Articles tagged with Drug Delivery Systems
Researchers developed a novel intranasal delivery system that utilizes the trigeminal nerve to deliver antidepressant drugs to the brain. The system showed efficacy at delivering the same dose as intracerebroventricular administration, highlighting a potential new approach for treating depression and other neurological disorders.
Researchers have created a chemical tag that can be added to drugs, allowing them to enter blood circulation via the intestines. The tag, called EPP6, is a neutral peptide that can deliver drugs orally, potentially replacing injections for diabetes and cancer patients.
A novel radiopharmaceutical treatment targeting prostate-specific membrane antigen effectively shrinks prostate tumors in mice, with minimal impact on major organs. Researchers plan to launch a clinical trial for refractory prostate cancer patients in two years.
Researchers have designed DNA-based transporters that can deliver precise concentrations of drugs, potentially improving cancer treatment. These nanotransporters can also be programmed to prolong the effect of a drug and minimize its dosage, reducing side effects.
Researchers have developed a way to load potent antibiotics like Polymyxin B into red blood cells, allowing them to selectively target and kill drug-resistant bacteria. This technology could help address the ongoing antibiotic resistance crisis and deliver drugs more quickly and directly to specific sites in the body.
A novel polysorbate-based formulation enhances carboplatin's therapeutic response in lymph nodes, amplifying antitumor effects and increasing drug penetration.
Scientists explore the dynamics of soft materials like toothpaste and hair gel using X-ray photon correlation spectroscopy (XPCS). The technique reveals microscopic dynamics and helps understand properties like viscosity and elasticity. Insights gained can aid in designing consumer products, nanotechnologies, and drug delivery systems.
Researchers at Brigham and Women's Hospital and MIT have developed RoboCap, a robotic capsule that delivers drugs to the gut by clearing mucus and churning to enhance absorption. In preclinical models, RoboCap increased drug permeability by over 10-fold for insulin and vancomycin.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
Researchers at Tohoku University have developed a novel cancer therapy combining lymphatic drug delivery with total-body irradiation, showing superior antitumor effects in early stage lymph node metastasis. The treatment enhances systemic tumor immune responses and alters the tumor microenvironment.
QUT researchers have developed an unprecedented methodology for producing microspheres using sunlight, providing a sustainable solution for various industries. This breakthrough is the result of over a decade of research into the power of light to create molecules.
Researchers at UNC School of Medicine developed a long-acting injectable formulation of the anti-TB drug rifabutin, showing efficacy in animal models and potential to improve adherence to medication. The formulation could provide an effective way to prevent TB infection and treatment failure.
Researchers from Osaka University have developed a system to coat nematodes with hydrogel sheaths that can carry functional cargo. The study found that the sheaths protect the worms from UV light and hydrogen peroxide while allowing them to deliver anti-cancer agents to kill cancer cells in vitro.
A new EU project, DeLIVERY, aims to develop a microscopy system for liver cells to test tolerability of drug interactions. The system will enable researchers to observe how liver cells react to different medications, dosages, and combinations, potentially leading to improved patient safety.
Researchers at Tokyo Institute of Technology developed a computational DNA droplet that can recognize specific combinations of chemically synthesized microRNAs as biomarkers of tumors. The droplet can perform logic computing operations and detect multiple cancer biomarkers simultaneously.
A recent study published in Pharmaceutics suggests that berberine can suppress the proliferation of lung cancer cells, reduce airway inflammation, and modulate genes involved in inflammation. The researchers used liquid crystalline nanoparticles to enhance safety and effectiveness.
Researchers from Brigham and Women's Hospital and MIT designed an oil-based gel system, oleogel, to deliver medications to children with swallowing difficulties. The system has been shown to be compatible with most drugs and can facilitate drug uptake at levels comparable to solid tablets.
Research at Columbia University Mailman School of Public Health found that cannabis vaping is the most popular method of cannabis delivery among all adolescents, with frequent use rising faster than occasional use. The study also highlights disparities in vaping use among different demographic groups and its link to nicotine use.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
A team of researchers from Kumamoto University has developed a transformable polyrotaxane carrier that can facilitate genome editing using Cas9RNP with high efficiency. The carrier, called amino-PRX, is multi-step transformable and has low cytotoxicity, making it an enormously promising candidate for safe and efficient delivery.
A study at the University of Helsinki found that a strong saline solution can quadruple morphine concentration in the spinal cord, intensifying pain relief. The glymphatic system enables faster drug delivery when administered with hypertonic solutions.
Researchers at UMass Amherst have developed a new class of material called pZC that can withstand acidic stomach conditions and dissolve in the small intestine. This innovation could revolutionize oral medication delivery, increasing the number of medications that can be taken orally.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers have engineered probiotic bacteria to produce the dopamine precursor L-DOPA, a potential treatment for Parkinson's disease. The new approach eliminates side effects and reduces treatment complications, offering a promising alternative to existing treatments.
The Experimental Biology (EB) 2022 meeting features live presentations and a moderated Q&A session on groundbreaking studies. The virtual press conference reveals potential treatments for Parkinson's disease, COVID-19 vaccine-associated side effects, and alleviating food allergies.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
Researchers at Jacobs University have developed a novel method for drug delivery using boron clusters, enabling efficient transport of bioactive substances into cells. The breakthrough has potential applications in overcoming antibiotic resistance and delivering innovative therapeutics, such as peptides and protein-based drugs.
Researchers at the University of Bologna have developed a new targeted cancer therapy based on a genetically modified phage that selectively eliminates tumour cells. The virus is engineered to transport a drug activated by light to target tumour cells, reducing side effects.
A new form of drug delivery microparticle mimics the properties of a red blood cell, enabling controlled release of drugs and targeting specific destinations. The goal is to bypass the body's filtration systems, allowing for improved efficacy and reduced negative side effects.
Researchers at Argonne National Laboratory discovered how microparticles can change direction when an electric stimulus is interrupted and reapplied with the same orientation. This emergent behavior has potential applications in microfluidic pumps for biomedical, chemical, and electronics applications.
Researchers develop a novel nanoplatform that can deliver drugs directly to T cells, which play a crucial role in immune reactions. The platform uses pH-sensitive dendrimers with phenylalanine and has shown promising results for cancer immunotherapy.
A new microsize-gap multiple-shot electroporation (M2E) device has been developed by SUTD researchers, offering improved effectiveness and accessibility for cancer drug delivery. The device is low-cost, manufacturable, and can be reused, making it a potential solution for under-resourced regions.
Researchers at Lawrence Berkeley National Laboratory have developed water-walking liquid robots that can retrieve and deliver precious chemicals autonomously. The robots use chemistry to control buoyancy and do not require electrical energy, making them ideal for applications such as chemical synthesis and drug delivery.
Scientists at UC San Diego create nanoparticles that mimic the flu virus's ability to escape endosomes, enabling efficient delivery of mRNA into cells. This breakthrough could lead to improved delivery of mRNA vaccines and therapies.
A wearable device has been developed to detect and reverse opioid overdoses by injecting naloxone, a lifesaving antidote. The device, which senses when a person stops breathing and moving, has shown promising results in clinical trials.
Researchers have developed fish-shaped microrobots that can guide themselves to cancer cells using magnets, where a pH change opens their mouths to release chemotherapy. The microrobots demonstrate promising capabilities for targeted cancer treatment, but need further improvements in size and tracking methods.
Researchers have demonstrated the effectiveness of polymer-coated nanoparticles in delivering drugs to the brain, overcoming the blood-brain barrier challenge. The study showed that zwitterionic polymers improve accessibility but are rapidly absorbed by blood vessel walls.
Researchers published safety and efficacy data for a novel nusinersen drug delivery method via subcutaneous intrathecal catheter system (SIC) for spinal muscular atrophy (SMA) patients. The study found improvements in arm and hand function, but no significant changes in motor scales or muscle force.
Patients with certain gene mutations are at high risk of fatal chemotherapy toxicity, with a 25-times increased risk detected in those with uncommon DPYD variants. The study suggests that adding pre-treatment screening may help prevent avoidable deaths without interrupting standard care.
Bioengineer Kevin McHugh is developing a platform to improve the performance of injectable drugs, which often release diminishing amounts of medication over time. The goal is to create predictable, long-lasting delivery systems for better patient outcomes and reduced dosing frequency.
A new gene delivery system promotes healing in rat models by preventing inflammation and bone degradation after tooth replantation. The study found that teeth treated with the system showed significantly greater dental root thickness and fewer osteoclasts, leading to improved success rates.
Researchers developed a pollen-based hybrid ink that can be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery. The ink is biocompatible, flexible and low in cost, allowing for the creation of customized flexible membranes tailored to human skin contours.
Researchers have developed a new way to deliver molecular therapies to cells using a programmable system called SEND, which harnesses natural proteins in the body to encapsulate and deliver different RNA cargoes. This could lead to safer and more targeted delivery of gene editing and other molecular therapeutics.
Researchers have discovered that dendrimer tentacles can avoid detection by the complement system, part of our immune system. This could lead to developing a new system for delivering drugs into the body without triggering an immune response.
Researchers have developed a way to precisely control defects within active liquid crystals by changing the gradient of activity around them. This can be achieved through pulses of light or chemical composition changes, enabling controlled movement and behavior of these materials.
Researchers at Children's Hospital of Philadelphia have developed a system that can fine-tune protein expression from gene therapy vectors, addressing the need for controlled dosing. The 'dimmer switch' uses alternative RNA splicing and an orally available small molecule to adjust levels of expression up or down as needed.
Researchers at the University of York developed a gel that adheres to nasal tissue, delivering levodopa directly to the brain. This innovation improves drug effectiveness and reduces dosage needs, potentially benefiting patients with Parkinson's disease.
Researchers at UC Riverside developed an implantable drug delivery system using piezoelectric nanofibers that can release therapeutic molecules on demand. The system offers robust control over release rate and precision in administering drug molecules, making it suitable for treating chronic diseases.
Researchers are developing an ocular drug delivery system based on RNA nanotechnology to deliver therapeutics into the eye without requiring eye injections. This method aims to create a reservoir for medications to treat diseases over time, reducing adverse effects and increasing treatment efficiency.
Researchers at POSTECH have developed an on-demand drug delivery system that utilizes organic photovoltaic cells and upconversion nanoparticles to convert near-infrared light into visible light, allowing for controlled drug release in medical devices.
The use of nanocarrier drug delivery systems can improve the bioavailability, stability and aqueous solubility of natural drugs. Four plant materials from China, including Epimedium, Rehmannia glutinosa, Panax ginseng and Angelica sinensis, are discussed in this review article.
Scientists at the University of Nottingham have developed a new protein imaging method that allows for the accurate analysis of biomaterials and tissue. This breakthrough technology has the potential to lead to the development of more effective drug delivery systems and medical devices.
Researchers at ETH Zurich have developed a non-invasive method for concentrating and releasing drugs in the brain with pinpoint accuracy using focused ultrasound. The new technique aggregates drugs at specific sites, reducing dosage requirements by 1,300 times, and preserves physiological barriers between blood and nervous tissue.
Researchers discover a new method for making nanoparticles that can efficiently capture over 95% of proteins, DNA, or small molecule drugs. The process uses a self-assembling polymer to create a nanonet that collapses into nanogels, trapping therapeutics with high efficiency.
A Rutgers-led team has created a smart drug delivery system to reduce inflammation and promote tissue repair in damaged nervous tissues. The system, which uses ultrathin biomaterials, aims to improve the treatment of spinal cord injuries and other neurological disorders.
Researchers developed a combination treatment using gas embolization and chemotherapy, achieving tumor regression and reducing regrowth in hepatocellular carcinoma models. The method is less invasive and more precise than traditional treatments.
A researcher has received a five-year, $1.8 million grant to develop and improve oral drug delivery systems for poorly water-soluble molecules. The goal is to increase the effectiveness of these drugs, which currently have limited technology options.
Researchers developed a comprehensive study on nanoprodrugs (NPDs) inside cancer cells, revealing their internalization rate, intracellular localization, and degradation. The study shows that NPDs consistently absorbed by cells as intact particles before being transported into lysosomes.
A new study uses a humanoid chewing robot to assess medicated chewing gum, replicating human chewing motion in a closed environment. The researchers found that the robot demonstrates a similar release rate of xylitol as human participants, with the greatest release occurring during the first five minutes of chewing.