Articles tagged with Pathology
Recent studies by Case Western Reserve University's Anant Madabhushi show that his diagnostic imaging lab's 'deep learning' computers can accurately diagnose heart failure and detect various cancers. The machines offer valuable tools for pathologists and radiologists, helping them become more efficient in their work.
A team of researchers has identified a previously unknown feature of human anatomy, revealing layers of the body as interconnected, fluid-filled compartments. This discovery has significant implications for understanding organ function, disease progression, and the development of new diagnostic tools.
A Chinese AI system can diagnose prostate cancer with accuracy comparable to human pathologists, offering potential benefits for streamlining cancer diagnosis and overcoming pathologist shortages. The system was developed using a learning algorithm and showed promise in accurately classifying malignancy levels and Gleason Grades.
Researchers developed AI software to predict glioma patient survival by analyzing tissue biopsies, outperforming human pathologists' predictions. The approach combines deep-learning and conventional methods to provide more accurate and consistent information for doctors.
The Association for Molecular Pathology (AMP) has published consensus-based recommendations for clinical CYP2C19 genotyping allele selection. The guidelines aim to standardize testing across laboratories and improve concordance, enabling better patient care.
Researchers found four cases of amyloid beta pathology in brain blood vessels after childhood neurosurgery, sparking concerns over potential transmission of protein pathology. The study's findings were supported by a review of medical literature and suggest that neurosurgical instruments may be responsible.
Researchers found that people from Western Germany have higher levels of narcissism than those from Eastern Germany, with a greater impact on the younger generation. Self-esteem scores were opposite, with East Germans recording higher scores.
A panel of experts has issued new guidelines for molecular diagnostic testing and treatment decisions in lung cancer. The updates reflect recent advancements and decades of work to identify the genetic underpinnings of lung cancer, helping oncologists match patients with effective therapies.
Researchers found that banded mongooses transmit a novel tuberculosis pathogen, Mycobacterium mungi, through olfactory secretions, infecting other animals in their social group. The study provides insight into the evolution of this unique transmission route and its implications for understanding tuberculosis.
Researchers discovered that a yeast protein's prion domain acts like a stress sensor, triggering the formation of protective droplets and gels to help cells recover from stress. This finding suggests that prion domains have a positive function beyond their association with disease-causing aggregates.
Dr. Jeffrey Actor has been awarded $1.7 million to investigate a novel recombinant lactoferrin for use as a preclinical research tool to alter granuloma pathology in tuberculosis. This could limit development of lung disease and slow transmission of organisms between individuals.
Researchers found that mild traumatic brain injury can lead to lifelong degenerative changes, including learning and working memory impairment. Studies on mice revealed ongoing neuroinflammation and neuron projection degeneration after a single or repetitive TBI, with some animals showing motor deficits.
The Universal Genomics Instructor Handbook and Toolkit provides a comprehensive 'how-to' guide for implementing genomics education in various medical specialties. The toolkit contains four exercises and resources for clinicians to gain introductory training in genomic medicine.
A new microscope technology using ultraviolet light enables fast and accurate imaging of fresh tissue samples, revolutionizing pathology and medical research. This approach eliminates the need for time-consuming slide preparation and preserving tissue, making it an essential tool for improving patient care and research nationwide.
The Association for Molecular Pathology publishes consensus recommendations for validating next-generation sequencing bioinformatics pipelines. The guidelines emphasize the critical role of trained molecular laboratory professionals and provide practical advice for laboratories.
A new diagnostic test found that disappearing of heart murmur while standing reliably rules out pathologic heart murmurs in children. The test showed a high predictive positive value and specificity, but poor sensitivity, making it a valuable tool for primary care docs to exclude costly cardiologist referrals.
A new study has re-examined a 1970s-discovered ichthyosaur, Protoichthyosaurus, and found major differences in its forefin structure compared to Ichthyosaurus. The discovery of fake fins added to some specimens led to the recognition of a new species, Protoichthyosaurus applebyi.
The Association for Molecular Pathology (AMP) has awarded prestigious honors to Drs. Andrew P. Feinberg, Gregory J. Tsongalis, and Alexis B. Carter for their outstanding contributions to the field of molecular diagnostics. AMP President Federico A. Monzon praised the award recipients for their decades of service to the society.
Aged chimpanzee brains exhibit pathology similar to human Alzheimer's disease, including Aβ plaques and tau lesions. The study provides the most extensive evidence of AD brain pathology in a primate species, shedding light on the evolution and potential targets for therapeutic interventions.
Researchers from Kent State University have identified pathologic hallmarks of Alzheimer's disease in the brains of aged chimpanzees, similar to human Alzheimer's disease brain pathology. The study found amyloid beta plaques and blood vessels in all 20 aged chimpanzee brains, with increasing sizes correlating to age.
Researchers develop a technique called expansion microscopy to physically expand tissues, enabling pathologists to diagnose diseases like early breast cancer with high accuracy and reliability. The method has been shown to improve the resolution of conventional microscopes and can be applied to any type of clinical sample.
A study of US pathologists reveals that melanoma diagnoses can be inaccurate and non-reproducible, particularly in the middle of the disease spectrum. The results suggest that only cases at the polar ends of the spectrum are accurately diagnosed.
A new microscope can rapidly image tumor margins during surgery, reducing the need for second surgeries. It also enables pathologists to view tissue in 3D, potentially leading to improved diagnosis and treatment decisions.
Researchers found that pathologists outside of academic centers were more likely to misdiagnose appendix tumors as invasive cancer. A significant number of patients had their diagnoses changed after a second evaluation, emphasizing the importance of expertise in appendix cancer diagnosis.
A deep-learning network developed through research at Case Western Reserve University was 100% accurate in determining the presence of invasive breast cancer in whole biopsy slides. The network correctly identified cancerous pixels with 97% accuracy, rendering near-exact delineations of tumors.
A small study reveals a significant variation in coroner decision-making processes, which can affect the prevention of future deaths. The findings highlight the need for a national coroner consensus to achieve a shared inference from available evidence.
Dr. French is recognized for his groundbreaking research and extensive writing about alcoholic liver disease, totaling over 450 peer-reviewed papers and 19,470 citations.
Researchers at Brigham and Women's Hospital have discovered a new genetic variant linked to Tau pathology in Alzheimer's disease. The study, published in Molecular Psychiatry, highlights the potential for targeting the protein tyrosine phosphatase receptor-type delta (PTPRD) gene as a therapeutic strategy.
A new gene variant has been identified in the PTPRD gene that is associated with the accumulation of neurofibrillary tangles (NFTs) in the brain. The study found that this variant affects more than one mechanism of tangle accumulation and may be a key target for developing therapies targeting Tau pathology.
The Association for Molecular Pathology published consensus recommendations to validate next-generation sequencing (NGS)-based oncology panels. The guidelines address NGS test development, optimization and familiarization, and best practices for establishing test performance characteristics.
The Association for Molecular Pathology (AMP) has published a joint guideline to standardize the interpretation and reporting of sequence variants in cancer. The guidelines aim to improve patient care by establishing standardized classification, annotation, interpretation, and reporting conventions for somatic sequence variants.
The Association for Molecular Pathology released a new report highlighting the potential of MALDI-TOF-MS in identifying invasive infectious diseases. The technology has been shown to accurately identify filamentous fungi and mycobacteria, but more testing is needed before its use can be recommended.
A study by Rush researchers found that TDP-43, a previously recognized pathologic protein, is more likely to result in diagnosed Alzheimer's dementia when combined with plaques and tangles. Mixed pathologies increase the risk of developing Alzheimer's dementia above and beyond just having these brain abnormalities.
Eric Lander receives the award for his lifetime achievements in molecular diagnostics, transforming our understanding of rare and common genetic diseases. The AMP Award recognizes Dr. Lander's seminal publications, fundamental discoveries, and significant scientific contributions.
A study found that men who gamble are more likely to act violently towards others, with the most addicted gamblers at greatest risk. The research also showed a strong association between gambling and violence, even after adjusting for other factors.
Researchers at Case Western Reserve University aim to understand the role of intestinal innate immunity in Crohn's disease. They will investigate how mice develop experimental Crohn's disease and replicate these findings in humans, with the goal of developing new medications and treatments to cure the devastating ailment.
The Association for Molecular Pathology has developed a new framework for defining the clinical utility of molecular diagnostics, emphasizing the importance of context in interpreting test results. This approach aims to improve patient care by providing clinically useful and appropriate testing based on realistic evidence levels.
A University of Colorado Cancer Center study found that only 4.6% of cases had discrepancies between initial and final evaluations, with most being due to process errors or interpretation errors. The study aimed to reduce discrepancy rates by identifying trends and implementing changes.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
Researchers at Allina Health have developed an algorithm to simplify the complex pathology classification process for pituitary adenomas. The new system helps pathologists make a more accurate diagnosis with fewer tests, saving time and reducing costs.
A systematic review of 40 studies found a weak correlation between signs, symptoms, and testosterone levels in ageing men. The authors suggest that it is difficult to extrapolate the diagnosis of pathologic hypogonadism from younger men to older men with age-related testosterone declines.
Researchers at Griffith University identified significant impairments in cellular function of CFS patients. They found dysfunctional signalling may contribute to impaired cell activity, aligning with symptoms. The study provides further evidence for the pathology of this disabling illness.
A novel intraocular therapy has been shown to prevent or reverse diabetic retinopathy in mice by increasing ACE-2 expression. The study found that the therapy reduced pro-inflammatory cells and reversed vascular degeneration, suggesting a potential new treatment for blindness and other vascular diseases.
A study found that nearly half of routine tests for monoclonal gammopathy are unnecessary and costly. An algorithm-driven approach can improve efficiency and reduce healthcare costs by putting more decision-making power in the hands of pathologists.
New research reveals bed bugs have developed thicker cuticles to resist insecticides, making control efforts more challenging. Understanding this resistance mechanism could lead to the development of new strategies for effective bed bug control.
A study found that pathologists agree on invasive breast cancer diagnoses but not on non-invasive lesions like DCIS and atypia. Women with borderline findings may benefit from revised guidelines for clinical treatment and management.
Researchers at the University of Texas Health Science Center at Houston found that smartphones can detect 90% of non-melanoma skin cancers and 60% of melanomas, improving diagnosis in remote areas. A DIY smartphone microscope can be made with a ball lens and tape, and additional studies are needed to enhance detection rates.
Mayo Clinic researchers found that using frozen section analysis during lumpectomies can reduce the need for second operations by 95%, saving patients time and financial burdens. The study estimates annual cost savings of $90.9 million to payers and $1.8 million to providers.
The University of Leeds has developed an innovative virtual microscope system to aid in cancer diagnoses. The technology allows pathologists to view large patient cases of up to 100 slides or more, making complex diagnoses faster and more accurate.
Research has made significant progress in understanding mood and psychotic disorders, enabling individualized treatment approaches. Key findings highlight the potential of biomarkers such as neuroanatomy, neuro-circuitry, and genetic markers to stratify patients into clinically distinct subgroups.
The Association for Molecular Pathology (AMP) has updated its pathology residency curriculum recommendations, focusing on 10 major molecular pathology topics. The new report aims to equip pathologists with the latest scientific breakthroughs and technological innovations in molecular pathology.
Children with Down syndrome who exhibit symptoms of both childhood dysarthria and apraxia may be inadequately diagnosed, leading to ineffective treatment. A new study suggests that these children should be treated for all symptoms, regardless of diagnosis.
The Journal of Neuropathology & Experimental Neurology will now be published by Oxford University Press USA, publishing original articles on neuropathology and experimental neuroscience since 1942. The journal is the official publication of the American Association of Neuropathologists, Inc.
A 25-year-old former college football player experienced over 10 concussions during his 16-year career, leading to CTE pathology and cognitive issues. The player's autopsy confirmed the diagnosis, making him the first person with CTE to undergo neuropsychological testing.
A team of researchers has identified a unique gait pattern among top Russian officials, including President Vladimir Putin and Prime Minister Dmitry Medvedev. The experts link this 'gunslinger's gait' to military or intelligence training, specifically KGB instruction on keeping the weapon close to the chest while walking.
A study by UPMC and KingMed Diagnostics researchers found that international telepathology consultations significantly improved patient care in China, altering treatment plans for over half of cases. The consultation service expanded access to pathology expertise, facilitating the diagnosis of rare malignancies.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
A new hand-held probe using optical coherence tomography (OCT) technology has been found to correlate well with traditional pathologists' diagnoses in a clinical study, enabling reliable real-time guidance for surgeons. The device can identify differences between cancer cells and normal tissue with high sensitivity and specificity.
A new study aims to understand MS pathology by activating metabolic stress in oligodendrocytes, a type of cell that produces myelin. The research seeks to determine if this nonimmune-mediated animal model can recapitulate MS pathology and find evidence for behavioral changes and cognitive decline.