Articles tagged with Pathology
Researchers at Case Western Reserve University aim to understand the role of intestinal innate immunity in Crohn's disease. They will investigate how mice develop experimental Crohn's disease and replicate these findings in humans, with the goal of developing new medications and treatments to cure the devastating ailment.
The Association for Molecular Pathology has developed a new framework for defining the clinical utility of molecular diagnostics, emphasizing the importance of context in interpreting test results. This approach aims to improve patient care by providing clinically useful and appropriate testing based on realistic evidence levels.
A University of Colorado Cancer Center study found that only 4.6% of cases had discrepancies between initial and final evaluations, with most being due to process errors or interpretation errors. The study aimed to reduce discrepancy rates by identifying trends and implementing changes.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
Researchers at Allina Health have developed an algorithm to simplify the complex pathology classification process for pituitary adenomas. The new system helps pathologists make a more accurate diagnosis with fewer tests, saving time and reducing costs.
A systematic review of 40 studies found a weak correlation between signs, symptoms, and testosterone levels in ageing men. The authors suggest that it is difficult to extrapolate the diagnosis of pathologic hypogonadism from younger men to older men with age-related testosterone declines.
Researchers at Griffith University identified significant impairments in cellular function of CFS patients. They found dysfunctional signalling may contribute to impaired cell activity, aligning with symptoms. The study provides further evidence for the pathology of this disabling illness.
A novel intraocular therapy has been shown to prevent or reverse diabetic retinopathy in mice by increasing ACE-2 expression. The study found that the therapy reduced pro-inflammatory cells and reversed vascular degeneration, suggesting a potential new treatment for blindness and other vascular diseases.
A study found that nearly half of routine tests for monoclonal gammopathy are unnecessary and costly. An algorithm-driven approach can improve efficiency and reduce healthcare costs by putting more decision-making power in the hands of pathologists.
New research reveals bed bugs have developed thicker cuticles to resist insecticides, making control efforts more challenging. Understanding this resistance mechanism could lead to the development of new strategies for effective bed bug control.
A study found that pathologists agree on invasive breast cancer diagnoses but not on non-invasive lesions like DCIS and atypia. Women with borderline findings may benefit from revised guidelines for clinical treatment and management.
Researchers at the University of Texas Health Science Center at Houston found that smartphones can detect 90% of non-melanoma skin cancers and 60% of melanomas, improving diagnosis in remote areas. A DIY smartphone microscope can be made with a ball lens and tape, and additional studies are needed to enhance detection rates.
Mayo Clinic researchers found that using frozen section analysis during lumpectomies can reduce the need for second operations by 95%, saving patients time and financial burdens. The study estimates annual cost savings of $90.9 million to payers and $1.8 million to providers.
The University of Leeds has developed an innovative virtual microscope system to aid in cancer diagnoses. The technology allows pathologists to view large patient cases of up to 100 slides or more, making complex diagnoses faster and more accurate.
Research has made significant progress in understanding mood and psychotic disorders, enabling individualized treatment approaches. Key findings highlight the potential of biomarkers such as neuroanatomy, neuro-circuitry, and genetic markers to stratify patients into clinically distinct subgroups.
The Association for Molecular Pathology (AMP) has updated its pathology residency curriculum recommendations, focusing on 10 major molecular pathology topics. The new report aims to equip pathologists with the latest scientific breakthroughs and technological innovations in molecular pathology.
Children with Down syndrome who exhibit symptoms of both childhood dysarthria and apraxia may be inadequately diagnosed, leading to ineffective treatment. A new study suggests that these children should be treated for all symptoms, regardless of diagnosis.
The Journal of Neuropathology & Experimental Neurology will now be published by Oxford University Press USA, publishing original articles on neuropathology and experimental neuroscience since 1942. The journal is the official publication of the American Association of Neuropathologists, Inc.
A 25-year-old former college football player experienced over 10 concussions during his 16-year career, leading to CTE pathology and cognitive issues. The player's autopsy confirmed the diagnosis, making him the first person with CTE to undergo neuropsychological testing.
A team of researchers has identified a unique gait pattern among top Russian officials, including President Vladimir Putin and Prime Minister Dmitry Medvedev. The experts link this 'gunslinger's gait' to military or intelligence training, specifically KGB instruction on keeping the weapon close to the chest while walking.
A study by UPMC and KingMed Diagnostics researchers found that international telepathology consultations significantly improved patient care in China, altering treatment plans for over half of cases. The consultation service expanded access to pathology expertise, facilitating the diagnosis of rare malignancies.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
A new hand-held probe using optical coherence tomography (OCT) technology has been found to correlate well with traditional pathologists' diagnoses in a clinical study, enabling reliable real-time guidance for surgeons. The device can identify differences between cancer cells and normal tissue with high sensitivity and specificity.
A new study aims to understand MS pathology by activating metabolic stress in oligodendrocytes, a type of cell that produces myelin. The research seeks to determine if this nonimmune-mediated animal model can recapitulate MS pathology and find evidence for behavioral changes and cognitive decline.
The study develops a method for label-free chemical imaging using infrared spectroscopic imaging, allowing molecular stains to be reproduced without tissue damage. This approach enables multiplexed molecular analysis and could revolutionize pathology in research and clinical practice.
Research found habitual gamblers exhibit probability matching behavior and perceive illusory patterns in random sequences. Gamblers are also less able to resist impulses, leading to impulsive betting decisions.
A new study published in the International Journal of Clinical Pharmacy found that diphenhydramine, an active ingredient in Dr. Cocoa's Nighttime formula, significantly inhibits cough reflex sensitivity in adults with acute pathological cough, commonly known as a cold.
Researchers validated a previously reported molecular finding on triple negative breast cancer, but found it was limited to a single patient and could not be applied to further clinical work. The study highlights the importance of independent study validation and careful assay development.
Researchers developed a new imaging technique that enables fast and broad diagnostic assessments using infrared light, eliminating the need for chemical stains. This allows pathologists to obtain precise information from tissue samples without damaging them.
A senior doctor's interviews reveal widespread irrational drug prescribing, kickbacks for referrals, and unnecessary investigations in India's private healthcare sector. The system largely treats patients as revenue generators, without rationality or medical logic.
A study by Johns Hopkins pathologists identified a unique pattern of injuries in the brains of combat veterans who survived IED blasts and later died. The honeycomb pattern of damaged nerve fibers is distinct from other types of brain injury, suggesting a possible signature of 'shell shock' or blast neurotrauma.
A study of over 3,000 women in Michigan found that nearly 40% did not receive alternative treatment before their hysterectomy. Nearly two in five women under 40 had unsupportive pathology, suggesting that treatment guidelines are often not followed.
A study by Mayo Clinic physicians found that high-definition optical lenses during colonoscopies can accurately evaluate polyps' precancerous or benign nature. The assessment was 96-97% accurate, potentially saving patients and healthcare systems substantial costs.
Researchers define sexual deviation by identifying common and rare fantasies in a general population survey. The study found that men have more and more vivid fantasies than women, while women distinguish between fantasy and desire more clearly.
Research suggests that pathological gamblers have a different response to the brain's opioid system, resulting in reduced feelings of euphoria compared to healthy individuals. This altered response may contribute to the addictive nature of gambling.
A study by University of Iowa researchers found that pathological gambling runs in families, with first-degree relatives eight times more likely to develop the problem. The study also identified connections between pathological gambling and other psychiatric disorders, such as social anxiety disorder and PTSD.
The challenges in cancer molecular testing require effective communication between oncologists and pathologists. Close communication, systems approaches, and new institutional protocols can help ensure efficient testing and optimal patient outcomes.
Researchers at Massachusetts General Hospital have developed a new CRISPR-based RNA-guided nuclease technology that significantly reduces off-target gene mutations. By doubling the length of DNA recognized for cleavage, the new platform improves genome editing precision and fidelity.
The Association for Molecular Pathology (AMP) released a report recommending a molecular diagnostics curriculum for medical laboratory scientists, balancing accreditation, certification, and job market needs. The recommendations aim to prepare future scientists for high-complexity testing and support the growth of genomic technology.
The Mayo Clinic uses frozen section analysis during breast cancer lumpectomies, sparing patients the need for repeat surgeries in 96% of cases. This technique significantly lowers the 30-day reoperation rate from 13.2% nationally to 3.6% at Mayo.
The AACR Team Science Award recognizes a Duke University/Johns Hopkins University/National Cancer Institute research team for their innovative work on glioblastoma multiforme, the most common and lethal type of brain cancer. The team's discoveries have led to novel insights into the biology of GBM and potential therapeutic targets.
The FINNO Study found that women are more likely to suffer from incontinence, while men experience problems with slow or incomplete urination. The study also identified post-micturition dribble as the most common cause of bother among men.
Researchers at Massachusetts General Hospital have found that shortening the guide RNA component of CRISPR-Cas nucleases can substantially reduce off-target DNA mutations. Truncated gRNAs, or tru-gRNAs, are just as efficient as full-length gRNAs in reaching their intended target but with greatly reduced off-target effects.
The Association for Molecular Pathology proposes a new term, Laboratory Developed Procedure (LDPs), to describe service-oriented tests. LDPs rely on laboratory professionals for design, consultation, and interpretive reporting in clinical care.
Studies suggest novel therapies for nicotine and heroin addiction are effective, with magnetic stimulation helping smokers quit and reducing rats' motivation to take heroin. Chronic pain also increases the risk of overdose among people with addiction, according to research findings presented at Neuroscience 2013.
Novel therapies for nicotine and heroin addiction show promise, while research reveals underlying brain mechanisms driving compulsive disorders like addiction and pathological gambling. Understanding these processes may lead to non-pharmaceutical interventions and new treatment approaches.
A nationwide study reveals huge disparities in death reporting to coroners, with inconsistent rates across jurisdictions. The research also exposes a significant gender disparity, where women's deaths are less likely to be reported and result in unnatural death verdicts.
Researchers identify novel gene mutation in NFKB2 that impairs antibody production and fight infection, leading to common variable immunodeficiency (CVID). The discovery provides a new mechanism for immune deficiency and enables early diagnosis and treatment.
Two University of Utah researchers, Adam Frost and Ryan O'Connell, received the NIH Director's New Innovator Award to launch innovative biomedical research projects. The awards support visionary investigators pursuing science with high potential to transform scientific fields and accelerate health improvements.
Researchers at Emory University have discovered a previously unrecognized type of pathology in Alzheimer's brains that sequesters proteins involved in RNA splicing. This finding could lead to new biomarkers, diagnostic approaches, and therapies by explaining how genes contribute their effects in the disease.
Researchers have developed an animal model to simulate the pathological process of Alzheimer's disease, focusing on the locus coeruleus. This study shows that degenerative alterations in noradrenergic neurons of the locus coeruleus are consistent with pathological changes observed in patients with Alzheimer's disease.
The new open access title provides high-quality video demonstrations of endoscopic findings and procedures, along with concise articles detailing procedures and findings. The video journal aims to be the premium international reference for endoscopic findings and procedures.
A study found that female deaths are underreported to coroners in England and Wales, with women being half as likely to proceed to an inquest. Men, on the other hand, were overrepresented in occupational diseases and suicide verdicts, while women were more likely to receive natural causes verdicts.
A recent study led by Loyola University Medical Center physician Matthew Kircher identified a simple way to reduce healthcare costs without compromising care. The researchers found that in 178 cases, there was virtually perfect agreement between otologists' findings and official diagnoses from the pathology lab, suggesting that these e...
Scientists developed a histology expression predictor for common types of lung cancer using paraffin samples, achieving accuracy comparable to pathologists. The technology has potential applications in predicting responses to therapies and prognostication.
A team of Johns Hopkins graduate students has designed a device to inspect breast tissue in real-time, reducing the need for follow-up surgeries. The device applies an adhesive film to the tissue, preventing damage and allowing pathologists to quickly review samples within 20 minutes.
Researchers discovered that the p63 protein acts as a genetic modifier for EEC Syndrome, with TAp63 determining its manifestation. The study reveals that levels of TAp63 determine whether children inherit the syndrome, providing new insights into this rare condition.
A new study published in Journal of Psychiatric Practice reports a hybrid categorical-dimensional diagnostic model proposed for DSM-5 aligns well with the current approach to personality disorder diagnoses. The findings support the adoption of this alternative model, which combines core dimensions of personality disorder with various m...
A University of Missouri expert analyzed the pelvis fragments of an early hominid fossil, revealing insights into the evolution of modern great apes. The study suggests that the ape's wider pelvis indicates greater lateral balance and stability, while its distinct finger bones indicate a different evolutionary path than initially thought.