Articles tagged with Drug Design
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have developed a way to create designer drugs that target multiple proteins simultaneously, potentially treating complex diseases like diabetes and schizophrenia. The new approach uses computational chemistry and experimental testing to validate drug compounds, showing promise for developing effective treatments.
A team of researchers at the University of Dundee has developed an automated design system for new drugs, using advanced statistical analysis to mimic human chemists' creative process. The system successfully predicted profiles across a range of drug targets, with 75% confirmed correct in experimental testing.
A study by Nationwide Children's Hospital identified alpha arrestins as crucial regulators of G-protein coupled receptor signaling. Targeting these proteins could lead to more effective and side-effect-free drugs, potentially revolutionizing the pharmaceutical industry.
Researchers at the University of Minnesota's Center for Drug Design developed a synthetic compound, psi-GSH, that prevents neurodegeneration associated with Alzheimer's disease in a mouse model. The compound enables the brain to use its own protective enzyme system against the disease process.
A novel 90-day intravaginal ring has been developed to deliver tenofovir, the only topical prophylactic shown to reduce HIV transmission, for up to 90 days. The ring overcomes limitations of standard technology and can be modified to deliver multiple drugs.
The American Association of Pharmaceutical Scientists (AAPS) has announced its 2012 Fellows, recognizing individuals for their outstanding contributions to the field. Alekha K. Dash and Glen S. Kwon are among those recognized for their research in novel drug delivery systems and cancer treatment.
AAPS honors top scientists in pharmaceutical sciences, recognizing their contributions to drug development, nanotechnology, and education. The awards celebrate innovative research on cell interactions with drugs and cancer treatment.
A new model explains dopamine's direct and indirect role in modulating the immune system. Recent research has opened up possibilities for treating diseases such as Parkinson's and Alzheimer's disease, schizophrenia, multiple sclerosis, or autoimmune disorders.
A new mathematical model developed by Harvard scientists helps predict the likelihood of drug resistance in HIV patients, enabling the design of more effective treatment cocktails. The model uses data from clinical trials to simulate patient responses to varying drug dosages, providing a valuable tool for researchers and clinicians.
Researchers at the University of Liverpool have developed novel compounds targeting the glycine receptor to treat chronic pain without sedative effects. The project aims to create a safe and effective oral tablet, addressing a huge unmet medical need for 20% of adults in Europe and the US.
Researchers have discovered a new compound with significantly higher anti-HIV activity and improved binding affinity to the CXCR4 receptor. This breakthrough has potential for developing new, more effective drugs against HIV-1 infections and related diseases.
Researchers demonstrate a minimally-invasive method to deliver drugs and particles to the eye's suprachoroidal space, targeting diseases like macular degeneration. The technique has the potential to reduce side effects and improve treatment outcomes for chronic eye diseases.
A new approach to drug design, called the magic shotgun method, promises to help identify future cancer drugs that are more effective and have fewer side effects. This approach sifting through the known universe of chemicals to find special molecules that broadly disrupt the whole disease process.
Researchers at Universitat Autonoma de Barcelona have developed a new multitarget molecule, ASS234, which inhibits ß-amyloid protein aggregation, stimulates cholinergic and monoaminergic transmission, and crosses the blood-brain barrier. This molecule has shown promising therapeutic effects in patients with Alzheimer's disease.
A phase III clinical trial demonstrated sunitinib's effectiveness in treating resistant GIST tumors. The crossover design allowed patients to receive sunitinib after initial placebo treatment, protecting patient interests while maintaining rigorous proof of the drug's safety and efficacy.
Researchers at MIT have developed a device that delivers a variety of drugs through the skin without using needles, potentially improving patient compliance and reducing accidental needle-stick injuries. The device can be programmed to deliver different doses to varying depths, addressing limitations of existing jet-injection systems.
A new report emphasizes the importance of mathematics in industry, highlighting various applications such as business analytics and optimization, manufacturing design, and financial risk analysis. The report also stresses the need to connect academic, government, and industrial scientists to better meet real-world demands.
The Georgia Institute of Technology will develop an energy-optimized warehousing and distribution system for vaccines and drugs in developing countries. The project aims to minimize environmental impact, energy consumption, and storage costs by employing low-energy cooling techniques.
The US Department of Health and Human Services has contracted with Archimedes Inc. to provide the advanced mathematical modeling tool, ArcheS, to its agencies for large-scale analyses of healthcare spending, treatment, and effectiveness. This will enable policymakers to make informed decisions on health care interventions.
BIND-014, a novel Accurin nanoparticle, demonstrates high drug concentration in tumors and promising clinical effects in advanced or metastatic cancers. Preclinical data show up to ten-fold increase in intratumoral drug concentrations with prolonged tumor growth suppression.
Research discovered a protein complex called the Translocation and Assembly Module (TAM), which forms a molecular pump allowing bacteria to shuttle disease-causing molecules from inside to outside the bacterial cell. This finding paves the way for designing new drugs that inhibit this process, potentially preventing antibiotic resistance.
Researchers at Scripps Research Institute have determined the three-dimensional atomic structure of a human opioid receptor, a molecule that binds to opioids and is involved in pain, pleasure, addiction, depression, and related conditions. The findings could lead to the development of better medicine for these conditions.
A team of researchers at Duke University has determined the structure of a concentrative nucleoside transporter, which works by moving nucleosides from outside to inside of cells. This discovery may lead to more effective drugs with fewer effects on healthy tissue.
Two research teams report new findings on the structure of enterovirus 71, a virus causing hand, foot and mouth disease and potentially fatal brain swelling. Researchers propose designs for antiviral drugs to treat the infection by targeting a unique 'pocket factor' exposed in EV71.
Researchers at the University of Minnesota developed an antidote for cyanide poisoning called Sulfanegen, which can be administered rapidly by intra-muscular injection. The treatment could save lives in mass casualty emergencies and smoke inhalation incidents, where current treatments require medical professionals' expertise.
Researchers at Brigham and Women's Hospital share details of novel processes involved in a successful face transplant program, including rigorous screening and consent processes. The team also discusses early functional outcomes, immunosuppression protocols, and cost-effectiveness of the procedure.
Researchers at University of Warwick have found that the CPT1 enzyme has a switch controlling its activity, which can lead to better understanding of individual metabolic rates. This discovery may lead to development of drugs targeting specific patients with conditions like diabetic keto acidosis.
Researchers have discovered a blueprint for how Helicobacter pylori survives in the human gut by exploiting an enzyme called urease to neutralize gastric acid. Disrupting the formation of the molecular machine responsible for this process may lead to new drug targets to combat antibiotic-resistant ulcers and stomach cancer.
A cartoon character is being used to promote the use of tranexamic acid, a life-saving drug that is not being used enough. The animation, designed by Hywel Roberts, aims to increase awareness and uptake of the generic drug among healthcare professionals.
Researchers have developed a method to design drugs that can target specific areas of the brain by selectively blocking subtype SK channels. This breakthrough could lead to more effective treatments for dementia and depression by enhancing nerve activity in specific nerves.
Researchers at Sam Houston State University are developing new methods to detect designer drugs like 'bath salts', which can produce powerful and unpredictable effects. The study uses solid phase extraction, chromatography, and spectroscopy to identify beta-keto amphetamines in biological samples.
Health Canada should make clinical trials registration mandatory to increase transparency and protect consumers. The lack of openness about trial designs and results puts patients at risk, according to recent analysis.
Researchers at The Donald Danforth Plant Science Center have discovered that green tea polyphenols can control a deadly congenital disease by hijacking the ADP activation site. This finding has also been validated in two types of tumors, glioblastomas and tuberous sclerosis complex disorder, suggesting potential for drug development.
Researchers from the University of Melbourne have developed a new cold electron source that enables enhanced nanoimaging at the atomic or nanoscale. This technology will aid in designing better drugs and understanding material vulnerabilities, leading to advancements in health and advanced technology industries.
Researchers have identified potential human molecular targets of Nelfinavir, an anti-HIV drug also effective as a cancer therapy. The study suggests that the collective effect of weak interactions with multiple protein kinases leads to clinical efficacy.
Researchers at Scripps Research Institute found that an E. coli enzyme must move to function properly, and blocking these movements renders it defective. The study may lead to the development of more specific and effective drugs targeting enzymes.
The article discusses the resurgence of covalent drugs, which have made a major positive impact on human health, and highlights the potential of rational covalent drug design to expand their use. Several rationally designed covalent inhibitors are advancing in clinical development, addressing problems of drug-resistance mutations.
Scientists have engineered a protein fragment that prevents the AIDS virus from entering cells, offering a potential breakthrough in treating and preventing HIV/AIDS infection. The discovery is based on a naturally occurring protein called RANTES, which was modified to remove harmful effects while maintaining its therapeutic properties.
Researchers have gained insight into how 'tidying up' enzymes, like cytochromes P450, break down drug molecules. The study reveals that the oxygen transfer process can be influenced by three factors: molecular docking, oxygen-accepting ability, and enzyme pocket shape.
The UCSF team identified a few dozen chemical compounds that alter fat storage in worms, which may be useful for understanding metabolism in other organisms. The discovery demonstrates the value of worm screening as a way to find new targets for human diseases.
Scientists have discovered an important insight into carbohydrate bonding, which could lead to improved medicines. The study reveals the shapes of carbohydrates when they are free from external influence and interacting with neighboring molecules.
Researchers at the University of Warwick have developed a simple method to give microscopic polymer vesicles 'stealth' capabilities, allowing them to avoid the body's defenses while releasing drugs. The new armor is made from nanoparticles and has been successfully tested using a cryo electron microscope.
Scientists from the Victor Chang Institute have discovered a key clue to understanding why certain medications cause abnormal heart rhythms. By studying the hERG potassium channel, they found that many common drugs bind to this channel when the outer gate is closed, blocking ions and increasing the risk of arrhythmia.
Researchers have developed a more robust approach to functional magnetic resonance imaging (fMRI) that can improve the detection of neural activity and allow for more precise interpretations of fMRI data. This new technique involves three stages: prediction, modeling, and inference, which can turn noisy data into discrete sequences of ...
Australian researchers have developed a method to analyze X-ray scattering data from XFELs, enabling the measurement of membrane protein structures even with significant electronic damage. This breakthrough will help fast-track the development of targeted drugs.
Researchers at Avila Therapeutics have developed the first-ever covalent irreversible inhibitors of a viral protease, achieving high selectivity and potency. The newly designed compounds irreversibly bind to molecular domains specific to proteases, offering a promising therapeutic approach for hepatitis C infection.
The American Association of Pharmaceutical Scientists (AAPS) has named 18 individuals as its 2010 Fellows, honoring their remarkable scholarly and research contributions. The new fellows include researchers who have made significant advances in drug delivery, pharmacokinetics, and cancer therapy.
Researchers at Brown University and international partners have identified a potential Achilles Heel in the rare but deadly JC polyomavirus, which binds to a specific sugar molecule on brain cells. The discovery provides a powerful platform for developing new therapeutics to prevent infection.
A massive international study found no association between a genetic marker and the risk of coronary artery disease. The study analyzed data from over 17,000 patients with cardiovascular disease and 40,000 others, concluding that carrying a particular variant of the KIF6 gene does not indicate a greater risk for the disease.
Researchers at U-M are investigating adaptive clinical trials to improve the efficiency of clinical trials. The goal is to accelerate drug and device evaluation, improve safety for patients, and reduce costs. Adaptive clinical trials make adjustments based on accumulated data to identify effective treatments more accurately.
Onconova Therapeutics has agreed with the FDA on a Special Protocol Assessment (SPA) for its Phase 3 trial of Estybon in patients with myelodysplastic syndromes. The trial is expected to begin in Q4 2010 and will compare Estybon to Best Supportive Care.
Researchers have identified gamma-secretase activating protein (GSAP) as a key player in the formation of Alzheimer's disease-plaque beta-amyloid. Gleevec, a cancer drug, shows promise in targeting GSAP and reducing plaque production.
Researchers have collected venom from Antarctic octopuses for the first time, discovering four new species and uncovering unique properties. The study provides insight into the adaptation of venom to sub-zero temperatures, which could lead to breakthroughs in pain management, allergies, and cancer treatment.
A team of MIT chemists has designed a new way to attach trifluoromethyl groups to compounds, which could allow pharmaceutical companies to create and test new drugs faster and more efficiently. The new synthesis uses a palladium catalyst and achieved yields ranging from 70 to 94 percent.
Researchers found that pyruvate kinase enzyme is reduced in pregnant women, leading to a modified immune response. This discovery may lead to the development of drugs targeting pyruvate kinase activity to treat conditions like pre-eclampsia and rheumatoid arthritis.
A new study uses Nuclear Magnetic Resonance to predict how flexibility affects drug-like properties, enabling systematic manipulation of candidate drug molecules. The research aims to overcome issues of resistance, transportation, and oral bioavailability in drug design.
The National Institute of General Medical Sciences has granted $1.18 million to the University of Missouri to improve their protein prediction software, MULTICOM. The system can help scientists design drugs by predicting protein structures in diseases.
Researchers use powerful computers to identify molecular structures that have high potential as new medications by simultaneously targeting multiple hot spots on protein surfaces. This method has the potential to complement and increase efficiency of existing time-consuming methods.
Researchers at IRB Barcelona have developed a new method to study intrinsically disordered proteins, crucial for designing drugs against Alzheimer's disease and prostate cancer. The approach uses computational predictions and laboratory experiments to obtain structural information about dynamic proteins.
Researchers have designed an experimental drug called OSU-CG12 that kills cancer cells by choking off their energy supply. The agent targets a survival mechanism used by many types of cancer, and its efficacy is 10 times better than a comparable drug, resveratrol.