Scientists at Cancer Research UK Scotland Institute and University of Glasgow identify a new pathway for delivering antisense oligonucleotides (ASOs) into cells, enhancing the effectiveness of ASO-based therapy for pancreatic cancer and other diseases. The researchers found that ASOs enter cells via endocytosis and bind to specific rec...
SourceRockefeller University Press·JournalJournal of Cell Biology·TypeExperimental study·DateAug 11, 2026
A research team from Göttingen University has discovered that antisense RNA (asRNA) plays a crucial role in cell transport, allowing cells to accelerate gene expression and produce proteins quickly in response to environmental stress or harm. This new understanding sheds light on the function of asRNAs and their potential link to disea...
SourceUniversity of Göttingen·JournalNature·TypeExperimental study·DateJun 24, 2024
Researchers developed a modified sugar that increases the effectiveness and safety of antisense oligonucleotides, a treatment strategy for central nervous system disease. The modification, called BNAP-AEO, decreases toxic side effects while improving gene silencing in brain cancer cells and mice.
SourceTokyo Medical and Dental University·JournalMolecular Therapy — Nucleic Acids·DateMay 22, 2024
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A study published in eLife reveals that a small signalling protein called ARL4C is overexpressed in pancreatic cancer patients, facilitating their aggressive behavior. By inhibiting ARL4C, researchers have shown promise in reducing the spread of pancreatic cancer cells, opening up new therapeutic avenues.
SourceOsaka University·JournaleLife·TypeExperimental study·DateNov 29, 2021
Researchers at Northwestern University have developed a new method to deliver antisense cancer drugs using gold nanoparticles, outperforming conventional agents. The nanoparticles improve stability, binding efficiency, and cellular uptake of the DNA, resulting in enhanced gene knockdown and lower toxicity.
SourceNorthwestern University·JournalScience·DateMay 18, 2006
Researchers at Thomas Jefferson University have developed a new gene therapy system that uses DNA and bacterial proteins to deliver genes to specific places in human DNA, avoiding viruses and their associated immune reactions. The technique shows promise for treating genetic diseases such as hemophilia and sickle cell anemia.
SourceThomas Jefferson University·JournalGene·DateAug 21, 2000
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Scientists at the University of Rochester have discovered that shape plays a crucial role in copying DNA, contradicting previous theories that relied on hydrogen bonds. This finding has significant implications for cancer diagnosis and potential applications in artificial DNA creation.
SourceUniversity of Rochester·JournalNature·DateJun 16, 1999