Articles tagged with Erk Activation
Researchers discovered a new role for extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that leads to cancer cell death. Hyperactivation of ERK causes stress in cells, triggering cell death through specific proteins DR5 and NOXA.
Researchers discovered ERK signalling is a crucial switch between scarring and regeneration, with prolonged activation promoting regenerative success. Modulating ERK activity could potentially stimulate regeneration in clinical settings.
A study by University of Alabama at Birmingham researchers reveals that cadmium-induced inflammation increases the severity and mortality of lung infections. The findings suggest that targeting the regulation of PPAR-gamma in macrophages may protect against severe pneumonia.
The study found that BRAF alterations, particularly Class I mutations like v600E, are associated with improved overall survival in adults with glioma. However, the effectiveness of targeted therapies depends on the specific type and combination of genetic alterations driving the cancer.
A team of researchers identified a protein kinase substrate downstream of the dopamine signaling pathway regulating brain reward behavior. The study found that phosphorylation of potassium voltage-gated channel subfamily Q member 2 (KCNQ2) decreases its channel activity, increasing neuronal excitability and promoting reward behavior.
Researchers at Kanazawa University develop a synthetic ligand that mimics the action of hepatocyte growth factor (HGF), inducing comparable biological responses. The macrocyclic peptide molecule activates the MET receptor, leading to tissue regeneration and gene expression profiles similar to HGF.
Researchers used transgenic mice to study the effects of RAS pathway alterations on lymphatic system development. They found that excess ERK activation leads to lymphatic defects in RASopathies, which can be reversed by ERK inhibitor treatment.
A study challenges the prevailing belief that a key human protein linked to cancer needs a partner to function, revealing it can initiate processes on its own. The researchers used high-resolution microscopy techniques to observe proteins in living cells and found that the protein's activation rate is directly linked to its nuclear entry.