breast cancer risk. The study found the AI was far better at predicting risk than current clinical benchmarks, offering improved treatment options for women.
A new prostate biopsy technique, transperineal biopsy, has been shown to lower the risk of infection compared to traditional biopsies. The PREVENT trial found no infections among men who underwent the transperineal procedure, while those with traditional transrectal biopsies had a 1.6% infection rate despite receiving antibiotics.
Researchers identified over 3,000 harmful genetic changes in the RAD51C gene that increase ovarian cancer risk six-fold and breast cancer risk four-fold. These findings can help doctors and diagnostic laboratory scientists better assess cancer risk and provide more personalized care.
A new study found that patients with 4 or 5 identified risk factors, including age 18-24 years and schizophrenia spectrum disorders, had over 100 times the incidence of Neuroleptic Malignant Syndrome. The data provide a basis for early identification and monitoring of children and youth at elevated risk.
Researchers found that cancer survivors with overweight or obesity are more likely to develop a second cancer, especially obesity-related ones. This study highlights the importance of promoting weight management and increasing awareness of second cancers among physicians and cancer patients.
Researchers found that humorous comic strip cartoons increased likelihood of agreeing to take a quiz on personal risk for colon cancer. Exposing people to funny content reduced information avoidance, making them more likely to choose to watch a video about colorectal cancer prevention.
A meta-analysis by Mass General Brigham researchers found that Black women face higher mortality rates from breast cancer across all tumor subtypes, attributed to socioeconomic inequality, delayed diagnosis, and inadequate access to timely quality treatment. This disparity is not limited to hormone-positive tumors, with differences als...
The RESILIENCE clinical trial explores the effectiveness of remote ischemic conditioning to prevent cardiotoxicity in lymphoma patients undergoing anthracycline-based chemotherapy. The trial aims to reduce heart failure prevalence and improve quality of life for cancer survivors.
A study published in JAMA Network Open found that body mass index (BMI) has a more complex relationship with mortality risk during cancer therapy than previously thought. For patients with advanced non-small cell lung cancer, higher BMI was associated with lower mortality when undergoing immunotherapy or conventional chemotherapy. Howe...
New research has identified four genes with a strong impact on menopause timing, which are also linked to an increased risk of cancer. The study found that women with only one working copy of these genes experience premature menopause, leading to a faster reproductive lifespan.
A new study found that skin cancer incidence in young adults declined in Sweden around 2015. The decrease in incidence and mortality is attributed to increased awareness of sun protection, reduced access to sunbeds, and changes in lifestyle habits such as spending more time indoors. The study suggests that continued emphasis on sun pro...
A Mayo Clinic study found that people with monoclonal B-cell lymphocytosis (MBL) have a 92% elevated risk of developing melanoma. MBL is a precursor to chronic lymphocytic leukemia and also increases the risk of cancers originating in the lymphatic system and serious infections.
A genetic variant in the Syntaxin 17 gene determines the speed of hair greying and susceptibility to skin melanoma in horses. The study found three gene variants at the Grey locus, with the G3 variant associated with a higher risk of melanoma.