Articles tagged with Drug Delivery Systems
Researchers discover a new method for making nanoparticles that can efficiently capture over 95% of proteins, DNA, or small molecule drugs. The process uses a self-assembling polymer to create a nanonet that collapses into nanogels, trapping therapeutics with high efficiency.
Researchers at ETH Zurich have developed a non-invasive method for concentrating and releasing drugs in the brain with pinpoint accuracy using focused ultrasound. The new technique aggregates drugs at specific sites, reducing dosage requirements by 1,300 times, and preserves physiological barriers between blood and nervous tissue.
A Rutgers-led team has created a smart drug delivery system to reduce inflammation and promote tissue repair in damaged nervous tissues. The system, which uses ultrathin biomaterials, aims to improve the treatment of spinal cord injuries and other neurological disorders.
Researchers developed a combination treatment using gas embolization and chemotherapy, achieving tumor regression and reducing regrowth in hepatocellular carcinoma models. The method is less invasive and more precise than traditional treatments.
A researcher has received a five-year, $1.8 million grant to develop and improve oral drug delivery systems for poorly water-soluble molecules. The goal is to increase the effectiveness of these drugs, which currently have limited technology options.
Researchers developed a comprehensive study on nanoprodrugs (NPDs) inside cancer cells, revealing their internalization rate, intracellular localization, and degradation. The study shows that NPDs consistently absorbed by cells as intact particles before being transported into lysosomes.
A new study uses a humanoid chewing robot to assess medicated chewing gum, replicating human chewing motion in a closed environment. The researchers found that the robot demonstrates a similar release rate of xylitol as human participants, with the greatest release occurring during the first five minutes of chewing.
Researchers at Houston Methodist have developed a fatty acid-based platform for biological drug delivery, demonstrating high absorption rates in mice models. The study published in Science Advances may pave the way for oral delivery of more biological drugs, including those used to treat rheumatoid arthritis and autoimmune diseases.
A team of international medical experts successfully delivered insulin via a drone to a patient living in a remote community in Ireland, addressing healthcare access issues. The project demonstrated the potential for autonomous drones to deliver life-saving medications and supplies in disaster scenarios.
Researchers have developed 'combo' nanoplatforms using graphene oxide and reduced graphene oxide to enhance chemotherapy therapy. These nanocarriers can target tumors and improve drug delivery, reducing side effects on normal cells/tissues.
Researchers at the University of Würzburg have discovered how increasing amounts of active ingredients in polymeric micelles reduce their dissolution and solubility. The study aims to improve drug delivery systems by understanding molecular interactions and potential structural changes to enhance absorption and dissolving capabilities.
Researchers at the University of Michigan have discovered that unstable metal organic frameworks can be used to deliver insoluble drugs in an amorphous state, increasing bioavailability. The MOF delivery system allows for rapid release of drugs, with controlled dosage and minimal toxicity.
Researchers Keefe Manning and Yong Wang propose a new method of surface modification of nanoparticles for local drug delivery to prevent thrombosis in medical devices. The goal is to develop a solution that would reduce side effects and increase drug concentration without frequent administration of antithrombotic drugs.
A NYU Tandon-led team created a biocompatible protein-based drug delivery system that can survive in the body for over two weeks and provide sustained medication release. The thermo-responsive protein hydrogel exhibits properties similar to synthetic hydrogels but is more desirable for use in biomedicine.
The study introduces a reverse method to grafted organic groups onto mesoporous silica, improving drug loading capacity and achieving controlled release. This enhances cancer therapy strategies by allowing targeted and sustained drug delivery.
Severe malaria cases in the US are increasing, with limited access to IV treatment. Malaria expert Mark Travassos calls for improved access to intravenous quinidine gluconate, a critical medication for serious cases.
A new approach combines acyclovir with activated carbon particles to improve the effectiveness of a common herpes medication. The combination reduces viral load and inflammation while minimizing side effects like kidney damage.
Scientists have created a microneedle patch based on snake fangs that can deliver therapeutic liquids and vaccines through the skin of rodents in under 15 seconds. The device uses capillary action to bypass pumping systems, making it an attractive alternative for simple and pain-free drug delivery.
The Russian Science Foundation has granted funding to 14 young scientists and six scientific groups at Ural Federal University, focusing on migration, demographic modeling, and nanomaterials. Researchers aim to develop a super-prolonged medication delivery system using hybrid organic-inorganic materials.
Researchers at Houston Methodist developed a remote-controlled nanofluidic device that delivers continuous, predetermined dosages of medications for chronic diseases like arthritis and high blood pressure. The device uses a grape-sized implant with controlled release of drugs without pumps or valves.
The team tested two devices, one that can change conformation in the esophagus to exit after drug delivery and another that can reside in the stomach until intentionally triggered. The devices were inspired by design principles of transformable materials and showed promise for fast and robust response.
Scientists have developed a retrievable wire-like device that safely delivers large dosages of drugs over several weeks to treat tuberculosis (TB) in pigs. The device, tested successfully, could help patients adhere to treatment regimens more easily, particularly in remote areas where healthcare resources are limited.
A new ingestible device, inspired by a tortoise's shell, can inject drugs through the stomach wall, overcoming challenges of oral delivery. The device has been shown to achieve similar insulin plasma levels as traditional subcutaneous injections in animal studies.
This article describes the preparation, characterization, and in vitro biological activity of Soyasapogenol B, a triterpene derived from soya beans. The compound demonstrates hypo-cholesterolemic effects and is loaded onto MWCNTs using miniemulsion technique with niosomes for drug delivery systems.
Soyasapogenol B (SSB) is a bioactive agent that can be loaded into Multi-Walled Carbon Nanotubes (MWCNTs) for targeted delivery. The SSB-loaded MWCNT systems exhibited controlled and sustained drug release profiles, with minimal cytotoxicity to normal melanocytes, liver cells, and breast carcinoma cells.
Researchers used electrospun polymeric nanofibers to create drug delivery systems for various biological functions, including anti-inflammatory, anticancer, and cardiovascular applications. The method improves treatment processes by loading low-solubility drugs into fibers for controlled release.
Researchers at MIT have developed a wireless ingestible capsule that can be controlled using Bluetooth technology. The capsule, which can deliver drugs or sense environmental conditions, can reside in the stomach for up to a month and transmit information to a user's smartphone.
Researchers have developed an implantable delivery system that enables patients to go 15 months in between treatments, significantly improving the conventional regimen of nearly monthly eye injections. The study found that patients treated with the highest drug concentration were able to maintain their vision for a longer period.
Researchers at Mount Sinai discover that an antimicrobial protein in the gut can prevent graft-versus-host-disease, a common and lethal side effect of bone marrow transplants. The protein, REG3α, may lead to new treatments for inflammatory bowel disease and other GI illnesses.
Researchers at Tohoku University have discovered that terahertz wave irradiation activates the filamentation of actin protein. This non-invasive method could overcome problems with current drugs used to control actin filamentation and expand its applications in biological technologies.
Scientists at Tohoku University successfully developed a method to create virus-like polymer particles with various nanostructures, which can be selectively functionalized. This technology has potential applications in immunoassay systems, drug delivery, and enzymatic reactions.
The study reveals unexpected molecular behavior in ultra-nanoscale channels, where neutral molecules behave as though carrying a charge. The team developed an algorithm for selecting optimal nanochannel size for each drug, but found that current theories were unable to explain the observed effects.
The University of Liverpool has been awarded £3m in funding to support two innovative projects focused on improving drug delivery and ophthalmic innovations. The projects aim to develop novel materials and technologies that can benefit patients with various healthcare needs.
A new antimalarial drug delivery system using MCM-41 has been developed, demonstrating a long release time of one week or longer and increasing treatment efficiency by 20 and 240 times compared to traditional medications.
Researchers aim to prevent, slow or reverse muscle breakdown with a new drug compound and nano-channel delivery system. The implantable device will provide constant, steady drug delivery without injections or pills.
A new 'long acting' medicine has been developed to prevent malaria using nanotechnology, providing therapeutic drug concentrations for months after a single dose. This innovation aims to remove the need for daily tablets and could provide an additional tool in combating malaria globally.
A recent study published in Nature Communications presents a proof-of-concept for an oral, once-weekly drug delivery platform for HIV antiretroviral therapy. The platform demonstrates sustained oral delivery of potent anti-HIV therapies, offering a potential solution to non-adherence issues.
A new micro-needle patch has shown promise in laboratory trials for reducing bulging tummy fats by turning energy-storing white fat into energy-burning brown fat. The patch reduces weight gain and fat mass in mice on a high-fat diet over four weeks.
Researchers at Kumamoto University developed a photothermal ablation system to enhance transdermal delivery of protein-based drugs. The system, using gold nanorods and near-infrared light, increased skin permeability and successfully delivered proteins in both in vitro and in vivo experiments.
Researchers at Uppsala University develop a small-scale method to determine bioavailability of drugs within cells, facilitating early-stage drug development. The method takes into account how drugs 'disappear' when binding to cell components, offering a promising tool for pharmaceutical companies.
A research group has developed a sweat-based glucose monitoring and maintenance device that allows rapid glucose measurement and precise multistep drug delivery. The system features a disposable strip sensor, enables precise and timely drug delivery, and offers a painless blood glucose monitoring method to control blood glucose levels.
A new study combines nanotechnology with gene editing to target HIV brain reservoirs and deliver morphine antagonists to protect neurons from opiate addiction damage. The approach uses Cas9/gRNA system and MENP drug-based delivery system to eliminate latent HIV copies and deliver medications non-invasively.
Researchers at Columbia University have developed a method to manufacture microscale-sized machines from biomaterials that can safely be implanted in the body. The technique uses hydrogels and stacks them in layers to create devices with three-dimensional, freely moving parts.
Researchers at UTSA developed a tiny implantable drug delivery system to treat various ailments over several weeks. The medicine diffusion capsule can deliver doses for days or weeks, making it suitable for treating cancer and other diseases.
Researchers at Kumamoto University have developed a novel, pot-shaped carbon nanomaterial with a deeper orifice than any previously produced hollow carbon nanostructure. The material's unique characteristic enables it to gradually release substances contained within, making it suitable for applications such as drug delivery systems.
Researchers have developed an implantable device that can deliver HIV prevention drugs sustainably for up to 60 days. The transcutaneously refillable device utilizes nanochannel delivery systems to control the release of pre-exposure prophylaxis drugs, addressing a significant challenge in current treatments.
Researchers from Oak Crest Institute of Science have demonstrated that a combination of tenofovir disoproxil fumarate and emtricitabine delivered via a sustained release intravaginal ring prevents HIV transmission for over four months. The study used a vaginal exposure model in macaques, showing complete protection against HIV infection.
Researchers create micro-sized gas bubbles coated with cancer drug particles that can be directed to a specific tumour using magnets and ultrasound. This innovative technique aims to overcome limitations of chemotherapy by delivering drugs directly to the core of the tumour.
Researchers developed a compact system that can synthesize various pharmaceuticals in short periods, reducing batch production and addressing drug shortages. The system produces high-quality drugs continuously over several hours or days, with the potential to facilitate on-the-spot production of pills through new approaches.
Researchers have successfully mapped the 3D structure of cubosomes, a biological 'capsule' that delivers molecules with high efficiency. The breakthrough can help promote the use of cubosomes in medicine and food science.
A new experimental treatment regimen combining a drug delivery system and URMC-099 has been shown to effectively combat HIV, reducing the need for daily medication. The nanoformulated protease inhibitor and URMC-099 prolonged therapeutic effects by increasing drug concentration in immune cells.
Two US studies published in The BMJ reveal a significant increase in drugs approved via expedited pathways, raising concerns about efficacy and safety. The findings suggest that most new drugs may not be significantly more effective than existing products.
Researchers at Duke University have deciphered the genetic code that instructs proteins to assemble or disassemble in response to environmental stimuli. This discovery provides a new platform for designer proteins and investigations into nanotechnology, biotechnology, and medical treatments.
Jin Kim Montclare's new research aims to deliver genes and drugs simultaneously, enabling the potential treatment of multi-drug resistant cancer cells. The engineered protein-lipid system breaks down naturally in the body, offering a safer alternative to traditional polymers.
Alternative drug-delivery systems are being explored to overcome syringe injection drawbacks, including ointments, dissolvable tablets and micro-needle skin patches. Several promising results have been shown in animal testing, but widespread adoption will require changing the mindset of pharmaceutical companies and regulators.
The MIT team devised a two-step process to create large quantities of complex emulsions with precise control over the composition of droplets. By adding different chemicals or exposing them to light or different acidity levels, they can finely tune the configuration of droplets. This allows for rapid, large-scale production and enables...
Researchers at OIST create non-spherical particles using a simple and low-cost method that can be scaled up for various industries. The study reveals four possible shapes: ellipsoid, mushroom, flake-like, and disc, with applications in food processing, cosmetics, and drug delivery systems.
An allergic response to a medication for allergies can often go undiagnosed due to its initial purpose of reducing inflammation. Patients experiencing worsening symptoms or an unresponsive rash may be reacting to the medication itself or one of its components, such as antibiotics or antifungals.
Researchers at Columbia University School of Engineering and Applied Science have developed a new non-invasive technique using acoustic pressure to control the size of molecules penetrating the blood-brain barrier. This breakthrough may help improve localized brain drug delivery for treatment of central nervous system diseases like Par...
The collaboration aims to overcome barriers in delivering antibodies directly into the brain to treat dementia, Alzheimer's disease and other neurological disorders. The project will utilize Nanomerics' Molecular Envelope Technology to develop effective treatments with potential to improve patient adherence and quality of life.