Articles tagged with Biomolecules
Researchers have repurposed a bacterial DNA synthesis system to enable DNA to act as an active 'field agent' inside living cells. This allows for the creation of programmable DNA fragments that can regulate gene expression and control protein behavior.
The review highlights LRRK2's diverse cellular functions and pathogenic mechanisms in various diseases, including Parkinson's disease and inflammatory disorders. Therapeutic strategies targeting LRRK2, such as kinase inhibitors and emerging approaches like PROTACs and gene therapy, show promise for correcting cellular imbalances and re...
A new imaging technique, Lipid-CLEM, has revealed the detailed organization of lipids in cellular membranes at the nanoscale. The technique allows for 3D visualization of lipid densities in membrane nanodomains, providing insights into lipid sorting and behavior within complex cellular structures.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Engineers at the University of Pennsylvania have developed LIBRIS, an automated microfluidic platform capable of generating lipid nanoparticle formulations at high speed and scale. This enables the creation of large, systematic datasets needed to train predictive AI models, accelerating the design of lipid nanoparticles for mRNA delivery.
Researchers have identified three new proteins, called epitopes, that help the body determine 'safe' foods, aiding in food tolerance and allergy understanding. The epitopes were found in seed proteins from corn, wheat, and soybean, and interact with regulatory T cells to inform tolerance-or-rejection decisions.
A new Cochrane review found that sucrose can effectively reduce pain in newborn babies during painful procedures like venepuncture. The study examined 29 clinical trials involving over 2,700 babies and showed that a small amount of sucrose given before the procedure significantly reduces pain when combined with non-nutritive sucking.
A team of scientists at the University of Sydney has discovered how three naturally occurring antibiotic compounds disrupt the ClpC1–ClpP1P2 complex, a vital protein degradation machine in Mycobacterium tuberculosis. This finding uncovers surprising complexity and provides valuable insight into designing more effective anti-TB treatments.
Researchers show enzymes can actively shift reactions away from equilibrium, controlling directionality and fine metabolic regulation. Enzyme diffusion enables 'memory' of past reaction events, driving system to new steady state.
Actin filaments and a fast plant motor protein called Chara corallina myosin XI (Cc XI) were combined to observe spontaneous ring formation. The rings rotated continuously in one direction and remained fixed, even as individual filaments moved within them.
Researchers have discovered that the Japanese scarab beetle uses mirror-image pheromones to distinguish between potential mates. The discovery could lead to improved monitoring and control methods for this invasive species.
Researchers have developed a device that cuts sample consumption by as much as 97% while producing high-quality structural data for X-ray crystallography. This innovation enables the study of rare proteins and accelerates drug discovery, unlocking new insights into disease mechanisms.
Recent advances in biomolecular archaeology enable museums to convert molecular data into accessible olfactory recreations. The Max Planck Institute research team developed a workflow for translating ancient chemical signatures into visitor-ready fragrances.
RNA droplets promote reduction and oxidation reactions, crucial for life, according to UC Santa Barbara researchers. The findings support the idea that these droplets acted as proto-enzymes, enabling the development of more complicated organic molecules.
A team of researchers from Chiba University discovered the structural evolution of poloxamer mixtures at different temperatures, enabling customized gelation behavior. Their findings support precise design of sustained-release formulations for localized therapies, enhancing drug retention and minimizing side effects.
Researchers have developed a new AI method called Riff-Diff to construct artificial biocatalysts, resulting in enzymes that are significantly faster, more stable and versatile. The technology allows for precise design of protein structures around active centres, making enzyme design more accessible to the wider biotechnology community.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
Researchers deciphered the structure of Tau proteins' fuzzy coat using nuclear magnetic resonance spectroscopy, revealing its dynamic regions and rigid core. The findings provide insight into how Tau proteins form tangles in the brain, which contribute to neurodegenerative diseases like Alzheimer's.
A recent study using Drosophila as a model organism reveals the involvement of linear ubiquitination in T-tubule biogenesis. The findings highlight LUBEL's role in triggering Amph-mediated T-tubule formation, which promotes membrane tubulation and curvature through self-ubiquitination and positive feedback loops.
Researchers develop experimental drugs that encourage mitochondria in cells to work harder and burn more calories. The findings offer a framework for designing safe and effective weight-loss treatments with potential benefits for metabolic health and neurodegenerative diseases.
The NAC protein complex regulates protein synthesis by slowing down the early stages of protein formation to ensure a smooth process. This optimization allows for reduced risk of collision and coordinates subsequent folding and logistics processes.
A novel microfluidics technology has been developed to produce highly uniform DNA condensates using a simple vibration platform. This approach enables precise control over condensation within a single aqueous phase, preserving biomolecular activity.
Researchers from Tokyo University of Science developed an efficient strategy to synthesize PROTACs using a three-step click chemistry method. This approach rapidly assembles functional molecules, enabling the easy introduction of ligand components and probe functionalities.
Scientists at Leibniz-HKI discovered an enzyme called BurK that cleaves the toxic molecule malleicyprol in human pathogenic bacteria. This mechanism regulates toxin levels and renders it harmless to humans, offering a potential therapeutic approach for antibiotic-resistant infections.
A study published in Science Signaling has identified the MRAP2 protein as a key player in supporting the function of appetite-regulating proteins MC3R and MC4R. The findings suggest that mutations in this protein may contribute to reduced energy balance and obesity risk.
Researchers developed a new way to stimulate the immune system to attack tumor cells by blocking an immune checkpoint. They created multifunctional molecules called AbLecs, which combine a lectin with a tumor-targeting antibody, and showed they could boost the immune response to cancer cells.
A new study suggests that sweat can reveal information about a person's health, including hormone levels, medication doses, and early detection of diseases like diabetes and cancer. Wearable sensors using artificial intelligence can detect specific metabolites in sweat, providing personalized health insights.
Researchers achieved hydroxyl groups esterification and lignin dissolution through a two-hour pyridine-benzoyl chloride bath. The resulting fibers became photobleaching and stable under accelerated weathering, with a 15-unit ΔE* swing and 96% plunge in tensile strength.
Researchers at the University of Gothenburg discovered that grey seal milk contains approximately 33% more sugar molecules than breast milk, including unique and powerful compounds against disease-causing bacteria. These findings could lead to improved infant formula and potential applications in human health.
A new broad-spectrum antivenom developed by DTU researchers covers 17 African snake species and provides better protection against tissue damage, with a lower risk of immune reactions. The antivenom has shown impressive results in laboratory studies and could revolutionize the treatment of venomous snakebites in Africa.
Researchers have developed new calcium channels that can be precisely controlled to study cellular signaling. The channels, built using artificial intelligence, were designed to mimic natural calcium channels and demonstrate their potential as tools for biomedical research.
Researchers at Nagoya University have developed a new technology that improves protein production efficiency in E. coli by reducing ribosome stalling. By identifying short translational-enhancing peptides, they created an AI prediction model to accurately predict translation enhancement strength for all 160,000 possible tetrapeptides.
A team of researchers developed a computational method that can design intrinsically disordered proteins with desired properties. The work uses automatic differentiation to optimize protein sequences and leverages molecular dynamics simulations for precision. This breakthrough has the potential to reveal new insights into diseases like...
The study reveals why some peptides are more effective and why certain bacterial cells are more vulnerable to membrane disruption. The findings provide a mathematical equation to identify optimal properties for efficacy, opening the door to designing novel compounds against antibiotic-resistant bacteria.
Researchers at the University of Basel discovered that certain RNA molecules in food can prevent harmful protein aggregates that drive aging and disease. A balanced diet promotes healthspan and activates quality-control mechanisms to protect against cellular stress.
A new study reveals how pathogenic bacteria construct Eut microcompartments to digest ethanolamine, a nutrient commonly found in the gut. Understanding their assembly offers new targets for antimicrobial therapies.
Researchers discover two distinct methods for producing psilocybin in mushrooms, one in Psilocybe species and another in fiber cap mushrooms. The finding sheds light on convergent evolution and the unique biochemical strategies employed by fungi to produce the same molecule.
Migrasomes, discovered in 2015, are cellular structures formed along cell migration trails carrying cargo such as nucleic acids and proteins. They play dual roles in processes like organ development and immune regulation, offering new insights into disease mechanisms.
Researchers review nuclear receptor role in brain cancer development and explore their potential as therapeutic targets. Modulating these receptors with selective agonists or antagonists may offer new avenues for therapy, such as blocking androgen and estrogen receptors.
Researchers developed a novel biomaterial called elastin domain-derived protein (EDDP) that overcomes natural elastin limitations. EDDP promotes cell adhesion and growth, aiding tissue regeneration in damaged tissues like heart valves, blood vessels, or torn ligaments.
Researchers from EPFL and MIT discovered that amino acids have a fundamental stabilizing effect on colloids in solution, not related to biology but rather a general property of small molecules. This finding has implications for controlling molecular interactions and may lead to more precise predictions of protein stability.
Researchers developed photo-inducible binary interaction tools (PhoBITs) to precisely control gene expression, cell signaling, and immune responses. PhoBITs enable targeted treatment with minimal side effects, opening new avenues for cancer therapy, immunotherapy, and regenerative medicine.
Researchers Jeremy McCormack and Andrei Kuzhelev at Goethe University are investigating the reasons behind prehistoric shark extinctions using new isotopic analysis methods. They also develop a novel nuclear magnetic resonance spectroscopy technique to study large biomolecules.
A team of Virginia Tech researchers has discovered new insights into blood thinners and bone builders, heparin. The findings may lead to designing safer and more reliable heparin therapies. Heparin's molecular composition affects its ability to bind calcium, influencing its effectiveness in biomineralization and blood clotting.
Researchers found that polyamines primarily activate glycolysis in cancer cells, upregulating eIF5A2 and five ribosomal proteins associated with cancer malignancy. In contrast, eIF5A1 promotes healthy aging by activating mitochondria via autophagy.
Angel Martí, David Sarlah, and Haotian Wang have been honored with national American Chemical Society awards for their outstanding work in chemistry. The ACS awards recognize individuals who not only advance the field but also inspire students from underrepresented backgrounds to pursue careers in chemical sciences.
Researchers at RIKEN have developed a mechanochemical method to increase hydrogen saturation in perovskite powder, doubling its capacity. This discovery has significant implications for environmental sustainability and the potential for a hydrogen-based economy, as it enables more efficient production of ammonia fertilizer.
Researchers at Cornell University developed an implant system that can treat Type 1 diabetes by supplying extra oxygen to densely packed insulin-secreting cells, enabling long-term treatment for chronic diseases. The system could also potentially provide treatment for other autoimmune diseases.
Newly developed DNA nanostructures form flexible, fluid, and stimuli-responsive condensates without chemical cross-linking. These findings pave the way for adaptive soft materials with potential applications in drug delivery, artificial organelles, and bioengineering platforms.
Researchers validated panels of antibodies targeting clinically relevant nucleic acid modifications to visualize antisense oligonucleotides in both in vitro and in vivo studies. The tools enable detection of modified nucleic acids irrespective of sequence, facilitating multiple clinical and pre-clinical workflows.
Tetrandrine modulates autophagy by selectively removing damaged lysosomes through lysophagy while promoting new lysosome formation. This unique mechanism highlights tetrandrine's therapeutic potential for treating neurodegenerative diseases.
Researchers found that vitamin D supplementation reduces liver inflammation and fibrosis in patients with chronic liver disease by upregulating the TXNIP gene in ductular cells. The study provides new insights into the underlying mechanisms of liver diseases and offers a potential therapeutic target for improving outcomes.
Complex organic molecules, precursors to life's building blocks, have been found in a planet-forming disc around the outbursting protostar V883 Orionis. This discovery supports the idea that life's seeds are assembled in space and are widespread.
Polyphenols are multifunctional agents with anti-inflammatory, antioxidant, microbiota-modulating, and neuroprotective properties. The Polyphenols Applications 2025 congress explores novel applications of polyphenols in various fields.
A novel AI-based approach identifies a distinct physicochemical signature near the cleavage site of gamma-secretase substrates, revealing dynamic properties essential for molecular recognition. The study highlights the potential of this methodology to improve understanding of gamma-secretase's role in diseases and aid drug development.
A research team led by Professor Joongoo Lee successfully expanded ribosome range to produce ring-shaped backbones in proteins. This breakthrough could open doors to novel therapeutics and advanced biomaterials.
Insilico Medicine's latest Pharma.ai updates showcase advancements in Biology42 and Chemistry42, enhancing antibody design and omics data analysis. The company's AI software suite has demonstrated significant efficiency improvements in practical applications, setting a benchmark for AI-driven drug research.
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
Research presents fig tree species storing calcium carbonate in trunks, converting CO2 from atmosphere. The oxalate-carbonate pathway increases soil pH and nutrient availability, making it a potential means to mitigate CO2 emissions.
Researchers developed a technique to peer inside the nucleolus and reveal its hidden system of creation, allowing them to watch RNA molecule movement and track protein-making machine assembly. The new method uses advanced imaging and genomics techniques without destroying the cell, providing a precise spatial and temporal map.