Articles tagged with Antibiotic Resistance
Researchers found piperacillin-tazobactam significantly less effective than meropenem in treating BSI caused by ceftriaxone-resistant E. coli and K. pneumoniae. The study concluded that piperacillin-tazobactam should be avoided when treating these organisms due to its inferior efficacy.
Researchers have discovered an alternative strategy to combat antimicrobial resistance by repositioning colloidal bismuth subcitrate, which effectively paralyzes multi-resistant superbugs and suppresses the development of antibiotic resistance. The findings offer a promising new approach to treat deadly infections caused by CRE and CRKP.
Researchers uncover how bacterial 'gene swapping' fuels emergence and spread of infectious diseases, including antimicrobial resistance crisis.
Recent studies published in PLOS Computational Biology have introduced novel computational methods to explore the molecular function of proteins. These approaches aim to simplify the challenge of determining functions for an ever-increasing amount of known proteins by identifying shared functional sites and predicting their activity.
The gonorrhea bacterium has developed resistance to multiple antibiotics, with ceftriaxone being the last effective option. Researchers identified mutations that enable resistance to ceftriaxone, which also impairs growth rate, but lab experiments showed resistant strains can quickly outcompete non-resistant strains.
Researchers analyzed the genome of a deadly, drug-resistant bacterial strain to identify molecular drivers of resistance. The study found four genes responsible for resistance to beta-lactams and other antibiotics.
A standardized set of actions has been established for hospital-based Antimicrobial Stewardship (AMS) programs globally. Seven core elements and 29 related checklist items describe essential standards for hospitals in high- and low-income countries.
A new study reveals that global antibiotic use increased by 39% between 2000 and 2015, with significant increases in low-income and middle-income countries. The study highlights the need for strategies to reduce unnecessary antibiotic use and support alternatives to address the growing threat of drug resistance.
Antibiotic use surged globally between 2000 and 2015, with defined daily doses increasing by 65% and the consumption rate rising by 39%. The trend was most pronounced in low- and middle-income countries, where antibiotic use rose by 114% and the consumption rate increased by 77%.
A study published in Open Forum Infectious Diseases found that patients with drug-resistant infections who received consultation from ID specialists had a 50% lower 30-day mortality rate. ID consultation was also associated with reduced mortality and hospital readmissions for certain types of resistant bacteria.
Researchers from Hong Kong University of Science and Technology identified a family of D-stereospecific peptidases (DRPs) that are involved in combating widely-distributed antibiotics. These genes are phylogenetically widespread and pose a significant threat to treating antibiotic-resistant bacteria.
A study published in BMJ Open found that GP surgeries with GPs trained in complementary and alternative medicine have lower antibiotic prescribing rates. This reduction is associated with a decrease in some antibiotic resistance. The authors suggest exploring additional treatment strategies to combat antimicrobial resistance.
Researchers at EMBL have unraveled the molecular basis of a major antibiotic resistance transfer mechanism and developed molecules to block its movement. This could help control the spread of antibiotic resistance genes in bacteria, including those that are part of our normal microbiome.
Researchers at CSIRO Australia and Deakin University have successfully replicated a unique protein in platypus milk that has antibacterial properties. The discovery could help combat superbugs and save lives.
Scientists at Leibniz-Institute of Photonic Technology developed a rapid test that identifies bacterial strains and their resistances in under three hours. This breakthrough reduces the analysis time from 72 hours, enabling faster diagnosis and treatment for infectious diseases.
Researchers at Emory University have discovered heteroresistance to colistin in already carbapenem-resistant Klebsiella pneumoniae, making it harder to monitor and treat. The findings pose a significant threat to public health, highlighting the need for novel diagnostics to rapidly detect colistin resistance.
A team of investigators found the mcr-1 drug resistance gene in Shigella flexneri, a common cause of diarrhea globally. The gene was detected on a transferable plasmid and can jump to other bacteria, raising concerns about its potential spread.
A study published in mBio reveals that a strain of typhoid acquired an additional piece of DNA encoding multiple antibiotic resistance genes, making it extensively drug-resistant. This outbreak highlights the urgent need for preventive measures, including vaccines, to combat the rising threat of antimicrobial resistance.
Researchers at Stanford University are using the vibrational Stark effect to measure an enzyme's electric field as it evolves into antibiotic-resistant form. They aim to understand the correlation between electric field changes and antibiotic resistance, with potential implications for developing new antibiotics.
Beewolves have successfully used a combination of antibiotics produced by symbiotic bacteria to protect their offspring from mold fungi for over 68 million years. The antibiotic cocktail has remained surprisingly stable despite the emergence of new pathogens.
The Veterans Health Administration has outlined recommendations to combat the 'crisis' of multi-drug resistant organisms (MDROs) in healthcare settings. The recommendations focus on four key areas: transmission dynamics, antimicrobial stewardship, microbiome research, and special populations.
Scientists at the University of York have developed a new method called hyperthermophilic composting that kills bacteria carrying antibiotic resistance genes. This process can reduce the spread of these genes in agricultural environments, making organic fertilizers safer for use.
A new study reveals that the WHO strategy to eradicate yaws is inadequate due to high rates of antibiotic resistance and relapse of latent infections. The research found that even with high coverage rates, mass treatment alone may not be sufficient to achieve elimination, highlighting the need for adapted strategies.
A new study published in The Lancet suggests that the current WHO strategy for yaws eradication is insufficient and may not be effective against antibiotic-resistant strains. Researchers recommend treating every individual living in an endemic zone to cure latent infections and achieve elimination.
Researchers discovered carbapenem-resistant plasmids in hospital pipes and sewers, suggesting a vast reservoir for antibiotic resistance. The findings imply that surveillance efforts can minimize patient infections, but the presence of resistant organisms in wastewater raises questions about their impact on public health.
A study published in PLOS Medicine found that resistance to azithromycin and ceftriaxone in China is increasing, threatening the effectiveness of dual therapy for gonorrhea treatment. The prevalence of dual resistance rose from 1.9% in 2013 to 3.3% in 2016.
Scientists have developed a new method to rank the risk of resistance genes in bacteria, allowing for better prediction of antibiotic evolution and development. By analyzing 200 genes, researchers identified key factors influencing gene transfer and integration into new hosts.
A new study reveals that millions of unapproved antibiotics are sold in India each year, posing a significant threat to global antibiotic resistance control. Multinational pharmaceutical companies manufacture dozens of unapproved formulations, contributing to the country's high rates of antimicrobial resistance.
A new study by the University of Exeter found that regular surfers and bodyboarders are three times more likely to have antibiotic-resistant E. coli in their guts than non-surfers. The researchers discovered that surfers swallow ten times more seawater, increasing their risk of ingesting bacteria that can survive antibiotic treatment.
A study identified new drug targets and resistance genes in malaria parasites resistant to 37 diverse antimalarial compounds. The research, published in Science, revealed a complex chemogenetic landscape of the parasite's underlying biology.
A multidrug-resistant Mycobacterium tuberculosis was found in eight refugees arriving in Europe, highlighting the need for early detection and isolation. The study's findings led to the development of a rapid PCR test and an EU-wide alert system to prevent further transmission.
Scientists have discovered predictable sensitivities to other classes of antibiotics in Pseudomonas infections, paving the way for personalized treatment strategies. The findings suggest that targeting specific mutations could lead to more effective treatments for cystic fibrosis patients.
Researchers at University of Queensland developed a new supercharged antibiotic called vancapticins that target bacterial membranes, potentially revitalizing old antibiotics. The rebooted vancomycin has the potential to treat MRSA and VRE, addressing the growing threat of multi-drug resistant bacteria.
Researchers discovered a new form of antibiotic resistance in pandemic cholera, where the enzyme AlmG modifies lipid A to prevent CAMPs from binding. This unique mechanism offers a new challenge for overcoming increasing antibiotic resistance.
Bacteria evolve resistance to antibiotics in small infections, which can drive superbug development; alternative treatments for these small infections could preserve antibiotic effectiveness
Researchers propose alternative therapies for mild infections to slow antibiotic resistance development, maintaining effectiveness for severe infections. This approach involves targeting milder bugs that can indirectly hinder the spread of resistant strains.
Researchers have discovered that bacteria can inject toxic proteins into their competitors, causing cell lysis and death, and then acquire antibiotic resistance by incorporating the released genetic material. This ability allows bacteria to rapidly develop resistance to antibiotics, posing a significant threat to patients in hospitals.
Researchers have identified 'sleeper cells' that can survive antibiotics and lie in a dormant state. These cells can evade detection using traditional methods, making them a significant public health concern.
Researchers found that antibiotic-resistant genes in honey bee guts spread to all strains of bacteria, highlighting the risk of transmission to humans. The study suggests reducing or eliminating antibiotic use can help prevent the spread of resistant genes.
Researchers at University of Warwick and Francis Crick Institute discovered a deeper understanding of how D-cycloserine works against bacteria, opening up possibility of developing new antibiotic drugs. The study highlights the need for more effective antibiotics to fight drug-resistant bacterial infections.
Bacteria resistant to ampicillin emerged several years before its widespread use in humans, according to a new study published in The Lancet Infectious Diseases. Low doses of penicillin added to animal feed in the 1950s and 60s may have encouraged antibiotic-resistant bacteria to evolve and spread.
Researchers found that antibiotic-resistant bacteria evolved and spread decades before the widespread use of ampicillin. The study suggests that low doses of penicillin fed to livestock may have triggered this evolution.
A team of scientists at Université de Montréal developed a novel strategy to block the transfer of antibiotic-resistant genes by binding molecules that target the TraE protein. This approach has the potential to reduce the spread of resistance genes, preserving the potency of antibiotics and improving human health.
Researchers found that bacteria can quickly share genes to maintain resistance, making it unlikely that reducing antibiotic use will reverse the trend. However, conjugation rates can be disrupted and reversed using existing drugs, paving the way for future development of new treatments.
A new review examines veterinary antibiotic use and its impact on soil resistance, highlighting the need for tighter controls. Recent studies show increased concentrations of antibiotics and diversity of resistant genes in animal manure and treated soils.
Natural killer cells play a crucial role in controlling bacterial growth during lung infections, and their communication with immune response regulators helps orchestrate an antibacterial program. This study provides new insights into the development of novel therapeutics against multidrug-resistant pathogens.
Researchers at Queen's University Belfast have made a breakthrough in treating antibiotic-resistant bacteria Klebsiella pneumoniae. They discovered that the body's natural defences, specifically interferons, can fight back against the infection, offering new avenues for therapy.
Researchers developed an algorithm capable of analyzing the spread of antibiotic resistance genes in gut microbiota, revealing new evidence of gene transfer between bacterial species. This method can contribute to effective therapy schemes and curb superbug emergence.
A study by UTHealth researchers found that a 'promiscuous' carbapenemase gene and a bacterial clone carrying an antibiotic-killing gene created the perfect storm for Colombia's antibiotic resistance epidemic. The gene spread horizontally across Gram-negative bacteria, while the clone was introduced via an infected patient from the US.
Researchers have discovered that a cellular pump can move drugs like antibiotics into E. coli bacteria, contradicting the long-held assumption of strict proton and drug movement in opposite directions. This finding opens up new avenues for exploring antibiotic entry mechanisms to combat bacterial resistance.
Researchers at the University of Lincoln have developed two simplified synthetic versions of teixobactin, a natural antibiotic effective against superbugs like MRSA. The new forms retain identical potency as the natural form and can be produced on a commercial scale, overcoming previous limitations.
The G7 Ministerial Meeting on Health emphasized the need for urgent strategies to mitigate and adapt to climate change's impact on health. Reducing emissions and reinforcing surveillance systems were identified as key measures to adopt globally.
A team of CSIC scientists has designed new molecules capable of destroying resistance to conventional antibiotics in bacteria. By targeting the cellular mechanisms that lead to antibiotic resistance, these molecules can break down the proteins responsible for making bacteria resistant to multiple drugs.
A new study found that most antibiotics decrease bacterial motility in multidrug-resistant Salmonella, but kanamycin increased swarming in one strain. Researchers hope to identify the accessory genes responsible for this effect to inform antibiotic choice.
Researchers developed a mathematical model of cefixime resistance in Neisseria gonorrhoeae, estimating that treating up to 25% of cases with cefixime would not lead to resistance re-emerging. The study suggests cefixime may be an effective alternative to current treatments in the fight against antimicrobial-resistant gonorrhea.
The Translational Genomics Research Institute (TGen) has been awarded a $9 million grant by the CDC to explore innovative solutions to the growing problem of drug-resistant bacteria. The grant will support a pilot investigation using human genomic technology to track person-to-person transmission of pathogens.
Researchers have developed novel antimicrobial compounds that can treat multidrug-resistant bacteria, enhancing the effectiveness of traditional antibiotics. The combination of colistin and a manganese tricarbonyl complex showed significant antibacterial activity in killing multidrug-resistant bacteria.
Researchers have made significant breakthroughs in understanding and combating antibiotic resistance, particularly through the development of β-lactamase inhibitors. These enzyme inhibitors have shown promise in reversing resistance to certain antibiotics, offering new hope in treating previously untreatable infections.
Researchers found that high genetic diversity can prime new mutations causing drug resistance in yeast cells, with varying degrees of impact. The study highlights the importance of understanding genetic diversity's role in evolving drug resistance, with potential implications for treating antimicrobial and anticancer diseases.
Researchers at Chalmers University of Technology and the University of Gothenburg have discovered 76 new types of antibiotic resistance genes. These genes can provide bacteria with the ability to degrade carbapenems, a powerful class of antibiotics.