Articles tagged with Lymphocytes
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Researchers found that IL-10 production by keratinocytes in donor skin is crucial for successful skin grafting between genetically identical mice. Monitoring IL-10 levels may improve therapeutic success in human patients.
Researchers have discovered the molecular structure of calmodulin's role in regulating L-selectin shedding, allowing white blood cells to move to sites of infection or inflammation. This understanding could lead to developing drug therapies to manipulate the immune system and address disorders caused by overactive immune responses.
Researchers found that severe sleep loss affects white blood cell counts, particularly granulocytes, which react immediately to physical stress and mirror the body's stress response. The study suggests implications for clinical practice and professions associated with long-term sleep loss.
Researchers found a specific enzyme, 5-lipoxygenase, linked to microgravity-induced cell death in astronauts, which may lead to therapeutics for aging-related immune problems. The discovery could also benefit the elderly on Earth by bolstering their immune systems.
A new study published in Nature has disproved the theory that pigeons' navigation skills are linked to iron-rich nerve cells in their beaks. Macrophages, specialized white blood cells, were found to contain tiny balls of iron instead, contradicting earlier research.
Researchers at Cardiff University discovered a new group of cells with strong immunosuppressive properties derived from cheek tissue. These cells can completely inhibit lymphocyte action with small doses, offering promise for combating diseases like diabetes and organ rejection.
Researchers found that variation in the level of expression of a gene called CMG2 affects the success of the anthrax toxin in gaining entry into human cells. The study highlights the importance of host genetics in determining individual susceptibility to pathogens like anthrax, HIV, and malaria.
Scientists have developed a handheld device that can accurately count white blood cells, revolutionizing the complete blood cell count test. The device uses a 'blood lab-on-a-chip' technology to break down red blood cells and produce comparable results to full-scale hematology labs.
Research suggests that certain strains of Pseudomonas aeruginosa can trigger an allergic reaction in white blood cells, leading to increased histamine production and worsening inflammation. This discovery sheds light on a potential link between environmental bacteria and asthma.
Researchers have developed a non-invasive method to diagnose Alzheimer's disease using infrared analysis of white blood cells. The technique distinguishes between mild and moderate stages of the disease, allowing for reliable early diagnosis.
A £3.6 million project seeks to illuminate a fundamental mechanism controlling cells in the immune system as we age. Understanding this process may lead to new possibilities for improving health in older people.
Researchers at Virginia Commonwealth University found that infiltration of white blood cells into expectant mothers' blood vessels may explain high blood pressure in pregnancy. This discovery could lead to novel treatments for preeclampsia, a leading cause of premature delivery and maternal mortality worldwide.
Researchers have discovered a strategy to accelerate arteriogenesis, allowing blood vessels to bypass occlusions and improve blood perfusion. This approach has therapeutic potential for treating ischemic diseases such as heart attacks and strokes.
A systematic review found that taking natalizumab for two years lowers the number of MS patients who experience relapses and progression of disability. The medication also delays disease progression, according to MRI brain scans.
Researchers have discovered a new mechanism controlling aging in white blood cells, opening up the possibility of temporary boosting of the immune systems of older people. This could help fight off infections and improve quality of life for older individuals.
Estrogen has been found to help regulate white blood cell activity, preventing them from sticking to blood vessel walls and causing vascular damage. This natural mechanism could have important implications for understanding and treating cardiovascular disease.
Large-scale genome-wide association studies have identified 15 gene variants associated with white blood cell count diversity among whites, African-Americans, and Japanese. These findings could lead to new clinical advances, including earlier disease risk assessments and potential gene therapies.
Researchers block PlGF to increase life expectancy in CML mice, even those resistant to imatinib. Chronic myeloid leukemia's uncontrolled white blood cell production is disrupted by a disruption in maturing process.
Researchers at Fox Chase Cancer Center discovered that a low lymphocyte count is a simple and effective prognostic indicator in patients with renal cell carcinoma. The study found that lower lymphocyte levels are associated with a higher tumor grade, pathologic tumor stage, presence of distant metastases, and lower overall survival rate.
A study found that low lymphocyte counts before surgery are associated with poor prognosis, higher tumor grades, and lower overall survival rates. The researchers suggest that this test could help doctors individualize therapies and change clinical decisions.
Cedars-Sinai researchers discovered how white blood cells identify invading fungi, using the molecular receptor Dectin-1. This finding sheds light on the immune system's ability to mount a response against pathogens.
Scientists demonstrate a novel mechanism for Chagas disease's devastating effects: a parasite-driven autoimmune response that alters host genome. This chicken model reveals the origin of Chagas-like heart disease in the absence of parasitism, shedding new light on this lethal endemic infectious disease.
A collaboration between researchers at the University of Helsinki has cracked the long-standing question of how the human immune system recognizes foreign structures. The key to unlocking this problem lies in the protein-based marking and destruction system called complement, which distinguishes between microbes and own structures.
A research team led by Richard Waugh is investigating the reasons behind the limited attraction of white blood cells to injured tissue. They aim to develop pharmaceutical treatments that can modulate the response of white blood cells.
Researchers at the University of California, San Diego discover that statins activate white blood cells' ability to kill bacteria. Statins stimulate phagocytes to release extracellular traps that ensnare and kill bacteria before they spread in the body.
Mice lacking CEACAM1 have excess neutrophils but suffer from accelerated mortality due to liver damage and severe tissue harm. These findings suggest that natural mechanisms restraining white blood cell proliferation are crucial in treating infectious and auto-inflammatory disorders.
A team of international scientists led by Dr Florent Ginhoux have uncovered the origins of microglia, white blood cells specific to the brain, revealing they derive from a particular structure in the mouse embryo. This understanding may lead to new strategies to manipulate microglia for treating various brain disorders.
Fibroblasts, a type of connective tissue cell, have been found to be metabolically active during quiescence, producing proteins that help replenish other cells. This discovery could lead to new strategies for attacking tumors and improving overall health.
Researchers at the University of Calgary have discovered that damaged tissue can release signals that attract white blood cells, leading to inappropriate inflammation. The team used innovative imaging techniques to observe this process in real-time, shedding light on potential new treatments for inflammatory diseases.
Researchers at Cedars-Sinai Medical Center found that massage alters the immune response in healthy adults, decreasing stress hormones and increasing white blood cell counts. The study, which involved 53 participants, showed significant changes in lymphocyte numbers and percentages.
Researchers at Duke University Medical Center discovered that the cytokine interleukin-17 plays a significant role in disc disease and may lead to the development of new therapeutic approaches. Targeting this immune response could reduce painful inflammation and halt the evolution of arthritis.
Researchers at the University of Rochester Medical Center discovered that filtering donor blood reduces cardiopulmonary complications in patients who received a transfusion. The study found an 83% decrease in acute lung injury and a 49% decline in circulatory overload.
Researchers at UCLA developed two PET scanning probes that target different cells in the immune system with high specificity. The probes work better when used together, revealing the extent and cellular composition of an immune response and its effects on various diseases, including cancer and auto-immune disorders.
Scientists discovered that Lupus patients lack or have blocked DNase-1, an enzyme degrading NETs, leading to their accumulation in the kidneys. This impairs NET degradation, increasing kidney failure risk. A new test based on this finding may enable early diagnosis and treatment.
A team of researchers has identified IL-15 as a key player in the development of enteropathy-associated T cell lymphoma, a high-grade invasive lymphoma associated with severe celiac disease. Treatment with an antibody directed at IL-15 successfully wiped out intraepithelial lymphocytes in mice overexpressing human IL-15.
Researchers at the US Department of Agriculture's Animal Diseases Research Unit have discovered the viral life cycle of malignant catarrhal fever (MCF), a leading cause of disease in American bison. The virus undergoes several changes inside the animal's body, targeting specific cell types at different stages of its own life cycle.
Researchers have discovered that an enzyme found in white blood cells can break down carbon nanotubes into harmless components. This breakthrough finding has significant implications for the future use of carbon nanotubes in medicine, potentially rendering them harmless and reducing toxicity.
A study published in Cell reveals that loss of the molecule miR-328 is essential for progression from chronic to blast crisis phase in chronic myeloid leukemia. Maintaining this microRNA level may represent a new treatment strategy for CML blast crisis patients.
A team of researchers at Karolinska Institutet has discovered a gene module underlying atherosclerosis development by analyzing total gene activity in organs relevant to coronary artery disease. The findings suggest that targeting the migration of white blood cells may help reduce the risk of adverse clinical effects.
A study published in International Journal of Low Radiation found that extracts of Ginkgo biloba leaves can protect human white blood cells from gamma radiation-induced apoptosis. The results suggest that the antioxidant compounds in Ginkgo biloba extract can neutralize free radicals and prevent cellular damage.
A study published in the Journal of Dental Research found that dental plaque accumulation led to increased neutrophil activity in black males, but not in other groups. This response may indicate a higher risk for infections and heart disease in these individuals.
Researchers have discovered that hydrogen peroxide is released from wounds and triggers the recruitment of white blood cells to combat infection. The finding suggests that high levels of hydrogen peroxide may be involved in conditions like asthma and inflammatory gut diseases, warranting further investigation.
Weizmann Institute scientists have discovered that white blood cells use a unique method of movement, similar to millipedes, to crawl along the lining of blood vessels. The cells create tiny 'legs' that attach and detach in sequence, allowing them to move rapidly while keeping a good grip on the vessel's sides.
Lung airway epithelial cells initiate an immune response to inhaled bacteria by signaling white blood cells to move into the lungs. Researchers have identified a way to inhibit proteases and restrict junctions between cells, reducing inflammation and allowing optimal white blood cell response.
A new study found that administering GM-CSF to premature babies did not reduce the risk of sepsis or improve survival rates. The trial, which studied 280 babies, showed that while white blood cell counts rose with GM-CSF treatment, there was no significant difference in infection-free survival between the two groups.
Researchers identified a peptide sequence that acts like a drug to break apart the MLL molecular switch, potentially slowing or stopping abnormal white blood cell production. The discovery may lead to more effective treatments with fewer side effects for some types of leukemia.
A new study found that self-induced DNA breaks in immune cells activate genes responsible for their migration and homing to fight invaders. This discovery sheds light on a rare genetic disorder, ataxia telangiectasia, and may have implications for cancer research.
Researchers at the Trudeau Institute have made a new discovery about how white blood cells are navigated to the lung airways during an influenza infection. The findings suggest that specific types of white blood cells can recognize chemical messages produced by infected lungs, allowing them to move into tissues and attack the virus.
Scientists at Yale University propose a new explanation for cancer metastasis, suggesting that the fusion of a cancer cell with a white blood cell is the key to its spread. This theory has been validated in mouse studies and could lead to new therapeutic approaches.
Researchers at the University of North Carolina at Chapel Hill have discovered aggregates of red and white blood cells in patients with sickle cell disease. These clumps may play a role in blocking small blood vessels, causing sudden painful episodes.
Researchers at St. Jude Children's Research Hospital discovered a crucial role of the Hax1 protein in protecting cells from apoptosis. The findings provide valuable insights into the biochemical interactions that control programmed cell death, which may lead to new treatments for diseases like Parkinson's.
A new study reveals microRNAs can directly control a protein's function, preventing immature blood cells from maturing and contributing to the development of blast-crisis CML. Altering microRNA levels may represent a potential therapeutic strategy for CML patients who don't respond to targeted agents.
Researchers at the University of Virginia Health System have identified a key enzyme involved in the development of Type 1 diabetes. The discovery, centered on the 12/15-lipoxygenase gene, has significant implications for understanding and treating the disease, with potential applications for preventing or reversing Type 1 diabetes.
A small study found that diesel exhaust increases clot formation and blood platelet activity in healthy volunteers, which could lead to heart attack and stroke. Researchers measured clot formation, coagulation, and inflammatory markers after exposure to diluted diesel exhaust.
Researchers at UT Southwestern Medical Center have identified a likely cause of kidney transplant rejection: antibodies attacking MICA antigens. The study found that patients who showed the most marked effect from these antibodies were those considered high-risk for clinical transplantation.
A study by National Space Biomedical Research Institute has found that osteopontin plays a significant role in the immune response to chronic stress. Mice with normal OPN gene experienced weight loss, spleen and thymus atrophy, and reduced white blood cells after three days of hindlimb unloading.
Researchers found that the MX2 gene is significantly down-regulated in narcoleptic patients' white blood cells, which may contribute to immune system abnormalities. This discovery could help elucidate the pathophysiology of narcolepsy and inform further studies on its functional relationship with the MX2 gene.
A study led by Duke University researchers found that a white blood cell booster can significantly reduce the risk of chemotherapy-related complications characterized by fever and low white blood cell levels. The study, published in the Journal of Clinical Oncology, involved over 3,000 patients and showed that patients taking the drug ...
Spanish researchers found that pigs fed large quantities of raw potato starch had a healthier bowel and decreased levels of white blood cells. The study, published in Journal of the Science of Food and Agriculture, suggests a potential beneficial effect on overall immune system health.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.