Articles tagged with Drug Discovery
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified an enzyme called Idol that destroys the LDL receptor, allowing more 'bad' cholesterol to circulate in the blood. By blocking Idol's activity, cells produce more receptors and absorb more cholesterol from the body.
Researchers at Johns Hopkins University School of Medicine have discovered a natural compound that can stop malaria parasite growth, interacting with the parasite's MetAP2 protein. The compound, fumarranol, was found to be less toxic than existing medications and showed promise in treating malaria in mice.
SRI International will screen a library of well-characterized drugs against the 2009 H1N1 influenza A virus. The project aims to identify new treatments with better efficacy and potency than current antiviral drugs. SRI's expertise in drug screening and development will help expedite the development of new therapies.
SRI International has received a $100,000 Grand Challenges Explorations grant to develop new antibiotics against antibiotic-resistant tuberculosis. The project aims to identify small organic molecule metabolites essential for bacterial growth and survival.
Researchers develop cheap and efficient method to identify small molecules for diabetes treatment, finding NAADP plays a crucial role in insulin secretion. This discovery could lead to a new class of drugs to treat type 2 diabetes.
Researchers at the University of Oxford have developed a cheap and efficient method to discover new drugs for type 2 diabetes. They identified a small molecule called Ned-19, which plays a crucial role in insulin secretion, representing a brand new target for diabetes drugs.
Researchers have discovered a drug that eases protein fusion, increasing learning capacity in mice with Alzheimer's disease. The treatment could offer new perspectives and alternatives to existing medications.
Researchers at Case Western Reserve University discovered a nanotechnology-based technique to block damaging gas transport through polymers, making them stronger and more efficient. This breakthrough has potential applications in food and medicine packaging, as well as electronic equipment protection.
Researchers at Monash University have made a breakthrough in treating malaria by deactivating the parasite's digestive machinery. The discovery could provide treatment for millions of people worldwide and offers hope against drug-resistant malaria.
Researchers at the University of Illinois Chicago have discovered compounds that show high antiparasitic activity against Leishmania parasite, which could potentially be modified to treat the disease. The new compounds are less toxic than miltefosine and can kill the parasite inside blood cells.
Biotech scientists are applying genomics technologies to toxicology research to better understand the effects of novel drug candidates. This trend towards predictive toxicogenomics aims to develop a new compound's mechanism of action and predict toxicity, with several companies and consortia already working on this technology.
A drug based on a garlic chemical, vanadium-allixin, reduces blood glucose levels in diabetic mice, offering promise as an oral treatment for diabetes. The study aims to test the drug in humans in future work.
Scientists from three universities will establish a new center to develop state-of-the-art chemical libraries, increasing the efficiency of compound synthesis. The center aims to identify new compounds for future drug development and basic biomedical research.
Researchers at Duke University Medical Center discovered that two common beta-blockers can stimulate a pathway that promotes cell survival and protects heart tissue. The study finds that alprenolol and carvedilol may have greater potential to repair the heart and prevent further damage.
Feldmann and Maini discovered tumor necrosis factor-alpha as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions. Their research led to the development of several anti-TNF drugs, transforming treatment for people diagnosed with chronic inflammatory conditions.
Researchers found that uninsured patients were more likely to receive brand-name drugs after the clinic closed its drug sample closet, leading to increased costs. In contrast, Medicaid patients showed no significant change in generic prescribing despite the availability of free samples.
The American Chemical Society has inducted 25 scientists into its Heroes of Chemistry hall of fame, including Bruce Roth, inventor of Lipitor, the world's largest selling drug. The honorees are being recognized for their groundbreaking research and contributions to humanity.
The European Bioinformatics Institute (EMBL-EBI) will gain free access to large collections of information on drug properties and small molecules after receiving £4.7 million from the Wellcome Trust. This will enable academia to participate in early-stage drug discovery, potentially improving prediction of side effects.
Researchers developed a computational tool to compare drug side effects and predict common targets, revealing hidden therapeutic potential. The approach successfully identified new uses for marketed drugs in treating diseases they were not specifically developed for.
Researchers found that brightly colored beetles and butterfly larvae are significantly more common on plants with compounds active against certain diseases, such as breast cancer and malaria. This discovery could speed up drug discovery and provide insight into the ecological relationships between tropical-forest plants and insects.
Researchers at Fox Chase Cancer Center have discovered a small molecule that locks an essential enzyme in an inactive form, potentially leading to the development of new antibiotics. The discovery targets morpheeins, proteins made from individual components that can reconfigure themselves within living cells.
Gamma-secretase modulators, a class of agents in testing to treat Alzheimer's, work by reducing long Abeta peptides and increasing shorter ones that inhibit aggregation. This could lead to new treatments for the disease, with one such drug, tarenflurbil, showing promise in patients with mild Alzheimer's.
Researchers at North Carolina State University have successfully reinvigorated a failed HIV drug by adding gold nanoparticles, which enhances its binding capability and prevents the virus from gaining a foothold. This innovative approach offers new hope for treating HIV infection.
Companies like UCB Pharma and CeeTox are using cell-based assays to assess the toxic characteristics of small molecule compounds. This early identification can improve clinical trial results and reduce the time to market.
Researchers at Uppsala University have made a breakthrough in treating eating disturbances, including obesity and anorexia, by targeting the melanocortin system. The system regulates energy balance and appetite, and tiny imbalances can lead to major changes.
A clinical trial shows that romiplostim significantly improved platelet levels in patients with chronic immune thrombocytopenic purpura (ITP), a hematologic disorder that can cause uncontrolled bleeding. The novel drug duplicates the action of a natural hormone discovered by MGH investigator, offering low toxicity and high response rates.
A physician-scientist is urging improved drug regulation to ensure the cardiovascular safety of non-heart drugs. This includes earlier testing and continued evaluation of drug effects post-approval.
TB drug resistance is a growing concern, with millions of cases worldwide each year. Doctors Without Borders advocates for increased funding and collaboration to develop new treatments.
A Portland researcher argues that overly restrictive intellectual property laws slow the availability of existing medications as life-saving treatments. Berger suggests that 'use' patents involving new uses for old medications need to be reformed to encourage pharmaceutical companies to develop these drugs.
A team of scientists, led by UCSF's Brian Shoichet, successfully translated the structure of an enzyme into its function. By modifying a molecular docking technique, they predicted the natural molecule that triggers enzyme action, confirming the approach's potential to determine how key enzymes work in the body.
A newly discovered transmembrane protein called 'Wurst' appears to play a decisive role in breathing, ensuring proper lung maturation and gas exchange in both insects and mammals. The protein's defect is linked to respiratory distress syndrome in premature infants, and researchers aim to develop new treatments for this condition.
The National Institute of Standards and Technology (NIST) has developed a new reference material for peptide analysis, which will improve the performance and reliability of experiments to measure peptides in biomolecular samples. The peptide standards project committee designed three synthetic peptides with varying lengths and net char...
Researchers at the University of Pennsylvania School of Medicine have found an absolute biochemical distinction between sporadic and hereditary forms of Lou Gehrig's disease, suggesting that current approaches to drug discovery should be re-examined. This distinction may impact therapeutic strategies for ALS patients.
The Wellcome Trust and GSK will collaborate on a new class of antibacterials to combat rising drug resistance in Gram-negative bacteria, which cause pneumonia and septic shock. The partnership aims to accelerate development of compounds for treating these resistant infections.
A team of Princeton University chemists has discovered a new method to synthesize molecules without toxic catalysts, reducing the risk of hazardous barriers in drug development. This breakthrough opens up new possibilities for working with ketones and aldehydes, potentially leading to more efficient synthesis of beneficial enantiomers.
Researchers at Scripps Institute have developed a new method for producing potential pharmaceuticals from natural compounds, eliminating the need for expensive protecting groups. This breakthrough could lead to significantly reduced production costs and expand interest in natural products for commercial development.
African scientists will receive training in drug discovery techniques to combat diseases such as HIV, tuberculosis, and malaria. The program aims to develop affordable, effective drugs using low operating costs and socially conscious investments.
Researchers found that antipsychotic drugs increase AMPK activity in the brain, triggering increased appetite. Blocking a specific histamine receptor reduces AMPK levels and appetite, offering hope for new, weight-neutral treatments.
Researchers developed a Bayesian network model to forecast the success of new drugs, reducing mean capitalized expenditures by an average of $283 million per successful new drug. More data sharing by the pharmaceutical industry could improve forecasting accuracy and benefit patients by eliminating unsafe investigational new drugs.
Glenn Micalizio, Yale Assistant Professor, has been awarded the Eli Lilly Grantee Award for his research on simplifying organic chemistry. His work focuses on developing new methods for forming carbon–carbon bonds to facilitate drug discovery.
Scientists at ProXara Biotechnology Limited have identified a way to prevent tumour cells from growing by switching off key enzyme PKB. The research, funded by the Wellcome Trust Seeding Drug Discovery initiative, aims to develop a drug that can be used in clinical trials for lung cancer treatment.
Researchers have identified pancreatic polypeptide as a potential solution to appetite suppression, which may lead to a new obesity treatment. The hormone is naturally released in the gut and acts as a neurotransmitter to indicate fullness to the brain.
Researchers are developing novel antibacterial compounds targeting MRSA, a life-threatening drug-resistant infection. The new medicines block the ability of MRSA bacteria to divide and multiply, reducing resistance levels.
A novel program in Panama trains professionals to advance drug discovery, reducing costs and promoting tropical biodiversity conservation. The International Cooperative Biodiversity Groups (ICBG) program provides economic and educational benefits for local students and communities.
Researchers found a new approach to treating chronic and debilitating neuropathic pain by blocking the alpha9alpha10 nicotinic acetylcholine receptor. The study suggests a previously unrecognized molecular mechanism for treating this condition, which affects hundreds of millions of people worldwide.
Diarrheal diseases kill over 2 million children annually, and the Institute for OneWorld Health aims to combat this with novel anti-secretory drugs. The $46 million grant will support the development of new treatments to complement traditional approaches.
A British drug discovery company is teaming up with a Brazilian firm to search for new medicines in the Amazonian and Atlantic rain forests. The partnership aims to combat diseases such as tuberculosis, avian flu, and tropical illnesses like hepatitis C and Chagas disease.
Researchers at Thomas Jefferson University have discovered a new way to sidestep gleevec resistance in leukemia cells. By reactivating the protein C/EBP-alpha, they found that leukemia development is halted. This discovery could lead to new treatment strategies for leukemias resistant to gleevec and other cancers.
J-P Garnier, GSK CEO, emphasizes the company's commitment to providing affordable HIV drugs and vaccines for diseases affecting the developing world. He highlights GSK's efforts to introduce modern HIV drugs at lower prices and protect innovation through patents.
Researchers have discovered that C. albicans can neutralize antifungal drugs by duplicating one arm of chromosome 5 and deleting the other, creating an 'isochromosome'. This finding could lead to strategies for making currently available antifungal drugs more effective.
Researchers at UCLA have discovered how the drug Ro15-4513 binds to specific receptors in the brain to block alcohol's effects on motor coordination. This breakthrough may lead to the development of sober-up pills, alcohol addiction medications, and treatments that harness the beneficial effects of moderate alcohol consumption.
Researchers at Michigan State University have developed a new, eco-friendly method for producing Taxol, a top-selling cancer-fighting drug. By harnessing enzymes from the Pacific yew tree and using water-based chemicals, they aim to reduce waste and minimize environmental impact.
Researchers at UCSB have discovered that rapamycin, a widely available immunosuppressant, can strongly reduce cyst growth in kidneys affected by polycystic kidney disease (PKD). The treatment was found to shrink cysts and retain kidney function in mice with PKD.
William Fenical, a Scripps Institution of Oceanography professor, has been awarded the Ernest Guenther Award for his pioneering work on marine natural products chemistry. His research has led to the discovery of potent anticancer agents and anti-inflammatory drugs from ocean sea floor bacteria.
The American Chemical Society has awarded a national recognition to a prominent chemist for their groundbreaking work in medicinal chemistry. Anderson has made significant contributions to the development of statins and HIV treatments, including Zocor and Crixivan.
Researchers at Georgia Institute of Technology have developed an algorithm that creates accurate three-dimensional models of over 900 GPCRs, a class of proteins targeted by many drugs. These models could help scientists discover new drug compounds more efficiently, and are now freely available to noncommercial users.
Researchers have created temperature-sensitive capsules that can release drugs at different rates, with the release rate controlled by the amount of wrinkling. The solution to cool the capsules without harming surrounding tissue lies in newly discovered nanoparticles chilled through magnetic cooling.
Researchers at Rensselaer Polytechnic Institute have successfully synthesized hundreds of milligrams of heparin using engineered enzymes and co-factor recycling. This breakthrough could enable the widespread use of synthetic heparin in human medical treatments, reducing reliance on animal-derived products.
Researchers at Northwestern University have developed a new compound that selectively inhibits pro-inflammatory proteins called cytokines by glia, slowing or reversing neuroinflammatory cascade progression. The compound also restored normal synaptic function and attenuated Alzheimer's-like behavioral deficits in mice.
Researchers believe that analyzing Medicare data will help assess medication use in real-life conditions, improving the nation's ability to understand risks and benefits of drug treatment. This can lead to increased data on whether drugs are used as intended and their potential risks.