Nephrology
Articles tagged with Nephrology
Mount Sinai Health System Chair of Pediatrics receives ASPN Founders’ Award for Lifetime Achievement in Pediatric Nephrology
Dr. Lisa M. Satlin, a renowned pediatrician-scientist, has been awarded the ASPN Founders' Award for her lifetime contributions to pediatric nephrology through research, education, and clinical care. She has advanced understanding of kidney function and development, with significant implications for hypertension and kidney disease.
An app that improves decision-making: Duke-NUS study shows myKIDNEY helps patients make better informed choices
A Duke-NUS study shows that pairing a web-based decision-aid with counselling significantly shifts patients' decisions towards conservative management, which focuses on symptom relief and quality of life. The myKIDNEY app reduced patients' decisional conflict and raised awareness of conservative management as an accepted alternative to...
Predicting CRRT risk after lung transplantation: A new tool for early AKI management
A new CRRT prediction model for AKI following lung transplantation identifies high-risk patients post-LTx, supporting timely intervention. The model integrates preoperative, intraoperative, and early postoperative indicators to estimate CRRT risk.
University of Cincinnati researchers discover clear link between chronic kidney disease and periodontal disease
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
Multi-task deep learning identifies four MASLD subtypes for precision cardiovascular– liver–kidney–metabolic management
The study developed a novel multi-task deep LASSO algorithm that identified six core clinical indicators, establishing four stable MASLD subtypes with distinct characteristics. The classification system enables targeted interventions, prioritizing fibrosis screening and aggressive cardiorenal protection for specific subgroups.
B-type natriuretic peptide as a predictor of kidney disease progression in diabetes
A recent study found that B-type natriuretic peptide is independently associated with chronic kidney disease progression in individuals with diabetes. Combining BNP with urinary markers such as UACR improves risk prediction, highlighting its potential role in early detection and management of kidney disease.
Dietary changes and medications could help prevent recurrent kidney stones
A systematic review of 31 studies found that diet changes and medications like thiazide diuretics, alkali therapy, and allopurinol may reduce stone recurrence in adults with calcium oxalate or calcium phosphate stones. However, evidence was generally limited, and more research is needed to confirm the effectiveness of these interventions.
Largest study of its kind tests hydration strategy for kidney stones
The largest behavioral study on kidney stone prevention tested a hydration program with Bluetooth-enabled smart water bottles and personalized hydration goals. While participants did hydrate more, the increase wasn't large enough to lower symptomatic kidney stone recurrence across the group.
Hidden acid imbalance in kidney disease raises red flags
A Japanese registry study reveals widespread underdiagnosis and undertreatment of metabolic acidosis in chronic kidney disease patients. Nearly half of patients with bicarbonate measured had metabolic acidosis, and diagnosis and treatment rates were low, highlighting a need for routine bicarbonate testing in CKD care.
Study finds early imaging after pediatric UTIs may do more harm than good
Researchers found that ultrasounds performed too early during hospitalization were more likely to produce false positives, leading to additional invasive testing. Waiting until a fever resolved and closer to discharge did not prolong the hospital stay, but reduced unnecessary tests and added stress for families.
Structural adaptations in aging podocytes
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
Eating a plant-forward diet is good for your kidneys
A large-scale study found that adhering to the EAT–Lancet planetary health diet was significantly associated with a reduced risk of incident CKD. The diet emphasizes fruits, vegetables, legumes, and limited consumption of added sugars and fats.
First global consensus on managing vertebral fractures in advanced chronic kidney disease
Vertebral fractures are a devastating complication of advanced kidney disease, associated with increased risk of further fractures and cardiovascular events. The first global consensus statement offers practical recommendations for clinicians to identify and manage vertebral fractures in patients with chronic kidney disease stages G4–G5D.
1 in 8 males undergo scrotal surgery 20 years after kidney donation
A population-based cohort study found that the cumulative incidence of scrotal surgery among male living kidney donors was 1 in 8 after 20 years, compared to 1 in 143 for non-donors. Most males who donate a kidney won't develop this complication, but it's essential to inform past and future donors about the risk and potential symptoms.
Study links shift work to higher risk of kidney stones, influenced by lifestyle factors
A study published in Mayo Clinic Proceedings found that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor. Lifestyle factors such as BMI, fluid intake, and smoking habits significantly contribute to the occurrence of kidney stones.
Pre-dialysis nephrology care disparities and incident vascular access among Hispanic individuals
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
How mutations in bodily tissues affect ageing
Two new studies from Karolinska Institutet investigate how somatic mutations in muscles and blood vessels affect ageing. The results show that such mutations can reduce muscle strength and accelerate blood vessel ageing.
Personalized chronic kidney disease management on the horizon, as new biomarker research spurs hope
Researchers have identified biomarkers that can predict and manage chronic kidney disease (CKD), offering a more nuanced understanding of patient disease progression and mortality risk. A combination of biomarkers, including sTNFR1 and hs-cTnT, were found to be comparable in predicting kidney failure and all-cause mortality.
First pilot therapeutic trial in Dent disease caused by OCRL1 gene mutations
A pilot clinical trial has been initiated to test the efficacy of alpelisib in treating Dent disease 2, a rare genetic disorder affecting kidney function. The trial aims to improve abnormal kidney function and potentially provide a breakthrough treatment for patients with life-threatening complications.
Combination finerenone and empagliflozin shows superior efficacy in reducing albuminuria in chronic kidney disease and type 2 diabetes patients
The CONFIDENCE trial demonstrates that combination therapy with finerenone and empagliflozin leads to significantly greater reductions in albuminuria than either agent alone. The study shows a 52% median reduction in urinary albumin-to-creatinine ratio, achieving the ADA-recommended target for 70% of patients.
Landmark study reveals survival limits of kidney transplantation in older and high-risk patients
A major international study found that deceased-donor kidney transplantation offers a consistent survival advantage with standard-criteria kidneys, but the benefit plateaus in older and high-risk recipients. The study used a robust target trial emulation framework to compare long-term survival between transplant patients and those on d...
Cancer therapies: AI-based image analysis detects early organ damage
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
New biomarkers could improve early detection, monitoring of kidney injury
Researchers have identified six promising biomarkers that can detect drug-induced kidney injury earlier than traditional markers, enabling more timely monitoring during drug development. These biomarkers could lead to the development of safer medications and improve patient outcomes.
Hypertension causes kidney changes at an early stage
A study by Medical University of Vienna reveals high blood pressure can cause abnormalities in podocytes, specialized cells in the renal filter, before other conditions like diabetes. Early detection and treatment are crucial to prevent kidney damage.
Updated chronic kidney disease management guidelines recommend SGLT2 inhibitors regardless of diabetes or kidney disease type
The American College of Physicians updates its guidelines recommending SGLT2 inhibitors for chronic kidney disease (CKD) management, regardless of diabetes type. The new guidelines emphasize the importance of tailored care and suggest individualized risk-based approaches to predict kidney failure.
Innovative technology enhances cellular and molecular insights into kidney lesions
A new method combines traditional histopathology with spatial transcriptomics data to improve understanding of chronic kidney disease lesions at the cellular and molecular levels. This approach has the potential to identify new biomarkers and therapeutic strategies for patients.
The effectiveness of intradialytic parenteral nutrition with ENEFLUID🄬 infusion
A 12-week randomized controlled trial found that IDPN using ENEFLUID increased energy intake from food and reduced hypoglycemia during dialysis, suggesting potential benefits for malnourished hemodialysis patients. However, the study did not demonstrate direct improvements in nutritional markers.
The RELIEF ureteral stent, invented by UH urologist Dr. Lee Ponsky, secures FDA clearance as first and only stent for prevention of vesicoureteral reflux
The RELIEF ureteral stent has achieved FDA clearance as the first and only stent to prevent vesicoureteral reflux. It features a unique suture design that allows natural opening and closing of the ureteral orifice, preventing reflux and discomfort.
New research reveals two types of fatty liver disease
Researchers at Karolinska Institutet have identified two types of metabolic-associated fatty liver disease, a liver-specific type and a systemic type that affects other organs. The discovery could lead to improved diagnosis and treatment of this growing patient group, with potential benefits for cardiovascular health.
Pathogenic role of dental caries-causing bacteria in IgA nephropathy
Research finds that Streptococcus mutans's collagen-binding protein may induce hematuria and IgA deposition in kidney disease, suggesting a potential pathogenic role. The study suggests a link between oral pathogens and renal lesions.
C-PATH announces Gender Equitable Medicines for Parkinson's Disease (GEM-PD) initiative
The C-Path initiative aims to generate drug development solutions that reflect each person's unique experience, leveraging diverse data and innovative technologies like AI and digital health. GEM-PD seeks to address unmet need in Parkinson's disease therapies by focusing on sex and gender differences.
Increasing trend of overweight and obesity among Japanese patients with incident end-stage kidney disease
A nationwide study in Japan reveals an increasing trend of overweight and obesity among patients with incident end-stage kidney disease (ESKD), mirroring the global obesity epidemic. Underweight individuals remain prevalent, presenting a dual challenge for public health strategies.
Early, individualized recommendations for hospitalized patients with acute kidney injury
A study published in JAMA found that personalized recommendations for hospitalized patients with acute kidney injury did not improve outcomes. Despite higher implementation rates in the intervention group, worsening acute kidney injury stage, dialysis, or mortality remained unchanged.
Glomerular filtration rate changes following UTI in children with vesicoureteral reflux
A cohort study of children with vesicoureteral reflux found that glomerular filtration rate changes after urinary tract infections. The study used data from the Children With Vesicoureteral Reflux trial to assess estimated glomerular filtration rate changes in participants with vs without recurrent UTIs.
New AI tool set to be a “game changer” in improving outcome predictions for kidney transplant patients
A new AI-powered model has been developed to predict kidney transplant outcomes with high accuracy, offering hope for more efficient organ allocation and improved patient outcomes. The tool, UK-DTOP, outperforms existing methods in predicting outcomes for deceased-donor kidney transplants.
New method predicts worsening of chronic kidney disease
Researchers from Aarhus University developed a new method to predict which patients with chronic kidney failure are at risk of losing kidney function over time. The method analyzes acid-base balances in urine samples, revealing early signs of acid buildup that can be harmful to kidney function.
AI-powered, big data research revolutionises understanding of autoimmune disease
Researchers have made a significant breakthrough in vasculitis research using AI-powered big data techniques, enabling more precise identification of disease patterns. The study offers new insights into the diagnosis and treatment of systemic vasculitis, a group of rare autoimmune diseases.
Increased risk of dementia after acute kidney injury
A new study published in Neurology found that acute kidney injury is associated with an increased risk of developing dementia. The study analyzed data from over 300,000 individuals and found a 49% higher risk of dementia overall, with significant increases for specific types of dementia such as Lewy body dementia and vascular dementia.
Researchers develop an AI model that predicts Continuous Renal Replacement Therapy survival
A UCLA-led team created a machine-learning model that can accurately predict short-term CRRT survival, providing a data-driven tool for clinical decision-making. The study aims to improve patient outcomes and resource use by serving as a basis for future clinical trials.
Boost for research aiming to cure chronic diseases in an aging population
The DRIVE-RM consortium, led by UMC Utrecht, aims to develop smart materials that assist the body in healing and regenerate tissues and organs using regenerative medicine. The project focuses on treating chronic diseases such as heart failure, kidney failure, and worn joints.
Semaglutide significantly reduces risk of major kidney disease events, cardiovascular outcomes and mortality in patients with type 2 diabetes and chronic kidney disease, groundbreaking study reveals
A groundbreaking study reveals semaglutide significantly reduces the risk of major kidney disease events, cardiovascular outcomes, and all-cause mortality in patients with type 2 diabetes and chronic kidney disease. Semaglutide also shows improved safety and efficacy profiles.
UCalgary researchers can predict kidney failure more accurately
A new digital tool, KDpredict, developed by University of Calgary scientists can more accurately predict the risks of kidney failure and death in adults with moderate-to-severe chronic kidney disease. The tool uses four variables readily available in clinic practice to calculate one-to-five year risks of kidney failure and death.
Kidney disease intervention outcomes encouraging, despite null result
The Kidney-CHAMP study found that the intervention helped primary care physicians identify and triage patients with kidney disease, improving patient access to specialists and educational materials. Despite a null result, the study's findings suggest that the framework is scalable and provides equitable access to healthcare.
Cleveland Clinic, Tufts University research ties gut microbial TMAO pathway to chronic kidney disease
Researchers discovered that participants with elevated TMAO blood levels were at increased risk for future development of chronic kidney disease, even after adjusting for other known risk factors. The study also found a faster rate of declining kidney function in people with normal or impaired kidney function.
Diabetes drug improves cardiovascular outcomes across a range of heart and kidney conditions
A meta-analysis of 11 trials involving 78,607 patients found a 9% reduction in major adverse cardiovascular events (MACE) and a 14% reduction in cardiovascular death with SGLT2 inhibitors. The analysis showed consistent effects across patient groups and subgroups.
Trends in the incidence of renal replacement therapy due to rapidly progressive glomerulonephritis in Japan, 2006–2021
A nationwide study in Japan found an increase in the number of patients with incident renal replacement therapy due to rapidly progressive glomerulonephritis (RPGN) from 2006 to 2021. The incidence rate increased in older age groups, peaking in 2018-2021.
University of Cincinnati study: Comparing pregnancy rates in patients undergoing two types of dialysis
A new University of Cincinnati study compares pregnancy rates in patients on two types of dialysis, finding a higher rate with home hemodialysis. The study found an overall pregnancy rate of almost 9 people per thousand, with black women and younger age associated with a higher likelihood of pregnancy.
Review in Chinese Medical Journal highlights the challenges and recent advances in targeted therapies for lupus nephritis
A comprehensive review of targeted therapies for lupus nephritis discusses the challenges of current treatments and proposes strategies to overcome obstacles. Recent advancements in B-cell targeting and alternative approaches such as CAR-T cells are highlighted.
When nutrition becomes a treatment: Low sugar and lots of fat against polycystic kidney disease
A clinical study found that a ketogenic diet can improve kidney function in patients with hereditary polycystic kidney disease. After three months, positive changes were seen in key parameters, with no unexpected side effects.
U of M Medical School research team finds novel drug improves outcomes for patients with rare kidney disorder
Researchers discovered that patients with FSGS who received sparsentan treatment experienced improved kidney function and reduced proteinuria, a key indicator of kidney damage. The study suggests sparsentan may be a potential new treatment option for the disorder, offering hope for patients affected by FSGS.
Regular health checkups may prevent the development of end-stage kidney disease (ESKD)
A new Japanese ecological study found that prefecture-specific SHC participation rates significantly negatively affect treated ESKD incidence and CKD prevalence. Higher SHC participation rates are associated with lower ESKD incidence, suggesting the importance of regular health checkups at a population level.
Abnormal lactate metabolism linked to kidney injury in diabetic patients
New research reveals that disrupted energy production in the kidneys contributes to progressive kidney disease in diabetes. Monitoring urinary lactate levels may help predict prognosis and guide management for diabetic kidney disease.
Uromodulin levels may indicate risk for kidney failure
A recent study published in the American Journal of Kidney Diseases found that lower uromodulin levels are associated with a higher risk of developing end-stage kidney disease. Participants who experienced steeper declines in uromodulin also showed an increased risk of kidney failure.
Low follow-up kidney testing after hospital discharge with moderate to severe AKI
Over 75% of hospitalized AKI patients lack proper follow-up kidney health testing after discharge. Less than 25% have kidney function monitored with blood and urine tests within 90 days of discharge.
Disparities in flu vaccine uptake persist in people with kidney disease
A study of over 15,000 individuals with chronic kidney disease found that young age, Black race, and low education and income were linked to lower flu vaccine uptake. The study suggests that targeted vaccination efforts could improve uptake among those with kidney disease.
Six North Carolina institutions collaborate to advance kidney, urology, hematology research
A five-year, $6.15-million NIH grant has enabled six North Carolina institutions to collaborate on advancing the science of nephrology, hematology, and urology. The NC KUH TRIO Program aims to train the next generation of researchers and foster academic and professional development across disciplines and institutions.
COVID-19 vaccination appears safe in study of patients with glomerular diseases
In a cohort study of 2,055 patients with glomerular diseases, COVID-19 vaccination did not worsen kidney damage or affect proteinuria. The data support vaccination for COVID-19 in patients with glomerular disease.
Plant-based protein intake may reduce kidney disease risk
A recent study found that higher plant protein intake is associated with lower risk of chronic kidney disease. The UK Biobank study data revealed that participants consuming more plant-based protein had a reduced risk of developing CKD.
A new mechanism may lead to new treatment options of chronic kidney diseases
A study from Aarhus University reveals that PCSK9 regulates a receptor in the kidneys controlling protein excretion, leading to potential new treatment strategies for patients with kidney overloads. The researchers hope to further investigate the use of PCSK9 inhibitors in treating kidney diseases.