Articles tagged with Lymphocytes
Researchers at Linköping University have discovered a previously unknown warning system in the immune defense that triggers an alarm, sending signals to surrounding cells. This process involves the release of mitochondrial DNA strands by white blood cells in response to infections like bacteria and viruses.
Researchers at Tokyo Medical and Dental University have discovered that overexpression of the MKL1 protein in macrophages contributes to inflammation development in IBD. Targeting this protein may hold potential for treating IBD, a condition with currently no cure.
Researchers have created a novel system that enables aggregates composed of magnetized particles to roll along a channel using a combined acoustic and magnetic field. The system has shown promise for delivering drugs to hard-to-reach sites within the body, with potential applications in cancer treatment.
UC Davis researcher Sean Collins receives $1.5M NIH award to develop smart immune cells that can control their recruitment and response to tumors without amplifying attack signals, reducing potential side effects. The goal is to create targeted therapies with controlled responses.
A new chip etched with fluid channels sends blood samples through a hydrodynamic maze to separate out rare circulating cancer cells into a relatively clean stream for analysis. The labyrinth chip is already in use in a breast cancer clinical trial, enabling doctors to plan customized treatments and monitor genetic changes.
Researchers have developed a new testing regime to diagnose severe combined immune deficiency (SCID) syndrome faster, enabling more infants to receive life-saving treatment within a critical timeframe. The regime uses a checklist of potential SCID markers, including family history, candidiasis, and low absolute lymphocyte counts.
A USC study found that the Zika virus targets specific white blood cells in pregnant women, handicapping their immune system and increasing the chances an unborn baby will be harmed. The virus exploits this weakness to infect and replicate, particularly during the first and second trimesters.
A new mechanism has been discovered that allows white blood cells to recognize and expel pathogens, preventing the spread of infections like Cryptococcosis to the brain. Researchers have identified a key molecule called ERK5 that can be manipulated to enhance this process, offering potential therapies for diseases such as this.
Researchers at the American Society of Hematology report on the effectiveness of enasidenib in treating a rare form of leukemia. Enasidenib demonstrates significant benefits as a targeted treatment for this aggressive disease, offering new hope for patients with limited options.
A new study links HMGB1 protein to post-sepsis immunosuppression and neutrophil dysfunction. Researchers found that neutralizing HMGB1 restores neutrophil function, offering a potential therapeutic approach for sepsis recovery.
A viral protein in the chickenpox virus enhances its ability to hijack white blood cells and spread throughout the body. The protein interacts with chemokines to attract more white blood cells to the site of infection, allowing the virus to spread to other parts of the body.
A new computational model reveals how mechanical forces from blood flow influence white blood cell migration into the artery wall, and suggests that neutrophils are primary cell types in plaque at two timepoints during atherosclerosis. The model provides insights into plaque growth and could inform clinicians in choosing treatment plans.
Researchers found that Ebola virus binds directly to white blood cells, causing their death and disrupting the immune system. This study provides new insights into the mechanisms of Ebola infection and may lead to the development of targeted therapies for Ebola virus disease.
Researchers have characterized the unusual cell death process triggered by starvation, where the endoplasmic reticulum plays a key role. This discovery may shed new light on tumor progression and ischemia-related cell death in cancer and other diseases.
Scientists identify a common mechanism in two forms of neurodegeneration affecting young adults and the elderly, linked to progranulin protein mutations. The discovery advances efforts to find better treatments and cures for these diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis.
White blood cells use their nuclei to exert force and insert themselves between endothelial cells, creating large holes in the blood vessel walls. This discovery sheds light on the movement of immune cells and may aid in cancer research.
The study used Fourier transform infrared spectroscopy to detect biomolecular changes in white blood cells stimulated with bacterial components, revealing a threefold increase in microvesicle production and altered lipid content.
Scientists at the Salk Institute have developed a new method to predict which individuals with bipolar disorder will respond to lithium therapy. Using a system trained on electrical firing patterns of neurons from six patients, the method achieved 92% accuracy in classifying responders and nonresponders.
Researchers found that H. pylori bacteria can alter the structure of white blood cells, known as neutrophils, allowing them to survive within the human body. This change enables the bacteria to evade the immune system, but also shares characteristics with tumor-associated neutrophils that may limit cancer growth.
Researchers at UTMB have identified inflammation as a major contributor to permanent vision loss after head trauma. Limiting inflammation may help preserve cell function and prevent nerve damage.
Researchers successfully repaired a defective gene in blood-forming stem cells from patients with X-linked chronic granulomatous disease, suggesting a potential treatment approach. The study used CRISPR-Cas9 technology to correct a specific mutation in the CYBB gene, restoring normal functioning of white blood cells.
Researchers found that treating white blood cells with antibodies targeting PD-1 and PD-L1 molecules can restore their function and ability to kill bacteria. This discovery offers new hope for treating sepsis, a devastating inflammatory disease.
Researchers at Université de Genève have developed an antibody that blocks the migration of cancer cells, preventing their spread and proliferation. The 'H225' antibody reduces cancerous cell transit into organs by over 50% and limits cell proliferation, offering a promising new therapeutic strategy against lymphoma.
Researchers developed an antibody that prevents the immune system from attacking the myelin sheath, reducing demyelination and axon degeneration. In experimental mouse models, treatment with the antibody blocked progression of motor disorders and reduced lymphocyte infiltration into the nervous tissue.
A team of scientists has discovered that the intestinal nervous system protects the bowel's lining against inflammation and microbial aggressions. The researchers found that this mechanism is under control of the Ret protein, which regulates the production of interleukin-22, a molecule important for gut repair.
Biologists have uncovered a key protein in the slime mold Dictyostelium discoideum that enables it to home in on bacteria, similar to human white blood cells. This discovery provides new insights into immune cell directionality and may lead to effective treatments for cancer and other diseases.
Researchers found swollen posterior cervical or axillary lymph nodes, fatigue, and enlarged spleen to be effective predictors of mono. Persistent symptoms lasting three to four weeks also characterize the illness, according to Dr. Mark Ebell.
A new lipid, LPA, has been found to regulate lymphocyte motility in narrow lymph nodes. LPA enables efficient movement through spaces jammed with immune cells and stromal cells. This discovery may lead to novel strategies for controlling immune responses.
Researchers discovered that neutrophils can internalize C. neoformans in the brain vasculature and circulate them back into the bloodstream for removal. This process enables the prevention of cryptococcal meningoencephalitis, a deadly brain infection.
Researchers at the University of Calgary have discovered a novel mechanism to stop autoimmune diseases without compromising immunity. A new class of drugs harnesses this mechanism to treat various autoimmune diseases, offering a highly specific treatment approach.
Researchers used model blood vessel systems to show that white blood cells' mechanical properties determine their location within the circulation. The study found that changes in cell stiffness can be triggered by drugs commonly used to fight inflammation or boost blood pressure.
Aging is associated with chronic low-level inflammation, which can impair white blood cells' ability to fight infection. Reducing inflammation in older adults helps clear infections and improve recovery.
Researchers have identified a new way in which methicillin-resistant Staphylococcus aureus (MRSA) exploits the body's own immune system to persist in infected tissues. By understanding this process, new treatments may be developed to reduce complications from infection after prosthetic surgery.
A recent study by the University of Chicago has found that loneliness triggers fight-or-flight stress signaling, leading to increased production of white blood cells and impaired antiviral responses. This shift in monocyte output contributes to loneliness' associated health risks, including premature death.
Research at Lund University reveals that mucus in the saliva stimulates white blood cells to form effective nets of DNA and proteins, capturing and killing bacteria. Patients with aphthous stomatitis and Behçet's disease often lack saliva with this property, highlighting a potential link between mucus and these diseases.
Researchers found that male mice recruit more white blood cells to the site of inflammation than females, highlighting the importance of sex differences in inflammatory responses. This discovery has implications for how we design and interpret experiments and evaluate anti-inflammatory therapeutics.
A low-cost, digital fluorescence microscope has been developed to diagnose diseases in rural areas by examining blood smears. The device can quantify white blood cell levels and differentiate between three types of cells, enabling accurate diagnoses with minimal infrastructure.
Researchers found that overcrowded conditions protect against developing a particular type of Hodgkin lymphoma, while female patients in the 20-24 age group have a higher incidence rate. The study also suggests that oestrogens may be responsible for this increased risk.
Researchers at UCSF have identified a family of daughter cells, called MPPs, which arise from stem cells in bone marrow to generate the entire blood system. The discovery raises the possibility of manipulating these cells to overcome imbalances and deficiencies in the blood system due to aging or cancer.
A team at CHUM Research Centre and University of Montreal has identified a molecule called MCAM that could delay the onset of multiple sclerosis. Blocking this molecule may significantly slow disease progression.
Researchers have developed a new equation that predicts the behavior of blood cells during flow, shedding light on mechanisms behind blood disorders such as sickle cell anemia. This theory could lead to innovative solutions for blood transfusions and disease treatment.
A study of 1144 US adults found that those with COPD had higher levels of white blood cell count and fibrinogen, as well as elevated C-reactive protein, which were linked to an increased risk of dying. Elevated fibrinogen concentrations were also modestly associated with premature death.
Researchers found that pioglitazone enhances ROS production in white blood cells, killing difficult-to-treat pathogens. This finding demonstrates a relevant contribution to host defense in mouse and cellular models of chronic granulomatous disease.
A new study by George Washington University researchers found that autoimmune disorders and cancer share common pathogenic mechanisms. The study identified survivin as a key mediator of autoreactive cell survival in myasthenia gravis, an autoimmune disease that can lead to severe muscle weakness. The findings suggest a potential therap...
A study of 50 returning veterans found that non-specific respiratory symptoms were common, with evidence of airway hyperreactivity in 36% of patients. Underlying mental health and sleep disorders were present in 66% of the patients. Airway hyperreactivity was seen in both asthma and nonspecific cases.
A team of scientists has identified a previously unknown form of lymphocyte that protects against intracellular infection, providing important insights into the human immune system. The discovery of these 'precursor cells' could lead to the development of new vaccination strategies to prevent intracellular infections.
Researchers sequenced blood and brain samples from a 115-year-old supercentenarian to identify somatic mutations. They found approximately 450 somatic mutations in white blood cells, with most being single nucleotide variants, which did not affect genetic fitness.
Scientists discovered over 400 genetic mutations in the white blood cells of a 115-year-old woman, indicating that these mutations may not contribute to disease. The study also found extremely short telomeres in the blood cells, suggesting 'stem cell exhaustion' as a possible cause of death at extreme ages.
A study published in Cell Death & Disease found that an overabundance of c-FLIPR protein disrupts the immune system's balance. Researchers discovered that this imbalance leads to autoantibodies attacking the body's own tissues, resulting in autoimmune diseases like systemic lupus erythematosus.
A new study published in Blood journal found that adhering to a Mediterranean diet is associated with lower levels of platelets and white blood cells, two markers of inflammation. This eating plan is linked to reduced inflammation and heart disease risk, particularly among healthy individuals.
A team of biologists and engineers at the University of California, San Diego has discovered how white blood cells generate traction forces to propel themselves forward by coordinated action of contractile proteins. This finding is crucial for developing new pharmacological strategies to treat chronic inflammatory diseases.
A study by researchers at the Medical College of Georgia has identified two players that must work together to destroy vision in patients with diabetes. The findings suggest that blocking the production of reactive oxygen species by either retinal cells or white blood cells may be a viable strategy for intervention.
Researchers used RIT to destroy HIV-infected cells in blood samples, reducing infection levels to undetectable. The treatment also showed effectiveness in targeting brain and central nervous system infections.
Researchers from the University of Missouri School of Medicine found a more accurate way to screen for bacterial meningococcal infection in its early stages. They discovered that abnormalities in neutrophil counts can indicate a serious infection, including meningococcal disease.
Researchers used cynomolgus monkeys to compare autologous and allogeneic transplantation of iPS cell-derived neural cells. Autologous transplantation produced almost no immune reaction, while allogeneic transplantation provoked an immune response.
Researchers found that platelets activate a screening process allowing lymphocytes to exit the bloodstream without causing bleeding. This discovery opens avenues for further research into the role of platelets in vascular health and inflammation.
A study by the NIH found that deleting a protein called Olfm4 improves white blood cells' ability to fight bacteria in mice with chronic granulomatous disease (CGD). This suggests a novel strategy for developing new treatments against common and deadly infections.
Researchers at RIKEN Center for Developmental Biology successfully cloned mice using a drop of peripheral blood from its tail. This method uses white blood cells, which allow for repeated sampling with minimal risk to the donor mouse. While not surpassing the success rate of cumulus cells, this technique demonstrates a promising altern...
Researchers found that stimulating the CB2 receptor in white blood cells weakens HIV-1 infection. Synthetic compounds may make current therapies more effective and provide protection against certain complications. The discovery holds promise for fighting other viral diseases.
Researchers have discovered that hematopoietic stem cells can perceive signals from the body during emergencies and produce specialized white blood cells, such as macrophages. This discovery could lead to new strategies for protecting patients undergoing bone marrow transplants from infections.