Articles tagged with Neurology
Scientists have discovered that microglia play a crucial role in regulating blood flow to the brain, and targeting them may improve blood flow deficits. The study suggests that restoring microglia function could prevent or reverse memory-stealing diseases caused by lack of adequate blood flow.
A new study found significant reductions in medication use, symptoms, and procedural interventions with GLP-1 receptor agonist therapy for idiopathic intracranial hypertension. Further prospective studies are needed to confirm these findings.
Researchers developed a blood-based indicator of organ age and found that individuals with young brains have a lower risk of developing diseases associated with their brain. The study also showed that organs' biological ages can predict health outcomes, such as increased risk of Alzheimer's disease for those with an old brain.
This special collection aims to bring together cutting-edge research on cognitive aging, exploring its cellular and molecular underpinnings, as well as psychosocial and environmental factors. The collection seeks to foster a holistic understanding of how cognitive function changes with age.
Scientists developed mouse models that survive premature death, enabling pre-clinical testing of alternating hemiplegia of childhood (AHC), a devastating neurological disorder. The research reveals how different mutations can lead to distinct outcomes in AHC and sets the stage for developing gene editing therapies.
A novel model reveals that local Ang II regulation plays a crucial role in maintaining kidney function balance. The study found that damaged kidneys compensate for the loss of function by increasing blood pressure and reducing glomerular atrophy.
A comprehensive study protocol has been developed to investigate pregnancy-related stroke risk factors and long-term implications for mothers and their children. The nationwide multicenter study aims to identify key risk factors associated with ASPP and assess its impact on offspring.
A new research paper introduces DoliClock, a biological aging clock based on lipid profiles in the human brain, showing accelerated brain aging in individuals with autism, schizophrenia, and Down syndrome. The study found that dolichol levels serve as reliable biomarkers of aging.
Researchers at the University of Illinois Urbana-Champaign have developed a new non-invasive MRI approach that visualizes brain metabolism and detects metabolic alterations associated with brain diseases. The technique uses magnetic resonance spectroscopic imaging to provide insights into brain function and disease processes.
Researchers at UCLA Health have made a groundbreaking discovery about the mechanisms underlying vascular dementia. They found that targeting inflammation in brain blood vessels can promote brain repair and functional recovery in mice. This breakthrough highlights a potential new treatment approach for this understudied form of dementia.
The new centre will investigate neural dynamics, developing novel interventions and devices to improve symptom relief and quality of life for people with brain disorders. It aims to harness neural dynamics for people with conditions like Parkinson’s disease or epilepsy.
The American Academy of Neurology (AAN) has issued a position statement on emerging therapies for neurological conditions. The statement emphasizes the importance of rigorous investigation, shared decision making between patients and neurologists, and FDA review before taking a definitive position. This guidance aims to facilitate conv...
A diabetes medication that lowers brain fluid pressure has been shown to reduce monthly migraine days by an average of 11. Disability scores also improved significantly, indicating a clinically meaningful improvement in work and social functioning. The study suggests that pressure modulation may drive the benefit, rather than weight loss.
Research found that certain heart rate variability patterns can predict future health conditions, including stroke, depression, and cognitive dysfunction. The study suggests that nocturnal HRV provides a unique window into how the body functions during sleep.
A study of 34 children found significant differences in basal ganglia volume between those exposed to prenatal Superstorm Sandy and those not exposed. The findings suggest that extreme heat may have amplified the risk of having a differently-sized basal ganglia.
A new study from Karolinska Institutet found that infants who survive serious health problems in the first few weeks of life have a higher risk of dying during childhood and adolescence. Children with neurological health problems had almost six times the risk of death compared to healthy children.
Researchers developed an AI model that uses real-time data to diagnose nystagmus, a condition linked to vestibular or neurological disorders. The system allows patients to record their eye movements using a smartphone and receive remote diagnostic analysis.
A large-scale study from Karolinska Institutet reports that individuals with an autism diagnosis are four times more likely to develop early-onset Parkinson's disease. The researchers believe that shared underlying biological mechanisms may be at play, particularly involving the neurotransmitter dopamine.
A survey of over 1,000 US adults examined perceptions of four neurotechnologies: deep brain stimulation, MRI-guided focused ultrasound, transcranial magnetic stimulation, and pills. Pills were rated as the most beneficial, acceptable, and likely to be used, while DBS was seen as the second most beneficial but also the riskiest.
Nontraumatic subarachnoid hemorrhage (SAH) is the third most common stroke type, accounting for 5-10% of all strokes. Despite declining age-standardized burden rates, SAH remains a major public health concern globally.
A new smartphone app, ECHAS, can help people determine if they are suffering from a heart attack or stroke and need medical attention. The app, developed by experts at UVA Health and other leading institutions, proved effective in identifying patients with cardiac and neurological emergencies.
Researchers have created a versatile set of gene delivery systems that can reach different neural cell types in the human brain and spinal cord with exceptional accuracy. The new platform has the potential to transform how scientists study neural circuits, providing access to specific cells and communication pathways known to be affect...
A new study published by the American Academy of Neurology found no increase in neurodevelopmental disorders such as autism and ADHD in children whose mothers took triptan medications before or during pregnancy. Researchers analyzed data from over 26,000 pregnancies and followed the children for an average of eight years.
Researchers at UCLA Health identified a candidate small molecule, DDL-357, that increases concentrations of secreted clusterin, reducing toxic protein phospho-tau and improving mitochondrial function. The drug also improved memory in treated mice in maze-based cognitive tests.
A new framework for assessing traumatic brain injuries (TBI) will provide more accurate diagnoses and treatments, leading to better patient outcomes. The framework incorporates clinical symptoms, biomarkers, imaging scans, and modifiers to determine the severity of injury and predict recovery.
A new study has found that combined oral contraceptives are associated with a threefold increase in the risk of cryptogenic ischaemic stroke (CIS) in young women. CIS accounts for up to 40% of all ischaemic strokes in young adults, and prior studies have linked hormonal contraception to vascular risk.
Researchers from Mass General Brigham have identified a key predictor of stroke risk among women: brain health scores. Women with higher McCance Brain Care Scores (BCS) had a reduced risk of experiencing a cerebrovascular event, with those with a five-point higher baseline score being 37% less likely to experience an event.
A new short film sheds light on the urgent need to address the impact of climate change on brain health, particularly for those living with neurological conditions like epilepsy and multiple sclerosis. The film features expert insights into the effects of rising temperatures on brain function and calls for research, awareness, and action.
Researchers at UC San Francisco have identified potential protein markers for frontotemporal dementia (FTD), a form of dementia affecting middle age. The study found changes in RNA regulation and brain connections that could lead to early diagnosis and targeted treatments.
A new research study published in Alzheimer's & Dementia found that increased sedentary behavior in aging adults is associated with worse cognition and brain shrinkage. Participants who spent more time sedentary were more likely to experience cognitive decline, even if they exercised regularly.
Richard Finkel, MD, is named to TIME100 Health for his pioneering work in treating spinal muscular atrophy prenatally with the orally administered drug risdiplam. This breakthrough has shown promising results, with no identifiable features of SMA observed two years after treatment.
A study published in Neurology found that eating more ultra processed foods may speed up early signs of Parkinson's disease. Participants who consumed over 11 servings of ultra-processed food per day had a higher likelihood of developing three or more early symptoms of the disease.
A study published in JAMA Neurology found no evidence supporting a diagnosis of the New Brunswick neurological syndrome of unknown cause, highlighting the need for independent clinical evaluations. The data revealed presence of several neurodegenerative and non-neurodegenerative conditions instead
The Psychedelics journal has expanded its focus to include all psychoactive drugs, challenging traditional classifications and embracing a broader understanding of consciousness-altering substances. This move aims to reveal novel therapeutic applications and deepen human knowledge of the mind.
Researchers from the University of Texas at San Antonio discovered a significant link between REM sleep disturbances and increased PTSD severity. The study suggests that targeting REM sleep could be a promising approach for improving PTSD treatment outcomes.
Researchers develop specialized enzymes to selectively increase or decrease specific mutation loads in mitochondria, allowing precise study of disease manifestation. This technology holds promise for treating patients with mitochondrial diseases by reducing mutant mtDNA load.
Researchers at Amsterdam UMC have developed a new diagnostic test that measures CRP protein in cerebrospinal fluid to quickly diagnose bacterial meningitis. The test has been shown to be very reliable and can start treatment within half an hour of diagnosis.
Researchers at UCSF found clinically significant improvements in mood, cognition, and motor function after psilocybin therapy for patients with mild to moderate Parkinson's disease. The study suggests that psilocybin could provide relief from multiple symptoms of the disease by reducing inflammation and promoting neuroplasticity.
A new brain-inspired algorithm developed at BU can help hearing aids tune out interference and isolate single talkers in a crowd of voices. In testing, researchers found it could improve word recognition accuracy by 40 percentage points relative to current hearing aid algorithms.
Research finds that 40Hz sensory stimulation promotes broad-based restorative neurological health response in mice with Down syndrome. The study shows improved cognition, increased neural activity, and enhanced neurogenesis, suggesting potential therapeutic benefits.
A significant proportion of patients who suffer a stroke due to carotid artery narrowing can be treated with medication only. Researchers found that up to 75% of patients may not need surgery, eliminating the risk of another stroke and saving healthcare costs.
Researchers at the University of Calgary investigate the effectiveness of transcranial magnetic stimulation combined with intensive speech therapy for treating poststroke aphasia. The study found significant improvements in speech, confidence, and mood among participants, offering new hope for those affected by stroke.
Severe RSV disease among children is more likely those aged 2 or older with pulmonary or neurologic conditions. Younger children under 6 months and prematurity are high-risk factors for severe RSV in younger kids.
A new analysis finds a significant increase in people dying at home due to ischemic stroke, reversing a 10-year decline, with rural communities and Black Americans more likely to die in less specialized care environments. The study also reveals rising death rates from stroke, despite improvements in access to palliative care.
Researchers found that mouse brains process active and passive touch through different pathways, with one region responding to surprise at touch. This distinction may help mice navigate their environments more effectively.
Research reveals that GLP-1RAs and SGLT2i medications significantly reduce the risk of Alzheimer's disease and related dementias in people with type 2 diabetes. No significant difference was found between these two treatments.
A global study led by UCalgary researchers found that one in five people who experience a minor stroke or TIA will have another stroke within 10 years. The study analyzed data from over 171,000 patients across four continents and shows a persistently high risk of future strokes for at least a decade.
Researchers at Temple University have discovered a new way to block the enzyme DLK, which plays a key role in neurodegenerative diseases. The breakthrough approach protects damaged neurons while preserving healthy neuron function.
Cognitive neuroscientists are using VR to develop innovative ways to assess cognitive decline, particularly in identifying age-related differences in spatial memory navigation. The study found significant impacts on memory performance due to the build-up of Alzheimer's proteins in the brain.
The study used AI analysis on over 4,200 clinical reports to identify key factors in autism diagnosis. Criteria related to repetitive movements and special interests were strongly linked to an autism diagnosis, while socialization criteria were not highly specific.
A new review article identifies major themes in AI application to neurosciences, including a 5-fold increase in AI-related publications. The study also notes a surge of over 13-fold in clinical neurology AI-related publications in the past decade.
A recent study by the University of Eastern Finland found that elderly neurological patients are willing to accept remote monitoring in their homes. The study identified factors such as family caregiver presence and educational level as determinants of RM acceptance.
The Open Brain Institute launches a groundbreaking platform to simulate and study digital brains, empowering researchers to explore brain complexity and diseases. With its virtual neuroscience laboratories, the OBI enables global collaboration and access to cutting-edge virtual labs.
A review article reveals CD2AP's crucial role in amyloid metabolism, tau pathology, synaptic function, and neuroinflammation in Alzheimer's disease. CD2AP deficiency accelerates plaque formation, while its loss in neurons leads to reduced spine density and impaired synaptic plasticity.
A University of Illinois Chicago study reveals that intranasal herpes infection can cause severe neurobehavioral symptoms, including anxiety and cognitive issues. The research suggests that the virus exploits a cellular enzyme to produce behavioral symptoms, emphasizing the need for prevention and treatment.
Researchers at UC San Francisco have enabled a paralyzed man to control a robotic arm through a device that relays signals from his brain to a computer. The device, known as a brain-computer interface (BCI), worked for a record 7 months without needing to be adjusted.
Researchers discovered that females' dormant X chromosome reactivates in late life, expressing genes related to brain development and cognitive health. This phenomenon may explain why women outlive men and retain their cognitive abilities longer.
Dr. Guy Rouleau, a renowned geneticist and neurologist, has founded the world's first academic institution committed to open science principles. The Neuro institute aims to transform how brain disease research is conducted worldwide by promoting data sharing and collaboration.
Studies have consistently shown that 40Hz gamma stimulation can improve cognitive function and reduce Alzheimer's pathology in mice. In human clinical trials, participants exposed to 40Hz light and sound experienced significant slowing of brain atrophy and improvements on some cognitive measures compared to untreated controls.
Researchers identified pathogenic thresholds for the CAG repeat units (RU) of the CACNA1A gene that causes SCA6. They found that over 90% of cases with 21 or more RU fell within a predicted age range. The study has important implications for SCA6 diagnosis and genetic counseling.