Articles tagged with Immune Response
Researchers have developed two COVID-19 vaccines that elicited durable neutralizing antibody responses to SARS-CoV-2 in pre-clinical research. The Moderna mRNA vaccine and a protein-based vaccine candidate showed strong immunity in infant rhesus macaques, with no adverse effects.
Researchers at Virginia Tech have identified a novel gene, Per2AS, that controls the sleep/wake cycle in mice, revealing the importance of non-coding genes in regulating biological processes. The study's findings could lead to breakthroughs in understanding internal body clocks and their role in various diseases.
A comprehensive review suggests that gut microbiota play a crucial role in immune responses to vaccinations. The study aims to improve vaccine effectiveness by understanding the microbiota's impact on B and T cell immune responses.
Researchers have discovered that non-professional cells can detect changes in metabolism and activate defensive measures against pathogens. This finding has implications for understanding immunity in humans and potentially developing new tools to prevent and treat infections.
Research finds that small chloroplasts in plant epidermal cells play a crucial role in controlling the entry of fungal pathogens. The study reveals that these chloroplasts migrate to the surface layer in response to fungal attacks, blocking their invasion into plant cells.
A University of Queensland study has found that reduced levels of metabolic hormone leptin are associated with poor vaccine antibody responses in both young and older individuals. The research could lead to the development of new strategies for improving vaccine protection in vulnerable populations.
Researchers at the University of Vermont have discovered new biomarkers for predicting clinical and immune responses to dengue virus infection. These findings could aid in the development of more effective vaccines against all four dengue strains, a crucial step in combating this deadly disease.
The vaccine has the potential to improve seasonal flu vaccine effectiveness, produce vaccines faster and use smaller doses. It achieved a strong immune response in mice, providing protection against two different strains of influenza.
A new study reveals key details of how SARS-CoV-2 variants escape the immune response created by natural infection or vaccination. The research highlights that several mutations are clustered in one site on the spike protein, disrupting antibody binding and neutralization.
Researchers developed a microparticle-based cancer vaccine that kickstarts an immune response, increasing the proportion of mice cured of tumors to 75%. Combining the vaccine with immune checkpoint inhibitors greatly improves treatment success, offering a promising approach to improving cancer treatment.
A large cohort study reveals that despite impaired immunity, dialysis patients maintain SARS-CoV-2 antibody levels for at least 6 months following infection. The researchers found no indication that subgroups with impaired immunity had a shorter-lived humoral response compared to healthy individuals.
A University of Colorado Boulder study suggests that invertebrate immunity can prevent disease transmission, offering insights into COVID-19 and other zoonotic diseases. Researchers observed that some plankton can stop fungal spores from entering their bodies, while others clear infections within a limited window after exposure.
Sperm deliver signals that increase the chances of conception by persuading female reproductive tissues to accept the male partner's genetic material. Factors like age, diet, and environmental exposures can affect sperm quality, impacting pregnancy health.
A novel screening strategy using cultured plant cells can identify microorganisms that stimulate plant immune mechanisms without harming plants. Eight bacterial strains were found to boost cryptogein-induced ROS production, inducing whole-plant resistance to bacterial pathogens.
Young zebra finches exposed to traffic noise developed songs with lower accuracy and were delayed in their vocal development. Chronic stress due to noise also suppressed the birds' immune function, leading to potential long-term health issues.
A dengue virus vaccine candidate has produced a protective immune response in infected mice, offering a promising alternative to existing vaccines. The UQ-developed vaccine uses an Australian insect virus and can be administered via a microarray patch for easy, needle-free delivery.
A new study found that five major kefir brands fell short of their claims, delivering between 10 million to 1 billion bacteria per gram. The researchers also identified discrepancies between the labeled species and those present in the products.
A study published in PLOS ONE found that participants who were touched by a humanoid robot during conversation reported a better emotional state. Those who received non-functional touch from the robot were more likely to comply with requests and exhibit positive behavioral responses, suggesting potential for robots to boost motivation.
Researchers developed an intranasal influenza vaccine using recombinant hemagglutinin and found it enhanced immune responses in mice. The vaccine showed superior immunoenhancing properties and conferred protection against both same and different virus strains.
The study created a genetic database that maps the function of genetic variants in autoimmune diseases, connecting DNA sequence changes to gene expression levels. The researchers analyzed 79 healthy volunteers and 337 patients with different types of immune-mediated diseases.
Corals use an ancient immune mechanism to select suitable microalgae as symbionts, tolerating them over time. The 'vomocytosis' process involves immune suppression that allows algae to establish a niche within the coral's cells, facilitating nutrient exchange.
New research from the University of Waterloo reveals shift work disrupts the circadian clock, affecting immune response and increasing risk of infection. The study shows sex differences in immune system reactivity, with males more prone to overactivation and females better prepared to fight off infections.
A study by Penn researchers found that people with schizophrenia have a compromised blood-brain barrier, allowing the immune system to improperly influence the central nervous system. This inflammation contributes to the condition's symptoms. The findings may also apply to other mental disorders.
A University of Minnesota Medical School study found that organ tissues develop immunity to viruses over time, leading to a broader understanding of the immune system's role in surveillance. The research reveals that up to 25% of cells in organs are immune cells, significantly contributing to the body's cellular makeup.
A large-scale evaluation of a federal policy aimed at reducing deaths from sepsis found that it was mostly ineffective in improving patient outcomes. Despite significant investments, the 'all or none' guidelines, known as SEP-1, did not translate to clinically meaningful changes in care delivery or reductions in deaths.
Research finds mRNA COVID-19 vaccine may have reduced efficacy in individuals with chronic lymphocytic leukemia and multiple myeloma. Patients with CLL who are treatment-naive or in remission tend to respond better to the vaccine.
The journal publishes an editorial, two mini review articles, two opinion articles, and an interview on various topics including COVID-19 diagnosis, dental implant biomaterials, ferroptosis resistance in cancer, and sonoporation. BIO Integration Journal is a peer-reviewed, open access international journal dedicated to modern medicine.
A new study reveals how Ebola virus's VP40 protein uses human mRNA to transform into different shapes, adapting to various functions. This discovery sheds light on the fundamentals of genome-encoded information and highlights VP40 as a key vulnerability for effective therapies.
A new study expands evaluation of gene therapy for spinal muscular atrophy (SMA), a rare genetic neurodegenerative disease. Treatment with onasemnogene abeparvovec is associated with an immune response, but showed no long-term adverse effects.
Researchers developed a personalized tumor cell vaccine strategy targeting Myc oncogenes combined with checkpoint therapy, creating an effective immune response. In the mouse neuroblastoma model, the vaccine showed a 75% cure rate and long-term survival.
Recent discoveries have revealed a complex picture of plant defense, with responses to PRR receptor signaling and NLR signaling extensively overlapping. The two immune branches are now considered to be more intimately connected than previously thought, leading to a re-thought model of separate ETI and PTI pathways.
A new study by researchers at WashU Medicine found that children hospitalized with RSV are likely to get sicker if they have high levels of defective viral genomes. These defective genomes can trigger a strong antiviral immune response, but timing matters in determining the course of illness.
A new study reveals a complex co-evolutionary relationship between bacterial antigens and plant immune receptors, with implications for our understanding of the plant microbiome. The research found that synthetic experiments can mimic natural diversity in molecular signals, allowing plants to detect and respond to 'non-self' pathogens.
A new study explores the role of MHC-I variants in SARS CoV-2 infection, finding that certain alleles are better at binding viral fragments and stimulating a strong immune response. This knowledge may help predict individual susceptibility and inform vaccine development.
Researchers developed lung-on-chip platforms that recapitulate the human lung's multicellular architecture and physiochemical microenvironment. These models provide a more rapid alternative for testing drug candidates to treat COVID-19-related lung infections.
A study by McGill University researchers found that delaying second COVID-19 vaccine doses can have benefits, but effects depend on population immunity. Increasing vaccination rates or changing dosing regimes can mitigate longer-term epidemiological effects.
The use of dental implants for tooth replacement requires careful consideration of biomaterials, which must integrate into the body while minimizing negative immune responses. Researchers have compared titanium and zirconia, highlighting the importance of surface modification processes and coatings in optimizing implant performance.
Research found that high vitamin D levels above traditional sufficient levels are associated with a lower risk of COVID-19, especially in Black individuals. Vitamin D deficiency is linked to an increased risk of testing positive for COVID-19.
Researchers have developed a new imaging technique that allows them to visualize immune T cells in three dimensions, revealing specialized niches that determine their function. The study identifies avenues for therapeutically targeting effector and memory cells, which could lead to improved vaccine strategies.
Researchers from Max Planck Institute of Molecular Physiology have developed a cell-based assay that identifies highly potent IDO1 inhibitors with different mechanisms of action, which could lead to promising immunotherapies for cancer treatment. The new approach overcomes limitations of existing cell-free assays and holds promise for ...
Researchers at Cleveland Clinic Florida have identified a novel mechanism that leads to MDA5 activation during virus infection, and found that inhibiting the PLpro enzyme may help strengthen the human immune response against SARS-CoV-2. This could potentially lead to new anti-COVID-19 therapeutics targeting the PLpro enzyme.
Researchers from Nanyang Technological University have developed a compound called ASO-1 that targets the TYK2 enzyme, which is linked to autoimmune disorders such as rheumatoid arthritis and type 1 diabetes, as well as severe COVID-19. The compound has been shown to potently reduce TYK2 levels and inhibit immune signalling pathways.
A new modeling study examines the impact of one versus two doses of a COVID-19 vaccine on infections and immune escape. The study finds that while one-dose strategies may reduce short-term infections, weak immunity could lead to long-term virus replication and mutation.
A Princeton University and McGill University study found that delaying second COVID-19 vaccine doses reduces case numbers in the short term. However, longer-term case burden and potential viral escape from immunity may depend on the strength and duration of immune responses generated by natural infections or one to two vaccine doses.
A study by Virginia Tech researchers reveals that a specific bacterium in mom's milk can educate an infant's antibody response, potentially strengthening their immune system. The findings suggest that probiotics could be used to protect infants from enteric infections and autoimmune diseases.
Researchers found that high levels of antibodies against a specific part of the virus may be key to understanding immune response to COVID-19. Individuals with stronger antibody responses showed immune functions associated with natural protection, offering a promising avenue for vaccine development and effective global rollout.
A recent study published in Eurosurveillance found that one dose of the Pfizer vaccine triggers a strong immune response in people who have previously been infected with SARS-CoV-2. The researchers also observed similar responses across multi-ethnic groups, suggesting that vaccination priority for those previously infected may not be n...
Researchers found a subpopulation of adults who don't sustain an antibody response after RSV reinfection, making them susceptible to reinfection. The 'original antigenic sin' phenomenon also emerged, where the immune system responds more to older infections than recent ones.
A new DNA-based vaccine platform has been shown to induce potent immune responses in mice, generating high levels of antibodies and strong T cell responses. The vaccine was found to be immunogenic, efficiently neutralizing the SARS-CoV-2 virus after a single immunization.
A new intranasal influenza vaccine demonstrated a durable immune response in a Phase 1 study, producing higher antibody levels compared to oral vaccination. The vaccine induced mucosal immunity and neutralizing antibodies at 26 weeks after vaccination, with sustained protection lasting up to five years.
A study by Hokkaido University reveals that tick saliva contains prostaglandin E2, which suppresses the immune response of helper T cells in cattle. This finding could lead to better protection for cattle against tick-borne diseases.
A recent study published in Cell Report Medicine has provided a detailed look at the vulnerable sites on the novel coronavirus SARS-CoV-2 that T cells can attack. The research found that T cells can recognize dozens of epitopes on the virus, including several additional sites on the spike protein.
Research suggests adult males are twice as likely to die from severe COVID-19 as females due to biological factors, according to a new Perspective article. Differences in antiviral immune responses between the sexes, including sex-specific genes and hormone roles, may underlie this male bias.
Researchers from RUDN University and RLT propose that stimulating lymphocyte regeneration with combined biophysical radiances can help fight COVID-19. They found a correlation between bioenergetics and immune system reactions, suggesting a potential solution to the disease's progression.
The study found new biomarkers related to changes in protein function involved in novel regulatory mechanisms of metabolic and immunological pathways in blue mussels, soft-shell clams, Eastern oysters, and Atlantic jackknife clams. Biomarker identification will benefit the aquaculture industry.
A recent study found that female COVID-19 patients experience less severe complications due to stronger immune responses triggered by their X chromosome-linked genes. Women's immune systems are enhanced by the presence of Toll-like receptor seven, allowing them to better tolerate virus infections.
A preliminary study found that a drug helping immune cells self-clean can improve vaccine protection in older adults. The drug boosts autophagy, which is blunted in older individuals, restoring immune cell function and enhancing vaccination efficiency.
A study published in Cell Reports identified a protein called SHP-1 as a key player in the Leishmania parasite's evasion of the human immune system. By activating SHP-1, the parasite can limit the capacity of dendritic cells to present antigens, thereby preventing autoimmune disorders and protecting itself from an immune response.
A new study suggests that targeting the RANK signaling pathway can enhance antitumor immune responses, making breast cancer more responsive to immunotherapy. The findings come from a clinical trial and preclinical research, demonstrating the potential of this approach to convert 'cold' tumors into 'warm' ones.
A computational method combining clinicodemographic variables and deep learning of pre-treatment histology images accurately predicts response to immune checkpoint blockade. The model, validated in an independent cohort, achieves high accuracy and can stratify patients into high versus low risk for disease progression.