Articles tagged with Antibiotic Resistance
A new five-year program will support 25 visiting professorships and two major scientific meetings between the UK and India to address antimicrobial resistance. The initiative aims to share knowledge, foster research collaborations and increase awareness to develop robust interventions against AMR.
A large-scale study found that patients who receive antibiotics before certain types of low-risk operations have the same risk for developing antibiotic-resistant infections as those who don't. The study analyzed data from over 22,000 patients and found no association between prophylactic antibiotic use and postoperative antibiotic res...
The UK's first nationwide PhD training program to tackle antimicrobial resistance has been launched, with the University of Bristol leading delivery. The program aims to train a new generation of researchers to develop innovative solutions to this major global health challenge.
Research finds that antibiotic use on people or pets, and biocidal cleaning products like bleach, contribute to MRSA multidrug resistance in the home environment. The presence of domestic pets and unwanted pests is also associated with multidrug-resistant strains.
Researchers found 132 antibiotic-resistant genes in commercially available fishmeal, which can boost the growth of harmful bacteria in marine farm sediment. This discovery suggests that fishmeal could be a reservoir for these genes, promoting their distribution globally.
Resistance levels to cefixime and ciprofloxacin have decreased, while azithromycin resistance remains high. The dual therapy of ceftriaxone and azithromycin is still effective, but its use contributes to the rise in cephalosporin susceptibility.
Guidelines recommending against routine PSA-based screening may be revised due to compatible evidence showing screening reduces prostate cancer mortality. The benefits of screening outweigh potential harms of overdiagnosis and overtreatment, but how to implement screening is still a question.
A recent study published in the BMJ Journal of Sexually Transmitted Infections warns of the rapid increase in drug resistance of Mycoplasma genitalium (MG), a common sexually transmitted infection. The study suggests that reducing azithromycin use, currently used to treat MG, is necessary to mitigate this issue.
Researchers found 132 antibiotic resistance genes in commercially available fishmeal, which can potentially confer resistance to common antibiotics. The application of fishmeal to marine farm sediment samples increased the abundance and diversity of antibiotic resistance genes, boosting potential human pathogenic bacteria.
Researchers found that microbes living at low population densities are more likely to mutate and develop antibiotic resistance. This discovery could lead to better understanding of antibiotic resistance and its prevention.
A new blood test developed by TUM researchers can predict drug resistance in patients with advanced prostate cancer, analyzing AR-V7 RNA molecules for early detection. The test has shown high sensitivity and accuracy, identifying approximately one-fifth of patients with large amounts of resistant tumor cells.
Researchers have identified a rare genetic mutation in Ureaplasma parvum that renders it resistant to levofloxacin, a commonly used antibiotic for treating urinary tract infections. This mutation limits treatment options for women with UTIs caused by this pathogen.
A study found that bacteria's past adaptation to antibiotics influences their evolutionary dynamics of multi-drug resistance. The researchers used Pseudomonas aeruginosa and sequenced the bacteria's genomes to understand the genetic basis for resistance.
Researchers at Uppsala University have developed a new method for rapidly determining bacterial resistance patterns in urinary tract infections, reducing the time from days to minutes.
Researchers have discovered a new antibiotic, closthioamide, effective against 146 of 149 gonorrhea samples tested in the lab. The antibiotic showed promise against resistant strains and could be a crucial step in fighting drug-resistant infections.
A study published in mSphere reveals that three Klebsiella species can cause severe infections in hospital patients, with all three sharing genes that confer resistance to commonly used antibiotics. This finding expands the understanding of Klebsiella infections and highlights the need for new treatments.
A nationwide survey found high levels of antimicrobial-resistant genes in urban sewage across China, with over 381 distinct resistance genes detected. The study suggests municipal sewage as a major conduit for transferring antibiotic resistance into the environment.
Experts argue that stopping antibiotics sooner is a safe and effective way to reduce antibiotic overuse, contradicting the long-held 'complete the course' message.
A team of scientists is pooling their expertise to develop fast diagnostic tests and alternative treatments for infection, aiming to address the growing problem of antimicrobial resistance. The University of Edinburgh's new research facility will bring together dozens of researchers worldwide to tackle this major health challenge.
Researchers at IRB Barcelona have identified histidine as a crucial component in the machinery that enables Staphylococcus aureus bacteria to acquire and spread antibiotic resistance. This discovery could lead to the development of molecules to prevent the spread of resistant strains, offering new hope in tackling hospital infections.
A novel LpxC inhibitor, LPC-069, has been shown to be effective in treating multi-drug resistant bacterial infections, including those caused by Yersinia pestis. The compound was found to have no serious side effects at high doses.
A new study from India reveals high levels of antibiotic-resistant pathogens in chickens raised for both meat and eggs on farms in Punjab state. The study found that nearly 60% of E. coli isolates contained enzymes conferring drug resistance to key medications, raising concerns about the consequences to human health.
Researchers found MRSA's resistance gene in S. aureus isolates dating back to the mid-1940s, 14 years before methicillin's introduction. The study highlights the importance of surveillance and genome sequencing to combat antibiotic resistance.
A large-scale genetic study of E. coli bloodstream infections in England found that drug-resistant 'superbugs' are not dominant causes of infection. Instead, new types of E. coli emerge frequently, but are quickly balanced by other strains, suggesting a complex picture of disease dynamics.
A recent study published in the British Journal of Surgery found that topical antibiotics are moderately effective but not justified due to limited information on adverse effects. The research highlights the need to fight antibiotic resistance and encourages a more cautious approach to their use.
Researchers found a high prevalence of resistant bacteria strains in Kenyan individuals, with agriculture and prophylactic use of antibiotics contributing to the issue. The study suggests the need for effective public health policies and improved infection control measures.
Gonorrhea is a growing global health crisis with over 60% of countries reporting resistance to last-resort treatments. Gardp and Entasis partner on zoliflodacin, a novel first-in-class oral antibiotic with potent activity against drug-resistant strains.
A UK-based consortium will develop a platform for producing new antibiotics using bacteriocins, potent toxins produced by bacteria. The aim is to generate derivatives with drug-like properties while preserving their original potent bacteria-killing abilities.
Researchers at the University of Lincoln have produced highly potent and simplified forms of teixobactin, which defeats multi-drug resistant infections like MRSA. The breakthrough comes after pinpointing exactly which amino acid makes teixobactin successful at killing off harmful bacteria.
A £1.5 million study led by the University of Warwick is investigating two biomarkers to guide safe reduction in antibiotic treatment time for patients with suspected sepsis. The trial will compare survival rates, discharge times, and antibiotic usage across three groups.
Research at Weizmann Institute of Science finds dust storm microbiomes differ by region, with rising bacterial species during storms. The study identifies a 'signature' for each source of bacteria based on antibiotic resistance genes, revealing that local sources pose less threat than imported genes.
A new method, MDK99, measures bacterial tolerance to antibiotics, allowing for more effective treatment and reduced risk of resistance. This metric helps classify bacteria as tolerant, resistant, or persistent, guiding treatment decisions.
A new method, MDK99, measures bacterial tolerance to antibiotics, allowing clinicians to effectively treat antimicrobial-tolerant strains. This metric can also estimate the duration of antibiotic treatments and provide insights into the prevalence of tolerance, ultimately reducing treatment failure and resistance.
Researchers have generated both novel and existing antibiotic resistance mechanisms in soil exposed to specific antibiotics. The study found 36 antibiotic resistance genes, including some multi-drug efflux pumps that pump antibiotics out of bacteria.
Researchers at Technical University of Denmark discover that resistance genes originate from the same group as antibiotics, Actinobacteria. The study reveals a new mechanism called 'carry back', where pathogens acquire genes through a primitive form of bacterial sex.
A new rational drug design technique identifies molecules targeting multiple receptor sites on key cellular proteins, making it challenging for microbes to develop resistance. The technique has been validated and shows potential in battling drug resistance and even cancer cells.
Ready-to-eat foods such as dairy products and fresh produce contain antibiotic-resistant bacteria, which can be directly consumed or contaminate kitchen surfaces. Organic produce had higher levels of resistance than dairy products.
Researchers found decreasing rates of resistance to oxacillin and other antibiotics in Staphylococcus aureus, while ceftaroline remained highly active against MRSA. The study's findings suggest a potential decrease in the prevalence of community-acquired MRSA, highlighting the importance of monitoring antimicrobial resistance.
A team of researchers at Kiel University has developed a new strategy to combat multi-resistant pathogens by identifying which antibiotics can lead to increased susceptibility to other drugs. This concept, known as 'collateral sensitivity', offers hope in the fight against antibiotic resistance.
Shigella uses multiple mechanisms to resist bile salts in the small intestine, including antibiotic resistance and increased virulence gene expression. The formation of protective biofilms allows the bacteria to survive transit through the small intestine and infect tissues in the colon.
Studies show a prevalence rate of 50-82% among hospitalized patients in Egypt's largest cities, while community-acquired MRSA rates range from 19-47%. Molecular characterization reveals various SCCmec types, highlighting the need for national surveillance and awareness.
A Canadian research team found a new antibiotic resistance gene, fosA7, in Salmonella from broiler chickens, which confers high resistance to the antibiotic fosfomycin. The researchers tested the gene's strength and confirmed its ability to boost resistance levels by over 256-fold.
Scientists at UCLA developed a laboratory test to determine the most effective treatment for gonorrhea. The new test led to a significant increase in the use of ciprofloxacin, from 0% to 34%, while reducing the use of ceftriaxone from 100% to 66%. This shift may help slow down the emergence of antibiotic resistance.
A study of 3,434 US MDR TB patients found that those on directly observed therapy had a 77% decrease in mortality compared to self-administered therapy. The study suggests that maximizing direct observation therapy coverage can help reduce all-cause mortality among MDR TB patients.
A global health threat, superbugs are bacteria resistant to commonly used antibiotics. Monash University researchers identified the first important clues on how to counter superbug strategies, using electron microscopes and comparing data from antibiotic-resistant Staphylococcus aureus samples with non-resistant strains.
The RESET and MedVet-Staph networks have investigated the development, spread, and mechanisms of resistance to antibiotics in humans and animals. Key findings include widespread occurrence of ESBL- or AmpC-producing E. coli in livestock and increasing hospital-acquired infections with these enterobacteria.
Cases of drug-resistant tuberculosis are expected to rise significantly in India, the Philippines, Russia, and South Africa between 2000 and 2040. The growing epidemic is predicted to be driven by person-to-person transmission, rather than strains acquiring resistance to anti-tuberculosis drugs.
Researchers at McGill University have discovered how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics. The study provides a detailed atomic view of the kinases and their interaction with different macrolide antibiotics, paving the way for the design of next-generation antibiotics.
Researchers developed an antimicrobial treatment inspired by naturally-occurring peroxidase enzymes that rapidly kill drug-resistant bacteria. The treatment consists of iodo-thiocyanate complexes producing highly reactive anti-microbial substances without a peroxidase enzyme.
The ResistoMap tool helps identify national trends in antibiotic use and control antibiotic resistance globally. By analyzing human gut microbiota, the map reveals correlations between antibiotic use patterns and resistome variations, shedding light on the global battle against antibiotic resistance.
Researchers review key two-component systems in pathogens causing CF lung disease, finding potential for histidine kinase inhibitors to treat infections. TCS inhibitors alone or combined with existing treatments show promise for addressing antibiotic resistance in CF patients.
Researchers have developed a quick and accurate diagnostic test for bacteria resistant to colistin, a last-resort antibiotic. The test can distinguish between bacteria with plasmid-encoded resistance, which is considered more dangerous, and those that are not.
A new study at the University of Nevada, Reno has found a potential way to reduce triclosan's presence in the environment, which is linked to antibiotic resistance. The research discovered that a combination of metal-reducing bacteria and natural organic matter can degrade triclosan faster.
Researchers identified a compensatory mechanism in bacteria that can be used as a new therapeutic target against multi-drug resistant bacteria. The study found that the pace of adaptation in multi-drug resistant Escherichia coli strains is faster than for strains with single resistance mutations.
A preclinical study found that an antimicrobial protein called EntV reduces the severity of oral thrush in a mouse model, blocking fungal growth and development. This new strategy may lead to the development of a novel antifungal drug that can combat multidrug-resistant yeast strains.
Researchers developed a new treatment pathway removing antibodies from the bloodstream to reduce chronic infections and hospital stays. The approach showed positive outcomes for two patients with resistant Pseudomonas aeruginosa lung infections.
Chinese scientists have developed a fluorogenic probe, CVB-1, to detect the activity of multidrug-resistant carbapenemases in an assay system. This technique allows for rapid detection of antibiotic resistance activity by fluorescence, enabling specific treatment strategies and reducing the overuse of ineffective drugs.
The global rise of multidrug-resistant tuberculosis (TB) poses a significant threat to progress made in controlling the disease. The emergence of extensively drug-resistant TB is associated with high mortality and is a serious public health problem.
Researchers have developed a new class of compounds called lysine-conjugated aliphatic norspermidine analogues (LANAs) that effectively kill certain bacteria, including MRSA. Testing on mice showed that the compounds can eliminate MRSA skin infections with no signs of acute toxicity or resistance development.
Researchers have discovered a new way to restore antibiotic susceptibility in multidrug-resistant (MDR) Klebsiella pneumoniae and Escherichia coli strains. By identifying genes essential for survival of MDR superbugs in the presence of antibiotics, the team developed innovative drugs that can defeat resistant bacteria.