Researchers at the University of Illinois have discovered a novel biosynthetic pathway in bacteria that can produce therapeutic compounds. The pathway, found in Pseudomonas syringae, combines elements of both ribosome-based and enzyme-mediated synthesis, allowing for efficient production of natural products.
SourceCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign·JournalScience·DateJul 19, 2019
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
The ABCE1 enzyme is essential for ribosome recycling, allowing cells to maintain protein quality and homeostasis. Its structure can adopt three conformations to boost recycling, influencing the interaction with ribosomes and ATP.
SourceGoethe University Frankfurt·JournalCell Reports·DateJul 18, 2019
A clinical trial is underway to treat acid attack victims with a revolutionary new approach using collagenase enzyme. The treatment aims to restore sight by softening the underlying tissue and allowing stem cells to repair damage.
A study by Clemson researchers found that the Cyp2b gene is associated with obesity and fatty liver disease in male mice, regardless of diet. The discovery suggests that enzymes involved in detoxification may play a role beyond diet and exercise in weight management and metabolic health.
SourceClemson University·JournalThe Journal of Nutritional Biochemistry·DateJul 11, 2019
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Scientists from Tokyo University of Science have discovered exactly how cell-free DNA (cfDNA) is generated, revealing its crucial role in tumor progression. The study's findings suggest that cfDNA can be targeted using DNase1L3, a novel molecule to prevent tumor metastasis and thrombosis.
SourceTokyo University of Science·JournalBiochemical and Biophysical Research Communications·DateJul 11, 2019
A deep learning-powered computational framework called DeepEC has been developed to predict enzyme commission numbers with high accuracy and efficiency. It uses convolutional neural networks and homology analysis to identify EC numbers, which is essential for understanding enzyme functions.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalProceedings of the National Academy of Sciences·DateJul 9, 2019
Researchers captured high-resolution images of a gene-editing tool called CRISPR-Cas9 using cryo-EM technology, revealing new information about its mechanism. The findings hold promise for developing more efficient and precise versions of the enzyme to correct disease-causing DNA mutations.
SourceUniversity of British Columbia·JournalNature Structural & Molecular Biology·DateJul 8, 2019
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Scientists have identified a marine bacterium that can break down the polysaccharide ulvan from sea lettuce into fermentable monosaccharides. This discovery opens up new possibilities for biotechnological exploitation of ulvan, particularly in the agrifood and cosmetics industries.
SourceCNRS·JournalNature Chemical Biology·DateJul 8, 2019
A defective degradation enzyme leads to the accumulation of gangliosides, causing deterioration in patients with storage diseases. Researchers have discovered that genetic disorders can trigger a cascade of consequential damages.
SourceUniversity of Bonn·JournalJournal of Lipid Research·DateJun 26, 2019
A new family of enzymes has been engineered to break down lignin, a key component of plants, enabling the production of sustainable materials such as nylon and bioplastics. This breakthrough could reduce reliance on oil and lower CO2 emissions.
SourceUniversity of Portsmouth·JournalProceedings of the National Academy of Sciences·DateJun 24, 2019
Scientists at the Paul Scherrer Institute elucidated the structure of enzymes that remove tyrosine from α-tubulin, revealing a key regulatory cycle in microtubule formation. This discovery holds promise for developing inhibitors to treat diseases like cancer and neurological disorders.
SourcePaul Scherrer Institute·JournalNature Structural & Molecular Biology·DateJun 24, 2019
Researchers from Chinese Academy of Sciences crack long-solved mystery by elucidating MPA biosynthetic pathway, revealing unique cooperation between enzymes and catabolic machinery. The study also sheds light on compartmentalized biosynthesis in fungi and plants.
SourceChinese Academy of Sciences Headquarters·JournalProceedings of the National Academy of Sciences·DateJun 21, 2019
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A team of scientists from Lawrence Berkeley National Laboratory has developed an eco-friendly production platform for a blue pigment called indigoidine. The engineered fungus, Rhodosporidium toruloides, produces the pigment with a high yield, using sustainable carbon sources and reducing toxic chemicals.
SourceDOE/Lawrence Berkeley National Laboratory·JournalGreen Chemistry·DateJun 21, 2019
A study published in Science reveals that certain gut bacteria can degrade levodopa, the primary treatment for Parkinson's disease, by converting it into dopamine outside the brain. Researchers identified Lactobacillus brevis as a key player in this process and found a molecule capable of inhibiting the bacterial enzyme responsible. Th...
Researchers at Goethe University have developed a novel method for producing new peptide drugs, using fragments of natural NRPS systems as building blocks. The approach enables the easy production of peptides in excellent yield, with applications for modifying clinically relevant drugs and producing peptide libraries.
SourceGoethe University Frankfurt·JournalNature Chemistry·DateJun 12, 2019
Researchers at the Donald Danforth Plant Science Center have identified a new sustainable method to produce lifesaving opiate antidotes by harnessing a microorganism that catalyzes N-demethylation, reducing waste and costs associated with current methods.
SourceDonald Danforth Plant Science Center·JournalNature Sustainability·DateJun 11, 2019
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers discovered that fibrinogen inhibits MMP2, an enzyme important for normal organ development and repair. High levels of fibrinogen may excessively inhibit MMP2, leading to arthritic and cardiac disorders.
SourceUniversity of Alberta Faculty of Medicine & Dentistry·JournalScientific Reports·DateJun 11, 2019
A novel enzyme from a soil fungus breaks down β-1,2-glucan into sophorose, revealing its potential role in the symbiosis of bacteria and plants. The discovery sheds new light on the diversity of glycoside hydrolases and their applications.
SourceTokyo University of Science·JournalJournal of Biological Chemistry·DateJun 11, 2019
Researchers discovered cytochrome P450 enzymes in giant ocean viruses, which may help develop treatments for life-threatening illnesses. The findings, published in Proceedings of the National Academy of Sciences, could also shed light on the biology and origin of these viruses.
SourceWoods Hole Oceanographic Institution·JournalProceedings of the National Academy of Sciences·DateJun 5, 2019
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers developed a fast and efficient way to engineer metabolic pathways using cell-free protein synthesis and SAMDI mass spectrometry. This enables the creation of thousands of potential mixtures to be tested in a single day, providing new insights for synthetic biologists.
SourceNorthwestern University·JournalScience Advances·DateJun 5, 2019
The NMR structure study provides unprecedented insights into the molecular mechanism of Ixolaris' action on Factor Xa, a key enzyme in blood clotting. The results may lead to the development of specific inhibitors that can prevent thrombosis without interfering with other enzymes.
SourceInstituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)·JournalBlood·DateMay 27, 2019
Scientists at the University of Bonn have developed a new method to study enzymes in action, allowing for the measurement of spatial positions and conformational changes. This breakthrough enables better understanding of biomolecules and potential insights into enzyme disorders.
SourceUniversity of Bonn·JournalChemistry - A European Journal·DateMay 14, 2019
Researchers at Harvard Medical School have uncovered a critical mechanism that enables segmented RNA viruses to replicate and survive. The discovery provides new potential targets for the development of antiviral drugs, which could help combat emerging and fatal viruses such as Lassa fever and Rift Valley fever.
SourceHarvard Medical School·JournalProceedings of the National Academy of Sciences·DateMay 13, 2019
The study found that Moringa leaves contain 30 times more iron and 100 times more calcium than spinach, making them a rich source of essential nutrients. The tree's roots and stem parts also exhibit anti-inflammatory and antioxidant properties, highlighting its potential as a superfood.
SourceNational Centre for Biological Sciences·JournalGenomics·DateMay 8, 2019
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A recent study by Cornell University has discovered a strong correlation between the AMY1 gene, which breaks down starch, and specific gut bacteria. This finding suggests that people with more copies of this gene may have benefited from increased starch digestion during times of scarcity.
SourceCornell University·JournalCell Host & Microbe·DateMay 2, 2019
A wearable system developed at KAUST can detect glucose and lactate levels in sweat, providing insights into blood sugar problems and oxygen deficiencies. The device uses a stretchy patch with MXene-based electrodes that can be repeatedly swapped out for improved detection accuracy.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalSmall·DateApr 25, 2019
Yu-ming Huang and Abhay Thakur have been awarded the Protein Science Best Paper Award for their pioneering work on biomolecular diffusion and protein folding. Their research has shed new light on the importance of diffusional channeling in metabolism, signaling, and other cellular processes.
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers have developed an enzyme-like heterogeneous TiO2 photocatalyst with high catalytic activity for hydrogen production. The catalyst's unique enzymatic characteristics enable it to efficiently convert light energy into H2, rivaling the performance of expensive Pt-TiO2 photocatalysts.
SourceInstitute for Basic Science·JournalNature Materials·DateApr 22, 2019
Researchers developed a method to detect and edit DNA methylation in individual mouse oocytes, enabling predictions of offspring phenotype. The technique allows for correction of genetic disorders, such as Angelman syndrome, and may facilitate study of epigenetic information.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateApr 22, 2019
Researchers have decoded the structure of MHETase, an enzyme that breaks down PET plastics into their basic building blocks. This discovery paves the way for developing more efficient enzymes to recycle PET, a key step towards a circular economy and mitigating plastic waste.
SourceHelmholtz-Zentrum Berlin für Materialien und Energie·JournalNature Communications·DateApr 12, 2019
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers develop new microscope, SCATTIRSTORM, to study cellulase and plant cell wall dynamics for more efficient biofuel production. The microscope enables high temporal resolution and spatial resolution, allowing for detailed understanding of enzyme activity.
A recent study by scientists from Brookhaven National Laboratory has revealed the mechanistic details of a protein involved in the assembly of lignin, a key cell-wall component. The discovery identifies an electron shuttle protein that delivers fuel for the construction of one specific type of lignin building block.
SourceDOE/Brookhaven National Laboratory·JournalThe Plant Cell·DateApr 8, 2019
Researchers at University of the Basque Country have discovered that vitamin B12 inhibits the LRRK2 enzyme, a key target for developing treatments for hereditary Parkinson's. The study shows promise for a new class of neuroprotective therapies.
SourceUniversity of the Basque Country·JournalCell·DateApr 4, 2019
The study reveals the full structure of human ACLY at high resolution, paving the way for targeted drug development. ACLY inhibition could provide a better approach for treating cancer and metabolic disorders.
SourceColumbia University·JournalNature·DateApr 3, 2019
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A new study sequencing the milkweed bug genome has revealed a link between diet and wing development, as well as toxic pigmentation. The research also highlights differences in metabolic enzymes between insects with specialized diets, offering insights into their biology and potential strategies for integrated pest management.
SourceUniversity of Warwick·JournalGenome Biology·DateApr 1, 2019
Researchers are exploring RNA editing as a way to treat diseases without permanent genetic changes. This approach uses an enzyme called ADAR to make precise edits to RNA, which can be reversible and avoid the risks of CRISPR.
SourceAmerican Chemical Society·JournalChemical & Engineering News·DateMar 27, 2019
Researchers found that C. elegans can acquire the molybdenum cofactor (Moco) by consuming E.coli bacteria, a molecule essential to enzyme function. This ability offers potential therapeutic avenues for treating Moco deficiency, a rare human genetic disorder.
SourceMassachusetts General Hospital·JournalNature Chemical Biology·DateMar 26, 2019
Researchers developed BridgIT, a tool that annotates proteins for 93% of enzymatic reactions, filling gaps in metabolic networks. The tool correctly predicts enzymes for 211 out of 234 non-orphan reactions and 334 out of 379 hypothetical reactions.
SourceEcole Polytechnique Fédérale de Lausanne·JournalProceedings of the National Academy of Sciences·DateMar 26, 2019
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers at the University of Liverpool have found that chromatin changes quickly in response to low oxygen, preceding gene expression activation. This discovery sheds light on how cells respond to oxygen deprivation and may pave the way for novel therapeutic approaches.
SourceUniversity of Liverpool·JournalScience·DateMar 20, 2019
Researchers found that a blood-clotting protein called thrombin can degrade nerves, but nerve-supporting glial cells like Schwann cells block its effects. This discovery could have implications for diseases such as ALS, MS, and Alzheimer's.
A new class of oral cholesterol-lowering drug bempedoic acid has shown effectiveness in reducing LDL cholesterol levels and preventing heart disease. The treatment is well-tolerated, with minimal side effects, making it a potential option for patients unable to take statins.
SourceImperial College London·JournalNew England Journal of Medicine·DateMar 13, 2019
Researchers identified 1,544 enzymes that play a key role in wheat's defense against fungal infections. The study found that proteases are involved in cell death induced by infection, but contradicting the current understanding that caspase-like enzymes initiate this process.
SourceSechenov University·JournalInternational Journal of Molecular Sciences·DateMar 8, 2019
A team of researchers from Ruhr-University Bochum has identified a crucial role for a sixth transport step in the regulation of peroxisome function. The study reveals that this step is essential for maintaining the balance between import and export of enzymes, preventing diseases such as infant mortality
SourceRuhr-University Bochum·JournalBiochimica et Biophysica Acta (BBA) - Molecular Cell Research·DateMar 8, 2019
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Scientists from two French teams have identified 79 new 'sugar cleavers' enzymes using bioinformatics methods, expanding the known families to over 200. These enzymes can serve as tools in domains like bioenergy, cosmetics, and nutrition.
SourceCNRS·JournalProceedings of the National Academy of Sciences·DateMar 4, 2019
A study published in Nature Communications found that an inhibitor of ACVR1 slows tumor growth and increases survival in an animal model of diffuse intrinsic pontine glioma (DIPG). Researchers believe this enzyme mutation cooperates with a histone mutation to initiate tumor development.
SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalNature Communications·DateMar 4, 2019
Researchers have discovered a way to block the VCC-1 enzyme, which disables a new antibiotic resistance gene found in benign Vibrio cholerae strains. The discovery uses Avibactam, a US FDA-approved combination drug, to effectively combat the resistant bacteria.
SourceAmerican Society for Microbiology·JournalAntimicrobial Agents and Chemotherapy·DateFeb 19, 2019
A study by LMU Munich microbiologists identified an enzyme crucial for Helicobacter pylori's ability to regulate gene expression and adapt to its environment. The discovery sheds light on the bacterium's genetic diversity and its impact on human health, including the development of stomach cancer.
SourceLudwig-Maximilians-Universität München·JournalNucleic Acids Research·DateFeb 12, 2019
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers have discovered that removing arginase 2 enzyme reduces neuron death and degeneration of nerve fibers in the retina after optic nerve injury. The study found that deleting this enzyme decreases inflammation and promotes recovery, suggesting it as a potential treatment target.
SourceMedical College of Georgia at Augusta University·JournalFrontiers in Neuroscience·DateFeb 11, 2019
A team of Harvard researchers has unraveled the process by which bacteria manufacture streptozotocin, a key compound used to treat pancreatic cancer. The study reveals an iron-dependent enzyme with two domains that catalyze different steps in the production of nitrosamine compounds.
Acarbose, a type II diabetes drug, changes the gut microbiome in a reversible and diet-dependent way, according to new research. The findings suggest that more attention should be paid to how medications affect the gut microbiome, particularly for diabetes treatments.
SourceAmerican Society for Microbiology·JournalmSphere·DateFeb 6, 2019
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A novel glycyl radical enzyme has been discovered in Bilophila bacteria, responsible for degrading taurine and producing toxic hydrogen sulphide. The enzyme's oxygen-sensitivity and role in intestinal barrier permeability and colon cancer are being further investigated.
SourceUniversity of Konstanz·JournalProceedings of the National Academy of Sciences·DateFeb 5, 2019
Researchers discovered rhomboid enzymes can move quickly through cell membrane by warping surroundings, allowing them to glide rapidly across. This ability enables them to scour the membrane for targets to cut, providing real-time signals to other cells.
SourceJohns Hopkins Medicine·JournalScience·DateFeb 1, 2019
Researchers developed a designer enzyme with an unnatural aniline side chain, increasing its activity by a factor of 90. Directed evolution led to variants with higher conversion rates, showing the potential for this method in producing highly effective enzymes.
SourceWiley·JournalAngewandte Chemie International Edition·DateFeb 1, 2019
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Scientists at MCG are studying a new treatment target for retinal damage, characterized by blood vessel disruption leading to vision loss. They believe the key lies in arginase 1, an enzyme that helps regulate inflammation, which can be either damaging or reparative.
SourceMedical College of Georgia at Augusta University·DateJan 31, 2019
Researchers created membraneless protocells that facilitate chemical reactions, providing insights into the prebiotic 'RNA world'. These assemblies concentrate RNA molecules and enzymes, allowing them to participate in fundamental chemical reactions.
SourcePenn State·JournalNature Communications·DateJan 31, 2019
Researchers have identified 10 genes encoding transaminases, which can synthesize compounds with special chirality. This breakthrough could aid bioprospecting and genetic engineering programs to produce new medicines.
SourceImmanuel Kant Baltic Federal University·JournalApplied and Environmental Microbiology·DateJan 30, 2019
A research team led by Professor Jaeheung Cho has found a new active intermediate synthesized in the oxidation process using biomimetic catalysts and artificial oxidants. This discovery clarifies the oxidation mechanism and clears the long-standing debate on the role of metal-iodosylbenzene intermediates.
SourceDGIST (Daegu Gyeongbuk Institute of Science and Technology)·JournalJournal of the American Chemical Society·DateJan 30, 2019
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
The University of Warwick has identified the enzyme DGAT1, which controls how much fat is added to particles released by the liver. Inhibiting this enzyme allowed scientists to 'slim down' particles and load them with less fat, reducing the amount of 'bad' cholesterol in the blood.
SourceUniversity of Warwick·JournalJournal of Lipid Research·DateJan 28, 2019
Scientists have discovered how COQ9 binds to aromatic isoprene lipids, accessing membranes through an amphipathic helix. This finding presents new insights into the production of CoQ and may inform strategies to treat lipid deficiency disorders.
SourceEcole Polytechnique Fédérale de Lausanne·JournalMolecular Cell·DateJan 25, 2019
Cyanobacteria assemble intricate carboxysomes to concentrate carbon dioxide, improving RubisCO efficiency. Researchers discovered that CcmM binds to RubisCO enzymes in a non-traditional manner.
SourceAmerican Society for Biochemistry and Molecular Biology·JournalJournal of Biological Chemistry·DateJan 24, 2019