Articles tagged with Antibiotic Resistance
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Researchers found DNA translocase Mfd accelerates mutations in bacteria, promoting antibiotic resistance. A new class of anti-evolution drugs targeting Mfd could complement existing antimicrobials and address the growing antimicrobial resistance crisis.
Healthcare-associated infections persist in the EU/EEA, with 8.9 million cases annually, due to overuse of antimicrobials and varying infection prevention practices. The European Centre for Disease Prevention and Control (ECDC) calls for continued action to address antimicrobial resistance in healthcare settings.
A study by the Julius Kühn Institute and BfR found antimicrobial-resistant bacteria with multiple transferable resistance genes on fresh produce, including mixed salads, arugula, and cilantro. Consumers can minimize risk by washing raw vegetables thoroughly and considering heat treatment for immunocompromised individuals.
A team of researchers from the University of Bristol has identified a key component of the antibiotic binding mechanism of VIM proteins, which protects bacteria from beta-lactam antibiotics. This discovery provides insights into how antibiotics can be designed to block the activity of these resistance mechanisms.
A new system, CAMR-R, can measure antimicrobial resistant phenotypes at single-cell resolution from clinical samples in three hours without cell propagation. The instrument uses D2O-feeding Raman Microspectroscopy to quantify AMR levels and has potential applications in diagnosing clinical pathogens.
Researchers have published the first estimates of antibiotic and pesticide planetary boundaries, revealing that Gram-negative bacteria are already beyond these limits. The study emphasizes the urgent need for new approaches to manage resistance, including promoting susceptibility to pesticides and antibiotics.
A combination therapy of polymyxin B/trimethoprim has shown promising results against bacterial keratitis, a leading cause of blindness. The treatment eradicated infections in 70% of animal models and showed a low rate of spontaneous resistance.
Research reveals Salmonella species, causing foodborne diseases, are resistant to multiple antibiotic classes. The study identified 39 genes linked to this resistance, shedding light on the epidemiology of salmonellosis in Brazil.
A study published in Applied and Environmental Microbiology found that antibiotic-resistant E. coli bacteria in wild giraffes most likely come from anthropogenic sources. The research suggests that young giraffes are more likely to harbor resistant bacteria, potentially due to competition between strains.
Scientists identify nine new potential vaccine candidates and six new proteins that could be effective targets for new antimicrobials to combat drug-resistant gonorrhea. The study represents a key step toward developing new weapons against the ever-evolving pathogen.
A Phase 2 clinical trial found that zoliflodacin cured most cases of uncomplicated gonorrhea, with cure rates ranging from 98% to 100%, depending on the dose. The antibiotic also showed promise in treating rectal and throat infections, although performance varied between doses.
Researchers found that supermarket produce is a reservoir for transferable antibiotic resistance genes, which can evade traditional detection methods. The study highlights the importance of characterizing the resistome in produce and emphasizes the need for improved detection methods.
Two Virginia Tech professors, Amy Pruden and Marc Edwards, are leading studies on antibiotic resistance in recycled water and plumbing. Their research aims to identify effective disinfectants and designs for preventing the spread of resistant bacteria in water systems, a growing concern that affects public health.
The study estimates that antibiotic-resistant bacteria cause a substantial burden of disease in the EU/EEA, with 75% attributed to healthcare-associated infections. The annual number of deaths due to these infections is comparable to that of influenza, tuberculosis, and HIV/AIDS combined.
Patients with drug-resistant urinary tract infections are more likely to experience worse clinical outcomes and relapses within a week. The study highlights the importance of close follow-up and proper antibiotic treatment to curb antibiotic resistance.
Researchers have discovered the mechanism by which Mycoplasma genitalium adheres to human cells, a crucial step in bacterial infection and disease development. The study reveals the three-dimensional structure of the P110 adhesin protein interacting with sialic acids on human cell surfaces.
Researchers developed a machine learning approach to identify and predict antibiotic resistance genes in Mycobacterium tuberculosis. The approach identified 33 known and 24 new resistance genes, which could aid in personalized treatment for different strains of the bacteria.
A new investigational antibiotic, cefiderocol, has been found effective against drug-resistant Gram-negative bacteria in a phase 2 randomised trial. The study suggested that patients treated with cefiderocol had a higher and more sustained level of pathogen eradication compared to those treated with imipenem-cilastatin.
The BacCapSeq platform detects signs of antibiotic resistance and virulence in 4.2 million genetic probes, outperforming traditional methods in sensitivity and speed. It has the potential to reduce mortality, morbidity, and healthcare costs by providing accurate, early differential diagnosis of infectious diseases.
A study in South Africa found that certain strains of Mycobacterium tuberculosis are resistant to the two primary antibiotics prescribed for TB. The resistance is not detected by standard DNA tests, leading to unsuccessful treatments and increased mortality.
Infants who were breastfed for at least six months had a smaller number of resistant bacteria in their gut than babies who were breastfed for a shorter period. Antibiotic treatment of mothers during delivery increased the amount of antibiotic-resistant bacteria in the infant gut.
A recent study reveals that TB resistance mutations evolved independently in various regions multiple times, with little international dissemination. This finding has significant implications for tuberculosis management and treatment, suggesting localized efforts could be successful.
A new study reveals that urban farmers in African cities are unknowingly spreading disease by irrigating vegetables with wastewater rich in virulent human pathogens. The risk of spreading bacteria and antimicrobial resistance among humans and animals is high, posing a significant health threat to millions of people.
A new study suggests that surface water dynamics are a crucial contributor to the global health concern of antibiotic resistance. The research team found that land use and season were statistically significant predictors of antibiotic resistant bacteria presence in surface water.
The three-toed amphiuma, a common species in Louisiana, has shown resistance to the fungus causing amphibian populations to decline worldwide. Researchers discovered compounds that inhibited fungal growth, highlighting its unique properties and potential for protection against chytridiomycosis.
A study of 768 E. coli isolates from elderly patients with urinary tract infections found a high prevalence of resistance to β-lactams and other antimicrobials. Independent risk factors for multi-resistant E. coli included diabetes, recurrent infections, hospitalization, and exposure to β-lactams.
Researchers develop structure-disrupting peptides to target bacterial proteins' structural core, reducing likelihood of resistance development. The study finds promising results in inhibiting multidrug-resistant bacteria growth and treating gonococcal infections.
A new study found all ESBL-producing E. coli isolates from US retail meat were resistant to at least three antimicrobial classes, carrying various types of CTX-M type ESBL genes. The presence in food-producing animals and retail meat supplies may contribute to a greater incidence of infections.
Researchers at Newcastle University have identified a naturally occurring antibiotic called kanglemycin A that is effective against rifampicin-resistant Tuberculosis. The compound was found to bind to the same groove as rifampicin but with extended structures, allowing it to maintain its affinity and inhibit the bacteria.
A new study finds that countries with better infrastructure, lower corruption, and higher spending on public health have lower rates of antibiotic resistance. Improving sanitation, access to clean water, and good governance are crucial in reducing antimicrobial resistance.
Research at the University of Edinburgh found that a previously thought-to-be ineffective antibiotic, fosfomycin, can actually kill Listeria bacteria in infected cells and mice. This breakthrough may provide new treatment options for life-threatening Listeria cases.
The European Union and European Economic Area experience stable rates of gonorrhea resistance to antibiotics, with azithromycin remaining a concern. The use of dual therapy regimens may contribute to increased susceptibility.
A California emergency department study found nearly 6% of urinary tract infections were caused by drug-resistant bacteria, with no identifiable risk factor for infection in many cases. The researchers urge wider use of urine culture tests and improved follow-up systems to address the growing problem of antibiotic resistance.
Using computer modeling, researchers have teased out the details of how an antibiotic pump works, revealing its 'lock' and mechanism. This breakthrough aims to develop new drugs that can plug the pump, potentially restoring antibiotics' effectiveness.
A recent study published in Molecular & Cellular Proteomics has uncovered changes in TB strains that make them vulnerable to other antibiotics. The research also reveals a potential target for developing new drugs against isoniazid-resistant tuberculosis.
Researchers have discovered synergy between colistin and other antibiotics, offering hope for treating multidrug-resistant Gram-negative bacterial infections. Combination therapy may allow clinicians to use lower effective doses of antibiotics, reducing toxicities and slowing antibiotic resistance development.
Researchers found that microbes from diverse travelers mix throughout the day, forming a uniform microbiome by evening. The study suggests that urban planning can impact bacterial types encountered, guiding public health strategies and transit designs.
The University of Nebraska-Lincoln is partnering with Iowa State University to create an institute addressing antimicrobial resistance, an urgent global public health concern. The institute aims to accelerate discoveries and enhance stewardship of disease prevention tools.
Researchers found that different types of efflux pump proteins, key to antibiotic resistance, may not have evolved from a common ancestor. Instead, they may have developed independently through convergent evolution, offering new insights into fighting drug-resistant superbugs.
Research reveals airborne transmission of antibiotic-resistant bacteria (ARGs) across the globe, with high levels detected in urban areas. ARGs resistant to multiple antibiotics, including vancomycin, were found in air samples from cities worldwide.
New research reveals that very low concentrations of antibiotics can lead to an increase in resistant bacteria, highlighting the environment as a critical battleground in the fight against antibiotic resistance. The study found that sewage waste water and natural environments can be breeding grounds for resistant bacteria, which can th...
A new study found that trace amounts of antibiotics in leeches' environment can increase resistant bacteria, which displaced healthy microbes. The research suggests a low threshold for antibiotic exposure to boost resistant microbes.
Research by UConn microbiologists found that tiny amounts of antibiotics in chicken blood can encourage bacterial resistance. The study used leeches as a perfect test case and discovered that low levels of ciprofloxacin in poultry blood were selecting for antibiotic-resistant Aeromonas bacteria.
A global study reveals 62% of antibiotics sold without prescription in community pharmacies worldwide, posing a significant risk to the development and spread of antibiotic resistance. The study highlights the urgent need for better enforcement of laws regulating antibiotic sales.
New evidence suggests that reducing antibiotic course length can reduce the risk of resistance. Microbial communities can reach a tipping point when exposed to antibiotics, leading to an irreversible shift towards drug resistance. Stopping treatment too soon may not prevent resistance from occurring.
Researchers at the University at Buffalo have discovered biomarkers that can accurately identify hypervirulent Klebsiella pneumoniae, a rare but increasingly common strain of the bacterium. The discovery provides a clear roadmap for developing a diagnostic test to optimize patient care and epidemiologic surveillance.
A study published in Antimicrobial Agents and Chemotherapy found that nearly half of all prescriptions reviewed were prescribed unnecessarily, with a third of cases involving non-face-to-face encounters. The research highlights the need for improved antibiotic stewardship in outpatient clinics.
A study published by Imperial College London shows that financial incentives led to a 3% decrease in antibiotic prescriptions for common respiratory tract infections. The reduction was particularly notable among children and those with sore throats, highlighting the potential of this approach to curb excessive antibiotic use.
A study involving wild and captive baboons found evidence of antibiotic resistance in their gut microbiomes, even without human-produced antibiotic exposure. The researchers used functional metagenomics to identify resistance genes, revealing a surprising enrichment of Actinobacteria in wild baboon populations.
A new study aims to identify drivers of antibacterial resistance in Thailand, focusing on two species of bacteria: Klebsiella pneumoniae and Escherichia coli. The researchers will investigate how farm management practices, chemical pollution, and human behaviors influence transmission of these bacteria.
A £3 million LSTM-led DRUM Consortium will investigate how human behavior drives antimicrobial resistance in Uganda and Malawi. The research aims to understand key drivers of resistance, including surveying human behavior around antibiotic use, water availability, sanitation, and hygiene.
Scientists at Scripps Research have discovered a previously unknown mechanism by which bacteria protect themselves from toxic substances, providing new clues for improving chemotherapies. The study reveals that three genes encode proteins that bind to toxins, keeping them separate from the rest of the organism.
New computational simulations suggest that antibiotic treatment can suppress resistant species via attack on sensitive partner species in mutualistic relationships, and spatial arrangement influences cross-protection. The study found that competing species are more susceptible to suppression than mutually interacting species.
Researchers at the University of Queensland found that triclosan can induce antibiotic resistance by accelerating the spread of multi-drug resistant bacteria. The study suggests that high residual levels of triclosan in everyday environments are contributing to the growing threat of antimicrobial resistance.
Researchers at Purdue University identified a new compound F6 that is as effective as FDA-approved antibiotics against life-threatening infections. Preliminary tests showed it was less susceptible to bacterial resistance. The compound has been tested against various antibiotic-resistant pathogens, including MRSA and VRSA.
A new study highlights the importance of educating nurses about antimicrobial stewardship and obtaining their buy-in to strengthen antimicrobial stewardship programs (ASPs). The research found that nurse participation leads to closer team coordination, cross-discipline collaboration, and ultimately saves lives.
A study found that 71.4% of residents in Nguyen Xa village, Vietnam harbored colistin-resistant E. coli bacteria, which showed multidrug resistance to at least one antibiotic drug in three or more classes. The prevalence of household members possessing colistin-resistant E. coli was also high (80.6%).
Researchers discovered a carbapenem-resistant, hypermucoviscous Klebsiella pneumoniae isolate with enhanced virulence and colistin heteroresistance from a patient in the US. The bacteria's increased virulence poses a significant threat to healthcare settings.
A study found that patients' beliefs in the harmlessness of antibiotics can lead clinicians to prescribe them more, despite knowledge of side effects, resulting in increased healthcare costs and adverse reactions. The 'WNTAR' belief can also contribute to antibiotic resistance, a growing global health threat.
Researchers at North Carolina State University have synthesized a new compound inspired by a natural product that is effective against drug-resistant bacteria like MRSA. The molecule, JJM-35, has been shown to be up to 50 times more effective than the original natural product against several bacterial strains.