Articles tagged with Drug Delivery Systems
A UniSA-led study is trialing medication safety rounds in aged care homes to identify and address potential problems with medication use. The project aims to reduce medication-induced harm and improve residents' health and wellbeing through pharmacist-led safety rounds, adapting an existing palliative care need rounds model.
A new long-acting contraceptive implant has been developed that can be delivered through tiny needles, reducing patient discomfort and increasing medication use. The Self-assembling Long-acting Injectable Microcrystals (SLIM) system slowly releases the drug levonorgestrel, providing a potential alternative to surgically implanted devices.
The researchers have created a way to deliver certain drugs in higher doses with less pain by injecting them as a suspension of tiny crystals. This approach can enable long-term delivery of contraceptives or treatments for diseases such as HIV, reducing the need for frequent injections.
Researchers at MIT successfully triggered a key enzyme in starfish egg cells using different patterns of light, prompting predictable movements and contractions. The study provides a new optical tool for controlling cell shape in its earliest developmental stages.
A natural citrus oil, when combined with a lipid formulation, may effectively relieve dry mouth in cancer patients. The new formula has demonstrated improved solubility and bioavailability compared to pure limonene.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
Scientists at the University of South Australia have developed a phospholipid complex to improve cannabidiol's effectiveness in treating epilepsy, multiple sclerosis, and other neurodegenerative diseases. The new formula increases cannabidiol's solubility by up to six times and improves its absorption in the gastrointestinal tract.
Researchers at the University of Birmingham have developed a new method for rapid scalable preparation of uniform nanostructures directly from block polymers, significantly reducing processing time from weeks to just minutes.
Researchers have developed an innovative acoustofluidics-based approach for delivering biomolecular cargos into cells, overcoming limitations of traditional methods. The new method enables controlled contact between cells and nanoparticles, enhancing membrane permeability and improving delivery efficiency.
Core-shell nanoparticles offer effective drug encapsulation, shielding from degradation, and controlled release. This innovation enables targeted drug delivery, improving treatment outcomes and reducing side effects. The versatility of these nanoparticles allows for tailored materials to suit different therapeutic needs.
A new drug screening method developed by Tampere University has found biologically active molecules that target specific tissues, potentially solving delivery issues in cancer and brain diseases. The method uses phage display and microdialysis to identify peptides with tissue-homing and penetration capabilities.
A new medication approved to treat type 2 diabetes and kidney disease also significantly reduces the risk of heart attacks and strokes among these patients. Sotagliflozin, a sodium-glucose cotransporter inhibitor, blocks proteins that help control blood sugar levels and has been shown to reduce cardiovascular events by 23%.
A new method allows for accurate measurement of blood-brain barrier permeability, revealing that many CNS drugs penetrate the barrier rapidly. The study found that plasma proteins play a crucial role in maintaining brain delivery of lipophilic agents.
The Terasaki Institute for Biomedical Innovation has announced the recipients of its inaugural Keith Terasaki Mid-Career Innovation Award. Dr. Liangfang Zhang and Dr. Aydogan Ozcan were recognized for their innovative approaches to translating groundbreaking research into real-world impact.
Researchers have found a way to improve the effectiveness of methotrexate in treating choriocarcinoma, a rare and aggressive form of cancer affecting pregnant women and new mothers. The new drug delivery system, known as polymersomes, targets a specific protein in cancer cells, reducing tumor size by 95%.
Researchers developed a novel AAV-equipped nanomachine that successfully overcame gene therapy challenges in mice, including reduced efficiency due to neutralizing antibodies and hepatotoxicity. The nanomachine demonstrated sufficient gene transfer activity and suppressed liver toxicity markers.
A new biodegradable polymer-based delivery system efficiently transports mRNA, outperforming existing lipid nanoparticles in delivery efficiency and expression duration. The study also shows improved immune response results without liver accumulation or toxicity.
A study by the University of Gothenburg found that Swedish pharmacy personnel report a deteriorating patient safety climate. Pharmacists gave lower ratings for teamwork, job satisfaction, and management, with only 37% having a positive outlook on working conditions. The study suggests that changes in the work environment, including inc...
A new nanotechnology-based drug delivery system has been developed to save patients from repeated surgeries. The approach, called Pericelle, uses a paste of nanoparticles containing hydrogel on transplanted veins to prevent blockages, which can lead to repeated surgeries in heart and dialysis patients.
The team's novel technique enables high-throughput screening of nanoparticle shapes, sizes, and modifications, reducing associated screening costs. The research demonstrates the distinct preferences of tumour cells for certain nanoparticle configurations, enabling personalized cancer treatments that are safer and more effective.
The study developed floating nanoballoons to improve ibuprofen's bioavailability and sustained release its anti-inflammatory effects. The formulation showed superior edema inhibition in acute inflammation studies, reducing TNF-α, hs-CRP, and IL-6 levels, while increasing anti-inflammatory IL-10 levels.
Researchers have developed a method for delivering therapeutics to targeted locations in the human body using universal milk exosomes. This technology could be used to treat common and rare diseases alike, offering a potential boon to rare disease communities.
A novel diagnostic system called TwinDemic Detection offers simultaneous and rapid detection of SARS-CoV-2 and influenza A virus. The system has a detection limit of 0.46 picomolar for CoV and 0.39 pM for IAV, correctly predicting positive and negative samples in high percentages.
The project aims to create novel platforms and formulations capable of delivering large, complex biologics with minimal toxicity and immune system responses. The developed technologies could be applied not only in combat areas but also in the general public to protect against infectious diseases and other health threats.
The ISS National Lab is soliciting flight concepts for technology advancement using the space-based environment of the International Space Station. The lab aims to develop and test products and processes with potential economic impact through this $650,000 funding opportunity.
The NSF is seeking proposals for research on transport phenomena and fluid dynamics in space, leveraging the ISS National Lab's microgravity environment. Selected projects will receive funding to advance fundamental and translational research benefiting humanity.
Scientists at the Institute of Physical Chemistry Polish Academy of Sciences created a method to measure molecular brightness and eliminate background light. This technique allows for counting individual photons emitted by molecules, enabling precise measurement of molecule concentrations. The researchers applied this approach to study...
Lanza joins 170 inventors from around the world who have generated over 20,000 licensed technologies and hold more than 2,000 patents. His nanoparticle-based innovations, including targeted PFC nanoparticles, are being used to detect blood clots and treat breast cancers.
A team of University of Melbourne researchers has developed a novel drug delivery system composed of metal-biomolecule networks (MBNs), which eliminate the need for toxic drug carriers. The MBNs show antiviral, antibacterial, antifungal, anti-inflammatory and anti-cancer properties, potentially increasing success in drug development.
Researchers developed an ultra-compact transparent ultrasonic transducer for simultaneous high-resolution ultrasound and photoacoustic imaging. This technology improves diagnostic sensitivity by providing detailed information about tissue vasculature, thereby enhancing early cancer detection.
Researchers will build a wireless bioelectronic device, named BIOSYNC, to regulate appetite through physiological satiety pathways. The device aims to produce two peptide therapeutics simultaneously with reduced side effects and better adherence to therapy.
Valentin Fuster, MD, PhD, has made significant contributions to the understanding of atherosclerosis through his research on inflammation, thrombosis, and treatment breakthroughs. His work has led to major advances in diagnosis and therapy, including the development of a cardiovascular 'polypill' that reduces cardiovascular mortality.
A large-scale clinical trial involving over 9,000 patients reveals that text message reminders failed to improve medication refill adherence over a year. The study included diverse representation from subgroups, including females, Hispanic ethnicity, and Spanish-speaking patients.
A team led by Associate Professor Giuseppe Barca has developed software capable of accurately predicting molecular behavior and setting a new benchmark in computational chemistry. This breakthrough enables scientists to simulate drug performance with accuracy rivaling physical experiments, accelerating new therapeutics design.
A study found that using an orbital atherectomy device to remove calcium from blocked coronary arteries before stenting procedures did not improve patient outcomes. The device was used on patients with moderately severe calcification, rather than extreme cases, and did not show significant benefits.
A team of researchers developed a wearable camera system that uses artificial intelligence to detect potential medication delivery errors. The AI achieved high sensitivity and specificity in identifying vial-swap errors, making it a critical safeguard in operating rooms, intensive-care units, and emergency-medicine settings.
Concordia researchers develop a novel method of 3D printing using acoustic holograms, capable of creating complex objects quickly and at once. This technique, called holographic direct sound printing (HDSP), stores information of multiple images in a single hologram, allowing for the creation of multiple objects simultaneously.
Scientists at Houston Methodist will focus on developing efficacious vaccines and therapeutic antibodies for viruses in the Nairoviridae, Hantaviridae, and Paramyxoviridae families. The goal is to prepare for potential outbreaks and develop effective medical countermeasures in response to a next pandemic.
Researchers at Houston Methodist are working on a national consortium to develop vaccines against two common and destructive strains of herpesviruses. The project aims to create prophylactic and therapeutic vaccines using a computational toolkit that could transform vaccine development.
A new method to construct protein complex-based therapeutics has been discovered using a polymer cloak, which stabilizes the delivery of protein complexes and enables tumor-targeted immunomodulation. The study presents an IL-15 nanosuperagonist with enhanced efficacy and specificity, promising a safer therapy for cancer treatment.
Scientists at RIKEN CPR created a method to change albumin's molecular ID card, allowing for targeted treatments against diseases like cancer. The new technology can transport proteins out of the body, mimicking drug delivery and removal.
Researchers at Michigan Medicine develop a composite hydrogel capable of steady, sustained drug release using ultrasound as a trigger. The fibrin hydrogel matrix vaporizes an emulsion upon exposure to ultrasound, releasing the encapsulated drug in a zero-order release process, providing consistent levels over time.
Researchers at Tokyo Institute of Technology developed a method to precisely control the timing of DNA droplet division, mimicking biological Liquid-Liquid Phase Separation (LLPS) droplets. This breakthrough enables precise control over synthetic droplet dynamics, key to developing bio-inspired systems.
Researchers have developed a semaglutide hydrogel that could reduce diabetes shots to once a month, improving drug adherence and quality of life. The hydrogel's slow release of semaglutide over one month was found to be well-tolerated in laboratory rats with no inflammatory reactions.
A new framework from a global team of scientists aims to overcome translational hurdles in nanomedicine development. The DELIVER guidelines provide early-stage recommendations for maximizing clinical translation and enabling the successful development of new nanomedicine treatments.
Researchers found that omitting the bolus-specific 5-fluorouracil (5-FU) portion from common chemotherapy regimens improves tolerability without sacrificing treatment effectiveness. The study of 11,765 patients shows no decrease in overall survival but a notable reduction in cytopenias.
Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.
A recent study found that approximately two-thirds of inhalers used by patients hospitalized with COPD were misused, leading to inadequate medication delivery and increased exacerbations. Regular therapeutic education and proper inhaler technique can improve health outcomes.
The baroreceptor-inspired microneedle skin patch delivers precise and controlled drug release in response to finger touching, significantly enhancing the precision and effectiveness of treatment. Experiments using Cy3 dye and insulin as model drugs demonstrated improved delivery efficacy compared to passive methods.
Brigham researchers created an implantable device that continuously monitors vital signs and delivers naloxone when detecting opioid overdose. The 'iSOS' device has shown effectiveness in preclinical models, offering a potential solution to the devastating effects of the opioid epidemic.
Researchers have developed an implantable device that can independently detect opioid overdose and automatically administer naloxone, with promising results in animal trials. The device, called iSOS, uses multiple sensors to continuously monitor vital signs and rapidly release naloxone when needed.
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
This innovative system combines remote health monitoring and drug delivery using 3D-printed hollow microneedles, advancing personalized medicine. The integrated theranostic microneedle array measures key health indicators like pH, glucose, and lactate levels, while enabling rapid, pumpless, and point-of-care drug administration.
Researchers explore inkjet printing's potential for creating advanced biomaterials with controlled particulate distribution. The review highlights the technology's applications in tissue engineering, drug delivery systems, and bioelectronics.
Researchers have created nanoparticles that can release drugs in multiple stages, allowing for more precise targeting of specific sites in the body. This technology has the potential to enhance the effectiveness of therapeutics and reduce side effects, paving the way for new treatments and improved patient care.
A new zwitterionic polymer complex has been developed to deliver plasmid DNA into skeletal muscle, achieving widespread gene expression in mice. This breakthrough could lead to new therapies for serious muscular diseases.
Researchers investigated spray-drying and freeze-drying methods to enhance fenofibrate's solubility and dissolution rate. Freeze-drying emerged as the preferred method due to its superior dissolution enhancement capabilities, while spray-drying offered economic and environmental benefits.
A new study has identified CCL27 and TNFRSF14 as genetic markers in inflammation that may contribute to stroke recurrence. These findings could lead to novel drug targets to mitigate disability and mortality after a first stroke.
A recent study published in Nature Medicine has shown that pulsed field ablation (PFA) is a safe and effective treatment for patients with atrial fibrillation. The study analyzed over 17,600 patients and found no significant risk of esophageal damage or other complications, increasing confidence in the use of PFA technology.