Articles tagged with Drug Delivery Systems
Research by Victoria O. Chan reveals that 68% of intramuscular injections do not reach the muscle due to excessive fat tissue. The study suggests a longer needle length may improve success rates for patients with obesity.
In a study published in Archives of Internal Medicine, researchers found that despite implementing multiple computerized interventions, medication errors continued to occur at high rates. The authors identified common error types, including failure to monitor adverse drug reactions and improper medication dosages.
Researchers at UNC Health Care System have developed a new continuous-infusion method for administering busulfan, which achieved more predictable levels of the drug in patients. The new method has the potential to increase treatment effectiveness while avoiding side effects by maintaining consistent drug levels.
Researchers developed a recombinant fusion protein that can be orally administered, increasing white blood cell count for three days. This breakthrough uses transferrin to bind to intestinal cells and transport the protein to the bloodstream.
Shelly Sakiyama-Elbert and her team have screened a large number of molecules to find peptide sequences with varying affinity for heparin, a sugar that binds nerve repair drugs. They aim to develop affinity-based drug delivery systems to stimulate tissue regeneration for conditions like nerve damage.
The editorial concludes that deworming programs have substantial public health benefits and reductions in global burden of disease. Simple, effective, safe, and cheap treatments are already available, but systematic delivery requires industry, funders, and political will.
The development of nanomedicines has led to significant advances in the diagnosis and treatment of disease. Thousands of patients are already benefiting from products used to treat conditions such as cancer, AIDS, and arthritis.
The Lancet calls for increased investment in nanomedicine research, citing its potential to revolutionize disease diagnosis and treatment. The field's benefits include novel means of imaging and delivery systems for drugs and gene therapies.
Researchers at Purdue University have demonstrated a method for delivering insulin orally using microscopic particles that protect the medicine from stomach acid until they can be released in the intestines. The system has been shown to be non-toxic and effective, with the potential to revolutionize treatment for insulin-dependent diab...
Researchers at Purdue University have developed a new gel-like material that can be used as a drug-delivery system, potentially replacing multiple daily medications with a single dose. The superporous hydrogels expand rapidly in the stomach, allowing medications to be absorbed more efficiently by the body.
A new study published in Annals of Internal Medicine found that HIV patients require at least 95 percent adherence to antiretroviral therapy for the drugs to work. The study also revealed that physicians often misjudge their patients' adherence, which could have serious consequences.
Researchers have developed a method to deliver nucleotides directly into tumor cells, assembling them on their own. This approach may lead to new treatments with improved efficacy and reduced side effects for various types of cancer.
The AAPS Workshop on Regulatory Issues Related to Drug Products for Oral Inhalation and Nasal Delivery will focus on quality assurance, CMC data, and bioavailability. The workshop aims to advance science through open exchange of knowledge and contribute to human health through pharmaceutical research.
Researchers found that rats born by Caesarean section showed marked differences in brain development compared to naturally born controls. They had altered dopamine systems and responses to stress tests. The findings hint at a potential link between Caesarean births and schizophrenia risk.
Using nebulizers to deliver glucocorticoid medication is effective in treating asthma in children, but long-term use can suppress growth, recommends Dr. Stanley J. Szefler of National Jewish Health. A new study suggests caution when prescribing glucocorticoids for children under 5 years old.
Researchers at Georgia Tech have developed microneedle arrays that can deliver small quantities of high-potency medications through the skin without causing pain. The arrays, produced with microelectronics industry techniques, penetrate only the outermost layer of skin with no nerve endings.
Researchers found that treating acute ischemic stroke patients with t-PA can result in a substantial net cost savings due to shorter hospital stays and decreased long-term disabilities. This treatment also improves patient outcomes and quality of life.
The University of Maryland Medical Center has successfully implanted a new device that can regulate a dangerously rapid heartbeat automatically and internally. The Metrix System TM delivers a small electrical shock to the heart, making it a more comfortable alternative to external shocks.
Researchers are developing genetically altered, edible plant products to create new vaccines for sexually transmitted diseases. Plant-based proteins could be incorporated into pills, providing a cost-effective solution for vaccinations like hepatitis B.
Researchers at Purdue University have developed an oral delivery method for insulin that may eventually treat human diabetes. The method uses a gel-like material to protect insulin from stomach enzymes, allowing it to release the drug in a location where it can work.
Researchers have designed a mini drug pump that can sense blood glucose levels and deliver the right amount of insulin, potentially simplifying the lives of diabetics. The device uses a novel alloy to create a closed-loop system, which could also be adapted for other medications.
Researchers develop tiny coated beads that can release drugs directly onto tumors in response to chemical signals. The beads are designed to remain intact until exposed to sodium-rich blood plasma, at which point they swell and burst explosively, releasing the entrapped drug. This technology has potential for targeted cancer treatment.
Brown University researchers have developed a novel oral drug delivery system using erodible plastic microspheres that can improve the efficacy of drugs like insulin. The microspheres, engineered with bioadhesive polymers, increase absorption rates and enhance therapeutic effects.
Researchers have developed a prototype drug pump that can monitor its own flow rate, ensuring steady stream of medicine and enabling diabetics to manage their condition more effectively. The device is made on a single silicon wafer and uses a titanium-nickel alloy to flex and regulate fluid flow.
Researchers at Ohio University have developed a nonviral gene therapy system that can express genes outside the nucleus of a cell, making it easier to deliver disease-fighting genes to tumor cells. This system has been successfully used in cell cultures and mouse models to promote anti-cancer activity.
A neural prosthetic system has been recommended for FDA approval, allowing paralyzed people to grasp objects without assistance. The system, developed over 25 years, enables users to regain hand function and perform routine activities with greater independence.
Johns Hopkins has started performing the new Port-Access technique for single-graft coronary artery bypasses and heart valve replacement and repair. The procedure is designed to reduce trauma, complications, and pain, resulting in shorter hospital stays and quicker recovery times.
Researchers show that taking an inhaled beta-agonist at regularly scheduled times is safe but provides no greater benefit than taking the medication only when symptoms occur. The study also demonstrates that asthma patients continue to have a good response to inhaled beta-agonists even after months of daily use.