Articles tagged with Drug Delivery Systems
Researchers have created a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation. The micropump utilizes temperature-dependent gas generation through yeast fermentation to push against a membrane, pumping for several hours.
Canada faces unpredictable and widespread drug shortages, affecting patient health and healthcare costs. A national approach with mandatory reporting and integrated leadership can minimize the impact of shortages.
Researchers at Tel Aviv University create gold nanoparticles that trigger an immune response when coated with specific chemical residues, revealing a key link between hydrophobicity and immune system activation. This breakthrough has the potential to improve drug delivery systems and lead to more effective medications and vaccinations.
A national trial has shown that autoinjectors are quicker and more effective in stopping seizures than traditional IV line treatment. The study found that patients who received midazolam via an autoinjector were 73% seizure-free upon arrival at the hospital, compared to 63% of those receiving IV lorazepam.
Researchers at Boston University have developed a unique material and drug delivery mechanism that can slow the release of anti-cancer drugs over months. The system uses a biocompatible, porous polymer material with air pockets to prevent immediate release in case of water flooding.
Researchers at Tufts University developed silk-based microneedle systems that can precisely control drug release rates and maintain bioactivity. The technology has the potential to address limitations in existing painless drug delivery mechanisms and prevent local infections.
Researchers developed a new statistical method to assess the bending elasticity of biological membranes, improving accuracy by up to 80%. The method uses Maxwell-Boltzmann distribution and has potential applications in cosmetics and pharmaceuticals.
A new transdermal patch has been developed to deliver HIV medication over seven days, offering a more convenient and affordable option for patients. The patch shows significant potential in reducing the number of pills patients need to take daily, as well as decreasing shipping costs.
Scientists have developed a battery-powered skin patch that can deliver medication for peripheral artery disease (PAD) and healing stubborn skin ulcers and burns. The patch uses transdermal iontophoresis to deliver fibroblast growth factors (FGFs), larger proteins that were previously ineffective when given by mouth or injected, result...
A team of scientists created a programable molecular transport system, observed in real time using atomic force microscopy. The system consists of a DNA origami track with a motor and fuel, allowing for adjustable speed and potential applications in drug delivery and synthetic ribosome creation.
Researchers at Brown University have developed a magnetic pill system that can safely hold pills in place in the intestine where they need to be absorbed into the bloodstream. The system uses an external magnet to sense the position of the pill and apply precise forces to keep it in place.
Researchers from Louisiana Tech University are presenting their work on smart nanofilms for regenerative medicine at the 2010 Experimental Biology meeting. Their presentation highlights the first known application of a smart nanofilm sprayed directly on living tissue, showing promising results in wound healing and potential application...
Scientists identified alternative routes for pharmaceuticals to enter the environment through bathing, showering, and laundering. These routes may lead to higher environmental impact for certain medications applied topically. Reducing consumption and developing better drug delivery systems can minimize environmental harm.
A new ultra-rapid acting mealtime insulin is orally inhaled for absorption via the lung, mimicking the natural early insulin response. This innovative technology uses a delivery system that applies to other drugs currently injected, with potential benefits including reduced hypoglycemia and weight gain.
A study published in Tobacco Control found that electronic cigarettes fail to deliver nicotine, with participants experiencing no significant increase in nicotine levels or heart rate. The research emphasizes the need for regulation and labeling of these products to protect consumers' welfare and rights.
Researchers design nanowire-based beads that release drugs in the gut, improving absorption and reducing degradation. The technology may also be used for delivering drugs to mucosal tissues like the nose, lungs, or vagina.
Researchers at Duke University have developed a simple and inexpensive method for loading cancer drugs into nano-scale delivery vehicles. The new formulation showed promising results in animal models, eliminating tumors after a single treatment while reducing side effects associated with systematic chemotherapy.
Researchers developed an optimized mouthpiece design to reduce medication waste and improve drug delivery to the lungs. The new design allows for more medication to pass through the mouthpiece, ensuring effective delivery of future inhaled medications.
The 20/20 Network will focus on developing new biomaterials, medical devices, and drug delivery systems for treating vision disorders. Researchers aim to improve treatment of vision loss with products like composite materials, ocular microgels, and contact lenses.
Scientists have created an implantable device that utilizes magnetism to control the release of medication, allowing for precise and repeatable dosing. The device uses nanoparticles that heat up when exposed to a magnetic field, causing the drug to be released into the body.
Researchers developed nanosized capsules compatible with various substances for medicine and energy applications. The capsules can carry anticancer drugs or medical-imaging agents to specific locations within the human body. A highly sensitive oxygen sensor was also created, detecting minute amounts of oxygen in confined spaces.
Von Maltzahn's innovations use nanotechnology to precisely target and destroy tumor cells, reducing side effects and overpowering drug resistance. His work also aims to improve intravenous delivery of therapeutics to tumors.
Researchers at MIT have designed gold nanoparticles that can deliver multiple cancer drugs in a controlled fashion using infrared light. The system allows for precise timing of release, enabling treatment of diseases commonly treated with multiple drugs.
Researchers at Harvard Medical School developed a self-assembling hydrogel drug delivery system that releases clinically approved drugs in high concentrations without carriers or toxic residues. The system, triggered by enzymes, has the potential to serve as a platform technology for developing targeted drug delivery systems.
Researchers at Case Western Reserve University have developed a technique that can deliver cancer-fighting drugs to diseased areas within hours, reducing the current delivery time from two days. The system uses gold nanoparticle vectors to deliver photodynamic therapy (PDT) drugs through the bloodstream.
Researchers developed a multistage delivery system to improve injectable drug efficacy, targeting diseased cells and releasing therapeutics in a controlled manner. The system uses mesoporous silicon particles to circumvent biobarriers and deliver diagnostic agents or therapeutic agents.
Researchers demonstrated that microneedle patches can deliver clinically-relevant doses of drugs like naltrexone, reducing side effects and required dosage. The study also found lower production of metabolites, which may cause adverse reactions.
A new research project aims to integrate radio frequency identification technology into cardiac sensor networks, improving remote medical delivery. The team will also work to enhance the security of the systems used in the process, reducing the possibility of identity theft and cyber-terrorism.
Scientists have developed a new class of designer materials using common amino acids, which exhibit excellent potential for solubilizing membrane proteins and enzymes. These lipid-like peptides can also stabilize self-assembled liquid crystalline nanostructures with varying surface charge density.
Researchers designed a pulsed microjet system to deliver protein drugs into the skin, eliminating pain and bruising. The system uses high-velocity jets with small diameters to deliver precise doses, enabling local and systemic applications.
A new drug delivery method developed by UBC researcher Kishor M. Wasan has shown promising results in treating devastating fungal infections, including candidemia and aspergillosis, with minimal toxic side effects compared to traditional intravenous administration.
Scientists have engineered tiny silica particles to carry pharmaceuticals into cells using biocompatible materials and controlled release mechanisms. The mesoporous nanospheres can selectively target cancer cells by releasing drugs in response to specific chemicals, reducing side effects and increasing treatment efficacy.
Researchers at the University of Toronto developed a new material, periodic mesoporous organosilica (PMO), that acts as a better insulator for microelectronics. The PMO film would take up less room than conventional silica glass and allow components to shrink further, enabling smaller and more efficient devices.
Researchers have created temperature-sensitive capsules that can release drugs at different rates, with the release rate controlled by the amount of wrinkling. The solution to cool the capsules without harming surrounding tissue lies in newly discovered nanoparticles chilled through magnetic cooling.
Research by Victoria O. Chan reveals that 68% of intramuscular injections do not reach the muscle due to excessive fat tissue. The study suggests a longer needle length may improve success rates for patients with obesity.
In a study published in Archives of Internal Medicine, researchers found that despite implementing multiple computerized interventions, medication errors continued to occur at high rates. The authors identified common error types, including failure to monitor adverse drug reactions and improper medication dosages.
Researchers at UNC Health Care System have developed a new continuous-infusion method for administering busulfan, which achieved more predictable levels of the drug in patients. The new method has the potential to increase treatment effectiveness while avoiding side effects by maintaining consistent drug levels.
Researchers developed a recombinant fusion protein that can be orally administered, increasing white blood cell count for three days. This breakthrough uses transferrin to bind to intestinal cells and transport the protein to the bloodstream.
Shelly Sakiyama-Elbert and her team have screened a large number of molecules to find peptide sequences with varying affinity for heparin, a sugar that binds nerve repair drugs. They aim to develop affinity-based drug delivery systems to stimulate tissue regeneration for conditions like nerve damage.
The editorial concludes that deworming programs have substantial public health benefits and reductions in global burden of disease. Simple, effective, safe, and cheap treatments are already available, but systematic delivery requires industry, funders, and political will.
The development of nanomedicines has led to significant advances in the diagnosis and treatment of disease. Thousands of patients are already benefiting from products used to treat conditions such as cancer, AIDS, and arthritis.
The Lancet calls for increased investment in nanomedicine research, citing its potential to revolutionize disease diagnosis and treatment. The field's benefits include novel means of imaging and delivery systems for drugs and gene therapies.
Researchers at Purdue University have demonstrated a method for delivering insulin orally using microscopic particles that protect the medicine from stomach acid until they can be released in the intestines. The system has been shown to be non-toxic and effective, with the potential to revolutionize treatment for insulin-dependent diab...
Researchers at Purdue University have developed a new gel-like material that can be used as a drug-delivery system, potentially replacing multiple daily medications with a single dose. The superporous hydrogels expand rapidly in the stomach, allowing medications to be absorbed more efficiently by the body.
A new study published in Annals of Internal Medicine found that HIV patients require at least 95 percent adherence to antiretroviral therapy for the drugs to work. The study also revealed that physicians often misjudge their patients' adherence, which could have serious consequences.
Researchers have developed a method to deliver nucleotides directly into tumor cells, assembling them on their own. This approach may lead to new treatments with improved efficacy and reduced side effects for various types of cancer.
The AAPS Workshop on Regulatory Issues Related to Drug Products for Oral Inhalation and Nasal Delivery will focus on quality assurance, CMC data, and bioavailability. The workshop aims to advance science through open exchange of knowledge and contribute to human health through pharmaceutical research.
Researchers found that rats born by Caesarean section showed marked differences in brain development compared to naturally born controls. They had altered dopamine systems and responses to stress tests. The findings hint at a potential link between Caesarean births and schizophrenia risk.
Using nebulizers to deliver glucocorticoid medication is effective in treating asthma in children, but long-term use can suppress growth, recommends Dr. Stanley J. Szefler of National Jewish Health. A new study suggests caution when prescribing glucocorticoids for children under 5 years old.
Researchers at Georgia Tech have developed microneedle arrays that can deliver small quantities of high-potency medications through the skin without causing pain. The arrays, produced with microelectronics industry techniques, penetrate only the outermost layer of skin with no nerve endings.
Researchers found that treating acute ischemic stroke patients with t-PA can result in a substantial net cost savings due to shorter hospital stays and decreased long-term disabilities. This treatment also improves patient outcomes and quality of life.
The University of Maryland Medical Center has successfully implanted a new device that can regulate a dangerously rapid heartbeat automatically and internally. The Metrix System TM delivers a small electrical shock to the heart, making it a more comfortable alternative to external shocks.
Researchers are developing genetically altered, edible plant products to create new vaccines for sexually transmitted diseases. Plant-based proteins could be incorporated into pills, providing a cost-effective solution for vaccinations like hepatitis B.
Researchers at Purdue University have developed an oral delivery method for insulin that may eventually treat human diabetes. The method uses a gel-like material to protect insulin from stomach enzymes, allowing it to release the drug in a location where it can work.
Researchers have designed a mini drug pump that can sense blood glucose levels and deliver the right amount of insulin, potentially simplifying the lives of diabetics. The device uses a novel alloy to create a closed-loop system, which could also be adapted for other medications.
Researchers develop tiny coated beads that can release drugs directly onto tumors in response to chemical signals. The beads are designed to remain intact until exposed to sodium-rich blood plasma, at which point they swell and burst explosively, releasing the entrapped drug. This technology has potential for targeted cancer treatment.
Brown University researchers have developed a novel oral drug delivery system using erodible plastic microspheres that can improve the efficacy of drugs like insulin. The microspheres, engineered with bioadhesive polymers, increase absorption rates and enhance therapeutic effects.
Researchers have developed a prototype drug pump that can monitor its own flow rate, ensuring steady stream of medicine and enabling diabetics to manage their condition more effectively. The device is made on a single silicon wafer and uses a titanium-nickel alloy to flex and regulate fluid flow.
Researchers at Ohio University have developed a nonviral gene therapy system that can express genes outside the nucleus of a cell, making it easier to deliver disease-fighting genes to tumor cells. This system has been successfully used in cell cultures and mouse models to promote anti-cancer activity.
A neural prosthetic system has been recommended for FDA approval, allowing paralyzed people to grasp objects without assistance. The system, developed over 25 years, enables users to regain hand function and perform routine activities with greater independence.