Articles tagged with Antibiotic Resistance
The pandemic E. coli strain H30 causes persistent and deadly infections, often undetected until severe complications arise. Researchers found that patients with underlying conditions and those in healthcare facilities are at higher risk for infection.
Researchers develop a new mathematical framework to compare different treatment therapies, including aggressive and moderate approaches. The model considers the role of the host immune system in infection clearance, suggesting that optimized treatments can minimize drug resistance without compromising patient health.
The new guidelines focus on customizing interventions based on local issues and resources, recommending preauthorization of broad-spectrum antibiotics, syndrome-specific interventions, and rapid diagnostic testing. This approach aims to improve patient outcomes and reduce the emergence of antibiotic resistance.
Researchers at Wayne State University are developing novel aminoglycoside antibiotics with reduced toxicity and decreased resistance, aiming to combat multidrug-resistant diseases. The project, led by David Crich, will evaluate synthetic compounds in vitro and animal models for efficacy and antibacterial activity.
Research by Michigan State University found that large-scale swine farms in China and the US are breeding ground for multidrug-resistant bacteria. Partner genes, which can confer resistance to multiple antibiotics, were discovered in Chinese soils and manure, highlighting the need for prudent agricultural antibiotic use.
Researchers at Duke University found that antibiotics do not promote the spread of bacterial antibiotic resistance through genetic swapping, contrary to previous assumptions. The study's results suggest that differential birth and death rates, rather than DNA donation, are to blame for the spread of resistance.
A study found that half of patients visiting their GP with dental problems were prescribed unnecessary antibiotics, despite these not providing a definitive treatment. This has raised concerns about the impact on long-term dental health and potential contributions to antibiotic resistance.
Researchers at Nanyang Technological University (NTU) have discovered a method to disrupt cell-to-cell communication and latch-on ability of bacteria, making them vulnerable to antibiotics. This breakthrough offers new treatment options for chronic bacterial infections and may help extend the lifespan of existing drugs.
A global review of 58 studies involving over 77,000 E. coli samples found a high prevalence of antibiotic resistance in children's urinary tract infections, particularly in non-OECD countries. Previous antibiotic use increased the risk of resistance for up to six months after treatment.
A study found that patients bring MDROs on their hands when discharged from hospitals and acquire more during their stay in post-acute care facilities. The study recommends routine hand washing to prevent further transmission, citing increased mobility and interactions with the environment as key factors.
Researchers discovered novel bacteria species in shower hoses of a US hospital, closely related to known opportunistic pathogens. The presence of antibiotic resistance genes raises concerns about the potential health implications for immunocompromised patients.
Researchers from KU Leuven found that frequent antibiotic use leads to the development of persister cells, which are dormant and tolerant to antibiotics. This phenomenon can lead to the recurrence of infections despite successful treatment.
A long-term study found a correlation between the use of animal manure and an increase in antibiotic-resistant genes in soil. Phasing out antibiotics led to a rapid decrease in resistant gene abundance, suggesting that stopping antibiotic use can help reduce resistance levels.
A new study found that premature infants' gut bacteria are vulnerable to antibiotic resistance, with almost 800 genes identified, including those associated with carbapenem-resistant Enterobacteriaceae. The study suggests that routine antibiotic use in preterm infants may not be effective and could lead to increased infection risk.
Whole-genome sequencing reveals the emergence and spread of the virulent Salmonella strain DT104 over 40 years in 21 countries. The strain's resistance to five antibiotics and ability to infect multiple livestock species contributed to its success.
A recent publication by Journal of Environmental Quality highlights the science behind antibiotic resistance in agroecosystems. Key findings include the widespread use of large quantities of antibiotics and animal waste leading to environmental contamination.
A mix of poor public health systems, high infectious disease rates, and inexpensive antibiotics contribute to increasing antibiotic resistance in India. Experts suggest regulating over-the-counter access to antibiotics, promoting behavior change, and improving the healthcare system to mitigate this growing threat.
Researchers found that strains resistant to bacteriocins grew poorly in iron-poor environments, suggesting a potential advantage in targeting resistant bacteria. The study suggests that bacteriocins could be used to target specific strains of multidrug-resistant or highly virulent bacteria.
New research reveals a clear parallel between antibiotic resistance in medicine and similar genes detected in agricultural soils treated with animal manure. The study found that repeated use of antibiotics in agriculture can increase soil bacteria's capacity to acquire new resistance genes.
A team of Dutch investigators has identified NS4B as a potential target for antiviral drug development against dengue virus. A metabolite of acetaminophen, AM404, inhibits replication of the virus. The researchers found that mutations in the viral NS4B protein render the virus insensitive to AM404.
Exposure to specific antibiotics is linked to the development of antibiotic-resistant C. difficile , one of the fastest growing bacteria superbugs. The study found that fluoroquinolone and macrolide exposure was more frequent in patients with a highly resistant strain, supporting targeted antibiotic stewardship monitoring programs.
The grant will explore various dosing regimens of daptomycin, a lipopeptide antibiotic, to treat vancomycin-resistant Enterococcus faecium (VREfm) bacteria. The research aims to prevent resistance development and improve treatment outcomes for patients with life-threatening infections.
Researchers at the University of Vermont discovered a new strategy for bacteria to become resistant to antibiotics by adopting an 'all-for-one' approach. This allows individual cells to assume high levels of resistance while others avoid extra work, enabling colonies to hedge their bets and persist in infections like cystic fibrosis.
A new study by UGA ecologist J. Vaun McArthur reveals high levels of antibiotic resistance in streams near the Savannah River Site due to environmental contaminants like metals. The contaminated streams have no known input from antibiotics and show that industrial legacy waste can contribute to antibiotic resistance.
A new computer program, Mykrobe Predictor, quickly analyzes bacterial DNA to predict antibiotic effectiveness and detect drug-resistant infections. The software streamlines genome analysis, detecting resistance in over 99% of Staphylococcus aureus cases, with faster results for tuberculosis.
Researchers discovered a unique antibiotic molecule that triggers a bacteria's adaptation strategy, enabling it to resist the drug. The resistant bacteria undergoes morphological changes and can move away from the antibiotic, allowing it to survive and spread.
A new method developed by UC San Diego biologists can quickly identify and characterize compounds capable of controlling antibiotic-resistant bacteria in natural product extracts. This breakthrough could shave years off screening efforts and lead to the discovery of new antibiotics, addressing a growing global crisis.
Researchers find migration between bacteria communities key to horizontal gene transfer and spread of traits like antibiotic resistance. Mathematical modeling reveals the secret behind bacterial sex lies in movement between communities, increasing DNA swap chances.
A review reveals prevalent antimicrobial resistance in horse bacteria, particularly E. coli, with emerging multidrug resistance posing a huge challenge for society.
Researchers found a new gene, mcr-1, that enables bacteria to resist polymyxins, the last line of defence against infections. The gene is widespread in E coli and K pneumoniae strains from pigs and patients in south China, suggesting its potential to spread rapidly into human pathogens.
A new study promoted better prescribing practices for urinary tract infections (UTIs), but unexpectedly saw an increase in antibiotic prescriptions. Patients were twice as likely to receive a first-line antibiotic, with nitrofurantoin being the preferred option.
Research suggests that cranberries can help reduce the incidence of symptomatic UTIs, potentially reducing antibiotic use and mitigating antibiotic resistance. Cranberry's unique blend of polyphenol antioxidants may also assist in preserving heart and cognitive health, protecting against oxidative stress.
Research found that composting is most reliable to kill bacteria with resistance genes in cow manure. Composting speeds up decomposition and reduces volume of manure. Manure management practices like composting and stockpiling can make it difficult for resistant bacteria to travel from farm to environment.
Recent gonorrhea susceptibility trends indicate a worsening of susceptibility to third-generation cephalosporin antibiotics, particularly cefixime. The CDC's Gonococcal Isolate Surveillance Project found that the percentage of resistant isolates increased from 0.1% in 2006 to 0.8% in 2014.
A nationwide study found a significant increase in CRE infections among US children aged 1-5, with rates rising from 0% to 4.5% between 1999 and 2012. The greatest increase was seen in intensive care units, where isolates of CRE in the bloodstream increased from zero to 3.2% during the study period.
Researchers report that up to half of surgical site infections and over a quarter of infections after cancer chemotherapy are caused by resistant bacteria. The study predicts that reducing antibiotic efficacy could lead to 120,000 more infections and 6,300 infection-related deaths annually in the USA.
UCSF scientists call on hospitals to oppose the overuse of antibiotics in animal agriculture, citing concerns about human health and the spread of antibiotic resistance. Experts say switching to antibiotic-free meat could create a market and drive down prices.
Researchers discovered that approximately 70% of different antibiotic sequences lead to resistance, highlighting the importance of careful ordering. The approach may help prevent antibiotic-resistant bacteria and could be tested in laboratory trials.
New Danish research reveals that wastewater treatment plants contain a vast pool of genes providing bacteria with antimicrobial resistance, but these genes are rarely found in hazardous bacteria. The study challenges the common perception that wastewater treatment plants are hotbeds for the spread of antimicrobial resistance genes.
A global team of experts aims to mitigate the spread of antibiotic-resistant organisms through contaminated water. The researchers focus on understanding how wastewater treatment processes affect resistance dissemination and develop novel approaches to stop it.
Researchers have found that parasites resistant to artemisinin-based therapies can also resist other antimalarial drugs, making combination therapies less effective. This new multi-drug resistance is a serious threat to malaria treatments in Southeast Asia.
Researchers developed a DNA sequencing device that can detect bacteria and antibiotic resistance in urine samples four times faster than traditional methods. The new method allows for quicker treatment and better stewardship of diminishing antibiotic reserves.
Researchers have developed three new rapid tests for diagnosing drug-resistant tuberculosis (TB), which can be completed in as little as a day. The tests were found to be accurate in detecting resistance to most anti-TB drugs, with the molecular techniques showing superior performance.
Bacteria can become highly resistant to antibiotics when exposed to their environment in the body, not just in lab tests. The study suggests incorporating animal models and biochemical environments into antibiotic development to improve accuracy.
Researchers discovered a significant increase in antibiotic resistance genes among Swedish exchange students returning from India and central Africa. The study highlights the role of human gut microbiomes in dispersing resistant bacteria, emphasizing the need for societal-level interventions to reduce further spread.
Researchers analyzed toilet waste from international flights to identify disease-causing microorganisms and resistance genes. The study found geographical differences in resistance genes and microorganism prevalence, highlighting the potential for airports as global surveillance sites.
Researchers are uncovering how bacteria acquire antibiotic resistance genes through conjugation, a process that involves exchanging genetic material with other microbes. Understanding this mechanism could lead to the development of more effective treatments, such as phage therapy, which uses viruses to target bacterial infections.
Researchers at Rice University have identified a genetic mechanism that enables bacteria to become more resistant to antibiotics while also spreading their resistance rapidly. The discovery highlights the need for new strategies to predict and prevent the emergence of antibiotic-resistant bacteria, potentially halting or slowing down t...
Researchers at Duke University have discovered the role of HipA in recurring urinary tract infections, finding that mutant versions of the protein can cause multidrug tolerance by putting bacterial cells into dormancy. The study provides a new method for combating drug-tolerant infections.
Researchers found that multidrug-resistant bacteria were widespread among African wildlife, including species with high exposure to antibiotics through diet. These findings suggest that wildlife may serve as sentinels for antimicrobial resistance in ecosystems, providing clues to the spread of resistant microbes.
A $4.8 million NIH study will provide essential information to clinicians on the proper intravenous dosing of polymyxin B in critically ill patients. The study aims to minimize unnecessary toxic side effects and preserve the drug's efficacy against superbug-resistant Gram-negative bacteria.
A study published in Clinical Infectious Diseases found that 47% of grocery store-bought meat products contained Klebsiella bacteria, with many strains resistant to antibiotics. This increase poses a significant risk to human health, particularly for urinary and blood infections.
A new study found that UK investment in pneumonia research was less than £43.08 per death, despite rising substantially since 2010. Total funding for pneumonia between 2011-2013 exceeded total investment across the previous 14 years for tuberculosis and influenza.
A Stanford study found that high out-of-pocket costs for antimicrobial drugs in developing countries lead to increased drug-resistant pathogens. Patients often turn to the black market or informal clinics, where poor-quality drugs and inadequate care contribute to resistance.
A new study suggests that restricting specific antibiotics could lead to an increased frequency of multi-drug resistance. The study found that using restricted antibiotics can facilitate the spread of resistant pathogens, despite potential short-term benefits in treatment effectiveness.
A study found that household contacts of multidrug-resistant tuberculosis (MDRTB) patients were 44% less likely to contract tuberculosis than those of drug-susceptible cases. The researchers suggest this may be due to a lower relative fitness of MDRTB strains.
The Community for Open Antimicrobial Drug Discovery aims to screen over 50,000 chemical compounds in the next 18 months to combat superbug-resistant bacteria, with the goal of preventing millions of deaths by 2050.
Researchers detected MRSA bacteria in UK supermarket sausages and minced pork through a survey of frozen meat products. The bacteria were identified as LA-MRSA CC398, associated with pigs and poultry, and pose a potential route of transmission from farms to the wider population.
Scientists from HIPS and HZI discover cyclohexylgriselimycin, a variant of griselimycin, effective against Mycobacterium tuberculosis with low risk of resistance development. The new agent targets DNA clamp, preventing bacterial proliferation and offering potential therapeutic approach to drug-resistant tuberculosis.
Scientists have discovered new antifungal compounds that selectively kill pathogens without evoking drug resistance. These novel compounds were designed to act as molecular sponges for ergosterol, found exclusively on fungi surfaces, and exhibit undetectable binding to human cells.