Articles tagged with Drug Design
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
National health systems play a crucial role in making progress in global health, according to Julio Frenk. Strengthening these systems can improve performance by addressing leadership, institutions, systems design, and technologies.
Researchers at Emerald BioStructures have developed new allosteric small molecule modulators of phosphodiesterase-4 (PDE4) with improved safety and efficacy. These discoveries validate the company's structure-based drug design capabilities for addressing previously undruggable targets in inflammatory diseases and cognitive impairments.
Researchers used computer search algorithms to identify fragments of FDA-approved drugs that could inhibit neuraminidase proteins, a key target for treating swine and avian influenza. The study suggests six compounds with potential as new medicines if emerging viruses develop resistance to current therapies.
Researchers developed a computer model to predict physiologically realistic drug delivery patterns from stents in branched arterial vessels. The model shows that spatial variation in drug distribution can be significant and may affect treatment outcomes.
Researchers design nanowire-based beads that release drugs in the gut, improving absorption and reducing degradation. The technology may also be used for delivering drugs to mucosal tissues like the nose, lungs, or vagina.
Researchers have developed a new drug, L803-MTS, that targets the GSK3 protein to prevent CNS diseases like Parkinson's and Alzheimer's. The compound slows down disease progression without exhibiting toxic side effects, offering a potential therapeutic approach for these devastating conditions.
The Wellcome Trust has awarded €2.8 million to the Laboratory for Virology and Experimental Chemotherapy at K.U.Leuven to search for new treatments for dengue fever, a viral disease prevalent in tropical and subtropical regions. Researchers will collaborate with the pharmaceutical industry to develop medications for this deadly virus.
Researchers developed an optimized mouthpiece design to reduce medication waste and improve drug delivery to the lungs. The new design allows for more medication to pass through the mouthpiece, ensuring effective delivery of future inhaled medications.
A new decision aid tool, developed by Mayo Clinic clinicians and designers, helps patients with type 2 diabetes make informed decisions about their medication. The tool, a set of cards, involves patients in the decision-making process and leads to better patient-centered care.
Scientists have discovered the atomic structure of an enzyme responsible for DNA replication in human mitochondria, which can cause harmful drug side effects. By targeting a different region of the enzyme, researchers aim to design more selective and less toxic anti-HIV drugs.
Researchers at Lund University have discovered that proteins change structure and stick together to form structures believed to underlie ALS. The discovery opens the possibility of designing drugs to prevent misfolding and its fatal consequences.
Researchers at the University of Pittsburgh School of Medicine have found that proteins have an intrinsic ability to change shape, allowing them to select the structure that permits the best binding. This discovery could lead to more effective treatment of diseases by designing compounds that target specific protein structures.
A team of MIT chemists has created a new synthesis technique that allows for the easy addition of fluorine atoms to aromatic compounds, commonly used in drugs. This breakthrough could lead to more flexible and cost-effective drug design and development.
Researchers from Stanford University School of Medicine propose requiring drug manufacturers to state how new medications compare with existing treatments. The proposed labeling would help patients and insurers make informed decisions about treatment options.
A new study has developed a combination of biochemical and MRI-based biomarkers that will improve the measurement of osteoarthritis progression. The aggregate cartilage longevity marker outperformed individual markers in diagnosis and prognosis, allowing for more effective treatment trials.
Researchers discover potential drugs that block the first step in the infection process, preventing flu viruses from infecting cells. This breakthrough could lead to a new genre of antivirals and be used to develop treatments for other medical problems.
A Monash University study has discovered a critical link between obesity and Type 2 diabetes, revealing that fat cells release PEDF, which triggers insulin resistance. Blocking PEDF reverses these effects, suggesting a potential breakthrough in treating the disease.
Researchers at the University of Minnesota Medical School have made a breakthrough in understanding how the commonly prescribed drug praziquantel works to treat Schistosomiasis. Praziquantel causes two-headed organisms by subverting normal regeneration, leading to the identification of key molecules that control its effects.
A TGen-led team has identified five genetic biomarkers that may predict response to the anti-diabetes drug Actos, enabling personalized medicine for patients with type 2 diabetes. These markers were found in genes associated with PPARG function and include variants in a key drug metabolizing gene called cytochrome P450 3A4.
Researchers at the University of Michigan have developed a new understanding of how chromosomes separate during mitosis, a crucial process in cell division. By manipulating chromosome size and observing its effect on movement, they validated the theory that polar ejection forces play a central role in guiding chromosome movements.
Researchers at Scripps Research Institute have discovered the structure of P-glycoprotein, a protein responsible for cancer cell resistance to chemotherapy. The study provides valuable insights into how P-gp transports substances out of cells and may lead to the design of more effective drugs.
The Journal of General Physiology explores the mysteries of TRP channels, which are crucial for various senses. The latest Perspectives series provides a comprehensive overview of their biophysics, protein structure, and gating processes, shedding light on areas in need of further exploration.
A new study by Brigham Young University researchers reveals how and where the rhinovirus genome evolves to evade the human immune system and drugs. The findings provide valuable insights for developing effective vaccines against this common cold virus.
Researchers have developed a new class of cancer drugs that target multiple signaling networks controlled by mitochondrial Hsp90, leading to effective tumor cell death in mice. This combinatorial drug design approach may prove more effective than targeting single signaling pathways.
Researchers developed small molecules targeting Hsp90 in mitochondria to induce tumor cell death. This combinatorial approach may be more effective than targeting single signaling pathways. Gene therapy also restored muscle strength in a mouse model of muscular dystrophy by anchoring nNOS to the sarcolemma.
CSIRO's DAC microscopy method measures proteins in solution, allowing accurate dimensions of membrane receptors to be taken. This will help drug companies design more effective pharmaceuticals by understanding the complex structures of these molecules.
Researchers explore approaches to preserve BBB function and permit effective medicine passage. One technology involves targeting endogenous nutrient transporters, such as SLCs, to facilitate small molecule transport across the BBB.
A study published in Health Affairs found that seniors in Medicare's doughnut hole gap reduced their medication use by 14% per month. The authors suggest mandating generic drug coverage to protect seniors and prevent potential healthcare costs from hospitalizations and physician visits.
Researchers at Oklahoma State University have made a significant breakthrough in understanding how poxviruses evade the human immune system. By unlocking the structure of a key protein, they may be able to design medications to stop the viruses from blocking immune signals.
Several herbal remedies commonly used for menopausal symptoms, such as black cohosh and red clover, lack strong evidence supporting their effectiveness. The study highlights the need for better-designed trials to assess the safety and efficacy of these herbal products.
A phase III trial found sorafenib to be effective in increasing overall survival by 6.5 months compared to 4.2 months in the placebo group, and prolonged time to progression and disease control rate. Sorafenib was generally well-tolerated with some side effects.
Researchers are exploring new techniques to combat visual impairment and blindness by delivering drugs through the eye. Alternative methods such as microneedles, nanoparticles and polymer carriers are being investigated to improve drug delivery and reduce side effects.
A team of researchers argues that the success of ACT in curing malaria demands a new approach to assessing new antimalarial drugs. The authors discuss the design and interpretation of clinical trials for new antimalarial drugs, emphasizing the need for improved efficacy and public health utility.
A new study by Rice University bioengineers provides a comprehensive mathematical analysis of virus evolution, incorporating gene swaps and recombination. The results suggest that designing drugs that force viruses to mutate themselves out of existence may be possible, potentially eradicating disease.
Researchers have identified five compounds that block the activity of the trypanosomal REL1 enzyme, which is crucial for the parasite's survival. The approach uses computational tools to predict the dynamics of proteins and test hundreds of compounds for their ability to inhibit the enzyme.
According to a study published in JAMA, approximately one in four approved biological medicinal products had at least one safety-related regulatory action issued 10 years after their approval. The average time to a safety-related regulatory action was 3.7 years, with 70.7% of actions occurring within five years after approval.
Researchers at IRB Barcelona and ICIQ have designed a compound that can stabilize the p53 protein, even when it has mutations that promote cancer. The study opens up a new approach for developing anti-tumor drugs.
The University of Michigan is developing the Community Structure-Activity Resource (CSAR) database, a centralized repository of experimental data on drug-making compounds. This resource will improve computer programs that predict drug effectiveness and significantly impact the drug development process.
A new Web-based resource is being developed to provide molecular data needed for computer-aided drug design. The resource aims to improve the prediction of potential drug candidates and advance biomedical research.
Scientists at Leiden University have discovered that receptor models commonly used in drug design may not be accurate, leading to a better understanding of how drugs work. The adenosine A2A receptor's crystal structure has been cracked, revealing a small molecule called ZM241385 with high affinity for the receptor.
Researchers at Penn State found that smaller grains require less force to initiate movement through sandy soils than larger ones. This discovery could lead to more efficient designs for power-line towers and industrial mixer blades in sandy environments.
Researchers at Duke University Medical Center discovered that two common beta-blockers can stimulate a pathway that promotes cell survival and protects heart tissue. The study finds that alprenolol and carvedilol may have greater potential to repair the heart and prevent further damage.
Scientists have uncovered the 3D structure of Mps1, a protein that regulates chromosome number during cell division and prevents cancer. The discovery will help design safer and more effective therapies.
Researchers found that calmodulin uses two lobes to sense local and global calcium levels, allowing it to detect fluctuations within cells. This discovery sheds light on the universal means of communication in cells and has implications for understanding neural diseases.
Researchers are developing novel hit-to-lead drug discovery strategies utilizing a combination of high-throughput screening, miniaturization, and advanced data analysis. This approach enables the identification of promising compounds with increased efficiency, leading to faster and more effective disease treatments.
The OptiNose Phase II study demonstrated that its nasal device combination achieves rapid and efficient migraine relief without needle-stick injuries. The results show that 74.3% of patients experienced headache relief within 60 minutes and 83.8% after 120 minutes.
A single VSOP protein can carry protons, regulating pH conditions during pathogen removal, and may aid in designing new medications for innate immunity enhancement.
Researchers at Montana State University have created the first three-dimensional map of the Steap3 protein, which regulates iron absorption. This breakthrough could lead to the development of targeted drugs for hemochromatosis and iron deficiency conditions.
Researchers at Mount Sinai School of Medicine have discovered a new window into the brain, revealing how addictive drugs trigger permanent changes in brain cells. The study's findings provide clues for targeting addiction with new drugs.
Giuseppe Di Benedetto and Micaela Caramellino received top scores at a student poster event for their innovative methods in manufacturing small drug particles. Their research has been recognized with grants from the National Science Foundation.
A study by researchers at the University of Toronto found that individuals with a specific enzyme deficiency may be protected from severe and fatal malaria. The enzyme pyruvate kinase plays a crucial role in energy production and its deficiency is linked to protection against malaria infection.
A new medication, pimecrolimus, failed to reduce arterial renarrowing after stenting, while a multi-reservoir stent design with the drug delivered better outcomes. The study used a combination of pimecrolimus and paclitaxel for comparison.
A new study has revealed in high definition how a blood protein gives blood clots their elasticity. Fibrinogen molecules form elastic fibers that seal the vessel, with cells like platelets filling the gaps. The protein's flexibility can be enhanced or altered by changing calcium levels or pH.
A team at CSHL led by Professor Leemor Joshua-Tor discovered a new wrinkle in the regulation of gene expression that governs metabolic state in yeast cells. The discovery revealed a key role for the NADP molecule in adapting to changes in nutritional environments.
A new chemical synthesis method based on a rhodium-based catalyst has the potential to dramatically improve the design and production of new drugs. The catalyst can produce large quantities of pharmaceutical products with unprecedented structural entities, making it an enabling technology for drug discovery.
Researchers developed a fast-acting antidote to cyanide poisoning that works in under three minutes and can be taken orally, giving emergency responders more time to respond. The new antidote has been tested on animals and shows exceptional effectiveness.
A recent study published in Nature captures enzymes in motion, revealing they engage in a dynamic dance before catalysis occurs. The research, led by Dr. Dorothee Kern, uses advanced techniques to document the tiny changes in enzyme shape and structure.
Texas A&M researchers Frank Raushel and Ricardo Marti-Arbona use molecular docking to predict enzyme function based on structure alone. The team's method ranks molecules by fit and scores them for physical testing, offering a faster alternative to existing methods.
Scientists at Northwestern University are mapping parts of lethal bacteria in three dimensions, exposing a fresh opening into the bacteria's vulnerabilities. This view will enable scientists to create drugs to disable or vaccines to prevent deadly infectious diseases such as anthrax, plague, and Ebola.
A new study using the Driving Reliability and Error Analysis Method (DREAM) found that four scenarios contribute to single-vehicle crashes: driver fatigue, loss of traction on slippery roads, overestimation of driving skills, and panicked steering. Vehicle safety features can now be designed to compensate for these unpredictable factors.