Articles tagged with Antibiotic Resistance
Researchers found that mutations in gene ydcI cause increased numbers of persisters, a type of bacteria resistant to antibiotics. Persisters have memory loss, leading to abnormal growth and making them difficult to treat.
University of Queensland researchers have discovered 23 metal compounds with antibacterial and antifungal activity, selectively killing bacteria like MRSA but not human cells. The findings offer promise for outwitting bacterial resistance, as the new compounds may use different mechanisms than existing antibiotics.
Researchers develop effective treatment for antibiotic-resistant bacteria Pseudomonas aeruginosa, a major cause of hospital-acquired infections. The novel therapy, AB569, kills the bacteria by targeting multiple processes, offering hope against superbug infections.
MIT researchers used a deep-learning model to identify a new antibiotic compound that can kill many species of antibiotic-resistant bacteria, including some strains resistant to all known antibiotics. The compound, called halicin, was found using an in silico screening method and showed effectiveness against various bacterial strains.
Researchers at Swansea University have published two international studies on antifungal drug resistance, which highlights the growing threat of this disease. The studies investigated different aspects of resistance and examined drug resistance in Aspergillus fumigatus, a fungus that causes life-threatening infections.
A global surveillance system for antimicrobial resistance can be established through genomic analysis of sewage, providing valuable information about the types of bacteria present in specific areas. This approach has great potential as a tool for monitoring diseases and managing outbreaks globally.
Sequencing sewage could provide a powerful tool for AMR surveillance, offering a diverse and anonymous sample of the population. The authors suggest that such a system could be established globally for under $1 million USD annually, providing valuable insights into AMR spread and other public health concerns.
A recent study analyzed the antimicrobial resistance genes in the mouth and gut microbiome, finding distinct resistome profiles with varying levels of diversity. The researchers' findings suggest that expanding human resistome studies to other body areas is crucial for understanding the spread of antibiotic resistance.
A four-year study found that antibiotic-resistant bacteria are prevalent in people, wildlife, and water sources in northeastern Tanzania. The researchers suggest that environmental transmission is the primary driver of resistance, making hygiene and sanitation a critical factor in combatting the issue.
Researchers found that at least 25% of antibiotic-resistant pathogens are capable of spreading their resistance genes directly to other bacteria. The study, which used a new high-throughput method, showed that antibiotics do not significantly affect the rate of gene transfer between bacteria.
Researchers found that genetic makeup of mice can influence transfer of antibiotic-resistant plasmids, suggesting new ways to stop resistance. The study analyzed how plasmids spread in genetically different groups of mice, leading to discovery of potential host factors triggering or reducing plasmid transfer.
Researchers have developed color-changing bandages that can sense drug-resistant and drug-sensitive bacteria in wounds and treat them accordingly. The bandages change color to indicate the type of bacteria present, allowing for targeted treatment with antibiotics.
A Northwestern University study found that indoor dust bacteria can transfer antibiotic resistance genes, potentially making infections more difficult to treat. The researchers believe this could lead to the spread of resistant pathogens, highlighting the need for increased caution in managing indoor environments.
Researchers discovered how an antibiotic, vancomycin, forms a mucoadhesive complex with gut mucins, trapping it and prolonging its exposure to the infectious microbe. This finding could lead to delayed transit of the antibiotic, improving its effectiveness in treating debilitating gut infections like PE.
A new probiotic drink has shown promise in combating antibiotic resistant bacteria by targeting the genetic basis of resistance. The drink, engineered with a key genetic element, works by preventing plasmids from replicating and displacing resistance genes.
Researchers at KU Leuven developed a new antibacterial strategy that prevents bacterial cooperation, reducing the emergence of resistance. Non-resistant bacteria outnumber resistant ones, making it harder for them to spread.
A study found that antibiotics are widely available without a prescription in Chinese retail pharmacies, hindering the government's goal to make them prescription-only by 2020. The survey revealed that 83.6% of pharmacies sold antibiotics without a prescription, with no significant differences between urban and rural locations.
A team of Israeli researchers has identified a short window of opportunity for treating antibiotic-resistant infections, where aggressive bacteria can be controlled with currently-available therapies. This breakthrough offers new hope for patients fighting life-threatening infections with weakened immune systems.
New study reveals antibiotic tolerance promotes the evolution of antimicrobial resistance even under combination drug treatments. The results suggest that designing antibiotic treatments must consider drug tolerance to prevent the emergence of resistance.
Researchers have identified two distinct types of antibiotics produced by bacteria that target the same cell wall component, offering a promising approach to combatting antimicrobial resistance. The discovery provides chemical blueprints for pharmaceutical chemists to design new, effective drugs.
The UK is losing 0.82 million tonnes of wheat yield each year due to herbicide-resistant black-grass, with potential implications for national food security. Researchers estimate that the worst-case scenario could result in an annual cost of £1 billion and a wheat yield loss of 3.4 million tonnes per year.
A new CRISPR-based gene-drive system, Pro-AG, has been developed to target antibiotic-resistant bacteria with increased efficiency. The system uses a self-amplifying editing mechanism to insert tailored genetic payloads into target sites with high precision.
The NIH is providing renewed funding for the Antibacterial Resistance Leadership Group (ARLG) to conduct clinical research and develop novel strategies to combat antibiotic-resistant infections. The ARLG has established collaborations in 19 countries and conducted over 40 clinical studies involving over 20,000 volunteers.
Researchers at SMART and NTU have designed a polymer that can kill bacteria resistant to commonly used antibiotics, including MRSA. The breakthrough could lead to the development of medicine to which bacteria are significantly less resistant, saving hundreds of thousands of lives.
A common first-line treatment for cryptococcal meningitis is being compromised by emerging drug resistance, according to a new University of Liverpool research. The study highlights the need for new drugs and treatment regimens to combat the lethal brain infection.
Researchers have uncovered the critical genetic components responsible for oat's natural defense against soil pathogens, including the notorious Take-all disease. The finding holds significant implications for breeding other crops with similar resistance mechanisms.
A multi-drug resistant Staphylococcus aureus lineage known as the Bengal Bay clone has spread globally, causing severe disease and raising concerns about antibiotic resistance. The bacteria combines high virulence potential with multi-drug resistance, making it a significant public health issue.
Device-associated infections show higher resistance rates for antibiotic-resistant bacteria compared to surgical site infections, highlighting the need for improved infection prevention and antibiotic stewardship in hospitals.
A Michigan State University study finds that antibiotic-resistant salmonella strains are increasing, leading to longer hospital stays and worse symptoms. The study also reveals regional differences in the types of salmonella infections, with rural areas affected by enteritis infections.
Researchers at McMaster University have discovered a potent new antimicrobial that works against the toughest infectious disease strains, including MRSA. The compound, MAC-545496, cripples MRSA's ability to cause infection by diminishing its tolerance to the immune system and blocking its resistance to antibiotics.
A recent study found high prevalence and diversity of antibiotic-resistant genes in wildlife enteric bacteria from Catalonia. The study highlights the risk of human exposure to these resistant traits through wildlife.
Researchers at Martin-Luther-Universität Halle-Wittenberg have developed new active ingredients that target the pyruvate kinase enzyme in pathogenic bacteria. These substances were shown to be effective against staphylococcus and MRSA, potentially offering a solution to the growing problem of antibiotic resistance.
Researchers have discovered a mechanism behind bacterial evolution of drug resistance, exploiting collateral sensitivity for novel and sustainable treatments. The study found that certain drugs can be used in combination to eliminate bacterial populations or prevent the emergence of multidrug resistance.
New research reveals that antibiotic-resistant bacteria carry dormant genes that can quickly become active, making them resistant to treatment. This study highlights the complexity of the fight against superbugs and the need for improved screening processes.
The American Dental Association recommends against prescribing antibiotics for healthy adults with toothaches, citing evidence that they do not alleviate symptoms and can cause harm. In cases where dental treatment is delayed or signs of infection are present, antibiotics may be considered, but only in specific scenarios.
Researchers at the University of Zurich have discovered a new family of synthetic antibiotics that target essential outer membrane proteins in Gram-negative bacteria, disrupting their synthesis and leading to cell bursting.
Researchers found that bacteria living in biofilms develop unique adaptations to resist antibiotics, whereas free-floating bacteria become more resistant but vulnerable to other classes of antibiotics. This discovery highlights the importance of studying bacteria in their natural lifestyle.
A recent yeast study found that combining gene deletions can lead to increased drug sensitivity, while some combinations result in hyper-resistance. Researchers used a model system to demonstrate the impact of perturbing many different gene combinations.
A new study reveals that antibiotic-resistant E. coli superbugs are more likely to be spread through poor toilet hygiene than the food chain, with human-to-human transmission being a primary route of infection. The research found that strains of E. coli resistant to ESBLs dominate in human faeces and bloodstream infections.
Researchers discovered a single nucleotide mutation in P. aeruginosa that caused rapid resistance to ceftolozane-tazobactam and partial resensitization to carbapenems and piperacilline-tazobactam. This finding may enable the use of these antibiotics in treating extremely drug-resistant P. aeruginosa cases.
A new study finds that antibiotic resistance to H. pylori has more than doubled in 20 years, from 9.9% in 1998 to 21.6% last year. This increase is particularly concerning for countries like Southern Italy and Greece, where rates of primary clarithromycin resistance are highest.
Researchers found antibiotic-resistant bacteria in over 60% of raw pet food samples, including E. coli that can cause infections in humans and animals. The study advises dog and cat owners to handle the food carefully and maintain strict hygiene standards.
The occurrence of antibiotic resistance in disease-causing bacteria from animals to humans has nearly tripled since 2000. Researchers found that antibiotics showing rates of resistance above 50% increased in chickens and pigs in developing countries between 2000 and 2018.
Researchers have developed a novel way to identify previously unrecognized antibiotic-resistance genes in bacteria using machine learning and game theory. The approach determined the presence of antibiotic-resistant genes in three different types of bacteria with high accuracy.
An interdisciplinary group of researchers will investigate antimicrobial use and resistance in Argentinian livestock farms, aiming to develop a complete picture of AMR levels and their environmental impact. The project will inform policy making and potential interventions to reduce antimicrobial use and AMR.
Researchers found ubiquitous presence of antibiotic resistant genes (ARGs) in groundwater samples, despite advanced treatment facility reducing ARGs to below detection limits. The study highlights the need for interdisciplinary approaches to address the global spread of antibiotic resistance and ensure clean water supply.
A two-year study in Sydney's urban coastal environments reveals that some beaches have elevated levels of antibiotic-resistant bacteria following rainfall. The research highlights the exchange between human wastewater streams and natural ecosystems, posing a risk to human exposure to antibiotic-resistance bacteria.
Researchers found that ant-associated bacteria produce continually evolving variants of antimicrobials, making it harder for parasitic fungi to become resistant. This strategy could hold promise as a means to address antimicrobial resistance in the clinic.
Scientists at the University of Surrey discovered that green tea's EGCG can restore antibiotic activity against antibiotic-resistant bacteria Pseudomonas aeruginosa. The study found that combining EGCG with aztreonam significantly reduced bacterial numbers and improved survival rates in infected larvae.
Biochemists at Nagoya University have found a way to selectively kill Pseudomonas aeruginosa bacteria using a hijacked haem acquisition system that targets other dangerous bacteria, providing an alternative treatment strategy for resistant infections.
Researchers mapped global trends in antimicrobial resistance rates among food animals in low- and middle-income countries between 2000 and 2018. The study found that antibiotic-resistant bacteria are on the rise, with high rates of resistance identified in antibiotics commonly used in food production.
A study found that nearly two-thirds of Danish hedgehogs carried mecC-MRSA, a type of antibiotic-resistant bacteria. However, there was no evidence of transmission from hedgehogs to humans or rehabilitators, dispelling fears about hedgehog visits in gardens.
A new study reveals a significant increase in antibiotic-resistant pathogens in chickens and pigs worldwide, particularly in developing countries. The researchers identified hotspots of resistance, including China and India, where more than half of the world's pigs and chickens are raised.
Scientists have detected extensively drug-resistant Salmonella strains in central Africa that are resistant to nearly all commonly available drugs, a significant threat to public health. The study reveals that these new strains exhibit genetic and behavioral changes that suggest ongoing evolution towards bloodstream infections.
The proportion of bacteria resistant to antimicrobials has increased significantly worldwide, with critical consequences for animal health and human consumers. A new map reveals high resistance rates in regions such as northeast China, northeast India, and southern Brazil, where key antibiotics have lost efficacy.
Researchers at Procarta Biosystems are developing a new type of antimicrobial that kills bacteria by blocking gene expression, potentially revolutionizing treatment of serious and life-threatening infections. The £7.4m funding from CARB-X aims to combat antibiotic resistance, a major global threat.
Scientists engineer a plasmid that removes antibiotic resistance genes from Enterococcus faecalis, reducing its abundance by threefold in mouse models. The technology uses CRISPR-Cas9 and aims to combat antimicrobial resistance in hospitals.
Researchers from Florida Atlantic University and Georgia Aquarium have found a significant increase in antibiotic resistance in bottlenose dolphins, with the prevalence of resistance to at least one antibiotic reaching 88.2 percent. The study's findings suggest that the isolates originated from human activities or discharges, highlight...
Researchers from Osaka University found that a relatively ancient Haemophilus influenzae drug efflux pump AcrB confers resistance to antibiotics similar to its more evolved counterparts. The study highlights the evolution and mechanism of multidrug efflux systems, suggesting a 'one size fits all' approach is not suitable.
A Wistar team is advancing a synthetic DNA technology called DNA-encoded monoclonal antibodies (DMAbs) to combat multidrug-resistant Pseudomonas aeruginosa. The researchers have demonstrated the effectiveness of DMAbs in controlling infection in mice, paving the way for further development and clinical testing.