Research on containing and managing disease. Covers critical-illness theory, zoonotic disease, immunotherapy trials, and historical epidemics.
A study found a significant increase in quinolone-resistant gonorrhea from 2% to 28% in Ontario between 2001 and 2006. Infections among heterosexual men are linked to the rising rate of resistance.
MIT researchers have developed a new computer model that analyzes different methods of controlling malaria's spread. The model shows that environmental measures such as leveling land and eliminating pools of water can be an effective strategy in the fight against malaria.
Expert authors advocate for a US foreign policy agenda focused on eliminating neglected tropical diseases, citing connections between NTDs and conflict. The control of these devastating diseases could be achieved at a fraction of the cost of other medical interventions.
A study of 153,268 TB patients in the US found that substance abuse is a significant modifiable behavior impeding TB elimination efforts. Substance abusers were more likely to have contagious forms of TB and experience treatment failure compared to non-abusers.
Researchers argue that integrating malaria and neglected tropical disease control interventions at the community level can increase antimalarial treatment rates by over twice as much. They propose that global funders recognize this approach to expand coverage of both diseases.
A comprehensive elimination strategy is proposed to significantly block the spread of schistosomiasis, a chronic inflammatory disease affecting over 207 million people worldwide. The approach incorporates supplementary education and sanitation with secondary environmental benefits.
The Chronic Care Model has been shown to improve health outcomes and reduce costs for patients with chronic diseases. The model guides quality improvement efforts in medical practices, promoting team-based care, self-management support, and integrated decision support.
Adult cystic fibrosis patients can accurately predict their mortality based on their own reported quality of life. Patient-reported pain was found to be a critical factor in determining survival rates, highlighting the importance of using patient-reported measures in clinical trials.
A new study examines the aftereffects of a chlorine gas disaster in South Carolina, providing insight into how to prepare emergency response systems for accidental or terrorist releases. The study found that many hospitalized patients showed evidence of severe lung damage, but most recovered quickly and were discharged within a week.
Research found that gene expression and alternative splicing vary significantly between blood and brain tissues, with potential implications for understanding diseases such as epilepsy and Alzheimer's. The study suggests that genetic variation affecting splicing may be more relevant to disease than variations in overall gene expression.
A study published in JAMA found that a diet high in low-glycemic foods, such as nuts and beans, improved glycemic control and cardiovascular risk factors in patients with type 2 diabetes. The ESC recommends structured lifestyle advice for diabetes management, suggesting it may be as effective as some drug interventions.
Case Western Reserve professor David Gurarie develops mathematical models to track symptoms, treatment outcomes and environmental conditions of diseases. These models allow doctors to make predictions about effective treatment and help identify areas where new diseases may emerge.
Researchers at UGA will develop and evaluate strategies to reduce morbidity from schistosomiasis in low- and middle-income countries. The project aims to identify, control, and eliminate the disease where feasible.
A study published in JAMA found that a low-glycemic index diet resulted in greater improvements in glycemic control and reduced cardiovascular risk factors compared to a high-cereal fiber diet. The researchers found that participants on the low-glycemic index diet had lower hemoglobin A1c levels and improved lipid profiles.
A recent study found that patients with idiopathic pulmonary fibrosis are three times more likely to experience severe coronary events, including heart attacks. The disease is also linked to increased risks of angina, stroke, and deep vein thrombosis.
Levodopa is recommended for treating both early and advanced stages of Parkinson's disease, improving motor skills, speech, and gait. The treatment can also confirm a suspected diagnosis of Parkinson's disease, providing relief from tremors and other symptoms.
A new study by Joslin researchers found that a common genetic variant associated with an increased risk of coronary artery disease is also linked to poor glycemic control in people with diabetes. Those with the variant and poor glucose control experienced a four-fold increased risk for CAD relative to those without the variant and good...
Insecticide-treated bednet coverage increased from 1.8% in 2000 to 18.5% by 2007, leaving 89.6 million children unprotected, with 25% in Nigeria alone.
A new study reveals proposed FDA regulation fails to address migrant worker suffering, smoking prevalence, or outsourcing of leaf production. The regulation may favor big tobacco by reducing liability and sustaining global operations.
The 'Cradle & Grave' white paper examines seismic changes in birth, health, and death trends, influencing the future administration and Americans contemplating their futures. Gary Stockman highlights outdated assumptions shaping unrealistic expectations and poor choices.
A new national survey by Queen's University shows that despite increased investment in infection control since the SARS crisis, the number of resistant bacterial infections has multiplied. The study highlights a need for continued investment in infection control resources and programs to combat the growing threat of superbugs.
Researchers found that smaller mosquitoes have higher infection rates and potential to transmit dengue virus than larger individuals. The study suggests that control strategies may benefit from producing larger, less competent adult mosquitoes in terms of infection, potentially mitigating dengue transmission.
A study found that the World Health Organization's (WHO) budget allocations do not align with global disease burdens. The WHO allocated 87% of its budget to infectious diseases, while non-communicable diseases received only 12%. This disparity in funding is concerning, particularly for injuries and violence, which are largely underfunded.
A recent study found a remarkable 75% decrease in severe malaria deaths from 10.8 to 1.2 per 10,000 between 2015 and 2020 along the Kenyan coast. The decline is attributed to improved treatment, bednet usage, and mosquito breeding site management.
A study from McMaster University found that media coverage greatly influences public perception of infectious diseases, making them appear more threatening. Researchers discovered that diseases receiving frequent press attention, like bird flu, are perceived as more serious than those without similar coverage.
MRSA infections cause only 14 percent of hospital infections, making targeted screening programs less effective. A study by VCU epidemiologists suggests that hospital-wide infection control practices can prevent more infections than focusing on a single pathogen.
The Chinese early detection system for infectious diseases has identified clusters of bird-flu in humans in real time, providing authorities with early warning of the start of a pandemic. The system has been instrumental in reducing the impact of infectious diseases, with significant gains in life expectancy and infant mortality rates.
China faces a significant health and economic challenge due to rising chronic diseases, including high blood pressure and smoking. The country has an ageing population and increasing rates of obesity, diabetes, and cardiovascular disease, with tobacco use being a major factor in these trends.
A new report highlights the urgent need to tackle pneumococcal disease, a leading cause of death among children under five. The UK All-Party Parliamentary Group recommends increasing vaccine availability and healthcare system strengthening in developing countries to reduce child mortality rates.
People with diabetes are at higher risk of visual impairment due to diabetic retinopathy and other ocular conditions. Approximately 11% of American adults with diabetes have some form of visual impairment, compared to 5.9% without the disease.
A study by Mayo researchers found that outpatient stem cell transplantation for multiple myeloma patients resulted in a high survival rate of 99% at 100 days. The treatment also showed significantly shorter hospital stays, with a median duration of four days for those who required some hospital care.
Researchers found that pistachio diets can beneficially affect cardiovascular disease risk factors in a dose-dependent manner. The study suggests that pistachios may decrease CVD risk profile through effects on Stearoyl CoA Desaturase (SCD) and other bioactive substances.
According to a new analysis, NTDs as a group may have surpassed HIV/AIDS, tuberculosis, and malaria as the most prevalent infectious diseases in Latin America and the Caribbean. The region is home to approximately 200 million people affected by NTDs, including intestinal worm infections and Chagas disease.
Researchers have discovered a new bacterium responsible for dermatitis and septicaemia in desert-dwelling lizards. The discovery could help control the disease and protect endangered species, particularly those bred in captivity for release into the wild.
Fibrotic diseases like cardiovascular disease, diabetes, and cancer involve scarring, affecting organ function. Research by the University of Western Ontario identified glycogen synthase kinase 3 as a brake that can be impaired, leading to scarring.
A study of 402 Parkinson's disease patients found that 69.9% experienced pain, compared to 62.8% in healthy controls. Pain types included cramping and central neuropathic pain, suggesting a link between brain structures and pain processing.
The University of Tennessee at Knoxville has been awarded a $16 million NSF grant to create the National Institute for Mathematical and Biological Synthesis, or NIMBioS. Researchers from around the world will collaborate on finding creative solutions to pressing problems in fields like animal disease control and wildfire management.
A new study led by Dr. Keiko Watanabe found that periodontitis accelerates insulin resistance in rats with a high-fat diet. The research will explore the impact of periodontitis on diabetic complications in the retina, aorta and pancreas.
A new study published in PLOS Medicine found that tobacco control programs in California reduced personal health care expenditures by $86 billion between 1989 and 2004. The program's cost savings grew over time, reaching 7.3% in 2003-2004, and represented a significant return on investment for the state.
Patients taking proton pump inhibitors for 7 years or more are at higher risk of osteoporosis-related fractures. The study found a significant increase in hip fracture risk after 5 years and any fracture risk after 7 years of continuous exposure.
A UC Irvine study found that only 17% of adults with cardiovascular diseases have optimal levels for all lipids, compared to 85% of those without heart disease. The researchers emphasize the importance of proper diet, exercise, and medication to target all lipids.
The Diabetes Checks & Balances program has shown positive outcomes in its first year, with 29% of participants receiving all four tests, including HbA1c and eye exams. This increase is nearly twice as high as in 2006, suggesting improved diabetes management among local residents.
A new study found that those who drink excessively are at increased risk for metabolic syndrome, a condition associated with cardiovascular disease. The study analyzed data from over 1,500 participants and found that most people in the US drink in ways that may increase their risk of metabolic syndrome.
A study identifies US foreign-born persons from certain regions as being at a higher risk of contracting and spreading tuberculosis. The research highlights the need for targeted TB control strategies to address the growing burden of latent TB infection in this population.
A study published in the Journal of Advanced Nursing found that online courses can enhance knowledge and skills in infection control procedures. Healthcare professionals who took part in the course reported improved hand hygiene practices, increased glove use, and better waste disposal processes.
Researchers from Stanford's Bio-X program have devised a needle-thin probe to observe sarcomeres, the basic contracting engines of muscle, in live humans. This microendoscopy technique provides an alternative to painful muscle biopsy and could prove useful in understanding muscular diseases.
Scientists have made significant progress in understanding the replication of bluetongue virus, a major economic threat to farming. The 'heart' of the virus lies in its enzymes, which are crucial for initiating and sustaining infection.
Researchers found that female mosquitoes are attracted to water containers with specific fatty acids and methyl esters from bacteria, which stimulate them to lay eggs. The study aims to use this knowledge to devise lures and traps to control yellow fever mosquito populations, preventing global diseases like dengue fever.
Researchers at UTSA have identified mast cells as a potential player in combating tularemia, a life-threatening respiratory pathogen. The study suggests that mast cells can interact with other cells to control bacterial replication, opening up new avenues for understanding the immune system's response to tularemia.
A commercially available fruit and vegetable wash has been found to be highly effective in killing disease-causing bacteria in produce-processing washwater. This could significantly reduce the risk of cross-contamination in food plants.
Overcrowding and understaffing in hospitals exacerbate MRSA control issues, leading to increased hospital stays and bed blocking. Effective infection control measures can help mitigate the problem, but addressing overcrowding and workforce shortages is crucial for improving patient safety and quality of care.
A new study shows that various interventions can motivate individuals to initiate walking behaviors, with certain strategies showing more promise than others. The review of studies found that frequency and duration of telephone prompts, as well as encouraging moderate-paced walking, were key factors in increasing walking behavior.
Women with type 2 diabetes and heart disease have poorer control of both diseases and receive less intensive medical treatment than do men. Women are also more likely to have uncontrolled high blood pressure and poor long-term control of their blood glucose levels compared to men.
A new two-week self-management programme significantly reduces healthcare visits, pain scores, and health distress in arthritis patients with chronic pain. The programme's benefits were sustained for six months with continued improvements up to a year later.
Researchers found that RA patients are nearly eight times more likely to have periodontal disease than healthy controls. The study suggests that impaired oral hygiene is only part of the connection and that other systemic inflammatory disorders may play a role.
Sub-Saharan Africa faces frequent stock interruptions of essential drugs for managing non-communicable diseases. Implementing standardized approaches to NCD management, as seen in TB control, can improve patient care and outcomes. A five-point framework called DOTS provides lessons for NCD control.
A recent study using Caenorhabditis elegans to examine the relationship between eating and weight gain found that increased eating does not necessarily lead to increased fat. The researchers discovered two separate signaling channels controlled by serotonin, which regulates feeding and fat metabolism.
The Caribbean region has a high burden of neglected tropical diseases (NTDs) due to poverty. A proposed $1 tourist tax could fund disease control efforts and is supported by industry donations of low-cost generic drugs.
The study found that Mayo Clinic's intensive care unit (ICU) pneumonia prevention rate is similar to the national average, but lower for trauma ICUs. The most common pathogen causing VAP was Pseudomonas aeruginosa, highlighting the need for targeted antibiotic treatment.
A recent survey found that nearly 40% of GERD patients on proton pump inhibitors (PPIs) experience breakthrough symptoms, requiring additional over-the-counter (OTC) treatments. More than half of these patients use OTC remedies to manage their symptoms, often using antacids as a stop-gap.