Articles tagged with Biomolecules
Researchers developed long-lived biological computers using RNA, which can persist inside cells. Unlike DNA-based devices, these RNA circuits are dependable and versatile, enabling continuous production in living cells.
Autophagy is induced when ER-bound ribosomes are stalled, rescuing them from cellular harm. The ERC grant aims to decipher the role of Autophagy in rescuing stalled ER-bound ribosomes.
Researchers have identified a previously unknown bacterial enzyme that can produce a new type of biodegradable polysaccharide called acholetin. Acholetin has wide-ranging potential as a biocompatible, biodegradable material for biomedical applications.
Researchers uncover the pleiotropic functions of hnRNPK in regulating skeletal muscle cell differentiation, including inhibition of myoblast differentiation and suppression of genes involved in endoplasmic reticulum stress. The study suggests that targeting hnRNPK could be a potential therapeutic strategy for treating human disorders.
Researchers have identified a novel enzyme that catalyzes the formation of glycosidic bonds in complex sugar moieties. The discovery provides fresh insights into carbohydrate metabolism and offers a breakthrough for the synthesis of sugar chains, which play key roles in various biological processes.
A team of scientists from Martin-Luther-University Halle-Wittenberg and the Max Planck Institute discovered the essential final step in mRNA production. The process involves 16 proteins that precisely control the structure of mRNA, which determines protein function and disease risk.
Researchers analyzed over 1.5 million SARS-CoV-2 genome sequences to understand the evolution of the virus, finding that increased infectivity is a driving force behind its spread. The omicron variant is predicted to compromise current vaccines and therapies, highlighting the need for new generation of vaccines and monoclonal antibodies.
A new protein group has been identified that functions as a switch to regulate biological activity, found in all domains of life and essential for cellular activities such as gene expression and metabolism. The discovery opens up new possibilities for the development of novel drugs targeting these switches.
Researchers developed Inducible Directed Evolution (IDE), a new technique for controlling directed evolution in bacteria, allowing up to 30 gene modifications at a time. This approach enables finely tuned changes to bacteria, making it suitable for biopharmaceutical and chemical manufacturing industries.
Markita del Carpio Landry, a young immigrant scientist, receives the Vilcek Prize for Creative Promise for her groundbreaking research on neurochemical communication and gene-editing technologies. Her work aims to address medicine's most compelling problems, including aberrations in neurotransmitter signaling.
Researchers have discovered that the tumor suppressor protein pVHL degrades SMAD3, inhibiting the TGF-β signaling pathway and suppressing tumour cell growth. This finding opens up new opportunities for developing cancer therapies by regulating pVHL activity.
A study led by Przemyslaw Nogly at PSI has detailed insight into the mechanism of a light-driven chloride pump in bacteria, revealing how light energy converts to kinetic energy and transports chloride ions inside cells. The pump uses two molecular gates to ensure one-way transport, with the process taking around 100 milliseconds.
Researchers used microscopic strands of DNA to guide the assembly of gel blocks that self-assembled in around 10-15 minutes. The process was highly specific and easily programmable, allowing the blocks to interact with each other in different ways by changing the sequence of DNA.
Scientists have discovered families of proteins that can predict liver transplant rejection, allowing for early detection and modification of immunosuppression. The Blood Proteoform Atlas outlines over 56,000 protein molecules associated with immune cell proteins that change with rejection.
Researchers have developed a combination of materials that can morph into various shapes before hardening, similar to the natural process of bone development in the human skeleton. The soft material can be used to create microrobots that can inject themselves into complicated bone fractures and expand to form new bone.
Phages weigh all options and make an informed decision whether to exit the dormant state and attack their bacterial host. The study found that some phage families have developed a complex decision-making strategy, receiving information from neighboring bacteria and controlling communication via arbitrium.
Scientists have observed that ionizing radiation can cause intermolecular Coulombic decay in organic molecules, leading to damage in DNA and proteins. This new understanding could lead to the development of more effective substances for radiation therapy and improve knowledge of how radiation damages healthy tissue.
A new study from Karolinska Institutet and the University of Helsinki reveals how integrating digital tools, classical laboratory tests, and biomolecular measurements can enable individualized disease prevention. The researchers also found significant correlations between health risks and molecular factors associated with overweight, d...
Researchers have developed plant-based gummy candies packed with vitamins B12 and D3, addressing nutritional deficiencies in vegan and vegetarian diets. The new product was well-received by taste testers, paving the way for more nutritious food options.
Researchers have developed a method to study proteins at their physiological temperatures by applying microscopic pulsed heating. They found that a critical protein complex regulating cell motility and morphology exhibits cooperative regulation of actin-myosin interaction by drebrin E, which is temperature-dependent.
Researchers at the Leibniz Institute for Food Systems Biology have identified the 'caramel receptor', which recognizes furaneol, a natural odorant found in fruits and coffee. This discovery contributes to a better understanding of molecular coding of food flavors.
Researchers have developed a new interface technology that can provide natural sensory feedback from robotic prosthetics to amputees, reducing abnormal sensations and cognitive burden. The innovation uses ultra-small recording sites and molecular guidance cues to stimulate sensory axons selectively, improving control of robotic limbs.
Researchers at Georgia Institute of Technology developed improved carbon membranes that can efficiently separate para-xylene from its siblings, reducing energy consumption by up to three times. The breakthrough could lower energy costs in producing commodity chemicals and fuels.
Researchers developed an AI tool that can quickly and accurately identify suspicious proteins in the body by analyzing their movements. The method, known as diffusional fingerprinting, uses machine learning algorithms to predict protein behavior with over 90% accuracy.
Flipon genetics proposes that evolution happens on a faster time scale than Darwin imagined, with rapid adaptations occurring in real-time within individuals. This is achieved through the simple sequence repeats of DNA, which can adopt alternative shapes and transmit adaptations to offspring.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
Distinguished Professor Sang Yup Lee at KAIST was elected as a foreign member of the Royal Society, one of the world's most prestigious national science academies. He is recognized for his pioneering work in systems metabolic engineering and developing micro-organisms for producing fuels, chemicals, and natural compounds.
Researchers developed a rapid detection method for SARS-CoV-2 using LAMP-based COVID tests that provide results in under an hour. These tests are designed to be used by non-experts in public spaces and workspaces, offering a convenient solution for early detection and response.
Prof. Thomas H. Epps, III has been elected to the AIMBE College of Fellows for outstanding contributions to self-assembly of polymeric materials for drug delivery and gene therapy applications. He will join a group of top medical and biological engineers in the US.
Research suggests that weathered microplastic particles are 10 times more likely to be internalized by mouse cells than pristine particles. The formation of a biomolecular crust on the surface of microplastics enhances their ability to be engulfed by cell membranes, potentially leading to inflammation and health risks.
Takashi Kozai aims to design a coating technology that can control neuron activity using biomolecules. The goal is to establish the relationship between different types of stimulation and their impact on excitability, which could improve BCI technology for rehabilitation of neurodegenerative diseases.
Scientists have developed a new imaging technique that allows for fast and precise tracking of biological molecules using gold, silver, and gold-silver alloy nanoparticles. This breakthrough enables the visualization of molecular movements in unprecedented detail, opening up new avenues for understanding cellular processes.
Conjugated polymers are stretched and flattened using polymer printing, enabling better charge transport. The new method produces flat conjugated polymers with exciting optoelectronic properties.
A team of scientists discovered that the elasticity of gels arises from the packing of clusters of particles in the gels. The researchers used graph theory to identify the boundaries between these clusters, which act as rigid units within the gel, determining its elastic modulus.
Researchers from OU and Smithsonian National Museum of Natural History are addressing the challenges of curating ancient biomolecules. The team is working toward the development and dissemination of best practices for museums in this field.
Scientists at University of Gættingen have developed an environmentally friendly strategy for drug and pesticide production, leveraging the properties of naturally occurring non-toxic metal manganese. The new approach reduces waste and uses water instead of toxic solvents.
Clemson University's new program aims to recruit doctoral students from underrepresented groups to become professors in chemical engineering. The goal is to create a diverse generation of educators who will serve as role models for women and minority students.
Researchers at Purdue University have developed a new flexible, transparent biopatch that can deliver exact doses of biomolecules directly into cells, expanding observational opportunities. The patch, which is minimally invasive, can also treat cancerous tissue, making it a potential breakthrough in healthcare.
A University of Akron engineer is working on antifouling materials to prevent unwanted organisms from accumulating on medical implants. This can help reduce the risk of foreign body reactions and improve patient outcomes.
Researchers developed a microfluidic technique to monitor specific biomolecules, indicating the health of living cell cultures. The technique uses electrospray ionization mass spectrometry and can detect low concentrations of biomolecules, guiding process control and improving quality control in cell manufacturing.
Benjamin Fingerhut, a junior group leader at the Max Born Institute, has been awarded the prestigious ERC Starting Grant to study ultrafast biomolecular dynamics. The project aims to elucidate fundamental processes in biological systems using innovative non-adiabatic approaches.
Professor Lee recognized for his work on metabolic engineering to develop sustainable chemical materials, with notable research in drug-drug and food interactions using AI and novel enzymes. He is the second Asian recipient of the prestigious award, honoring Professor Peter V. Danckwerts.
Researchers developed a high-resolution mass spectrometry imaging system capable of analyzing live biological samples at a resolution of several micrometers. The system uses femtosecond lasers and plasma jets to ionize biomolecules, allowing for accurate analysis without chemical pretreatment.
Researchers have developed graphene nano tweezers that can efficiently trap individual biomolecules, opening up new possibilities for point-of-care diagnostics. The technology has the potential to be miniaturized into a single microchip and operate on portable devices like smartphones.
The NSF grant will enable Lehigh to acquire an E-XPS instrument, giving researchers unparalleled access to surface elemental composition and chemical state information. This capability will overcome limitations of traditional XPS instrumentation, advancing the fundamental science and design of advanced functional materials.
Researchers at KAIST have developed a novel fabrication technology to produce superomniphobic surfaces that can repel liquids, including water and oil. The new approach uses localized photofluidization of azobenzene molecule-containing polymers, resulting in a superior superomniphobic property.
Researchers at Johns Hopkins University developed a system that considers cellular and molecular factors to determine functional age of cells. The results show that biophysical qualities of cells, such as movement and structural features, are better measures of functional age than other factors.
Professor Sang Yup Lee was elected as a foreign associate to the US National Academy of Sciences (NAS) and previously to the US National Academy of Engineering (NAE). He is the first Korean to be elected to both prestigious academies, recognized for his leadership in microbial biotechnology and metabolic engineering.
Researchers use ultra-bright X-ray light to ionize a molecule, creating a 'molecular black hole' that explodes within a trillionth of a second. The study provides crucial information for analyzing complex molecules with X-ray lasers.
Researchers at OIST have created a novel sensor that detects biomolecules more accurately than ever before, using the additional function of measuring mass. This allows for more confident encapsulation of disease-detecting biomolecules within microfluidic platforms.
For the first time, a biodegradable polymer coating has been synthesized using chemical vapor deposition, addressing a long-standing gap in degradable implant coatings. The coating's degradation rate can be controlled by adjusting the ratio of monomer types and side groups.
Mesenchymal stem cells exhibit significant cell-to-cell variation in their capacity to survive upon implantation. The Tulane professor's three-year project aims to gain insight into the molecular mechanisms underlying this variation, with the goal of improving survival rates and advancing regenerative therapies.
Researchers at Bielefeld University have developed an open source software solution to process raw data from ultra-high resolution fluorescence microscopy. This technology allows for the attainment of higher resolutions than physical limits, enabling the study of dynamic processes in living cells.
Scientists at NIST create non-invasive technique to map trapped light vibrations and fine-tune resonator frequency, enabling ultrasensitive sensors and identical resonances. The focused lithium-ion-beam technique allows for high-resolution imaging without disturbing near-fields.
A special issue of Future Science OA examines nitric oxide's role in human biology, its challenges in quantification, delivery, and generation, as well as its applications in cancer and cardiovascular diseases. The publication aims to stimulate discussion and further research on harnessing NO's therapeutic potential.
Actin filaments exhibit complex behaviors, including self-organization and active motion. New research reveals that molecular motors play a crucial role in forming strong bends and enabling collective motions.
Researchers developed a smartphone sensor using surface plasmon resonance to detect biomolecules, including those for pregnancy testing and diabetes monitoring. The sensor is tiny, affordable, and comparable in sensitivity to current equipment.
The FASEB MARC Program has selected four students and postdoctorates from underrepresented groups to receive travel awards. The awards totaled $7,400 and aim to promote diversity in the biomedical research community. The recipients include Hamid Hussaini, Ibrahim Osumanu, Isavannah Reyes, and Kimberly Herard.
Researchers used X-ray laser to capture PYP photocycle with atomic spatial resolution and ultrafast temporal resolution. The study revealed finer details of the cycle, including steps shorter than 1 picosecond.
Researchers have developed a microfluidic technique to fabricate molecular sieving membranes inside hollow polymer fibers, offering a potential solution to large-scale energy-intensive chemical separations. The new process could cut costs and reduce carbon dioxide emissions in industries such as petrochemicals.