Articles tagged with Drug Delivery Systems
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
Researchers explore inkjet printing's potential for creating advanced biomaterials with controlled particulate distribution. The review highlights the technology's applications in tissue engineering, drug delivery systems, and bioelectronics.
Researchers have created nanoparticles that can release drugs in multiple stages, allowing for more precise targeting of specific sites in the body. This technology has the potential to enhance the effectiveness of therapeutics and reduce side effects, paving the way for new treatments and improved patient care.
A new zwitterionic polymer complex has been developed to deliver plasmid DNA into skeletal muscle, achieving widespread gene expression in mice. This breakthrough could lead to new therapies for serious muscular diseases.
Researchers investigated spray-drying and freeze-drying methods to enhance fenofibrate's solubility and dissolution rate. Freeze-drying emerged as the preferred method due to its superior dissolution enhancement capabilities, while spray-drying offered economic and environmental benefits.
A new study has identified CCL27 and TNFRSF14 as genetic markers in inflammation that may contribute to stroke recurrence. These findings could lead to novel drug targets to mitigate disability and mortality after a first stroke.
A recent study published in Nature Medicine has shown that pulsed field ablation (PFA) is a safe and effective treatment for patients with atrial fibrillation. The study analyzed over 17,600 patients and found no significant risk of esophageal damage or other complications, increasing confidence in the use of PFA technology.
A novel peptide, KS-133, has been developed to target genetic mechanisms associated with schizophrenia. The nanoparticle-based drug delivery system, where KS-133 is encapsulated with a brain-targeting peptide, shows effective distribution in the brains of mice and improves cognitive functions in mice with induced schizophrenia.
Pharmaceutical companies exploited a loophole in the DEA's monitoring system, leading to an oversupply of opioids in communities. The study highlights the impact on Black communities, where overdose deaths tripled from 2014 to 2020. High supply chain complexity played a key role in evading regulations.
A new study by UC San Francisco's ANSIRH program found that patients who received care remotely for medication abortion had similar outcomes to those who got ultrasounds and in-person care. The researchers analyzed the experiences of over 500 patients and found a high success rate for the
Researchers have devised an algorithm to rationally engineer enzymes for improved performance, taking into account evolutionary history. The new method successfully introduced up to 84 mutations over a sequence of 280, resulting in improved activity and stability at higher temperatures.
Researchers at Linköping University and the Medical University of Graz have developed a new cancer treatment using an iontronic pump to deliver continuous, low-dose chemotherapy directly to brain tumors. This approach significantly reduces tumor growth by bypassing the blood-brain barrier, a common obstacle to effective treatment.
Researchers are developing advanced electronic bandages to improve chronic wound monitoring and healing. These 'smart' dressings can sense and respond to changing conditions, providing continuous data on healing and potential complications.
A team of scientists from Tohoku University and Kyoto University created a DNA-based molecular controller that enables swarm molecular robots to assemble and disassemble autonomously without external manipulation. This technology marks a significant step towards advanced autonomous molecular systems.
A new alpha-ray therapeutic agent ([At-211] PSMA-5) has been developed to target prostate-specific membrane antigen (PSMA) in refractory prostate cancer patients. The therapy has shown efficacy in animal models and is now being tested in a first-in-human clinical trial.
Researchers discover a microscopic phenomenon that enables hydrogels to swell and contract quickly, improving the flexibility of soft robots. This breakthrough could lead to faster and more agile robots with applications in healthcare, manufacturing, and search and rescue operations.
Researchers have developed a method to fabricate customized pharmaceutical tablets with tailored drug release profiles using Multi-Material InkJet 3D Printing. This technology can print multiple drugs in a single tablet, simplifying complex medication regimens and providing precise treatment options for patients.
LyoWave is commercializing microwave heating technologies developed at Purdue University, improving speed, cost-effectiveness, and product throughput. The company has entered a collaboration with Millrock Technology, applying its technology to boost freeze-drying systems' capacity for pharmaceuticals and diagnostic reagents.
Researchers developed a simple and efficient method for diversifying reactive end-groups on poly(2-oxazoline)s, enabling rapid exploration of poly(2-oxazoline)-based nanomedicine platforms. The approach was shown to produce POx-based lipid nanoparticles comparable in transfection capability to their PEGylated counterparts.
Researchers from Osaka University have discovered a way to deliver antisense oligonucleotides to their targets inside cancer cells by opening specific calcium permeable channels. The new compound, L687, promotes efficient uptake of ASO into cancer cells, suppressing target gene activity and enhancing ASO efficacy.
A new American Heart Association Scientific Statement highlights the importance of patient-centered care in cardiovascular health, combining expert knowledge with consideration of patients' beliefs, preferences, and values. The statement provides practical guidance on incorporating person-centered care into routine clinical practice.
Researchers developed a multifunctional drug delivery system that can carry both hydrophilic and hydrophobic compounds, overcoming previous limitations in conventional methods. The system utilizes switchable peptide-stabilized emulsions, allowing for precise release of drugs in tumor cells.
Researchers found that withdrawing aspirin one month after PCI significantly reduced major and minor bleeding incidents by 55% compared to dual antiplatelet therapy. The study, ULTIMATE-DAPT, showed no increase in adverse ischemic events, suggesting continuing aspirin may cause harm without benefit.
A novel acoustofluidic micropump has been developed to efficiently drive liquid in energy and space, providing robust technical support for portable systems. The micropump exhibits high volume efficiencies and superior energy efficiency, exceeding reported values.
Researchers have identified a combination of medications that may improve blood flow within granulomas, benefiting drug delivery and reducing bacterial burden in tuberculosis-infected rabbits. The study leverages decades of cancer research to study tuberculosis-affected lung tissue and improves treatment.
A phase 3 trial co-led by a University of Cincinnati researcher found that subcutaneous levodopa delivery through an infusion pump is safe and effective in reducing symptoms for longer periods. The study resulted in almost two hours of additional 'on time' compared to traditional oral medication, paving the way for potential FDA approval.
Researchers at MIT have developed a new type of nanoparticle that can both deliver vaccines and act as an adjuvant to generate a strong immune response. The particles, called metal-organic frameworks (MOFs), were shown to be effective in delivering the SARS-CoV-2 spike protein and boosting the immune system's response.
Researchers are developing minimally invasive techniques to repair and regenerate tissue in aortic aneurysms using actively targeted, drug-releasing nanoparticles. The team found that rod-shaped particles with high aspect ratios were selectively taken up by diseased endothelial cells, leading to improved therapy outcomes.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
Researchers at the University of North Carolina Health Care developed a wearable patch that can receive wireless commands to schedule and trigger drug release from individual microneedles. The patch enables precise and customized drug delivery for various conditions, including Alzheimer's disease.
A new exhalation delivery system using fluticasone directly targets the sinuses, reducing symptoms and inflammation in patients with chronic rhinosinusitis. The system showed significant improvements compared to a placebo, providing hope for non-invasive treatment options.
Researchers at Istituto Italiano di Tecnologia receive 5 million euros in funding to bridge gap between basic research and real-world applications. The projects aim to address key issues such as tumors, neurodevelopmental disabilities, and new quantum technologies.
A new poll found that only 7.5% of people between 50-80 have used at least one direct-to-consumer health care service, with most receiving prescriptions for a one-time treatment. Many users didn't inform their regular providers about the prescriptions.
Researchers at Tohoku University developed a novel approach for treating lymph node metastasis by administering anticancer drugs directly into the LNs, improving efficacy and reducing side effects. The Lymphatic Drug Delivery System (LDDS) targets sentinel lymph nodes, generating antitumor effects locally.
A recent study analyzed a prominent dark web fentanyl-selling operation that grew at an alarming rate, offering consumers significant discounts. The organization's sales growth and price markups made it difficult for law enforcement to shut down, allowing other organizations to fill the gap.
Scientists in Germany developed a new analytical method to precisely elucidate the size of particles, structure, and RNA molecules in pharmaceutical products. This information can help evaluate product quality, enabling improved development of new products.
Rice University researchers have developed a new method for making covalent organic frameworks (COFs) that could revolutionize various fields such as energy applications, semiconductor devices, and drug delivery. The fast and low-cost approach uses vapor deposition to produce ordered 2D crystalline COFs.
Researchers developed novel nanoparticles that deliver RNA to microglia immune cells, reducing inflammation linked to Alzheimer's disease. The study showed a 42% reduction of PU-1 expression and multiple inflammatory markers in human cell cultures and mice models.
The ASHP/ASHP Foundation Pharmacy Forecast Report identifies growing societal challenges that will alter healthcare delivery, including the impact of ultra-high-cost drugs on service lines. Pharmacists' engagement is crucial to ensuring safe care for all patients, particularly in addressing mental health and substance use disorders.
Researchers developed an adhesive gel to seal and heal challenging gastrointestinal tract-to-skin connections, showing promising results in studies. The gel's unique composition ensures it can effectively seal fistulas, preventing further complications and aiding in healing.
Researchers at Cornell University have found that silica-based C’Dots can be taken up by the bloodstream after oral administration, making them a potential therapeutic delivery method. The particles' ability to induce ferroptosis, a cell death program, may also provide health benefits due to their natural presence in food.
A novel device, ecO2, produces oxygen at the site to keep cells alive for up to a month in vitro or weeks in vivo. This innovation improves the outcomes of cell-based therapies for diseases and injuries by increasing metabolic demand.
Researchers developed injectable nanoparticles that release naloxone when triggered by blue light, potentially preventing opioid overdose deaths. The system showed effectiveness up to a month after injection and could be incorporated into a wearable device.
A vaginal film designed to dissolve in 30 days is being tested for its feasibility and acceptability as a potential HIV prevention method for women. The study will enroll 100 women and assess the comfort, usability, and safety of two prototype films with different shapes.
Engineers use module assembly to develop vascularized organotypic tissues with high cell density and well-organized vasculature. This approach enables the rapid generation of functional tissue substitutes with improved efficacy in treating diseases.
A team of researchers at ETH Zurich has developed a suction cup capable of delivering large molecule medications like peptides to the bloodstream through the mucosal lining of the cheek. The device uses an endogenous agent to fluidise cell membranes, allowing the drug to penetrate deeper tissue layers and enter the bloodstream directly.
Researchers develop novel measurement technique to analyze desorption of molecules from microbubbles under ultrasound irradiation. The study reveals that significant amounts of adsorbed molecules are released into surrounding media, and the process depends on bubble size.
A new drug delivery platform uses ultrasound to target cancer cells, reducing side effects and increasing precision. The system employs gas vesicles and mechanophores to control the release of drugs in response to ultrasound waves.
Researchers developed a new diffraction-gated real-time ultrahigh-speed mapping (DRUM) camera that captures dynamic events in a single exposure at 4.8 million frames per second. The camera uses off-the-shelf components and is fast enough to capture highly dynamic biomedical processes or enable high-speed lidar systems.
Researchers at UniSA develop nanocarriers to deliver the antibiotic Narasin to acne-prone areas, demonstrating a 100-fold increase in absorption compared to traditional treatments. The findings have significant implications for treating drug-resistant acne and improving treatment outcomes.
A US research team has developed a prophylactic to help protect US troops from acute radiation syndrome (ARS), a condition caused by high levels of radiation exposure. The Defense Health Agency has awarded $24.5 million to advance the drug's development, building on over $35 million in funding since 2017.
Scientists at the University of Groningen created an oscillating system using simple molecules to achieve periodic catalytic activity. The system enables enhanced chemical selectivity, favoring one reaction over others, and has potential applications in polymer synthesis and drug delivery.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers developed a minimally invasive microneedle platform capable of detecting protein biomarkers in response to immunotherapy against melanoma. The approach integrates with ultra-sensitive single-molecule detection and shows promise for effective drug screening and patient stratification.
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
Scientists have teamed up to improve drug delivery by designing more effective lipid nanoparticles. Their latest study documents how high-throughput workflows can produce and characterize LNPs at record speed, with neatly ordered structures leading to better silencing of faulty genes in human neurons.
Research reveals e-cigarettes carry potential health risks, including increased blood pressure and heart rate. Long-term studies are needed to fully understand the effects of e-cigarette use on the heart and lungs.
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
Researchers at CiQUS developed biomimetic nanocarriers that fuse with host cell membranes to release drugs into cytosol. This approach enhances therapeutic efficacy and bioavailability by increasing selectivity and safety.