Articles tagged with Antibiotic Resistance
The NIH-funded Antibacterial Resistance Leadership Group has reviewed over 70 study proposals and initiated more than 30 clinical studies to address antibacterial resistance. The group's key accomplishments include the launch of the CRACKLE study, a prospective multicenter cohort study designed to characterize CRE infections.
Researchers at the University of Pennsylvania have broken the limit of organic synthesis, allowing for more efficient gene and drug delivery. The study suggests that the conformation of the core molecule plays a role in this self-limiting growth phenomenon.
Researchers have discovered a new variant of the mcr-1 gene in a healthy individual carrying Salmonella, highlighting the potential for spread of antimicrobial resistance. The finding raises concerns about food safety and the need for increased monitoring of this gene and its variants.
Innovative ways to target antibiotic resistance include combining antibiotics with non-antibiotics, such as loperamide, which enhances effectiveness against multi-drug resistant bacteria. Rapid diagnostic tests that can quickly identify bacterial infections and their resistance to antibiotics are also crucial in reducing further develo...
Researchers identified cultural factors influencing transmission of antimicrobial resistant bacteria from livestock to humans in Tanzania. The study found Maasai households were less likely to follow withdrawal periods, highlighting the need for targeted interventions.
A new national study found a 700-percent surge in antibiotic-resistant infections among children in the US, with more than 75 percent already present when admitted to hospital. The study also shows that infected children stayed 20% longer in hospital and faced greater risk of death.
Research reveals bacterial spread from drainpipes to patients occurs via a staged mode of transmission, with colonies growing towards sink strainers before splattering onto surfaces.
A Rutgers-led study found that oil and gas wastewater spills altered the diversity, numbers, and functions of microbes in West Virginia stream water and sediments. The changes indicated shifts in respiration and nutrient cycling, as well as signs of stress, but did not reveal hot spots of high antibiotic resistance.
A new study published in the Journal of the Pediatric Infectious Diseases Society found that resistant infections caused by bacteria from the Enterobacteriaceae family are increasing in U.S. children, associated with longer hospital stays and a trend towards greater risk of death.
Scientists have detected antimicrobial protein fragments in Komodo dragon blood that help resist deadly infections. Eight peptides from the plasma showed significant potency against bacteria Pseudomonas aeruginosa and Staphylococcus aureus, offering a potential lead for new therapeutics.
Researchers at Broad Institute of MIT and Harvard discovered novel genetic mutations promoting antibiotic resistance in bacteria. These mutations enhance resistance to multiple classes of antibiotics, including non-ribosomal targets, while reducing growth rates.
Researchers found that 80% of online pharmacies let customers choose their own dosages and treatments, increasing the risk of serious side effects and antimicrobial resistance. This can lead to infections being undertreated or over-treated, allowing bacteria to develop resistance to antibiotics.
Klebsiella pneumoniae is a multi-drug resistant microbe causing severe infections with mortality rates of 25-60 percent. Researchers have identified the underlying molecular explanations preventing treatment, highlighting the need for innovative solutions to counteract its effects.
A study published in the Journal of Antimicrobial Chemotherapy reveals that epidermicin is as effective as mupirocin in eradicating MRSA from cotton rats' nostrils. The results justify further development of epidermicin as an alternative to existing antimicrobial agents.
Researchers have discovered a new, potent antibiotic against MRSA and VRE bacteria. The formicamycins produced by Streptomyces formicae isolated from an African plant-ant show promising activity in early tests.
A new method called poreFUME can rapidly detect resistance genes in gut bacteria, leading to improved treatment outcomes. The study found the method to be 97% accurate and significantly cheaper than current methods.
A large-scale study detected high levels of antibiotic resistance genes in estuaries along China's coastline, with some samples containing up to 100 million genes per gram of sediment. The study suggests that human activity, particularly inadequate wastewater treatment, is the primary cause of this environmental pollution.
A recent study found that antibiotic use among travelers increases the risk of contracting antibiotic-resistant ESBL intestinal bacteria. In fact, up to 80% of those taking antibiotics brought the most resistant strains back home with them. The use of antibiotics while traveling selects for the broadest spectrum of resistance.
Researchers found that bacteria can quickly adapt to antibiotic treatments by evolving dormancy mechanisms. Once tolerant, they rapidly acquire resistance mutations, making it difficult for antibiotics to kill them. This discovery has important implications for the development of new antibiotics.
A new study reveals that disease-causing bacteria become resistant to antibiotics by acquiring mutations that allow them to tolerate the antibiotic. The research found that strains with pre-existing tolerant mutations developed resistance more quickly than those without tolerance.
A rapid genotypic resistance test for colistin has been developed to detect the mobile resistance gene mcr-1, which threatens emergency antibiotics. The test demonstrated 100% sensitivity and specificity in detecting mcr-1 on plasmids.
Researchers have discovered a novel combination therapy that successfully treats infections caused by a pernicious form of antibiotic resistance. The treatment regimen, which includes ceftazidime/avibactam and aztreonam, overcomes the resistance caused by metallo-ß-lactamases, a growing global public health problem.
A UCL-led study published in Scientific Reports discovered that certain antibiotics, such as oritavancin, can still kill drug-resistant bacteria by exerting strong mechanical forces on their cell surfaces. The findings open up a promising new way to overcome antibiotic resistance and could lead to the development of more effective drugs.
Researchers at the University of Lincoln have determined the molecular structure of a new antibiotic, teixobactin, which holds promise in tackling drug-resistant bacteria. The discovery reveals that the antibiotic's disordered structure is essential for its biological activity, providing insight into how to produce effective derivatives.
A recent study found the mcr-1 gene has spread to a wide variety of Escherichia coli strains in China, raising concerns about the emergence of multi-drug resistance. The introduction of colistin in clinical settings is crucial, but caution must be exercised due to risk factors for its spread.
Researchers at Oregon State University have developed a molecule that neutralizes bacteria's genetic resistance to antibiotics. The PPMO molecule restores the effectiveness of an ultra-broad-spectrum drug, meropenem, against three different genera of bacteria with NDM-1 enzyme.
A new report calls for improved fungal disease diagnosis to reduce antibiotic resistance. Inadequate attention to fungal infections leads to overprescription of antibiotics, resulting in harmful resistance and increased healthcare costs. The report highlights four clinical situations where fungal disease misdiagnosis worsens the problem.
Scientists have identified two bacteriophages, dubbed superspreaders, that promote the transfer of antibiotic resistance genes in bacterial communities. These phages, SUSP1 and SUSP2, can efficiently release plasmid DNA intact upon phage lysis, which may drive bacterial evolution in natural environments.
A UK-based international team of researchers has made a breakthrough in understanding the mechanism of mcr-1 gene-mediated resistance to colistin. They identified key features necessary for the protein that modifies bacterial surface to reduce colistin binding, and constructed computer models to block MCR-1 function.
Researchers found that susceptible bacteria can survive longer when resistant bacteria are present and even outcompete them. This new understanding can inform doctors on how to use antibiotics more effectively, but also highlights the need for a personalized-medicine approach.
A study sequencing genomes of Shigella sonnei isolates found two clusters of outbreaks, one causing severe gastrointestinal problems due to a toxin gene acquired from other Shigella species and another resistant to fluoroquinolone antibiotics. The findings provide insights into the bacteria's virulence and antibiotic resistance genes.
Researchers at UConn have developed experimental antibiotics that successfully target and kill MRSA bacteria by blocking the enzyme pathway critical to its survival. By understanding the molecular structure of the enzyme and designing tailored inhibitors, the team created compounds that evade previously resistant strains.
A landmark trial found that shortened antibiotic courses for ear infections in young children (9-23 months) resulted in more treatment failures and adverse events without reducing antibiotic resistance. The study showed a significantly higher risk of recurrent infections when residual fluid was present after treatment.
A new approach to prevent burn injury infections was developed by UTSW researchers, which targets the bacteria's ability to bind to host cells rather than killing them. The method, using an engineered adhesion inhibitor molecule, substantially decreased bacterial levels and prevented infection for three days.
A new battery-powered detection system can identify 16 virulent pathogens with high sensitivity and provides positive identification from as few as 10 DNA sequences. The device is designed for use in remote locations where laboratory resources are lacking, addressing the lack of timely diagnosis and effective treatment.
A team of UCLA researchers has developed an automated diagnostic test reader for antimicrobial resistance using a smartphone. The device connects to a phone and conducts testing on up to 96 wells, with results returned in under one minute.
Researchers discovered a bacterium in Lechuguilla Cave that resists 18 different antibiotics, including 'drugs of last resort'. This finding suggests evolutionary pressure has driven resistance for millions of years, not just since antibiotics were introduced.
The FDA's triclosan ban is a starting point for addressing antibiotic resistance and environmental concerns. Researchers emphasize the need for new chemicals that demonstrate both efficacy and safety in replacing banned substances.
Bacteria carrying a transmissible carbapenem resistance gene have been detected in US farm animals, posing a risk to public health. The finding highlights the need for monitoring farms and re-examining agricultural practices that may be contributing to antibiotic resistance.
A novel sulfur-containing molecule has been identified with potent anticandidal activity, offering a new lead for designing effective drugs against Candida species. This discovery highlights the potential of endophytes as a source of bioactive compounds for developing novel medicines.
Antibiotic resistance increased across Europe in 2015, with EU-wide carbapenem resistance in Klebsiella pneumoniae rising to 8.1%. Prudent use of antibiotics is crucial to prevent the spread of resistant bacteria. The European Commission will launch a new action plan to tackle antibiotic resistance.
Researchers have found worrying traces of resistant bacteria in the air, which could lead to the development of last-resort antibiotic-resistant infections. The study analyzed DNA from humans, animals, and environments worldwide and found a wide mix of resistance genes, including those that make bacteria resistant to carbapenems.
Highly drug-resistant Pseudomonas aeruginosa infections are on the rise among US children, with increasing antibiotic resistance rates reported over the last decade. The study highlights the need for better tracking and prevention strategies to address these concerning infections.
Researchers at the University of Oklahoma have identified four new chemicals that disrupt bacterial proteins called efflux pumps, a major cause of antibiotic resistance. These molecules could drastically reduce the time needed to move from experimental phase to clinical trials.
A study by Johns Hopkins Bloomberg School of Public Health found that some hog workers are carrying livestock-associated, antibiotic-resistant bacteria in their noses and may be developing skin infections. The researchers suggest that these bacteria can spread more broadly between animals and humans if not properly controlled.
A new study reveals that a global, transmissible, and increasingly virulent M. abscessus infection is spreading rapidly among cystic fibrosis patients, requiring combination treatment with multiple antibiotics for extended periods.
A new study reveals that small DNA molecules known as plasmids accelerate the evolution of new forms of antibiotic resistance. Plasmids are found in many bacteria and are capable of transferring resistance genes between them.
Research reveals that isolates of Helicobacter pullorum from Indian poultry markets are resistant to multiple classes of antibiotics, posing a potential public health risk. The study suggests that the bacterium could be transmitted from poultry to humans, highlighting the need for increased awareness and regulation.
A recent study published in BMC Medicine found that the prevalence of multidrug-resistant tuberculosis (MDR-TB) in West Africa is significantly higher than previously thought. The study revealed that MDR-TB strains were widely circulating and drug resistance was a much bigger problem in the region than anticipated.
Researchers have engineered a new antimicrobial peptide that can destroy many types of bacteria, including those resistant to most antibiotics. The peptide also suppresses the overactive inflammatory response and destroys biofilms, making it a promising alternative for treating infections.
A new study from the University of Chicago Medicine found that social media platforms can effectively inform young physicians about proper antibiotic use, improving their knowledge and behavior. The strategy successfully directed medical residents to relevant clinical pathways, resulting in a significant increase in correct usage.
A study has found a link between chlorhexidine exposure and antibiotic resistance in Klebsiella pneumoniae bacteria. The researchers discovered that certain strains of the bacteria could survive high concentrations of chlorhexidine and develop resistance to colistin, a last resort antibiotic.
A new monoclonal antibody, ibalizumab, has shown promise in treating patients with multidrug-resistant HIV. Eighty-three percent of patients achieved a virologic response after treatment, making it a potential option for those resistant to all other medications.
A first-of-its-kind study of 900,000 hospital admissions found a significant increase in ESBL positive organisms (322%) and C. difficile cases (222%), while MRSA rates decreased by 32%. The study highlights the need for new diagnostic tests to address the growing threat of antibiotic-resistant bacteria.
Scientists have developed a new class of small molecules that prevent bacteria from causing urinary tract infections by interfering with a critical factor on the surface of UTI-causing bacteria. The treatment, called C-mannosides, has shown promising results in animal testing and may move to clinical trials.
Scientists at Imperial College London discovered that MRSA releases decoy molecules to escape being killed by daptomycin. The decoys are made of the same type of fat as MRSA cells and allow the bacteria to evade destruction. Further experiments showed that a second antibiotic, oxacillin, can partially prevent decoy release.
Rhode Island Hospital has been awarded a $500,000 CDC grant to investigate the relationship between antibiotics and multi-drug resistant bacteria. The research aims to identify patients at risk of acquiring these resistant bacteria by analyzing their microbiome.
A team of researchers has unraveled the mechanism of a key enzyme involved in bacterial antibiotic resistance. The study, published in the Journal of Biological Chemistry and PLOS One, reveals the structure of Rifampicin monooxygenase and provides detailed information on its mechanism of action.
A recent UCLA-led study found that nearly 12% of people diagnosed with pyelonephritis had antibiotic-resistant infections, up from 4% a decade ago. The emergence of ESBL-producing E. coli strains limits treatment options, highlighting the need for new medications and guidelines.
A team of Chinese researchers characterized the 'mobile resistome,' a network of easily transferred antibiotic resistance genes between bacteria, including humans and animals. The study found that these genes are shared among multiple human pathogens and can be disabling for six major classes of antibiotics.