Research on how bacteria evade antibiotics. Covers adaptive metabolism, water-source resistance, drug-efflux pumps, and microplastic pollutant shuttles.
Researchers at Stanford University are using the vibrational Stark effect to measure an enzyme's electric field as it evolves into antibiotic-resistant form. They aim to understand the correlation between electric field changes and antibiotic resistance, with potential implications for developing new antibiotics.
Beewolves have successfully used a combination of antibiotics produced by symbiotic bacteria to protect their offspring from mold fungi for over 68 million years. The antibiotic cocktail has remained surprisingly stable despite the emergence of new pathogens.
Scientists at the University of York have developed a new method called hyperthermophilic composting that kills bacteria carrying antibiotic resistance genes. This process can reduce the spread of these genes in agricultural environments, making organic fertilizers safer for use.
The Veterans Health Administration has outlined recommendations to combat the 'crisis' of multi-drug resistant organisms (MDROs) in healthcare settings. The recommendations focus on four key areas: transmission dynamics, antimicrobial stewardship, microbiome research, and special populations.
A new study reveals that the WHO strategy to eradicate yaws is inadequate due to high rates of antibiotic resistance and relapse of latent infections. The research found that even with high coverage rates, mass treatment alone may not be sufficient to achieve elimination, highlighting the need for adapted strategies.
A new study published in The Lancet suggests that the current WHO strategy for yaws eradication is insufficient and may not be effective against antibiotic-resistant strains. Researchers recommend treating every individual living in an endemic zone to cure latent infections and achieve elimination.
A study published in PLOS Medicine found that resistance to azithromycin and ceftriaxone in China is increasing, threatening the effectiveness of dual therapy for gonorrhea treatment. The prevalence of dual resistance rose from 1.9% in 2013 to 3.3% in 2016.
Scientists have developed a new method to rank the risk of resistance genes in bacteria, allowing for better prediction of antibiotic evolution and development. By analyzing 200 genes, researchers identified key factors influencing gene transfer and integration into new hosts.
Researchers discovered carbapenem-resistant plasmids in hospital pipes and sewers, suggesting a vast reservoir for antibiotic resistance. The findings imply that surveillance efforts can minimize patient infections, but the presence of resistant organisms in wastewater raises questions about their impact on public health.
A new study reveals that millions of unapproved antibiotics are sold in India each year, posing a significant threat to global antibiotic resistance control. Multinational pharmaceutical companies manufacture dozens of unapproved formulations, contributing to the country's high rates of antimicrobial resistance.
A new study by the University of Exeter found that regular surfers and bodyboarders are three times more likely to have antibiotic-resistant E. coli in their guts than non-surfers. The researchers discovered that surfers swallow ten times more seawater, increasing their risk of ingesting bacteria that can survive antibiotic treatment.
A study identified new drug targets and resistance genes in malaria parasites resistant to 37 diverse antimalarial compounds. The research, published in Science, revealed a complex chemogenetic landscape of the parasite's underlying biology.
A multidrug-resistant Mycobacterium tuberculosis was found in eight refugees arriving in Europe, highlighting the need for early detection and isolation. The study's findings led to the development of a rapid PCR test and an EU-wide alert system to prevent further transmission.
Scientists have discovered predictable sensitivities to other classes of antibiotics in Pseudomonas infections, paving the way for personalized treatment strategies. The findings suggest that targeting specific mutations could lead to more effective treatments for cystic fibrosis patients.
Researchers at University of Queensland developed a new supercharged antibiotic called vancapticins that target bacterial membranes, potentially revitalizing old antibiotics. The rebooted vancomycin has the potential to treat MRSA and VRE, addressing the growing threat of multi-drug resistant bacteria.
Researchers discovered a new form of antibiotic resistance in pandemic cholera, where the enzyme AlmG modifies lipid A to prevent CAMPs from binding. This unique mechanism offers a new challenge for overcoming increasing antibiotic resistance.
Bacteria evolve resistance to antibiotics in small infections, which can drive superbug development; alternative treatments for these small infections could preserve antibiotic effectiveness
Researchers propose alternative therapies for mild infections to slow antibiotic resistance development, maintaining effectiveness for severe infections. This approach involves targeting milder bugs that can indirectly hinder the spread of resistant strains.
Researchers have discovered that bacteria can inject toxic proteins into their competitors, causing cell lysis and death, and then acquire antibiotic resistance by incorporating the released genetic material. This ability allows bacteria to rapidly develop resistance to antibiotics, posing a significant threat to patients in hospitals.
Researchers have identified 'sleeper cells' that can survive antibiotics and lie in a dormant state. These cells can evade detection using traditional methods, making them a significant public health concern.
Researchers found that antibiotic-resistant genes in honey bee guts spread to all strains of bacteria, highlighting the risk of transmission to humans. The study suggests reducing or eliminating antibiotic use can help prevent the spread of resistant genes.
Researchers at University of Warwick and Francis Crick Institute discovered a deeper understanding of how D-cycloserine works against bacteria, opening up possibility of developing new antibiotic drugs. The study highlights the need for more effective antibiotics to fight drug-resistant bacterial infections.
Bacteria resistant to ampicillin emerged several years before its widespread use in humans, according to a new study published in The Lancet Infectious Diseases. Low doses of penicillin added to animal feed in the 1950s and 60s may have encouraged antibiotic-resistant bacteria to evolve and spread.
Researchers found that antibiotic-resistant bacteria evolved and spread decades before the widespread use of ampicillin. The study suggests that low doses of penicillin fed to livestock may have triggered this evolution.
A team of scientists at Université de Montréal developed a novel strategy to block the transfer of antibiotic-resistant genes by binding molecules that target the TraE protein. This approach has the potential to reduce the spread of resistance genes, preserving the potency of antibiotics and improving human health.
Researchers found that bacteria can quickly share genes to maintain resistance, making it unlikely that reducing antibiotic use will reverse the trend. However, conjugation rates can be disrupted and reversed using existing drugs, paving the way for future development of new treatments.
A new review examines veterinary antibiotic use and its impact on soil resistance, highlighting the need for tighter controls. Recent studies show increased concentrations of antibiotics and diversity of resistant genes in animal manure and treated soils.
Natural killer cells play a crucial role in controlling bacterial growth during lung infections, and their communication with immune response regulators helps orchestrate an antibacterial program. This study provides new insights into the development of novel therapeutics against multidrug-resistant pathogens.
Researchers at Queen's University Belfast have made a breakthrough in treating antibiotic-resistant bacteria Klebsiella pneumoniae. They discovered that the body's natural defences, specifically interferons, can fight back against the infection, offering new avenues for therapy.
Researchers developed an algorithm capable of analyzing the spread of antibiotic resistance genes in gut microbiota, revealing new evidence of gene transfer between bacterial species. This method can contribute to effective therapy schemes and curb superbug emergence.
A study by UTHealth researchers found that a 'promiscuous' carbapenemase gene and a bacterial clone carrying an antibiotic-killing gene created the perfect storm for Colombia's antibiotic resistance epidemic. The gene spread horizontally across Gram-negative bacteria, while the clone was introduced via an infected patient from the US.
Researchers have discovered that a cellular pump can move drugs like antibiotics into E. coli bacteria, contradicting the long-held assumption of strict proton and drug movement in opposite directions. This finding opens up new avenues for exploring antibiotic entry mechanisms to combat bacterial resistance.
Researchers at the University of Lincoln have developed two simplified synthetic versions of teixobactin, a natural antibiotic effective against superbugs like MRSA. The new forms retain identical potency as the natural form and can be produced on a commercial scale, overcoming previous limitations.
The G7 Ministerial Meeting on Health emphasized the need for urgent strategies to mitigate and adapt to climate change's impact on health. Reducing emissions and reinforcing surveillance systems were identified as key measures to adopt globally.
A team of CSIC scientists has designed new molecules capable of destroying resistance to conventional antibiotics in bacteria. By targeting the cellular mechanisms that lead to antibiotic resistance, these molecules can break down the proteins responsible for making bacteria resistant to multiple drugs.
A new study found that most antibiotics decrease bacterial motility in multidrug-resistant Salmonella, but kanamycin increased swarming in one strain. Researchers hope to identify the accessory genes responsible for this effect to inform antibiotic choice.
Researchers developed a mathematical model of cefixime resistance in Neisseria gonorrhoeae, estimating that treating up to 25% of cases with cefixime would not lead to resistance re-emerging. The study suggests cefixime may be an effective alternative to current treatments in the fight against antimicrobial-resistant gonorrhea.
The Translational Genomics Research Institute (TGen) has been awarded a $9 million grant by the CDC to explore innovative solutions to the growing problem of drug-resistant bacteria. The grant will support a pilot investigation using human genomic technology to track person-to-person transmission of pathogens.
Researchers have developed novel antimicrobial compounds that can treat multidrug-resistant bacteria, enhancing the effectiveness of traditional antibiotics. The combination of colistin and a manganese tricarbonyl complex showed significant antibacterial activity in killing multidrug-resistant bacteria.
Researchers have made significant breakthroughs in understanding and combating antibiotic resistance, particularly through the development of β-lactamase inhibitors. These enzyme inhibitors have shown promise in reversing resistance to certain antibiotics, offering new hope in treating previously untreatable infections.
Researchers found that high genetic diversity can prime new mutations causing drug resistance in yeast cells, with varying degrees of impact. The study highlights the importance of understanding genetic diversity's role in evolving drug resistance, with potential implications for treating antimicrobial and anticancer diseases.
Researchers at Chalmers University of Technology and the University of Gothenburg have discovered 76 new types of antibiotic resistance genes. These genes can provide bacteria with the ability to degrade carbapenems, a powerful class of antibiotics.
A new five-year program will support 25 visiting professorships and two major scientific meetings between the UK and India to address antimicrobial resistance. The initiative aims to share knowledge, foster research collaborations and increase awareness to develop robust interventions against AMR.
A large-scale study found that patients who receive antibiotics before certain types of low-risk operations have the same risk for developing antibiotic-resistant infections as those who don't. The study analyzed data from over 22,000 patients and found no association between prophylactic antibiotic use and postoperative antibiotic res...
The UK's first nationwide PhD training program to tackle antimicrobial resistance has been launched, with the University of Bristol leading delivery. The program aims to train a new generation of researchers to develop innovative solutions to this major global health challenge.
Research finds that antibiotic use on people or pets, and biocidal cleaning products like bleach, contribute to MRSA multidrug resistance in the home environment. The presence of domestic pets and unwanted pests is also associated with multidrug-resistant strains.
Researchers found 132 antibiotic-resistant genes in commercially available fishmeal, which can boost the growth of harmful bacteria in marine farm sediment. This discovery suggests that fishmeal could be a reservoir for these genes, promoting their distribution globally.
Resistance levels to cefixime and ciprofloxacin have decreased, while azithromycin resistance remains high. The dual therapy of ceftriaxone and azithromycin is still effective, but its use contributes to the rise in cephalosporin susceptibility.
Guidelines recommending against routine PSA-based screening may be revised due to compatible evidence showing screening reduces prostate cancer mortality. The benefits of screening outweigh potential harms of overdiagnosis and overtreatment, but how to implement screening is still a question.
A recent study published in the BMJ Journal of Sexually Transmitted Infections warns of the rapid increase in drug resistance of Mycoplasma genitalium (MG), a common sexually transmitted infection. The study suggests that reducing azithromycin use, currently used to treat MG, is necessary to mitigate this issue.
Researchers found 132 antibiotic resistance genes in commercially available fishmeal, which can potentially confer resistance to common antibiotics. The application of fishmeal to marine farm sediment samples increased the abundance and diversity of antibiotic resistance genes, boosting potential human pathogenic bacteria.
Researchers found that microbes living at low population densities are more likely to mutate and develop antibiotic resistance. This discovery could lead to better understanding of antibiotic resistance and its prevention.
A new blood test developed by TUM researchers can predict drug resistance in patients with advanced prostate cancer, analyzing AR-V7 RNA molecules for early detection. The test has shown high sensitivity and accuracy, identifying approximately one-fifth of patients with large amounts of resistant tumor cells.
Researchers have identified a rare genetic mutation in Ureaplasma parvum that renders it resistant to levofloxacin, a commonly used antibiotic for treating urinary tract infections. This mutation limits treatment options for women with UTIs caused by this pathogen.
A study found that bacteria's past adaptation to antibiotics influences their evolutionary dynamics of multi-drug resistance. The researchers used Pseudomonas aeruginosa and sequenced the bacteria's genomes to understand the genetic basis for resistance.
Researchers at Uppsala University have developed a new method for rapidly determining bacterial resistance patterns in urinary tract infections, reducing the time from days to minutes.
Researchers have discovered a new antibiotic, closthioamide, effective against 146 of 149 gonorrhea samples tested in the lab. The antibiotic showed promise against resistant strains and could be a crucial step in fighting drug-resistant infections.
A study published in mSphere reveals that three Klebsiella species can cause severe infections in hospital patients, with all three sharing genes that confer resistance to commonly used antibiotics. This finding expands the understanding of Klebsiella infections and highlights the need for new treatments.
A nationwide survey found high levels of antimicrobial-resistant genes in urban sewage across China, with over 381 distinct resistance genes detected. The study suggests municipal sewage as a major conduit for transferring antibiotic resistance into the environment.
A team of scientists is pooling their expertise to develop fast diagnostic tests and alternative treatments for infection, aiming to address the growing problem of antimicrobial resistance. The University of Edinburgh's new research facility will bring together dozens of researchers worldwide to tackle this major health challenge.