Articles tagged with Drug Delivery Systems
Scientists at UC San Diego create nanoparticles that mimic the flu virus's ability to escape endosomes, enabling efficient delivery of mRNA into cells. This breakthrough could lead to improved delivery of mRNA vaccines and therapies.
A wearable device has been developed to detect and reverse opioid overdoses by injecting naloxone, a lifesaving antidote. The device, which senses when a person stops breathing and moving, has shown promising results in clinical trials.
Researchers have developed fish-shaped microrobots that can guide themselves to cancer cells using magnets, where a pH change opens their mouths to release chemotherapy. The microrobots demonstrate promising capabilities for targeted cancer treatment, but need further improvements in size and tracking methods.
Researchers have demonstrated the effectiveness of polymer-coated nanoparticles in delivering drugs to the brain, overcoming the blood-brain barrier challenge. The study showed that zwitterionic polymers improve accessibility but are rapidly absorbed by blood vessel walls.
Researchers published safety and efficacy data for a novel nusinersen drug delivery method via subcutaneous intrathecal catheter system (SIC) for spinal muscular atrophy (SMA) patients. The study found improvements in arm and hand function, but no significant changes in motor scales or muscle force.
Patients with certain gene mutations are at high risk of fatal chemotherapy toxicity, with a 25-times increased risk detected in those with uncommon DPYD variants. The study suggests that adding pre-treatment screening may help prevent avoidable deaths without interrupting standard care.
Bioengineer Kevin McHugh is developing a platform to improve the performance of injectable drugs, which often release diminishing amounts of medication over time. The goal is to create predictable, long-lasting delivery systems for better patient outcomes and reduced dosing frequency.
A new gene delivery system promotes healing in rat models by preventing inflammation and bone degradation after tooth replantation. The study found that teeth treated with the system showed significantly greater dental root thickness and fewer osteoclasts, leading to improved success rates.
Researchers developed a pollen-based hybrid ink that can be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery. The ink is biocompatible, flexible and low in cost, allowing for the creation of customized flexible membranes tailored to human skin contours.
Researchers have developed a new way to deliver molecular therapies to cells using a programmable system called SEND, which harnesses natural proteins in the body to encapsulate and deliver different RNA cargoes. This could lead to safer and more targeted delivery of gene editing and other molecular therapeutics.
Researchers have discovered that dendrimer tentacles can avoid detection by the complement system, part of our immune system. This could lead to developing a new system for delivering drugs into the body without triggering an immune response.
Researchers have developed a way to precisely control defects within active liquid crystals by changing the gradient of activity around them. This can be achieved through pulses of light or chemical composition changes, enabling controlled movement and behavior of these materials.
Researchers at Children's Hospital of Philadelphia have developed a system that can fine-tune protein expression from gene therapy vectors, addressing the need for controlled dosing. The 'dimmer switch' uses alternative RNA splicing and an orally available small molecule to adjust levels of expression up or down as needed.
Researchers at the University of York developed a gel that adheres to nasal tissue, delivering levodopa directly to the brain. This innovation improves drug effectiveness and reduces dosage needs, potentially benefiting patients with Parkinson's disease.
Researchers at UC Riverside developed an implantable drug delivery system using piezoelectric nanofibers that can release therapeutic molecules on demand. The system offers robust control over release rate and precision in administering drug molecules, making it suitable for treating chronic diseases.
Researchers are developing an ocular drug delivery system based on RNA nanotechnology to deliver therapeutics into the eye without requiring eye injections. This method aims to create a reservoir for medications to treat diseases over time, reducing adverse effects and increasing treatment efficiency.
Researchers at POSTECH have developed an on-demand drug delivery system that utilizes organic photovoltaic cells and upconversion nanoparticles to convert near-infrared light into visible light, allowing for controlled drug release in medical devices.
The use of nanocarrier drug delivery systems can improve the bioavailability, stability and aqueous solubility of natural drugs. Four plant materials from China, including Epimedium, Rehmannia glutinosa, Panax ginseng and Angelica sinensis, are discussed in this review article.
Scientists at the University of Nottingham have developed a new protein imaging method that allows for the accurate analysis of biomaterials and tissue. This breakthrough technology has the potential to lead to the development of more effective drug delivery systems and medical devices.
Researchers discover a new method for making nanoparticles that can efficiently capture over 95% of proteins, DNA, or small molecule drugs. The process uses a self-assembling polymer to create a nanonet that collapses into nanogels, trapping therapeutics with high efficiency.
Researchers at ETH Zurich have developed a non-invasive method for concentrating and releasing drugs in the brain with pinpoint accuracy using focused ultrasound. The new technique aggregates drugs at specific sites, reducing dosage requirements by 1,300 times, and preserves physiological barriers between blood and nervous tissue.
A Rutgers-led team has created a smart drug delivery system to reduce inflammation and promote tissue repair in damaged nervous tissues. The system, which uses ultrathin biomaterials, aims to improve the treatment of spinal cord injuries and other neurological disorders.
Researchers developed a combination treatment using gas embolization and chemotherapy, achieving tumor regression and reducing regrowth in hepatocellular carcinoma models. The method is less invasive and more precise than traditional treatments.
A researcher has received a five-year, $1.8 million grant to develop and improve oral drug delivery systems for poorly water-soluble molecules. The goal is to increase the effectiveness of these drugs, which currently have limited technology options.
Researchers developed a comprehensive study on nanoprodrugs (NPDs) inside cancer cells, revealing their internalization rate, intracellular localization, and degradation. The study shows that NPDs consistently absorbed by cells as intact particles before being transported into lysosomes.
A new study uses a humanoid chewing robot to assess medicated chewing gum, replicating human chewing motion in a closed environment. The researchers found that the robot demonstrates a similar release rate of xylitol as human participants, with the greatest release occurring during the first five minutes of chewing.
Researchers at Houston Methodist have developed a fatty acid-based platform for biological drug delivery, demonstrating high absorption rates in mice models. The study published in Science Advances may pave the way for oral delivery of more biological drugs, including those used to treat rheumatoid arthritis and autoimmune diseases.
A team of international medical experts successfully delivered insulin via a drone to a patient living in a remote community in Ireland, addressing healthcare access issues. The project demonstrated the potential for autonomous drones to deliver life-saving medications and supplies in disaster scenarios.
Researchers have developed 'combo' nanoplatforms using graphene oxide and reduced graphene oxide to enhance chemotherapy therapy. These nanocarriers can target tumors and improve drug delivery, reducing side effects on normal cells/tissues.
Researchers at the University of Würzburg have discovered how increasing amounts of active ingredients in polymeric micelles reduce their dissolution and solubility. The study aims to improve drug delivery systems by understanding molecular interactions and potential structural changes to enhance absorption and dissolving capabilities.
Researchers at the University of Michigan have discovered that unstable metal organic frameworks can be used to deliver insoluble drugs in an amorphous state, increasing bioavailability. The MOF delivery system allows for rapid release of drugs, with controlled dosage and minimal toxicity.
Researchers Keefe Manning and Yong Wang propose a new method of surface modification of nanoparticles for local drug delivery to prevent thrombosis in medical devices. The goal is to develop a solution that would reduce side effects and increase drug concentration without frequent administration of antithrombotic drugs.
A NYU Tandon-led team created a biocompatible protein-based drug delivery system that can survive in the body for over two weeks and provide sustained medication release. The thermo-responsive protein hydrogel exhibits properties similar to synthetic hydrogels but is more desirable for use in biomedicine.
The study introduces a reverse method to grafted organic groups onto mesoporous silica, improving drug loading capacity and achieving controlled release. This enhances cancer therapy strategies by allowing targeted and sustained drug delivery.
Severe malaria cases in the US are increasing, with limited access to IV treatment. Malaria expert Mark Travassos calls for improved access to intravenous quinidine gluconate, a critical medication for serious cases.
A new approach combines acyclovir with activated carbon particles to improve the effectiveness of a common herpes medication. The combination reduces viral load and inflammation while minimizing side effects like kidney damage.
Scientists have created a microneedle patch based on snake fangs that can deliver therapeutic liquids and vaccines through the skin of rodents in under 15 seconds. The device uses capillary action to bypass pumping systems, making it an attractive alternative for simple and pain-free drug delivery.
The Russian Science Foundation has granted funding to 14 young scientists and six scientific groups at Ural Federal University, focusing on migration, demographic modeling, and nanomaterials. Researchers aim to develop a super-prolonged medication delivery system using hybrid organic-inorganic materials.
Researchers at Houston Methodist developed a remote-controlled nanofluidic device that delivers continuous, predetermined dosages of medications for chronic diseases like arthritis and high blood pressure. The device uses a grape-sized implant with controlled release of drugs without pumps or valves.
The team tested two devices, one that can change conformation in the esophagus to exit after drug delivery and another that can reside in the stomach until intentionally triggered. The devices were inspired by design principles of transformable materials and showed promise for fast and robust response.
Scientists have developed a retrievable wire-like device that safely delivers large dosages of drugs over several weeks to treat tuberculosis (TB) in pigs. The device, tested successfully, could help patients adhere to treatment regimens more easily, particularly in remote areas where healthcare resources are limited.
A new ingestible device, inspired by a tortoise's shell, can inject drugs through the stomach wall, overcoming challenges of oral delivery. The device has been shown to achieve similar insulin plasma levels as traditional subcutaneous injections in animal studies.
This article describes the preparation, characterization, and in vitro biological activity of Soyasapogenol B, a triterpene derived from soya beans. The compound demonstrates hypo-cholesterolemic effects and is loaded onto MWCNTs using miniemulsion technique with niosomes for drug delivery systems.
Soyasapogenol B (SSB) is a bioactive agent that can be loaded into Multi-Walled Carbon Nanotubes (MWCNTs) for targeted delivery. The SSB-loaded MWCNT systems exhibited controlled and sustained drug release profiles, with minimal cytotoxicity to normal melanocytes, liver cells, and breast carcinoma cells.
Researchers used electrospun polymeric nanofibers to create drug delivery systems for various biological functions, including anti-inflammatory, anticancer, and cardiovascular applications. The method improves treatment processes by loading low-solubility drugs into fibers for controlled release.
Researchers at MIT have developed a wireless ingestible capsule that can be controlled using Bluetooth technology. The capsule, which can deliver drugs or sense environmental conditions, can reside in the stomach for up to a month and transmit information to a user's smartphone.
Researchers have developed an implantable delivery system that enables patients to go 15 months in between treatments, significantly improving the conventional regimen of nearly monthly eye injections. The study found that patients treated with the highest drug concentration were able to maintain their vision for a longer period.
Researchers at Mount Sinai discover that an antimicrobial protein in the gut can prevent graft-versus-host-disease, a common and lethal side effect of bone marrow transplants. The protein, REG3α, may lead to new treatments for inflammatory bowel disease and other GI illnesses.
Researchers at Tohoku University have discovered that terahertz wave irradiation activates the filamentation of actin protein. This non-invasive method could overcome problems with current drugs used to control actin filamentation and expand its applications in biological technologies.
Scientists at Tohoku University successfully developed a method to create virus-like polymer particles with various nanostructures, which can be selectively functionalized. This technology has potential applications in immunoassay systems, drug delivery, and enzymatic reactions.
The study reveals unexpected molecular behavior in ultra-nanoscale channels, where neutral molecules behave as though carrying a charge. The team developed an algorithm for selecting optimal nanochannel size for each drug, but found that current theories were unable to explain the observed effects.
The University of Liverpool has been awarded £3m in funding to support two innovative projects focused on improving drug delivery and ophthalmic innovations. The projects aim to develop novel materials and technologies that can benefit patients with various healthcare needs.
A new antimalarial drug delivery system using MCM-41 has been developed, demonstrating a long release time of one week or longer and increasing treatment efficiency by 20 and 240 times compared to traditional medications.
Researchers aim to prevent, slow or reverse muscle breakdown with a new drug compound and nano-channel delivery system. The implantable device will provide constant, steady drug delivery without injections or pills.
A new 'long acting' medicine has been developed to prevent malaria using nanotechnology, providing therapeutic drug concentrations for months after a single dose. This innovation aims to remove the need for daily tablets and could provide an additional tool in combating malaria globally.
A recent study published in Nature Communications presents a proof-of-concept for an oral, once-weekly drug delivery platform for HIV antiretroviral therapy. The platform demonstrates sustained oral delivery of potent anti-HIV therapies, offering a potential solution to non-adherence issues.
A new micro-needle patch has shown promise in laboratory trials for reducing bulging tummy fats by turning energy-storing white fat into energy-burning brown fat. The patch reduces weight gain and fat mass in mice on a high-fat diet over four weeks.
Researchers at Kumamoto University developed a photothermal ablation system to enhance transdermal delivery of protein-based drugs. The system, using gold nanorods and near-infrared light, increased skin permeability and successfully delivered proteins in both in vitro and in vivo experiments.
Researchers at Uppsala University develop a small-scale method to determine bioavailability of drugs within cells, facilitating early-stage drug development. The method takes into account how drugs 'disappear' when binding to cell components, offering a promising tool for pharmaceutical companies.
A research group has developed a sweat-based glucose monitoring and maintenance device that allows rapid glucose measurement and precise multistep drug delivery. The system features a disposable strip sensor, enables precise and timely drug delivery, and offers a painless blood glucose monitoring method to control blood glucose levels.