Articles tagged with Lymphocytes
Researchers at UT Southwestern Medical Center have identified a likely cause of kidney transplant rejection: antibodies attacking MICA antigens. The study found that patients who showed the most marked effect from these antibodies were those considered high-risk for clinical transplantation.
A study by National Space Biomedical Research Institute has found that osteopontin plays a significant role in the immune response to chronic stress. Mice with normal OPN gene experienced weight loss, spleen and thymus atrophy, and reduced white blood cells after three days of hindlimb unloading.
Researchers found that the MX2 gene is significantly down-regulated in narcoleptic patients' white blood cells, which may contribute to immune system abnormalities. This discovery could help elucidate the pathophysiology of narcolepsy and inform further studies on its functional relationship with the MX2 gene.
A study led by Duke University researchers found that a white blood cell booster can significantly reduce the risk of chemotherapy-related complications characterized by fever and low white blood cell levels. The study, published in the Journal of Clinical Oncology, involved over 3,000 patients and showed that patients taking the drug ...
Spanish researchers found that pigs fed large quantities of raw potato starch had a healthier bowel and decreased levels of white blood cells. The study, published in Journal of the Science of Food and Agriculture, suggests a potential beneficial effect on overall immune system health.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.
A study by Washington State University found that Iyengar yoga reduces demands of illness and stimulates lower lymphocyte NF-?B activation in breast cancer survivors, indicating improved immune function and quality of life. The practice has also been shown to decrease physical and emotional burdens associated with cancer survivorship.
Researchers found significantly less salivary gland damage in a group treated with green tea extract, suggesting a reduction of Sjogren's Syndrome symptoms like dry mouth. Green tea's EGCG component may also suppress inflammation and turn on the body's defense system against TNF-alpha.
A University of Rochester study concludes that filtering white cells from donor blood before a transfusion is much safer for patients and long overdue as a national standard. The practice reduces post-surgical infection rates by 30%, saving lives and reducing costs nationwide.
Researchers developed a new imaging technique to capture the movement of white blood cells in real-time, allowing for a better understanding of Sickle Cell disease. The technique, called digital multi-channel videomicroscopy, has the potential to aid investigations and develop therapeutics for this debilitating disease.
Researchers discovered a new protein, Carabin, that acts as an internal brake to limit the immune system's response, preventing excessive inflammation. This discovery may have potential applications in stopping unwanted immune reactions, such as organ rejection.
Researchers found a blood test ratio to be an effective alternative to the expensive mononucleosis spot test. The lymphocyte-white blood cell count ratio can correctly diagnose mononucleosis with high sensitivity and specificity, differentiating it from tonsillitis.
Researchers developed a method to selectively bind and remove prion protein, effectively eliminating disease-causing agents. The approach could significantly reduce the risk of transmission through blood donation, particularly in cases of variant Creutzfeldt-Jakob disease (vCJD).
A new study suggests that blood transfusions during heart bypass surgery may be linked to a higher risk of developing potentially dangerous infections and dying in the first few months after operation. Women are more likely to receive blood transfusions than men, which may explain their increased mortality risk.
Researchers at the University of Cincinnati are studying whether environmental toxicants can worsen lung disease by activating a receptor that causes the immune system to attack stressed lung tissue. Chronic exposure to toxins like tobacco smoke and air pollutants may exacerbate damage, leading to additional health problems.
Researchers found that eliminating a molecular switch allows immune cells to enter the central nervous system (CNS), leading to symptoms similar to multiple sclerosis. Eliminating this switch prevents destructive immune cells from entering CNS tissue, keeping mice healthy.
Researchers found that compounds binding to CB2 receptor suppress white blood cell migration, a key step in fighting infections and inflammation. This discovery suggests potential therapeutic applications for cannabinoids in treating inflammatory diseases.
A study published in Blood found that the newborn immune system functions differently than adults, but one portion of the response is fully functional and can be harnessed to improve immunity. The researchers identified a specific Toll-like receptor, TLR8, that triggers a robust immune response in newborns.
The study found that the three-dimensional structure of SOCS3 enables the design of selective inhibitors, which may extend the activity of G-CSF in restoring white blood cells. Additionally, an engineered version of SOCS3 with improved stability and repressive functions shows potential for treating inflammatory diseases.
Researchers uncover first molecular insight into eosinophilic esophagitis by identifying genetic program distinguishing it from other forms of esophagitis. The study reveals eotaxin-3 as a key gene contributing to the disease, offering new potential for diagnosis and therapy.
Researchers found that high white blood cell counts were associated with an increased risk of cancer mortality, even after controlling for other factors. The association was strongest for lung cancer and suggested that aspirin may have a greater protective effect against cancer for those with high WBC counts.
Researchers analyzed the expression levels of genes in circulating white blood cells after injection with bacterial endotoxin, identifying novel pathways and associations with inflammatory processes. The findings aim to improve trauma treatment by tailoring treatments to patients' individual needs.
Scientists at UCSD found that white blood cells increase production of protein HIF-1 in response to bacteria, stimulating antimicrobial compounds to kill invading organisms. Treating white blood cells with chemicals can enhance their bacterial killing ability.
A new study has developed an oral rinse test that can detect the presence of white blood cells in patients undergoing bone marrow transplants. The test was found to be effective in predicting which patients are at risk of infection during their recovery, with a difference of less than four days being an indicator of susceptibility.
Researchers created a genomic analysis tool to study critically ill patients, enabling physicians to predict treatment responses and develop new therapeutic strategies. The technology allows for the detection of significant gene activity differences between trauma patients and healthy individuals.
A study of postmenopausal women found that a high white blood cell count is associated with an increased risk of cardiovascular events and death. Women in the highest quartile had a doubled risk for coronary heart disease death, 40% higher risk for nonfatal heart attacks, and 50% higher risk for total mortality.
Researchers using 'heavy water' tracked leukemia cell birth and death rates, revealing dynamic process with mortal cells that proliferate and die. The study found faster birth rates of leukemia cells correlate with poorer patient outcomes, paving the way for potential new methods of prediction and treatment guidance.
Researchers found that nanotubes were ingested by white blood cells and retained their fluorescent properties, allowing for selective detection. The discovery builds on a previous finding of unique fluorescent signatures from individual types of nanotubes.
A team of biomedical engineers is using $11.5 million grant from the National Institutes of Health to understand how mechanical forces govern white blood cells' behavior. The research aims to develop new treatments for diseases caused by inappropriate immune responses, such as diabetes and heart disease.
Researchers are investigating whether neglecting oral hygiene increases the risk of heart disease by allowing plaque to accumulate on teeth. The new study will examine white blood cell counts and other inflammatory markers in African American volunteers.
The study reveals that Strep bacteria employ a dual strategy to outsmart the immune system: producing a toxic 'sword' called hemolysin to kill immune cells, and an antioxidant 'shield' made of carotenoids to protect itself from oxidative damage. This unique approach makes GBS a more lethal pathogen.
The study characterizes lymphocyte microvilli, dynamic structures that alternate between assembly and disassembly. Disrupting these receptors could lead to a less toxic form of immune suppression and prevent metastasis in cancer cells.
Researchers at Boston College are studying the molecular mechanisms of B-1a cells, which can lead to autoimmune diseases and leukemias like chronic lymphocytic leukemia. The new NIH-funded program project aims to understand how these cells proliferate and enter the cell cycle.
A new study found that blocking the protein FcRn reduces autoantibody production and protects against arthritis in mice, offering a potential therapeutic target for autoimmune diseases. The research suggests that FcRn may be responsible for promoting autoimmunity in patients with conditions like lupus and rheumatoid arthritis.
A new study using nucleic acid amplification technology (NAT) screening detected a significant rate of West Nile Virus viremic donations, preventing recipient infections. Another study investigated the role of monocytes in transfusion-transmitted cytomegalovirus infections, shedding light on the underlying processes involved.
Scientists report evidence of catch bonds regulating white blood cell activity, offering potential targets for anti-inflammatory compounds and cancer metastasis control. Researchers discovered prolonged bond lifetimes with increasing force, contrary to initial theories.
Researchers found that alcohol consumption increased host susceptibility to SIV/HIV infection by increasing infectivity of cells and lymphocyte turnover. The study suggests that chronic or binge alcohol consumption may contribute to the risk of HIV infection, particularly through behavioral factors.
Scientists at UCSD discovered a protein, HIF-1, that enables white blood cells to function in low-oxygen environments, leading to inflammation. Inhibiting this protein blocks inflammatory responses in mice, offering new hope for treating arthritis and potentially improving cancer treatment.
Scientists have successfully transplanted human and porcine 'kidney precursor cells' into mice, resulting in functional kidneys that produce urine. The optimal time for transplantation is between 7-8 weeks (human) and 4 weeks (porcine), reducing the risk of immune rejection.
A study published in Brain, Behavior and Immunity found that individuals experiencing cardiac reactors showed a greater immunologic response to stress, as measured by lymphocyte redistribution. This response may play a role in inflammatory diseases and heart attack.
Researchers will use tiny devices called nanosensors that can detect early signs of radiation-induced cell damage. The sensors, which pass easily through blood membranes, aim to avoid problems with current implantable sensors and eliminate blood sampling.
Researchers found two genes associated with human cancer play a central role in orienting cells towards chemical cues. They discovered that PI3K acts as an internal compass and steering mechanism, allowing cells to move efficiently towards chemical attractants.
A UNC scientist found that trauma and human herpesvirus 8 (HHV8) contribute to the development of Kaposi's sarcoma, a cancer linked to HIV. The researcher also discovered that HHV8 can be detected in saliva prior to disease development, suggesting new treatment possibilities for high-risk individuals.
A study led by Dr. Lena Lavie found that sleep apnea patients have increased adhesion molecules and free radicals on their white blood cells, which contribute to the development of atherosclerosis. Effective treatment with CPAP may not reverse this process, highlighting the need for further research.
Researchers found that uncomplicated labor and vaginal delivery do not stimulate the babies' immune systems to HIV infection. Babies born to mothers with chorioamnionitis or preterm labor, however, showed activation of their white blood cells and higher risk of transmission.
Researchers investigated adhesive interactions in contact dermatitis, a common skin condition. Key findings indicate that adhesions play a significant role in the development and progression of this disease.
Researchers distinguish a new type of leukemia called mixed-lineage leukemia (MLL) that is genetically different from acute lymphoblastic leukemia (ALL). The study used DNA microarrays to compare gene expression profiles and found clues about the origin of MLL, suggesting it is caused by arrested maturation of lymphocytes.
A study published in the American Journal of Clinical Nutrition found that elderly subjects had a lower white blood cell count increase after refeeding, indicating impaired immune function. This suggests that poor nutritional status in elderly patients may amplify the risk of infection or disease.
Estrogen controls lymphocyte formation and replenishment of the immune system by binding to hormone receptors found only in rare "precursors" within adult bone marrow. This discovery reveals that various kinds of stem cells may differ between fetal and adult life, protecting the fetus's immune system from estrogen-related compounds.
Researchers have discovered a new antibody treatment that prevents severe lung injury in premature babies without using steroids, which can stunt brain cell growth. The treatment, anti-CINC-1, blocks the action of white blood cells and reduces inflammation, promoting normal lung development and function.
A study published in JCI Journals reveals that an excess of healthy cells may hold leukemia in check. The researchers found that these healthy cells could be used as a therapeutic target to develop new treatments for the disease.
Researchers have discovered that killer lymphocytes recognising HPV can be found in tumour tissues, and that they may be able to boost the immune system's response to prevent cancer. A novel vaccine is also being developed to stimulate killer lymphocytes to target HPV-infected cells.