Articles tagged with Antibiotic Resistance
Researchers discovered a unique antibiotic molecule that triggers a bacteria's adaptation strategy, enabling it to resist the drug. The resistant bacteria undergoes morphological changes and can move away from the antibiotic, allowing it to survive and spread.
A new method developed by UC San Diego biologists can quickly identify and characterize compounds capable of controlling antibiotic-resistant bacteria in natural product extracts. This breakthrough could shave years off screening efforts and lead to the discovery of new antibiotics, addressing a growing global crisis.
Researchers find migration between bacteria communities key to horizontal gene transfer and spread of traits like antibiotic resistance. Mathematical modeling reveals the secret behind bacterial sex lies in movement between communities, increasing DNA swap chances.
A review reveals prevalent antimicrobial resistance in horse bacteria, particularly E. coli, with emerging multidrug resistance posing a huge challenge for society.
Researchers found a new gene, mcr-1, that enables bacteria to resist polymyxins, the last line of defence against infections. The gene is widespread in E coli and K pneumoniae strains from pigs and patients in south China, suggesting its potential to spread rapidly into human pathogens.
A new study promoted better prescribing practices for urinary tract infections (UTIs), but unexpectedly saw an increase in antibiotic prescriptions. Patients were twice as likely to receive a first-line antibiotic, with nitrofurantoin being the preferred option.
Research suggests that cranberries can help reduce the incidence of symptomatic UTIs, potentially reducing antibiotic use and mitigating antibiotic resistance. Cranberry's unique blend of polyphenol antioxidants may also assist in preserving heart and cognitive health, protecting against oxidative stress.
Research found that composting is most reliable to kill bacteria with resistance genes in cow manure. Composting speeds up decomposition and reduces volume of manure. Manure management practices like composting and stockpiling can make it difficult for resistant bacteria to travel from farm to environment.
Recent gonorrhea susceptibility trends indicate a worsening of susceptibility to third-generation cephalosporin antibiotics, particularly cefixime. The CDC's Gonococcal Isolate Surveillance Project found that the percentage of resistant isolates increased from 0.1% in 2006 to 0.8% in 2014.
A nationwide study found a significant increase in CRE infections among US children aged 1-5, with rates rising from 0% to 4.5% between 1999 and 2012. The greatest increase was seen in intensive care units, where isolates of CRE in the bloodstream increased from zero to 3.2% during the study period.
Researchers report that up to half of surgical site infections and over a quarter of infections after cancer chemotherapy are caused by resistant bacteria. The study predicts that reducing antibiotic efficacy could lead to 120,000 more infections and 6,300 infection-related deaths annually in the USA.
UCSF scientists call on hospitals to oppose the overuse of antibiotics in animal agriculture, citing concerns about human health and the spread of antibiotic resistance. Experts say switching to antibiotic-free meat could create a market and drive down prices.
Researchers discovered that approximately 70% of different antibiotic sequences lead to resistance, highlighting the importance of careful ordering. The approach may help prevent antibiotic-resistant bacteria and could be tested in laboratory trials.
New Danish research reveals that wastewater treatment plants contain a vast pool of genes providing bacteria with antimicrobial resistance, but these genes are rarely found in hazardous bacteria. The study challenges the common perception that wastewater treatment plants are hotbeds for the spread of antimicrobial resistance genes.
A global team of experts aims to mitigate the spread of antibiotic-resistant organisms through contaminated water. The researchers focus on understanding how wastewater treatment processes affect resistance dissemination and develop novel approaches to stop it.
Researchers have found that parasites resistant to artemisinin-based therapies can also resist other antimalarial drugs, making combination therapies less effective. This new multi-drug resistance is a serious threat to malaria treatments in Southeast Asia.
Researchers developed a DNA sequencing device that can detect bacteria and antibiotic resistance in urine samples four times faster than traditional methods. The new method allows for quicker treatment and better stewardship of diminishing antibiotic reserves.
Researchers have developed three new rapid tests for diagnosing drug-resistant tuberculosis (TB), which can be completed in as little as a day. The tests were found to be accurate in detecting resistance to most anti-TB drugs, with the molecular techniques showing superior performance.
Bacteria can become highly resistant to antibiotics when exposed to their environment in the body, not just in lab tests. The study suggests incorporating animal models and biochemical environments into antibiotic development to improve accuracy.
Researchers discovered a significant increase in antibiotic resistance genes among Swedish exchange students returning from India and central Africa. The study highlights the role of human gut microbiomes in dispersing resistant bacteria, emphasizing the need for societal-level interventions to reduce further spread.
Researchers analyzed toilet waste from international flights to identify disease-causing microorganisms and resistance genes. The study found geographical differences in resistance genes and microorganism prevalence, highlighting the potential for airports as global surveillance sites.
Researchers are uncovering how bacteria acquire antibiotic resistance genes through conjugation, a process that involves exchanging genetic material with other microbes. Understanding this mechanism could lead to the development of more effective treatments, such as phage therapy, which uses viruses to target bacterial infections.
Researchers at Rice University have identified a genetic mechanism that enables bacteria to become more resistant to antibiotics while also spreading their resistance rapidly. The discovery highlights the need for new strategies to predict and prevent the emergence of antibiotic-resistant bacteria, potentially halting or slowing down t...
Researchers at Duke University have discovered the role of HipA in recurring urinary tract infections, finding that mutant versions of the protein can cause multidrug tolerance by putting bacterial cells into dormancy. The study provides a new method for combating drug-tolerant infections.
Researchers found that multidrug-resistant bacteria were widespread among African wildlife, including species with high exposure to antibiotics through diet. These findings suggest that wildlife may serve as sentinels for antimicrobial resistance in ecosystems, providing clues to the spread of resistant microbes.
A $4.8 million NIH study will provide essential information to clinicians on the proper intravenous dosing of polymyxin B in critically ill patients. The study aims to minimize unnecessary toxic side effects and preserve the drug's efficacy against superbug-resistant Gram-negative bacteria.
A study published in Clinical Infectious Diseases found that 47% of grocery store-bought meat products contained Klebsiella bacteria, with many strains resistant to antibiotics. This increase poses a significant risk to human health, particularly for urinary and blood infections.
A new study found that UK investment in pneumonia research was less than £43.08 per death, despite rising substantially since 2010. Total funding for pneumonia between 2011-2013 exceeded total investment across the previous 14 years for tuberculosis and influenza.
A Stanford study found that high out-of-pocket costs for antimicrobial drugs in developing countries lead to increased drug-resistant pathogens. Patients often turn to the black market or informal clinics, where poor-quality drugs and inadequate care contribute to resistance.
A new study suggests that restricting specific antibiotics could lead to an increased frequency of multi-drug resistance. The study found that using restricted antibiotics can facilitate the spread of resistant pathogens, despite potential short-term benefits in treatment effectiveness.
A study found that household contacts of multidrug-resistant tuberculosis (MDRTB) patients were 44% less likely to contract tuberculosis than those of drug-susceptible cases. The researchers suggest this may be due to a lower relative fitness of MDRTB strains.
The Community for Open Antimicrobial Drug Discovery aims to screen over 50,000 chemical compounds in the next 18 months to combat superbug-resistant bacteria, with the goal of preventing millions of deaths by 2050.
Researchers detected MRSA bacteria in UK supermarket sausages and minced pork through a survey of frozen meat products. The bacteria were identified as LA-MRSA CC398, associated with pigs and poultry, and pose a potential route of transmission from farms to the wider population.
Scientists from HIPS and HZI discover cyclohexylgriselimycin, a variant of griselimycin, effective against Mycobacterium tuberculosis with low risk of resistance development. The new agent targets DNA clamp, preventing bacterial proliferation and offering potential therapeutic approach to drug-resistant tuberculosis.
Scientists have discovered new antifungal compounds that selectively kill pathogens without evoking drug resistance. These novel compounds were designed to act as molecular sponges for ergosterol, found exclusively on fungi surfaces, and exhibit undetectable binding to human cells.
Researchers have developed new anti-microbial compounds that specifically target fungal infections without harming human cells. These derivatives of the antifungal drug amphotericin B are highly effective in killing invasive yeast infections while showing minimal toxicity to humans.
Research published in BMJ Open found that many UK patients with gonorrhoea are being prescribed outdated antibiotics. The study analyzed electronic health records and found that between 2000 and 2011, nearly 17,000 people were diagnosed with gonorrhoea, accounting for 6-9% of all cases in England.
A recent study reveals the emergence of a highly resistant strain of typhoid in Africa, with data showing its rapid spread across the continent. The H58-strain has been found to acquire resistance to commonly available antibiotics, making it easier for the bacteria to retain these genes.
Researchers found phages in 49 out of 50 chicken samples that can transduce antimicrobial resistance genes to E. coli bacteria, highlighting the need for phage therapy and improved disinfection methods.
A Virginia Tech team, led by Amy Pruden and Monica Ponder, is examining the impact of antibiotic use in agriculture on human health. They aim to identify ways to control the spread of antibiotic-resistant bacteria and genes in the food chain.
Researchers found that nearly half of chicken meat samples contained viruses capable of transferring antibiotic resistance genes. Phages were able to transfer resistance to multiple antibiotics, including extended spectrum betalactam antibiotics.
A new test developed by a UCL-led team can identify drug-resistant tuberculosis strains in days, reducing the time needed for genetic sequencing from weeks to days. This could lead to better treatment outcomes and control of transmission.
A landmark genomic study reveals a single clade of typhoid bacteria, H58, is driving global spread, displacing other strains and creating a previously underappreciated epidemic. The study highlights the urgent need for global surveillance and coordinated efforts to prevent and control antimicrobial-resistant typhoid.
A fecal microbiota transplant successfully cured a patient's C. difficile infection, eliminating populations of multi-drug resistant organisms from the gut and other body sites. The treatment method replenishes normal gut flora, stopping the release of antibiotic-resistant microbes and potentially saving lives.
A team of researchers from UC Merced and American University has discovered a way to restore the efficacy of antibiotics and help doctors deal with resistant bacteria in a clinical setting. The study found that combining lab work with mathematics and computer technology can reverse bacterial resistance and provide optimal treatment opt...
Researchers found antibiotic resistance genes in Yanomami tribespeople who had never been exposed to antibiotics, suggesting that bacteria have resisted antibiotics since long before their use. The study reveals a link between decreased bacterial diversity and increased diseases such as obesity and diabetes.
Researchers at London School of Hygiene & Tropical Medicine discovered a genetic mutation in the ap2mu gene that makes Plasmodium falciparum malaria parasites less susceptible to artemisinin and quinine. This finding suggests a different route to drug resistance may be developing independently in Africa.
Case Western Reserve University is leading an international team studying resistance to bacteria causing TB. The goal is to develop a new approach to treating and curing the disease by understanding how resistant individuals fight off infections.
The University of Texas at Austin researcher is working on developing small-molecule inhibitors that counter antibiotic resistance in Gram-negative bacteria. The goal is to create a suite of drugs for treating bacterial infections resistant to most antibiotics.
The article highlights the importance of antimicrobial resistance, citing its impact on human and animal health. Global collaboration and innovative approaches are necessary to tackle this complex issue.
A study published this week found that over 6.3 million people may be exposed to antibiotic-resistant bacteria while engaging in water sports, with surfers and swimmers at highest risk. The research highlights the importance of maintaining good water quality standards to minimize exposure to these harmful microbes.
Researchers warn that increased antibiotic use in livestock could lead to decreased effectiveness in humans. A study found that global demand for animal protein is rising dramatically, driving antimicrobial consumption.
The FDA approves new antibiotics with minimal evidence of efficacy against antimicrobial resistance. Despite this, industry and medical societies claim the drugs address the issue, sparking concerns over safety and efficacy standards.
Two antibiotic resistance genes, KPC and NDM-1, can be shared among bacteria responsible for hospital-associated infections. The study found that genetic similarity between US and South Asian strains suggests easy transmission of these superbugs.
Researchers used genetic analysis to trace the source of infection in a British patient with multidrug-resistant tuberculosis (TB). The study found that the patient caught the infection from a healthcare worker who had worked in South Africa, highlighting the need for effective infection prevention measures.
Antibiotics are widely used in lab experiments for microbiology, molecular biology, and genetic research. However, this practice contributes to the growing problem of antibiotic resistance, posing a catastrophic threat to modern medicine. Researchers must use antibiotics more responsibly and sparingly.
Researchers have linked antibiotic resistance with poor governance and corruption around the world, citing alarming rates of 23,000 deaths annually in the US due to antibiotic-resistant infections. The study suggests that addressing corruption and control of antibiotics could help lower resistance levels and save lives.
Researchers have discovered a new mechanism of antibiotic resistance in bacterial cells, which could help develop solutions to the growing problem of antibiotic resistance. The study found that a mutation in the efflux pump makes it more efficient at pumping antibiotics out of bacterial cells.
Scientists have found a tool that could help fight bacterial infections, including strep throat and flesh-eating disease. A drug approved to treat HIV has been shown to inhibit the production of a deadly toxin in lab tests, offering new hope for developing therapies against these deadly pathogens.
A study on the Thames river found that greater numbers of resistant bacteria exist close to waste water treatment works, which are likely responsible for increasing antibiotic resistance. The researchers suggest that improvements in treatment processes could hold the key to reducing the prevalence of resistant bacteria in the environment.