Articles tagged with Cancer Risk
Patients with hormone receptor-positive and HER2-negative breast cancers face a higher risk of death from the cancer if they wait more than 42 days after diagnosis to have surgery. Delayed surgery increases the patient's risk exponentially, with risks of death increasing by 21%, 79%, and 183% at 60, 90, and 120 days, respectively.
New research suggests that maintaining a healthy weight throughout life and losing weight later in life may reduce the risk of kidney cancer. Higher BMI at various ages across adulthood was associated with increased risks of developing different types of kidney cancer, including renal cell carcinoma, papillary RCC, and chromophobe RCC.
A study published in The Journal of the National Cancer Institute found that waist circumference is a stronger risk marker than body mass index (BMI) for obesity-related cancers in men. However, this association was not observed in women.
A new study found that new-onset type 2 diabetes is associated with an increased risk of certain obesity-related cancers, such as bowel and pancreatic cancer. The study analyzed data from the UK Biobank and found a 48% increased risk in men and a 24% increased risk in women for overall obesity-related cancers.
A Swedish study of over 1,300 participants found that losing a significant amount of weight still offers protection against health issues like cancer and cardiovascular disease, even if some weight is regained. However, regaining weight can increase the risk of microvascular disease and other health problems.
A recent study has found that people diagnosed with colorectal cancer are more likely to die from cardiovascular causes, particularly in the first two years after diagnosis. The study analyzed data from over 630,000 US adults and found a 16% increased risk of cardiovascular mortality among those with colorectal cancer.
A sub-analysis of 20-year follow-up data from the European Randomized study of Screening for Prostate Cancer (ERSPC) reveals that men who consistently decline prostate cancer screening appointments have a 45% higher risk of dying from the disease compared to those who attend screening appointments.
A $1.2M grant will fund a comprehensive study on the potential links between neighborhood environment and cancer risk. The research team, led by Dr. Chris Lim, will analyze data from two ongoing studies to identify factors contributing to increased obesity-related cancer risk in specific neighborhoods.
Researchers found that detectable mutant KRAS circulating tumor DNA (ctDNA) indicates a higher risk of cancer spread and worse survival rates for patients with pancreatic ductal adenocarcinoma. The study suggests that ctDNA assays should be performed prior to treatment to have the highest yield.
A recent cohort study published in JAMA Internal Medicine found that statin use was associated with a reduced risk of hepatocellular carcinoma and hepatic decompensation in patients with chronic liver disease. This suggests that statins may play a role in preventing the progression of liver disease and reducing the risk of liver cancer.
A new study in the Circulation Journal reveals that babies born with heart defects may be at a higher risk of developing childhood cancer. Mothers of infants with congenital heart defects also show an increased cancer risk. The study highlights the importance of maternal factors and genetic traits in understanding this connection.
Excessive alcohol consumption causes severe digestive problems, including liver damage, stomach disorders, and increased cancer risk. Chronic alcohol use can lead to conditions like cirrhosis, pancreatitis, and colorectal cancer.
Researchers investigated skin cancer risk perceptions and sun-protective behaviors in US adults, finding associations between sociodemographic factors and sunburn risks. Higher education levels, Hispanic origin, and income groups were linked to lower sunburn risks, while married or partnered individuals had higher risks.
A new study found that birds have lower cancer rates despite high blood sugar levels, challenging existing assumptions. The research suggests that some species have evolved natural biological defenses against cancer, which could inspire new approaches to prevention and treatment in humans.
Genetic changes triggered by environmental factors like pollution, diet, and stress can increase cancer risk. Nearly everyone is exposed to cancer risk factors daily, highlighting the need for public awareness and policy action to reduce exposure.
Researchers found no clear evidence that red wine mitigates cancer risk, and instead observed a distinction in skin cancer risk. White wine consumption was associated with an increased risk of skin cancer compared to red wine, particularly among women. Heavy wine consumption may correlate to high-risk behaviors.
A new study reveals that firefighters are more likely to have a specific type of brain tumor with gene mutations linked to chemical exposure. The research found that firefighters were more likely to have the mutational signature associated with haloalkane exposure, especially those who worked for many years.
A study of nearly 2,500 postmenopausal women found that taking more daily steps and engaging in moderate-to-vigorous physical activity were associated with a significantly reduced risk of death from cardiovascular disease. Even walking fewer than 5,000 steps per day showed a risk reduction.
Researchers assess two approaches to test patients' hereditary cancer risks in primary care clinics, finding the point-of-care approach increases completion rates while the direct patient engagement method boosts testing rates among those eligible. The study's goal is to develop ways to improve uptake and reduce barriers to testing.
A recent study by Professor Mamas highlights the significant risk of cardiovascular diseases (CVD) in patients with cancer, particularly in aging populations. The review emphasizes the need for early diagnosis and regular monitoring to improve quality of life.
Breast cancer mortality rates have stopped decreasing in two age groups: women under 40 and those over 74. This shift is attributed to an increase in stage IV breast cancers at diagnosis, leading to poor prognoses.
Researchers create microfluidic device to sort tumor cells based on adhesive strength, revealing potential method to predict aggressive cancer behavior. The study's findings offer a promising approach for personalizing treatment plans and identifying high-risk patients.
A new study published in the European Journal of Preventive Cardiology found that a type of diabetes medication called SGLT2 inhibitors can significantly lower the risk of heart failure and hospital visits related to heart failure in cancer patients. The benefits were particularly promising for breast cancer patients receiving anthracy...
A risk prediction model was developed to identify patients unlikely to complete HPV vaccination. The model uses patient demographics and clinical characteristics to guide targeted interventions, increasing vaccination rates among high-risk groups.
A large study of nearly 80,000 men found that those with better semen quality lived two to three years longer than those with poorer semen quality. The research suggests that poor semen quality may be an indicator of underlying health issues, and could potentially detect early signs of disease.
A survey reveals that most people are unaware of HPV's impact on cancer risk and its spread. The human papillomavirus (HPV) is more common among men than women, and the virus is associated with rising rates of oropharyngeal cancers, which can take years to develop after initial infection.
Researchers developed a risk-prediction model based on four factors: family history, body mass index, sex, and smoking. A score equal to or greater than 9 indicates an above 14% likelihood of developing cancer or advanced precancerous lesions in adults under 45.
Researchers from the University of Southern Denmark found that tattooed individuals are more frequently diagnosed with skin and lymphoma cancers compared to those without tattoos. The study suggests that chronic inflammation in the lymph nodes triggered by tattoo ink may lead to abnormal cell growth and an increased risk of cancer.
A new federal mandate aims to improve patient awareness about breast density, which affects cancer detection and risk. Women with dense breasts may need supplemental screening, such as MRI, to detect breast cancer earlier, but this comes with potential downsides.
A nationwide study found that patients with alcoholic liver disease have a significantly higher risk of developing colorectal cancer. The study highlights the importance of comprehensive CRC screening and risk stratification based on new consensus-based definitions of liver disease.
A pioneering study identified a crucial interaction between Helicobacter pylori and non-H. pylori bacteria in pre-cancerous stage of gastric cancer. Researchers found that bacterial leakage into deeper gastric tissues may represent a previously overlooked factor in cancer progression.
Researchers found that added sugars contribute between 7% and 21% to the risk of gastric cancer, while sodium intake is the main mediating factor. Healthy diets characterized by high vegetable and fruit consumption can reduce this risk.
A UC Irvine-led study found associations between prenatal PFAS exposure and certain childhood cancers, including acute myeloid leukemia and Wilms tumors. Higher PFAS concentrations were linked to increased cancer risk in California children.
A new study published in The Lancet Digital Health found that accelerated ageing in specific organs can predict diseases across the entire body. Organ ageing rates were linked to increased risks of various diseases, including cardiovascular disease, respiratory infections, and dementia.
A recent study published in JAMA Network Open has found that higher adherence to the Mediterranean diet is associated with a modest reduction in the risk of obesity-related cancers. The findings suggest that further research is needed to clarify the mechanisms by which the Mediterranean diet may contribute to cancer prevention.
Sylvester's Firefighter Cancer Initiative reduces cancer risk among firefighters and community members by addressing electric vehicle fires. A new gene-editing study aims to treat mitochondrial diseases, while a program connects patients with pathologists to improve understanding of complex results.
Groundbreaking research from the CLEAR study reveals that greater tumor shrinkage improves survival outcomes for patients with advanced renal cell carcinoma. The lenvatinib and pembrolizumab combination regimen demonstrates significant long-term benefits, including enhanced effectiveness of subsequent treatments.
A new study found that breast cancer incidence in US women under 40 varies significantly across different states and regions, with the Western region experiencing the highest rate of increase from 2001 to 2020.
A new study from the University of East Anglia finds that European life expectancy has slowed down since 2011 due to factors such as poor diets, lack of physical activity, and obesity. The research suggests that prioritizing healthier lifestyles in younger years is crucial for extending old age.
ABT-263 eliminates harmful aging cells in the gut, reducing inflammation and lowering cancer risk in a mouse model of GI cancer. The study suggests that removing senescent cells could help prevent radiation-related GI cancer, highlighting the potential of senolytic drugs as a preventive treatment.
Amplified Sciences has received CLIA certification for its PanCystPro test, which helps risk stratify patients with pancreatic cystic lesions. The company plans to commercialize the test through an early access program and a clinical utility trial in 2025.
A large-scale screen of single nucleotide variants has identified 380 variants controlling cancer-associated genes. These variants regulate biological pathways such as DNA repair, energy production, and cell microenvironment interaction. The findings suggest new therapeutic targets for preventing or stopping cancer growth.
A study found that 77.9% of lung cancer patients had detectable atherosclerosis on CT scans, with smoking being the most prominent cardiac risk factor. The results suggest using concurrent coronary calcium scoring to aid in identification and earlier intervention for these patients.
A new review study found significant gaps in existing research on breast cancer within the Black community and barriers preventing eligible but non-participating women from screenings. The study highlights the need for culturally sensitive research to address emotional and psycho-social barriers faced by Black women.
Researchers at The Jackson Laboratory have created an atlas of how healthy breast tissue ages, revealing key cellular and molecular changes that may contribute to breast cancer development. The study found that epithelial cells lose their job descriptions, becoming more prone to malignancy, while stromal cells lose their specialized id...
The study reveals that certain DNA regions are more prone to damage but also better repaired by cells. Transcription factors can either help or harm DNA, highlighting the importance of efficient repair in determining mutation formation.
A preclinical study reveals that tumors drive clot formation by releasing chemokines, prompting immune cells to release small vesicles that attach to cell fragments, forming life-threatening clots. The findings may lead to diagnostic tests and safer therapies to target the root of blood clotting risk.
A large study found pregnant women with cervical cancer face higher health risks during pregnancy and childbirth, including premature birth and cesarean sections. However, the babies' health is largely unaffected, with no significant differences in birth defects or stillbirths.
Researchers found that women who had used the oral contraceptive pill had a lower risk of ovarian cancer, with a 39% reduced risk for those who had given birth to two or more children. The study also identified certain biomarkers and lifestyle factors associated with a lower risk of ovarian cancer, including lower body weight and short...
A mathematical modeling study suggests that removing fallopian tubes during other abdominal surgeries can lower ovarian cancer incidence by five percent. The approach could also reduce total healthcare costs in Germany, with estimated annual savings of over €10 million.
A recent study suggests that prolonged exposure to low-dose traffic-derived PM2.5 particles can cause fatty liver disorder in mice. The study found changes in liver function, inflammation, and scar tissue formation, highlighting the potential health risks of air pollution on the liver.
A recent study found that young individuals with cancer living in previously redlined neighborhoods have a 32% higher risk of dying compared to those in other neighborhoods. The study also shows lower survival rates at both 5 and 10 years after diagnosis.
Researchers found two distinct epigenetic states linked to cancer risk, one associated with a lower lifetime risk and the other with a higher lifetime risk. The study's findings suggest that developmental epigenetic risk may be common across cancers.
The RSClin Tool N+ provides more accurate estimates of recurrence risk and individual chemotherapy benefit in node-positive breast cancer. The tool combines clinical and pathologic factors with the 21-gene Oncotype DX Breast Recurrence Score to predict patient-level prognosis and treatment benefit.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
A systematic review found that genomic classifier tests can influence risk classifications and treatment decisions for patients with localized prostate cancer, but more research is needed to understand their cost-effectiveness and impact on racial groups. The tests may lead to more conservative management options, such as active survei...
The new NCCN Guidelines for Patients: Genetic Testing for Hereditary Breast, Ovarian, Pancreatic, and Prostate Cancer provide evidence-based recommendations for assessing and testing for inherited genetic mutations. The resource aims to inform individuals about their cancer risks based on personal or family history.
A meta-analysis found a dose-dependent relationship between alcohol consumption and the risks of cirrhosis and HCC in HBV patients, with daily alcohol consumption exceeding 12g increasing risk by 6.2% and 11.5% respectively.
The FDA has revoked authorization for the use of Red Dye 3 in food and ingested drugs, citing studies linking it to cancer in laboratory male rats. This decision is an important step forward in addressing modifiable risk factors that have the potential to reduce cancer risk.
A recent study found that U.S. soldiers are 10 times more likely to use nicotine pouches, which can cause serious health issues, compared to the general population. The study analyzed anonymous responses from 1,957 soldiers and found that 23.8% reported using nicotine pouches in the previous 30 days.