Articles tagged with Drug Delivery Systems
Researchers at MIT have developed a new type of nanoparticle that can both deliver vaccines and act as an adjuvant to generate a strong immune response. The particles, called metal-organic frameworks (MOFs), were shown to be effective in delivering the SARS-CoV-2 spike protein and boosting the immune system's response.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
Researchers at Istituto Italiano di Tecnologia receive 5 million euros in funding to bridge gap between basic research and real-world applications. The projects aim to address key issues such as tumors, neurodevelopmental disabilities, and new quantum technologies.
Researchers at the University of North Carolina Health Care developed a wearable patch that can receive wireless commands to schedule and trigger drug release from individual microneedles. The patch enables precise and customized drug delivery for various conditions, including Alzheimer's disease.
A new exhalation delivery system using fluticasone directly targets the sinuses, reducing symptoms and inflammation in patients with chronic rhinosinusitis. The system showed significant improvements compared to a placebo, providing hope for non-invasive treatment options.
A new poll found that only 7.5% of people between 50-80 have used at least one direct-to-consumer health care service, with most receiving prescriptions for a one-time treatment. Many users didn't inform their regular providers about the prescriptions.
Researchers at Tohoku University developed a novel approach for treating lymph node metastasis by administering anticancer drugs directly into the LNs, improving efficacy and reducing side effects. The Lymphatic Drug Delivery System (LDDS) targets sentinel lymph nodes, generating antitumor effects locally.
A recent study analyzed a prominent dark web fentanyl-selling operation that grew at an alarming rate, offering consumers significant discounts. The organization's sales growth and price markups made it difficult for law enforcement to shut down, allowing other organizations to fill the gap.
Scientists in Germany developed a new analytical method to precisely elucidate the size of particles, structure, and RNA molecules in pharmaceutical products. This information can help evaluate product quality, enabling improved development of new products.
Rice University researchers have developed a new method for making covalent organic frameworks (COFs) that could revolutionize various fields such as energy applications, semiconductor devices, and drug delivery. The fast and low-cost approach uses vapor deposition to produce ordered 2D crystalline COFs.
Researchers developed novel nanoparticles that deliver RNA to microglia immune cells, reducing inflammation linked to Alzheimer's disease. The study showed a 42% reduction of PU-1 expression and multiple inflammatory markers in human cell cultures and mice models.
The ASHP/ASHP Foundation Pharmacy Forecast Report identifies growing societal challenges that will alter healthcare delivery, including the impact of ultra-high-cost drugs on service lines. Pharmacists' engagement is crucial to ensuring safe care for all patients, particularly in addressing mental health and substance use disorders.
Researchers developed an adhesive gel to seal and heal challenging gastrointestinal tract-to-skin connections, showing promising results in studies. The gel's unique composition ensures it can effectively seal fistulas, preventing further complications and aiding in healing.
Researchers at Cornell University have found that silica-based C’Dots can be taken up by the bloodstream after oral administration, making them a potential therapeutic delivery method. The particles' ability to induce ferroptosis, a cell death program, may also provide health benefits due to their natural presence in food.
A novel device, ecO2, produces oxygen at the site to keep cells alive for up to a month in vitro or weeks in vivo. This innovation improves the outcomes of cell-based therapies for diseases and injuries by increasing metabolic demand.
Researchers developed injectable nanoparticles that release naloxone when triggered by blue light, potentially preventing opioid overdose deaths. The system showed effectiveness up to a month after injection and could be incorporated into a wearable device.
A vaginal film designed to dissolve in 30 days is being tested for its feasibility and acceptability as a potential HIV prevention method for women. The study will enroll 100 women and assess the comfort, usability, and safety of two prototype films with different shapes.
Engineers use module assembly to develop vascularized organotypic tissues with high cell density and well-organized vasculature. This approach enables the rapid generation of functional tissue substitutes with improved efficacy in treating diseases.
A team of researchers at ETH Zurich has developed a suction cup capable of delivering large molecule medications like peptides to the bloodstream through the mucosal lining of the cheek. The device uses an endogenous agent to fluidise cell membranes, allowing the drug to penetrate deeper tissue layers and enter the bloodstream directly.
Researchers develop novel measurement technique to analyze desorption of molecules from microbubbles under ultrasound irradiation. The study reveals that significant amounts of adsorbed molecules are released into surrounding media, and the process depends on bubble size.
A new drug delivery platform uses ultrasound to target cancer cells, reducing side effects and increasing precision. The system employs gas vesicles and mechanophores to control the release of drugs in response to ultrasound waves.
Researchers developed a new diffraction-gated real-time ultrahigh-speed mapping (DRUM) camera that captures dynamic events in a single exposure at 4.8 million frames per second. The camera uses off-the-shelf components and is fast enough to capture highly dynamic biomedical processes or enable high-speed lidar systems.
Researchers at UniSA develop nanocarriers to deliver the antibiotic Narasin to acne-prone areas, demonstrating a 100-fold increase in absorption compared to traditional treatments. The findings have significant implications for treating drug-resistant acne and improving treatment outcomes.
A US research team has developed a prophylactic to help protect US troops from acute radiation syndrome (ARS), a condition caused by high levels of radiation exposure. The Defense Health Agency has awarded $24.5 million to advance the drug's development, building on over $35 million in funding since 2017.
Scientists at the University of Groningen created an oscillating system using simple molecules to achieve periodic catalytic activity. The system enables enhanced chemical selectivity, favoring one reaction over others, and has potential applications in polymer synthesis and drug delivery.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers developed a minimally invasive microneedle platform capable of detecting protein biomarkers in response to immunotherapy against melanoma. The approach integrates with ultra-sensitive single-molecule detection and shows promise for effective drug screening and patient stratification.
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
Research reveals e-cigarettes carry potential health risks, including increased blood pressure and heart rate. Long-term studies are needed to fully understand the effects of e-cigarette use on the heart and lungs.
Scientists have teamed up to improve drug delivery by designing more effective lipid nanoparticles. Their latest study documents how high-throughput workflows can produce and characterize LNPs at record speed, with neatly ordered structures leading to better silencing of faulty genes in human neurons.
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
Researchers at CiQUS developed biomimetic nanocarriers that fuse with host cell membranes to release drugs into cytosol. This approach enhances therapeutic efficacy and bioavailability by increasing selectivity and safety.
Researchers developed a new method to deliver drugs into the inner ear, using the cerebrospinal fluid flow. This innovation restored hearing in deaf mice and may pave the way for gene therapy to treat human hearing loss.
Scientists create optically controllable liposomes called LiDLs, which can selectively release contents inside cells upon exposure to acidic pH induced by green light. The researchers demonstrated that LiDLs efficiently deliver substances without causing side effects, showcasing exceptional extracellular stability.
Researchers aim to identify best practices for increasing viral suppression in low-income populations with HIV. They will examine state AIDS Drug Assistance Programs to understand disparities in care and outcomes.
Researchers have developed a microgel delivery system that keeps beneficial bacteria safe while actively clearing out harmful ones in the gut. In mice, this system treated intestinal inflammation without side effects and showed promise as a viable treatment strategy for intestinal diseases.
A novel 'robotic pill' has been found to safely deliver the osteoporosis medication teriparatide orally, with comparable bioavailability to traditional injections. This breakthrough technology could offer a painless and more accessible treatment option for patients suffering from chronic conditions.
A new research centre will focus on developing new types of RNA medicine for treating metabolic diseases. The centre, led by Professor Jørgen Kjems at Aarhus University, aims to create targeted treatments for conditions like diabetes and atherosclerosis.
A study suggests that ketamine nasal spray is a convenient alternative to intravenous infusion for treating refractory chronic migraine. The treatment showed promise in reducing daily headaches and improving quality of life, with most participants reporting 'very effective' results.
A team of researchers at Johannes Gutenberg University Mainz studied the collective behavior of small robots and found that they can solve tasks that a single machine cannot. The study uses statistical physics to analyze how the robots interact and move, revealing potential applications in medical and pharmaceutical applications.
Researchers used AI models to predict effective peptide sequences for safe drug delivery in eye cells, promising new treatments for glaucoma and macular degeneration. The model accurately predicted a peptide sequence that bound to melanin, releasing medications over several weeks.
A research team at Hokkaido University has developed a system to deliver antioxidants to mitochondria in the liver, reducing oxidative stress and damaging caused by ROS. The system, called CoQ10-MITO-Porter, was found to be more effective when downsized particles were used.
Researchers at RMIT University have designed a new oral capsule that can deliver insulin and other protein drugs in a pain-free manner. The technology has shown promising results in pre-clinical studies, with good absorption rates for slow-acting insulin and potential for dosing over specific time periods.
Researchers have developed an implantable nanofluidic device that delivers CD40 monoclonal antibodies to shrink pancreatic tumors, reducing treatment dosage by fourfold. The device's long-term controlled release avoids systemic side effects, offering a promising alternative for cancer patients.
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
Researchers have developed a new type of nanoparticle that can efficiently deliver CRISPR/Cas9 components to the lungs, allowing for targeted gene editing. In mice studies, the particles delivered mRNA to up to 60% of lung epithelial cells, offering a promising approach to treating genetic diseases such as cystic fibrosis.
Scientists have developed a new vaccine delivery method using powdered vaccines and a system driven by compressed gas, called MOF-Jet. The device can deliver therapeutics against cancer and other diseases in a relatively painless way, eliminating the need for needles and potentially reducing pain.
Researchers from Kessler Foundation found that transcutaneous spinal stimulation does not interfere with implanted intrathecal baclofen pump delivery systems. However, communication between the pump and its interrogator may be briefly affected due to electromagnetic interference.
A team of scientists has developed a novel, implantable drug delivery system that can be controlled by external light sources and is absorbable by the body. This technology has promising implications for treating various medical conditions, including pain management and cancer treatment.
Gene therapy using CRISPR-Cas9 lipid nanoparticles has been shown to be highly effective in reducing target protein expression in mice. The new delivery system increases the efficiency of in vivo gene therapy, paving the way for safe and effective treatment.
Scientists at Aarhus University and Berkeley Laboratory developed a method called RNA origami to design artificial RNA nanostructures. The technique allowed for the discovery of rules and mechanisms for RNA folding that will make it possible to build more ideal RNA particles for use in RNA-based medicine.
Researchers from TIBI have developed an advanced electronic skin patch that provides simultaneous, continuous monitoring of multiple bodily parameters. The new E-skin patch offers enhanced flexibility, thermal cooling abilities, and fluid absorption over conventional substrates while demonstrating excellent biocompatibility and biodegr...
Researchers designed a new long-acting injectable drug formulation using machine learning algorithms, achieving a slow-release rate in just one iteration. The study demonstrates the potential for machine learning to accelerate the development of innovative drug delivery technologies.
Researchers have developed an orally administered tablet powered by chemical micromotors that deliver insulin to the colon, reducing blood glucose levels for over five hours. The mini-tablets protected from stomach acid and used hydrogen gas bubbles as micromotors to propel insulin into the bloodstream.
Researchers have developed a novel oral drug delivery platform using probiotic bacteria to treat rheumatoid arthritis, reducing the need for lifelong injections. The bioengineered probiotic, LrS235, secretes peptide ShK-235, which dramatically reduces clinical signs of disease in animal models.
A wafer-thin device called NICHE has been developed to treat Type 1 diabetes by delivering islet cells and immunotherapy directly into the body. The device restored healthy glucose levels and eliminated symptoms for over 150 days, avoiding severe adverse effects of anti-rejection therapy.
The SpaceX Dragon spacecraft will launch onboard a Falcon 9 rocket with critical research and supplies for the International Space Station. ISS National Laboratory-sponsored projects aim to bring value through space-based research and technology development.
Researchers demonstrate a new way to deliver medication to malignant brain tumors in mice, using a modified peptide that can penetrate the blood-brain barrier. The study shows promising results, with a 50% increase in survival rate for treated mice, and offers hope for future treatment breakthroughs.