Articles tagged with Pathology
A recent pathology study suggests that mifepristone could be a therapeutic option for women with severe uterine fibroid symptoms. The research confirms that the drug does not trigger cancerous lesions in the uterus, but rather causes benign changes such as fluid-filled glands and abnormal blood vessels.
A new University of Michigan study suggests that routine analysis of pediatric tonsillectomy specimens may not be worth the money. The analysis rarely leads to the discovery of hidden disease. Pathologists examine tonsillectomy specimens in two ways, but microscopic examination is nearly three times more expensive than visual inspectio...
Researchers developed computer-assisted diagnosis tools to grade Follicular Lymphoma samples more accurately and efficiently. The tools use high-resolution images and machine learning algorithms to identify malignant regions and classify disease grades, promising faster and more accurate diagnoses.
A combination of lapatinib, trastuzumab, and paclitaxel significantly improved tumor response rates compared to single-agent treatments in patients with HER2-positive breast cancers, according to early data from the NeoALTTO Trial. The study suggests that dual blockade against HER2 is an efficient way to target HER2-positive tumors.
A recent study by University of Montreal researchers found that pathological gamblers are three times more likely to commit suicide than non-gamblers due to co-occurring personality disorders. The study also showed that these individuals rarely seek health professional help, exacerbating their financial and emotional problems.
Researchers at the University of Alberta have developed a new method to analyze biopsies from heart transplant patients by examining their genes, allowing for early prediction of treatment success. This approach uses software algorithms to reduce data to key numbers necessary for diagnosis and prognosis.
A survey of 11,888 Quebec adults found that nearly 70% have gambled in the past year and spend an average of $483. Researchers also identified higher risks among video lottery terminal users and online gamblers.
Loyola University Hospital reduced blood transfusions by 10% in 2009, saving $453,355, while improving patient safety without compromising care. The new blood management program implemented evidence-based indications and protocols to reduce unnecessary transfusions.
A study has discovered that progerin, the protein responsible for Progeria, is present in the vasculature of the general population and increases with age. Researchers found that progerin levels in coronary arteries increased by an average of 3.3% per year between one month and 97 years.
Indiana University-Purdue University Indianapolis researchers have developed a new methodology to improve identification of breast cancer tissue by pathology laboratories. Their work, recognized internationally, has been selected as the best scientific paper in the
Physicians in Northern Ontario communities can now access specialized UHN pathologists for fast and accurate diagnosis, saving time and improving patient care. The new telepathology system enables instant transmission of digital images of pathology samples, reducing travel times from hours to minutes.
Experts in pathology are advocating for a comprehensive training program to integrate genomics and personalized medicine into daily practices. The proposed curriculum would cover laboratory medicine, genetic counseling, and health information technology, enabling pathologists to serve as primary consultants for physicians and patients.
A study found that having a pathologist on-site during ultrasound-guided thyroid biopsies decreased the inadequacy rate from 13.5% to 5%. This improvement could reduce repeat biopsy rates by up to 60%, making more efficient use of resources. The study recommends using on-site pathology for large numbers of thyroid biopsies.
Researchers used MR spectroscopy to analyze the biochemical makeup of prostate glands and accurately identified the location of tissue confirmed to be malignant. The approach achieved an accuracy of over 90% in detecting stage II tumors and could potentially guide treatment planning.
Researchers developed a mathematical methodology to reduce biologic variation in laboratory results, improving the sensitivity of detecting physiologic changes. By using multiple paired sets of patient data, they found a substantial decrease in the difference necessary to achieve a given confidence interval.
Mark A. Smith, Ph.D., has been awarded the American Association for the Advancement of Science (AAAS) Fellowship for his distinguished contributions to neurodegenerative disorders and Alzheimer's disease research. He is recognized for his work on oxidative stress and cell cycle alterations in Alzheimer's disease.
Researchers found that medications used to treat substance addictions can also help suppress the urge to gamble, particularly for those driven by urge. Medications targeting the brain opioid system or catechol-O-methyl-transferase (COMT) enzyme showed positive outcomes in treating pathological gambling disorder.
Researchers found that 66% of inner city pediatric voice clinic patients presented with hoarseness, while 77% had vocal nodules. This suggests a significant prevalence of vocal health issues in this population, highlighting the importance of laryngeal examination in all pediatric patients with vocal nodules.
UQ researchers developed a rapid molecular assay to detect swine flu in under two weeks, diagnosing the first Australian case. The tests have been implemented at several hospitals and used to detect cases in the Northern Territory.
A study reinterpretated proximal colon polyps as hyperplastic in 2001 revealed a significant inter-observer variation among gastrointestinal pathologists. This discrepancy highlights the need for clarification on the pathologic interpretation of serrated colorectal polyps and their clinical significance.
The MOSAIC program is a four-year training initiative for graduate students to work with immigrant children learning English as a second language. The program addresses inadequate training of speech-language pathologists to diagnose communication disorders in multilingual children, targeting rural states with high numbers of ESL learners.
Researchers investigated chronic acid-reflux esophagitis in a rat model, discovering epithelial thickening and inflammatory cell infiltration in the middle to lower esophagus. Ecabet sodium inhibited these changes, suggesting its potential role in preventing reflux esophagitis.
Researchers found that only 61.9% of patients assigned a billing diagnosis code for Barrett's esophagus actually had the condition after manual record review. A pathologic diagnosis was highly likely to be reproduced by separate reviews, but electronic coding confirmed only 61.9% of cases.
The study analyzes the feet of Homo floresiensis, finding they had human-like and early hominin traits, with a primitive big toe and lack of arch, suggesting inefficient gait. This evidence supports the idea that Homo floresiensis was an isolated population of early hominins.
Dr. Cun-Yu Wang is recognized for his groundbreaking research in cancer therapy and oral health, with a focus on molecular signaling, inflammation, and adult human stem cells. He joins an elite group of scientists honored by IADR for their contributions to advancing oral health knowledge worldwide.
A new technique for staging bladder cancer has shown encouraging results, accurately identifying tumors in 95.2% of specimens and avoiding unnecessary bladder removals in some cases. The technique uses an antibody to distinguish between deep muscle layers, reducing the risk of mistaken diagnoses.
Researchers at UQ found that speech and language disorders can be validly and reliably assessed over the internet using a telerehabilitation application. This technology holds promise for addressing inequities in access to rehabilitation services, particularly in rural and remote areas.
A brain imaging study found that individuals with higher education levels scored higher on cognitive tests despite having evidence of brain plaques associated with Alzheimer's disease. The study supports the 'cognitive reserve' hypothesis, which suggests that greater cognitive abilities can delay symptoms of the disease. Education was ...
A Mayo Clinic study implemented a radio-frequency identification system to track biopsy specimens and automate identification. The initiative resulted in a significant reduction of specimen-labeling errors, from 765 in 2007 to 47 in 2008. The new labeling system improved safety and quality efforts in specimen management.
A study published in the World Journal of Gastroenterology found that HCV-infected patients without initial liver damage are at risk of fibrosis progression. Factors associated with this development include elevated transaminases, body mass index above 25, and time interval between biopsies.
A new prognostic biomarker has been identified in cases of soft tissue sarcoma (STS), suggesting a direct relationship between pRb2/p130 expression and clinical outcome. Lower levels of the gene are associated with higher risk of recurrence and death from STS, offering potential for improved treatment strategies.
A new computer program may reveal a way to predict premature birth with greater accuracy. The system, developed by Australian researchers and a pathology company, analyzes hormone levels to identify high-risk pregnancies.
A study published in Neurology found that physical frailty is associated with Alzheimer's disease pathology in both people with and without dementia. The researchers found that participants with high levels of AD pathology had approximately twice the level of frailty compared to those with low levels.
Bernardino Ghetti, a renowned Indiana University Alzheimer's disease researcher, has been awarded the Henry M. Wisniewski Award for his lifetime contributions to Alzheimer's research and understanding of dementia mechanisms.
The International Association for Dental Research presents the 2008 Oral Medicine & Pathology Research Award to Dr. Paul Speight for his contributions to understanding oral cancer, screening, and early detection of lymphoma in Sjögren's syndrome patients. His research focuses on photodynamic therapy and has been widely published.
Researchers have developed a chemically modified protein that neutralizes inhibitor antibodies in people with Hemophilia A, offering a potential new treatment option. The modified protein, called electrophilic FVIII analog (E-FVIII), permanently inactivates these antibodies, paving the way for more effective blood clotting correction.
A study published in Clinical Practice and Epidemiology in Mental Health found that pathological gamblers exhibit cognitive rigidity, which hinders their ability to learn from mistakes. This rigidity affects the prefrontal region of the brain, leading to impulsive behavior and compulsive gambling.
A study of 703 burn patients found that younger age, neck or arm burns, and surgical procedures increased the risk of abnormal scarring. Females and those with multiple surgeries had a higher risk of pathologic scarring.
Dr. Peter H. Byers has received the March of Dimes/Colonel Harland Sanders Award for Lifetime Achievement in Genetics for his groundbreaking research on collagen gene mutations and their role in inherited disorders such as Ehlers-Danlos syndrome and osteogenesis imperfecta. His work has significantly advanced our understanding of these...
Researchers found Ki-67 expression associated with poorer disease-free survival, but not predictive of chemotherapy benefit. Pathology reports offer a reliable alternative for determining ER status in breast cancer trials.
Researchers present a new framework for mapping mild cognitive impairment, including an online diagnostic algorithm. The framework characterizes different classifications of MCI and their patterns of etiology, cognitive decline, and clinical outcome.
Researchers found that excessive glucose chains induce neuronal death and cause Lafora disease by disrupting glycogen levels. This discovery may lead to new treatment strategies for other neurodegenerative diseases.
A recent study reveals Deinococcus geothermalis, a highly radiation-resistant bacterium, originated on Earth, not Mars. Contrary to previous speculation, the research defines a minimal set of genes responsible for its extreme resistance, offering hope for conferring this trait to other organisms.
Researchers at UT Southwestern Medical Center have identified nearly 350 genes related to female fertility, providing a new understanding of the causes of female infertility. These discoveries may lead to improved diagnostic tests and tailored therapy for infertile women.
A University of Minnesota study found that N-acetyl cysteine, a health food supplement, reduced urges to gamble in 60% of participants. This pilot study suggests the potential for this glutamate-modulating agent in treating various addictions.
A large-scale virtual microscopy slide seminar is held with over 800 pathologists from Europe and worldwide participating. The event features digitized samples of rare cases and a European Virtual Microscopy Network for future collaboration.
Fragile X tremor/ataxia syndrome (FXTAS) is a recently identified neurological disorder affecting middle-aged adults, causing Parkinson's-like symptoms and cognitive decline. Researchers discovered that the mutation causing FXTAS triggers a failure of messenger RNA transport within neurons, leading to lethal clogging of brain cells.
A study by Indiana University School of Medicine found that pediatricians and pathologists cannot agree on half the time whether a child's death from traumatic brain injury should be investigated as potential child abuse. Researchers developed a framework to help compare cases, aiming to improve uniform definitions for future studies.
A recent study found that radiology residents use approximately 15% of their average annual salary for educational expenses. Senior residents reported an average out-of-pocket expense of $7,515 for review courses and board examinations, with many struggling to pay off student loans from medical school.
A study published in JCSM found that 'night owls' experience more sleep/wake irregularities and waking distress due to insomnia. Insomnia affects 30% of adults, leading to serious health problems like depression, obesity, and cardiovascular disease.
A recent study found that patients with recurrent silent brain lesions on magnetic resonance imaging (MRI) had a higher risk of subsequent ischemic strokes and vascular-related deaths. The study, published in Archives of Neurology, suggests that MRI may depict pathological changes before the development of clinical stroke symptoms.
A new study published in PLOS Pathogens suggests that doxycycline can reduce the pathology of lymphatic filariasis by targeting Wolbachia bancrofti. The treatment shows promise as an ameliorating option for individuals with adult worms, potentially providing relief from debilitating swelling and genital areas.
Dr. Polverini, a renowned expert in oral pathology, has received the prestigious IADR Oral Medicine and Pathology Research Award for his groundbreaking work on angiogenesis and oral cancer. The award is supported by Sunstar Butler and recognizes his contributions to the field.
A study of 134 older adults found that nearly a third had Alzheimer's disease, yet most did not show obvious dementia symptoms. The research suggests that some people may have a neural reserve that allows them to tolerate significant brain damage without developing cognitive decline.
According to the study, underage drinkers and pathological drinkers collectively spent at least $48.3 billion on alcohol in 2001, accounting for nearly one-third of total consumer expenditures. The majority of adult drinkers who developed abuse or dependence began drinking before age 21.
A study of 31 pathological gamblers and their relatives found a genetic link to the disorder. The research suggests that family members share genes that increase the likelihood of impulsive behavior.
A new open-source software tool successfully removed over 98% of unique identifiers from pathology reports, including name, address, and social security numbers. The developers found that hospital-specific customization may be necessary to achieve optimal performance.
Research finds activation of specific brain regions depends on participants' preferences for risk or ambiguity, shedding light on why people make risky choices. The study's results contribute to the emerging field of neuroeconomics, a new area of research that combines neuroscience and economics.
Researchers at Yale University School of Medicine used Automated Quantitative Analysis (AQUA TM ) technology to standardize biomarker detection methods. The study found that antibody concentration can dramatically alter the relationship between biomarker levels and clinical outcome, particularly for breast cancer biomarkers.
Dr. Harold F. Dvorak, M.D.'s groundbreaking work on vascular permeability factor/vascular endothelial cell growth factor (VEGF) has led to significant clinical benefits in cancer patients. His discovery has enabled the development of anti-VEGF therapies with outstanding clinical antitumor activity.