Articles tagged with Drug Discovery
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Charles P. O'Brien, a leading expert on alcohol dependency, is being honored with the French Legion of Honor Medal for his pioneering work in addiction treatment. He has made significant contributions to the field through his research, advocacy, and leadership.
Researchers at NHCS successfully reversed effects of hERG mutation in patient-specific heart cells, scoring a world's first. The discovery could revolutionize drug development and lead to a potential cure for the life-threatening condition within 5-8 years.
Researchers have discovered that a drug increasing sudden cardiac death risk interacts with mistranslated protein-coding genes in heart muscle. The study provides insight into how cardiac death risk might be increased by these drugs, opening the way for further research.
A new nonprofit initiative aims to bridge the gap between laboratory discoveries and clinical trials, tackling the 'Valley of Death' in drug development. Emory University's DRIVE program invests in promising compounds with potential to become new drugs.
Researchers at KU Leuven have identified a series of chemical compounds that are highly potent inhibitors of dengue virus replication. The compounds will be further developed by Janssen into a first-in-class drug candidate for the prevention and treatment of dengue infections.
Researchers at MIT have developed nanosensors that can detect variations in binding strength of antibody drugs, enabling more efficient production. The sensors also measure weak interactions with sugar chains, which are essential for drug effectiveness.
A study found that a fifth of US neurologists are unaware of serious drug safety risks associated with anti-epilepsy drugs, which can jeopardize patient health. The researchers suggest better communication from the FDA to specialists and more systematic methods for doctors to receive updated safety warnings.
Researchers at EPFL have developed a new method for connecting molecules like drugs or polymers to thiols using the alkynes, allowing for quick and efficient alkynylation reactions. The breakthrough has far-reaching implications for chemical biology, drug design, and materials science.
A collaborative EU-funded project aims to discover and develop novel antifungal drugs to combat drug-resistant fungal infections, which kill two million people annually. The NOFUN project brings together partners to accelerate development of broad-spectrum antifungal agents with new modes of action.
Researchers at McMaster University have discovered that removing a key protein can significantly improve the lifespan and neurological function of mice with Tay-Sachs disease. The findings suggest that FDA-approved drugs, readily available on the market, may help alleviate symptoms of the devastating condition.
Researchers at OHSU's Vollum Institute have discovered a new NMDA receptor subtype that is the most common at synapses, contradicting previous drug development efforts. The study suggests that this subtype may be a new target for developing effective therapies for neurological disorders.
A mathematical model of tumor growth inhibition predicts treatment effect with bevacizumab for patients with metastatic colorectal cancer. The best metric for predicting overall survival was time to tumor growth, which worked equally well in Western and Chinese patients.
Top scientists from $3.5 trillion enterprise will share advice on challenges and solutions for thriving in the global economy. The symposium focuses on market-driven innovation, collaboration, and new methods to address pressing issues like feeding the world and reducing dependence on fossil fuels.
A new paradigm for therapeutics discovery is proposed by Garret FitzGerald, MD, FRS, to address the unsustainable model of current drug development in the US. The approach aims to integrate knowledge of preclinical science with an understanding of drug action in humans, leading to improved prediction of efficacy and safety.
A new centre will focus on lead optimisation for diseases of the developing world, including TB. The centre will create 11 new posts and receive a £6.5 million investment over five years.
A new approach by Yale University scientists offers greater control over the three-dimensional structure of molecular compounds, enabling more effective drugs. This breakthrough can lead to the creation of novel piperidine derivatives with improved binding properties.
Researchers have found a way to 'mine' bacterial genomes for new drug leads by exploiting the process of antibiotic resistance. The study, published in the Proceedings of the National Academy of Sciences, reveals that bacteria can produce hundreds of compounds when exposed to antibiotics, many of which are potential secondary metabolites.
Scientists at Nottingham University are part of a €18m European-wide project using high-tech laser technology to study how drugs interact with cells. They aim to design more effective treatments for chronic illnesses like cancer and asthma by understanding how drug molecules bind and unbind from proteins.
The UCI Center for Autism Research & Treatment is launching an innovative drug discovery effort to develop effective pharmaceutical therapy for core deficits of autism. Researchers are using a synergistic approach, integrating multiple disciplines and compounds to target neural pathways altered in the disorder.
A team of researchers at the University of Dundee has developed an automated design system for new drugs, using advanced statistical analysis to mimic human chemists' creative process. The system successfully predicted profiles across a range of drug targets, with 75% confirmed correct in experimental testing.
A team of chemists at USC developed a method to convert fluoroform, an ozone-destroying chemical waste product, into useful reagents for producing pharmaceuticals. The discovery is based on the precise conditions needed to coax fluoroform into useful compounds, including trifluoromethanesulfonic acid.
Avermectins, a well-established family of anti-parasitic drugs, have shown surprising potential in treating tuberculosis. In vitro tests have killed bacteria that cause TB, including drug-resistant forms, offering hope for new therapies against multi-drug resistant TB.
Researchers from the University of British Columbia have discovered that a well-established family of anti-parasite drugs can be repurposed to effectively treat tuberculosis, including drug-resistant forms. The study highlights the potential for investing in research to find new uses for approved drugs and synergistic combinations.
University of Utah medical researchers have identified a new pathway to block inflammation while minimizing the risk of infection, which could lead to more effective treatments for conditions like arthritis, diabetes, and traumatic brain injury. The discovery has vast potential for developing safer anti-inflammatory medicines.
A new genetic sequencing tool, Next-Gen Lab-on-Bead, has been developed to speed up drug discovery and disease diagnostics. The technology uses next-generation sequencing to test millions of potential drug candidates simultaneously.
Scientists at Northwestern University have created a mouse model that replicates the human response in rheumatoid arthritis. The new prototype uses human stem cells implanted in mice, which showed authentic human reactions, paving the way for more accurate drug discovery and treatment options.
Christina Smolke, a Stanford bioengineer, has won a $2.5 million grant to explore using microbes to produce complex chemicals for advanced natural-product drugs. Her approach aims to transform the manufacturing scale and efficiency of microbial systems.
Scripps Research scientists have devised a powerful new technique to discover and expand the power of large numbers of antibodies, immune system proteins that detect and destroy invaders. The method rapidly identifies antibodies with useful biological activity, enabling the creation of unusual antibodies with desired effects.
Researchers create a new explosive with a blast wave traveling 225 miles per hour faster than the current standard, HMX. The new explosive combines CL-20 and HMX, producing a more powerful but stable material with potential to replace HMX as military-grade explosives
Researchers at University of Missouri have developed a new cancer drug with exceptional potency, outperforming current treatments by 10 times. The carborane-based drug efficiently targets energy production in cancer cells, minimizing side effects and increasing therapy effectiveness.
Computer simulations shed light on the dynamic structure of the LSD1/CoREST protein complex, a major target for therapies. The study reveals that binding to histone H3 triggers significant changes in shape, which may help develop epigenetic drugs that reprogram cancer cells.
A new study finds that enzalutamide significantly extends life and improves quality of life in men with advanced prostate cancer. The fourth drug in two years to demonstrate this effect, it offers improved treatment options for men with the disease.
Seven pharmaceutical companies, including Abbott, AstraZeneca, and Sanofi, have joined forces with four research institutions to accelerate the development of new tuberculosis (TB) drugs. The TB Drug Accelerator aims to shorten treatment regimens from six months to one month, reducing mortality rates and combating drug resistance.
Researchers at Mayo Clinic discovered an association between Olmesartan and severe gastrointestinal issues. Patients taking the medication exhibited symptoms similar to celiac disease, but without typical test results or response to gluten-free diets.
By combining modeling, simulation, analysis, and visualization, researchers can identify potential binding sites on a virus. The work of discovering a breakthrough new drug begins with analyzing the virus, bacteria or mutation that causes the illness, and creating a three-dimensional model to understand its structure and shape.
A team of researchers has discovered a novel combination of two previously approved FDA drugs that can be used to treat advanced/late stage lung cancer by activating key genes involved in the disease. The treatment targets a pathway to accelerate cancer diagnosis and treatment.
Researchers found that Exendin-4 significantly minimizes damage in TBI animal models when administered shortly after the incident. The breakthrough discovery is a step towards developing a cocktail of medications to prevent as much brain damage as possible following injury.
A research team at the University of Melbourne has discovered the biological mechanisms behind drug hypersensitivities, revealing how the immune system perceives the body's own tissues as foreign. The finding could lead to the development of a diagnostic test to determine drug hypersensitivity.
Researchers at UC San Diego School of Medicine have identified an existing drug, auranofin, that effectively targets the Entamoeba histolytica parasite. The parasite causes over 70,000 deaths worldwide each year, and current treatment with metronidazole has adverse effects.
Researchers discovered that metformin blocks uveitis in laboratory rats, reducing inflammation and potential for blindness. The drug's anti-inflammatory properties make it a promising alternative to steroid therapy, which has serious side effects.
A large study of 1,896 14-year-olds found differences in brain networks that precede drug use and are associated with impulsivity. The findings suggest that certain teenagers are at higher risk for drug experimentation due to their brain's structure and function.
The NIH and Lilly are collaborating to create a publicly available resource profiling thousands of approved and investigational medicines. This comprehensive database will enable researchers to better predict treatment outcomes and improve drug development.
Scientists at UC San Diego School of Medicine developed a new strategy for faster anticancer drug discovery by analyzing the genetic pathway of disease. They identified Peruvoside, a cardiac glycoside, as a potential treatment for prostate cancer with minimal side effects.
Researchers determined the mechanism by which sulfa drugs kill bacteria, revealing a chemical reaction known as an Sn1 reaction. This discovery provides a basis for developing new antibiotics that are harder to resist and cause fewer side effects.
A team of researchers at the University of Dundee has identified fexinidazole as a possible new treatment for visceral leishmaniasis, a disease affecting 500,000 people in Africa, Asia, and Latin America. The drug showed a greater than 98% rate of suppressing infection in mice, comparable to current treatments.
Italian researchers found a DNA sequence called enhancer HS1.2 that accelerates the activity of genes involved in Lupus, an autoimmune disease affecting 60,000 people in Italy. The discovery could lead to more effective therapies against severe cases of Lupus.
Researchers found that AICAR, an experimental therapy, protected animals from heat-induced sudden death and may hold promise for treating people with enhanced susceptibility to heat stroke. The drug works by reducing calcium leakage from RYR1, thus diminishing heat-induced contractions and muscle damage.
Sathyanaryanan Puthanveettil, a Scripps Research scientist, has been awarded two notable grants to study the critical component of long-term memory formation. He will investigate the role of kinesin in this process using the marine snail Aplysia.
The collaboration aims to build on Professor Susann Schweiger's discovery of the mechanism controlling disease-causing protein production. The project seeks to prevent toxic protein buildup in the brain and potentially provide a treatment for Huntington's Disease.
A NYBG scientist estimates that at least 540 to 653 new drugs could be discovered from plants, with potentially thousands more waiting to be evaluated. This analysis highlights the potential value of continuing to screen plants for novel bioactive compounds.
Researchers at Brown University have discovered a new compound that can defeat drug-resistant bacteria by blocking their efflux pumps. The compound, called BU-005, was found to inhibit the activity of two different families of drug-efflux pumps, one associated with Gram-positive bacteria and the other with Gram-negative bacteria.
A recent Van Andel Research Institute study found that decanoic acid acts as a modulator of PPAR receptors, which play a key role in glucose and lipid metabolism. The findings suggest that decanoic acid could be used to design better and safer PPARγ-based drugs for diabetes treatment.
A Scripps Research Institute scientist has successfully produced a simpler relative of Taxol called eudesmane and created a retrosynthesis pyramid to produce target compound. The researchers hope that the innovation will lead to understanding of nature's processes and develop more widely applicable techniques.
A collaborative research partnership between Institut Pasteur Korea and Sanofi aims to combat Hepatitis B by developing a high-throughput assay to screen chemical libraries for novel compounds. The goal is to identify inhibitors targeting specific steps in the viral life cycle, offering new insights into HBV mechanisms.
Scientists have discovered that Alzheimer's protein tangles involve at least three different proteins, including neurofilaments and vimentin, in addition to the previously identified tau protein. This discovery could lead to a better understanding of the disease's progression and potential new drug targets.
Researchers at UC Santa Barbara have discovered a potential treatment for autosomal-dominant polycystic kidney disease (ADPKD), an inherited kidney disease affecting millions worldwide. The drug Leflunomide inhibits the STAT6 signaling pathway, which is activated in kidney cysts and leads to excessive cell growth.
Researchers at Rensselaer Polytechnic Institute and the University of North Carolina, Chapel Hill, have discovered a new process to manufacture ultra-low molecular weight heparin drug. The discovery uses chemicals and enzymes to reduce production steps from 50 to 10-12, increasing yield 500-fold and decreasing cost.
Researchers found a molecule in intestinal cells that induces immune tolerance and reduces excessive immune reactions. This discovery has the potential to revolutionize treatment for autoimmune disorders such as asthma, inflammatory bowel disease, and Lupus.
Researchers have discovered a potential new treatment for EKC, a highly infectious eye disease affecting millions annually in the US. A molecular wipe targeting viruses responsible for EKC could relieve symptoms, speed up healing and reduce transmission risk.
SuviCa Inc. has partnered with the University of Colorado at Boulder to develop and commercialize a drug screening technology that identifies novel therapies for cancer treatments. The patented tool uses genetically modified Drosophila fruit flies to screen compounds effective against various types of cancer.