Articles tagged with Drug Delivery Systems
Researchers developed a compact system that can synthesize various pharmaceuticals in short periods, reducing batch production and addressing drug shortages. The system produces high-quality drugs continuously over several hours or days, with the potential to facilitate on-the-spot production of pills through new approaches.
Researchers have successfully mapped the 3D structure of cubosomes, a biological 'capsule' that delivers molecules with high efficiency. The breakthrough can help promote the use of cubosomes in medicine and food science.
A new experimental treatment regimen combining a drug delivery system and URMC-099 has been shown to effectively combat HIV, reducing the need for daily medication. The nanoformulated protease inhibitor and URMC-099 prolonged therapeutic effects by increasing drug concentration in immune cells.
Two US studies published in The BMJ reveal a significant increase in drugs approved via expedited pathways, raising concerns about efficacy and safety. The findings suggest that most new drugs may not be significantly more effective than existing products.
Researchers at Duke University have deciphered the genetic code that instructs proteins to assemble or disassemble in response to environmental stimuli. This discovery provides a new platform for designer proteins and investigations into nanotechnology, biotechnology, and medical treatments.
Jin Kim Montclare's new research aims to deliver genes and drugs simultaneously, enabling the potential treatment of multi-drug resistant cancer cells. The engineered protein-lipid system breaks down naturally in the body, offering a safer alternative to traditional polymers.
Alternative drug-delivery systems are being explored to overcome syringe injection drawbacks, including ointments, dissolvable tablets and micro-needle skin patches. Several promising results have been shown in animal testing, but widespread adoption will require changing the mindset of pharmaceutical companies and regulators.
The MIT team devised a two-step process to create large quantities of complex emulsions with precise control over the composition of droplets. By adding different chemicals or exposing them to light or different acidity levels, they can finely tune the configuration of droplets. This allows for rapid, large-scale production and enables...
Researchers at OIST create non-spherical particles using a simple and low-cost method that can be scaled up for various industries. The study reveals four possible shapes: ellipsoid, mushroom, flake-like, and disc, with applications in food processing, cosmetics, and drug delivery systems.
An allergic response to a medication for allergies can often go undiagnosed due to its initial purpose of reducing inflammation. Patients experiencing worsening symptoms or an unresponsive rash may be reacting to the medication itself or one of its components, such as antibiotics or antifungals.
Researchers at Columbia University School of Engineering and Applied Science have developed a new non-invasive technique using acoustic pressure to control the size of molecules penetrating the blood-brain barrier. This breakthrough may help improve localized brain drug delivery for treatment of central nervous system diseases like Par...
The collaboration aims to overcome barriers in delivering antibodies directly into the brain to treat dementia, Alzheimer's disease and other neurological disorders. The project will utilize Nanomerics' Molecular Envelope Technology to develop effective treatments with potential to improve patient adherence and quality of life.
Researchers have found that applying ice packs after major abdominal operations reduces postoperative pain and opioid use, with patients experiencing 50% less pain on the first and third days. An experimental prolonged drug delivery system using lidocaine also showed superior results in animal studies.
A new optical device can identify the contents of intravenous (IV) fluid lines in real-time, offering a promising solution to prevent medication errors. The device uses Surface-Enhanced Raman Scattering (SERS) technology to detect molecular signatures of drugs and confirm their presence.
Researchers have developed a new temperature-regulated delivery system that can release drugs or fragrances in response to body heat, offering greater control over delivery. The system uses microscopic bottle-like structures with melting corks made of fatty acids, which can be tailored to specific temperatures.
Researchers develop nanoparticles that can assemble and disassemble using temperature, improving drug delivery and anticancer treatment. The new system uses thermosensitive polymers to control nanoparticle interactions, enabling more precise structures and potentially increasing the efficacy of anticancer drugs.
Duke University engineers developed a novel delivery system that overcomes the limitations of peptide drugs, which are used to treat diseases like diabetes and cancer. The new system, called POD, uses a fusion protein that releases the drug slowly and steadily, reducing side effects.
The Deshpande Center has awarded grants to ten MIT research teams working on early-stage technologies with the potential to significantly impact various fields. These projects aim to develop new technological innovations in areas such as cancer treatment, computation, and food production.
Researchers at UC Davis have developed a novel drug delivery system using nanoparticles that targets bladder cancer cells, allowing for higher doses of chemotherapy while reducing side effects. The system also enables diagnostic imaging, offering potential benefits for advanced bladder cancer treatment and management.
Researchers have created a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation. The micropump utilizes temperature-dependent gas generation through yeast fermentation to push against a membrane, pumping for several hours.
Canada faces unpredictable and widespread drug shortages, affecting patient health and healthcare costs. A national approach with mandatory reporting and integrated leadership can minimize the impact of shortages.
Researchers at Tel Aviv University create gold nanoparticles that trigger an immune response when coated with specific chemical residues, revealing a key link between hydrophobicity and immune system activation. This breakthrough has the potential to improve drug delivery systems and lead to more effective medications and vaccinations.
A national trial has shown that autoinjectors are quicker and more effective in stopping seizures than traditional IV line treatment. The study found that patients who received midazolam via an autoinjector were 73% seizure-free upon arrival at the hospital, compared to 63% of those receiving IV lorazepam.
Researchers at Boston University have developed a unique material and drug delivery mechanism that can slow the release of anti-cancer drugs over months. The system uses a biocompatible, porous polymer material with air pockets to prevent immediate release in case of water flooding.
Researchers at Tufts University developed silk-based microneedle systems that can precisely control drug release rates and maintain bioactivity. The technology has the potential to address limitations in existing painless drug delivery mechanisms and prevent local infections.
Researchers developed a new statistical method to assess the bending elasticity of biological membranes, improving accuracy by up to 80%. The method uses Maxwell-Boltzmann distribution and has potential applications in cosmetics and pharmaceuticals.
A new transdermal patch has been developed to deliver HIV medication over seven days, offering a more convenient and affordable option for patients. The patch shows significant potential in reducing the number of pills patients need to take daily, as well as decreasing shipping costs.
Scientists have developed a battery-powered skin patch that can deliver medication for peripheral artery disease (PAD) and healing stubborn skin ulcers and burns. The patch uses transdermal iontophoresis to deliver fibroblast growth factors (FGFs), larger proteins that were previously ineffective when given by mouth or injected, result...
A team of scientists created a programable molecular transport system, observed in real time using atomic force microscopy. The system consists of a DNA origami track with a motor and fuel, allowing for adjustable speed and potential applications in drug delivery and synthetic ribosome creation.
Researchers at Brown University have developed a magnetic pill system that can safely hold pills in place in the intestine where they need to be absorbed into the bloodstream. The system uses an external magnet to sense the position of the pill and apply precise forces to keep it in place.
Researchers from Louisiana Tech University are presenting their work on smart nanofilms for regenerative medicine at the 2010 Experimental Biology meeting. Their presentation highlights the first known application of a smart nanofilm sprayed directly on living tissue, showing promising results in wound healing and potential application...
Scientists identified alternative routes for pharmaceuticals to enter the environment through bathing, showering, and laundering. These routes may lead to higher environmental impact for certain medications applied topically. Reducing consumption and developing better drug delivery systems can minimize environmental harm.
A new ultra-rapid acting mealtime insulin is orally inhaled for absorption via the lung, mimicking the natural early insulin response. This innovative technology uses a delivery system that applies to other drugs currently injected, with potential benefits including reduced hypoglycemia and weight gain.
A study published in Tobacco Control found that electronic cigarettes fail to deliver nicotine, with participants experiencing no significant increase in nicotine levels or heart rate. The research emphasizes the need for regulation and labeling of these products to protect consumers' welfare and rights.
Researchers design nanowire-based beads that release drugs in the gut, improving absorption and reducing degradation. The technology may also be used for delivering drugs to mucosal tissues like the nose, lungs, or vagina.
Researchers at Duke University have developed a simple and inexpensive method for loading cancer drugs into nano-scale delivery vehicles. The new formulation showed promising results in animal models, eliminating tumors after a single treatment while reducing side effects associated with systematic chemotherapy.
Researchers developed an optimized mouthpiece design to reduce medication waste and improve drug delivery to the lungs. The new design allows for more medication to pass through the mouthpiece, ensuring effective delivery of future inhaled medications.
The 20/20 Network will focus on developing new biomaterials, medical devices, and drug delivery systems for treating vision disorders. Researchers aim to improve treatment of vision loss with products like composite materials, ocular microgels, and contact lenses.
Scientists have created an implantable device that utilizes magnetism to control the release of medication, allowing for precise and repeatable dosing. The device uses nanoparticles that heat up when exposed to a magnetic field, causing the drug to be released into the body.
Researchers developed nanosized capsules compatible with various substances for medicine and energy applications. The capsules can carry anticancer drugs or medical-imaging agents to specific locations within the human body. A highly sensitive oxygen sensor was also created, detecting minute amounts of oxygen in confined spaces.
Von Maltzahn's innovations use nanotechnology to precisely target and destroy tumor cells, reducing side effects and overpowering drug resistance. His work also aims to improve intravenous delivery of therapeutics to tumors.
Researchers at MIT have designed gold nanoparticles that can deliver multiple cancer drugs in a controlled fashion using infrared light. The system allows for precise timing of release, enabling treatment of diseases commonly treated with multiple drugs.
Researchers at Harvard Medical School developed a self-assembling hydrogel drug delivery system that releases clinically approved drugs in high concentrations without carriers or toxic residues. The system, triggered by enzymes, has the potential to serve as a platform technology for developing targeted drug delivery systems.
Researchers at Case Western Reserve University have developed a technique that can deliver cancer-fighting drugs to diseased areas within hours, reducing the current delivery time from two days. The system uses gold nanoparticle vectors to deliver photodynamic therapy (PDT) drugs through the bloodstream.
Researchers developed a multistage delivery system to improve injectable drug efficacy, targeting diseased cells and releasing therapeutics in a controlled manner. The system uses mesoporous silicon particles to circumvent biobarriers and deliver diagnostic agents or therapeutic agents.
Researchers demonstrated that microneedle patches can deliver clinically-relevant doses of drugs like naltrexone, reducing side effects and required dosage. The study also found lower production of metabolites, which may cause adverse reactions.
A new research project aims to integrate radio frequency identification technology into cardiac sensor networks, improving remote medical delivery. The team will also work to enhance the security of the systems used in the process, reducing the possibility of identity theft and cyber-terrorism.
Scientists have developed a new class of designer materials using common amino acids, which exhibit excellent potential for solubilizing membrane proteins and enzymes. These lipid-like peptides can also stabilize self-assembled liquid crystalline nanostructures with varying surface charge density.
Researchers designed a pulsed microjet system to deliver protein drugs into the skin, eliminating pain and bruising. The system uses high-velocity jets with small diameters to deliver precise doses, enabling local and systemic applications.
A new drug delivery method developed by UBC researcher Kishor M. Wasan has shown promising results in treating devastating fungal infections, including candidemia and aspergillosis, with minimal toxic side effects compared to traditional intravenous administration.
Scientists have engineered tiny silica particles to carry pharmaceuticals into cells using biocompatible materials and controlled release mechanisms. The mesoporous nanospheres can selectively target cancer cells by releasing drugs in response to specific chemicals, reducing side effects and increasing treatment efficacy.
Researchers at the University of Toronto developed a new material, periodic mesoporous organosilica (PMO), that acts as a better insulator for microelectronics. The PMO film would take up less room than conventional silica glass and allow components to shrink further, enabling smaller and more efficient devices.
Researchers have created temperature-sensitive capsules that can release drugs at different rates, with the release rate controlled by the amount of wrinkling. The solution to cool the capsules without harming surrounding tissue lies in newly discovered nanoparticles chilled through magnetic cooling.
Research by Victoria O. Chan reveals that 68% of intramuscular injections do not reach the muscle due to excessive fat tissue. The study suggests a longer needle length may improve success rates for patients with obesity.
In a study published in Archives of Internal Medicine, researchers found that despite implementing multiple computerized interventions, medication errors continued to occur at high rates. The authors identified common error types, including failure to monitor adverse drug reactions and improper medication dosages.
Researchers at UNC Health Care System have developed a new continuous-infusion method for administering busulfan, which achieved more predictable levels of the drug in patients. The new method has the potential to increase treatment effectiveness while avoiding side effects by maintaining consistent drug levels.
Researchers developed a recombinant fusion protein that can be orally administered, increasing white blood cell count for three days. This breakthrough uses transferrin to bind to intestinal cells and transport the protein to the bloodstream.
Shelly Sakiyama-Elbert and her team have screened a large number of molecules to find peptide sequences with varying affinity for heparin, a sugar that binds nerve repair drugs. They aim to develop affinity-based drug delivery systems to stimulate tissue regeneration for conditions like nerve damage.
The editorial concludes that deworming programs have substantial public health benefits and reductions in global burden of disease. Simple, effective, safe, and cheap treatments are already available, but systematic delivery requires industry, funders, and political will.
The development of nanomedicines has led to significant advances in the diagnosis and treatment of disease. Thousands of patients are already benefiting from products used to treat conditions such as cancer, AIDS, and arthritis.