Articles tagged with Drug Discovery
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers from National University of Singapore and Tsinghua University found that 88% of nature-derived drugs come from previously known drug-producing families. The study suggests focusing on these pre-existing families to discover new drugs, leveraging knowledge of clustered distribution patterns like oil fields.
The Seattle Structural Genomics Center for Infectious Disease has solved over 375 protein structures, providing a blueprint for fighting infectious disease. The center's work may lead to new drug therapies urgently needed to prevent outbreaks of multi-drug resistant and XDR strains of TB.
The U.S. Department of Energy's national laboratories enabled the discovery of a groundbreaking new drug treatment for malignant melanoma, with FDA-approved drug Zelboraf (vemurafenib) showing great promise in disrupting disease progression.
A new computational method using genomic information predicts new uses for existing medicines, including treating Crohn's disease with prednisolone and inflammatory bowel diseases with topiramate. This approach could improve treatments, save time and money, and provide insights into disease progression and drug mechanisms.
Langer's research launched the controlled-release drug industry, delivering advances in pharmaceuticals, chemical engineering, and medical devices to patients. His work also led to significant progress in regenerative medicine and tissue engineering to address organ shortages.
Researchers have discovered how TB drug pyrazinamide effectively shortens the required duration of TB therapy. The drug acts on latent TB bacteria that exist in an acidic environment, converting to its active form to bind and block vital protein RpsA, ultimately killing the bacteria.
Researchers discovered that when rats tasted fatty foods, cells in their upper gut produced endocannabinoids, triggering a surge in cell signaling that prompts overeating. The study suggests that obstructing endocannabinoid activity may curb this tendency, offering new potential treatments for obesity and related diseases.
A boron-based compound has shown safety and efficacy against stage 1 and 2 of the disease, with its oral formulation and short treatment duration promising for patient care. The collaboration between biotechs Anacor Pharmaceuticals and SCYNEXIS Inc., and not-for-profit DNDi, brings hope for a breakthrough in treating sleeping sickness.
Researchers identified six distinct subtypes of triple-negative breast cancer, each responding differently to chemotherapies. The study provides molecular targets for drug discovery and development efforts, offering hope for personalized therapy.
Researchers at University of Michigan developed a new way to search for drugs that target RNA, a molecule essential to retroviruses like HIV. They successfully predicted the binding of six new small molecules to HIV's genetic material and demonstrated their efficacy in inhibiting viral replication.
UBC researchers used an innovative method to uncover the molecular mechanism behind some anti-arrhythmia drugs, which control irregular heartbeats. The study found that variations in electrostatic interactions between the drugs and amino acids in the cardiac sodium channel affect their binding and effects.
Combination therapy of loperamide and minocycline may provide a safer method for treating devastating lung infections in people with cystic fibrosis. The approach could cut drug development time in half, offering new hope for those affected by this genetic disease.
Researchers identify small molecule blocking key protein involved in cholesterol production, successfully lowering cholesterol levels in isolated nerve cells and brain slices from mice. The discovery could lead to broader applications in other neurological conditions like Alzheimer's disease.
The article discusses the resurgence of covalent drugs, which have made a major positive impact on human health, and highlights the potential of rational covalent drug design to expand their use. Several rationally designed covalent inhibitors are advancing in clinical development, addressing problems of drug-resistance mutations.
Researchers at Tel Aviv University have found that mucus can facilitate the penetration of toxic substances into cells, potentially leading to new treatments for diseases like cancer. The study suggests a new approach for delivering hydrophobic drugs, which could be absorbed through the lungs or digestive system.
The UCSF team identified a few dozen chemical compounds that alter fat storage in worms, which may be useful for understanding metabolism in other organisms. The discovery demonstrates the value of worm screening as a way to find new targets for human diseases.
Scientists have solved the three-dimensional structure of a key biological receptor, enabling chemists to design molecules for experimental drugs. This finding has the potential to expedite drug discovery in various areas, including arthritis, respiratory disorders, and wound healing.
Dr. A.K. Ganguly, a renowned pharmaceutical researcher, received the Topliss Award Lecture at the University of Michigan for his lifetime contributions to medicinal chemistry. His lecture discussed lessons learned in drug discovery, highlighting approaches taken at Schering-Plough and ongoing work at Stevens.
A team of researchers has discovered a new enzyme, squalene mono-oxygenase (SM), that plays a key role in cholesterol production. Inhibiting SM may lead to more effective treatments with fewer side effects than current medications.
Researchers found that public sector research played a significant role in discovering new drugs and vaccines, particularly those targeting cancer and infectious diseases. Over 30 years, 153 new FDA-approved drugs and vaccines were discovered through research conducted in public sector institutions.
Scientists have discovered an important insight into carbohydrate bonding, which could lead to improved medicines. The study reveals the shapes of carbohydrates when they are free from external influence and interacting with neighboring molecules.
Researchers have made significant breakthroughs in understanding how HIV mutates and evades treatment, providing new insights into developing better tests and treatments for patients. The study found that a specific mutation allows the virus to resist two main families of drugs, highlighting the need for tailored therapies.
A synthetic derivative of turmeric has been found to be highly neuroprotective against ischemic stroke and traumatic brain injury in animal models. The compound, CNB-001, improved behavioral and molecular deficits in both conditions, offering potential clinical promise for current treatment-limited diseases.
Researchers have successfully recreated the metabolic process of a critical enzyme responsible for breaking down drugs and nutrients. By trapping the enzyme at a specific stage, they gained insight into how people respond differently to certain chemicals, which could aid in developing more efficient drugs and household products.
Researchers linked hundreds of approved drugs to M. tuberculosis proteins, identifying new anti-tuberculosis targets and repurposing potential. The study provides a promising computational strategy for novel drug discovery.
A new Penn study has found a class of drug that can enter the brain and stabilize degenerating neurons in an animal model of Alzheimer's disease. The epothilone D class of microtubule-stabilizing drugs may offer hope for treatment by restoring microtubule tracks to their original supportive structure.
Researchers have identified a preclinical candidate that may slow the natural decline in memory associated with ageing. The new synthetic compound selectively blocks an enzyme involved in high levels of 'stress' steroid hormones, which are linked to memory loss.
Researchers at the University of Alberta have developed a drug that can reduce or eliminate airborne disease transmission when someone coughs. The new treatment uses a spray form and has shown promise in suppressing droplet emission from lung fluid.
Researchers have discovered that an enzyme called NOX4 produces hydrogen peroxide after a stroke, leading to nerve cell death. Inhibiting this enzyme with a new drug reduces brain damage and preserves brain functions in mice with stroke.
Researchers have discovered a novel compound that amplifies the effects of anandamide, a natural chemical in the body similar to THC found in marijuana. The synthetic drug URB937 inhibits FAAH enzyme, enhancing anandamide levels and producing analgesic effects without sedation or addiction.
The Open Source Drug Discovery (OSDD) Consortium is a worldwide scientific community working together to discover and develop new drugs. Key findings include the development of a comprehensive map of Mycobacterium tuberculosis genome, paving the way for a potential new drug for tuberculosis.
Two research teams discovered life-saving medications, JANUVIA for type 2 diabetes and CHANTIX for smoking cessation, enhancing people's ability to regulate blood sugar levels and reduce nicotine cravings. These treatments have helped millions worldwide, with CHANTIX being approved in 86 countries and over 7 million prescribed in the US.
A Yale team has discovered the secrets of a 'magic' antidepressant that can take effect in hours, rather than weeks or months. The study found that ketamine restores connections between brain cells damaged by chronic stress.
Researchers at the University of Strathclyde found that a substance called beeglue, originating from beehives in the Pacific region, was active against MRSA. The study isolated two compounds, Propolin C and Propolin D, which showed good activity against all MRSA strains tested.
Researchers at Neurocentre Magendie in Bordeaux found that addiction is caused by a persistent impairment of synaptic plasticity, leading to a permanent loss of the brain's ability to adapt and learn. This lack of plasticity results in compulsive consumption and loss of control over drug use.
A team of MIT chemists has designed a new way to attach trifluoromethyl groups to compounds, which could allow pharmaceutical companies to create and test new drugs faster and more efficiently. The new synthesis uses a palladium catalyst and achieved yields ranging from 70 to 94 percent.
The TB Alliance has made significant progress in developing new TB drugs, with three co-developed by the organization and its partners, and two others currently being tested through the Critical Path to TB Regimens (CPTR) initiative.
Researchers have discovered high-activity mutants of human butyrylcholinesterase that could be used to develop anti-cocaine medication. Additionally, a microbiocide-based HIV prevention measure holds promise for developing countries, particularly in sub-Saharan Africa.
Researchers have developed compounds that inhibit bacterial enzymes with longer residence times, correlating with improved in vivo activity. This discovery may lead to the development of agents for non-invasive bacterial imaging using positron emission tomography.
The Wellcome Trust extends its Seeding Drug Discovery initiative with a £110 million investment over five years. This support enables the progression of promising drug discovery projects to attract follow-on investors and develop novel medicines.
Scientists are developing new medications to block abnormal clumps of amyloid-beta protein in the brain, which may slow Alzheimer's disease progression. Clinical trials could lead to new treatments within 5-10 years if successful.
Scientists have identified a new approach to tackling human African trypanosomiasis (HAT), also known as sleeping sickness. A valid drug target has been found and leads for orally administered drugs have been identified, showing promise for effective treatment of the disease.
Researchers at Scripps Research Institute have discovered that the old drug closantel may be useful in combating river blindness by inhibiting the molting process of the parasite. This finding holds tremendous potential for the treatment of this neglected tropical disease, which affects over 37 million people.
A consortium of scientists, including top researchers from academic institutions and pharmaceutical companies, is developing new methods for drug discovery in depression and schizophrenia. The project aims to overcome bottlenecks such as lack of accurate animal models and symptom-based diagnostic categories.
Scientists at the University of Kentucky have discovered that withaferin A can simultaneously target two key proteins, vimentin and GFAP, implicated in reactive gliosis. This finding could lead to new treatments for diseases such as multiple sclerosis, Alzheimer's disease, stroke, and traumatic brain injury.
Researchers at McMaster University have developed a way to propel microscopic worms using an electric field, enabling high-throughput micro-screening devices for drug discovery. The technique demonstrates movement of worms forward and in reverse guided by the direction of the electric field, allowing for rapid screening of chemicals an...
Researchers at Emerald BioStructures have developed new allosteric small molecule modulators of phosphodiesterase-4 (PDE4) with improved safety and efficacy. These discoveries validate the company's structure-based drug design capabilities for addressing previously undruggable targets in inflammatory diseases and cognitive impairments.
Researchers found that antibiotic drugs can alter bacterial cell gene expression levels, leading to increased survival. The study suggests that antagonistic drug pairings can slow down the evolution of antibiotic resistance by restoring cellular equilibrium.
A new imaging technique developed by a team of researchers could lead to the discovery of new antibiotics, antifungal, antiviral, and anti-cancer drugs. The method uses mass spectrometry to analyze chemical communication between microorganisms.
Researchers at Johns Hopkins University discovered a 1930s gonorrhea medication, acriflavine, that can halt the growth of new blood vessels in cancer cells. By inhibiting HIF-1, a protein essential for tumor growth, acriflavine may one day be incorporated into chemotherapy cocktails to fight cancer.
A team of researchers from Pitt and Walter Reed Army Institute of Research have identified compounds that hold promise for treating leishmaniasis, a parasitic infection affecting millions worldwide. The newly developed strategy, called HILCES, uses high-throughput screening to identify effective drug candidates.
The Wellcome Trust has awarded €2.8 million to the Laboratory for Virology and Experimental Chemotherapy at K.U.Leuven to search for new treatments for dengue fever, a viral disease prevalent in tropical and subtropical regions. Researchers will collaborate with the pharmaceutical industry to develop medications for this deadly virus.
Researchers have developed a novel method to generate functional hepatocytes for drug testing, offering an unlimited and reliable source of liver cells. The new technique uses induced pluripotent stem cell technology to create hepatocytes from adult skin cells, overcoming the limitations of primary human hepatocytes.
Dabigatran, a new blood-thinner, has been shown to be as effective as warfarin in preventing strokes and major bleeding, but with significantly fewer side effects. This finding could lead to a change in standard anticoagulant therapy.
The CRIMALDDI project, led by Liverpool School of Tropical Medicine, aims to coordinate European and international antimalarial drug discovery efforts. The project will develop a prioritized roadmap and 5-year action plan to deliver on this roadmap.
SRI International was chosen to lead three research and development centers in the NCI's Chemical Biology Consortium program. The goal of the program is to discover and develop new cancer therapeutics against novel molecular and genetic targets.
Scientists have developed a more efficient method to produce a novel form of acetaminophen with reduced liver toxicity risk, offering a potential solution to the growing concern over the drug's effects.
Researchers found that quinine blocks cells' ability to take up essential amino acid tryptophan, leading to adverse side effects. Dietary tryptophan supplements may help alleviate these issues by improving quinine's effectiveness against malaria parasites.
Researchers at the University of Minnesota Medical School have made a breakthrough in understanding how the commonly prescribed drug praziquantel works to treat Schistosomiasis. Praziquantel causes two-headed organisms by subverting normal regeneration, leading to the identification of key molecules that control its effects.
Researchers have developed a low-cost strategy to discover new drugs for neglected diseases, utilizing global educational resources and distributed problem-solving. Students worldwide are synthesizing candidate molecules, meeting industry standards, and participating in the process.