Scientists from Dresden have developed new proteins that emit fluorescence in the near-infrared and short-wave infrared ranges, allowing for high sensitivity visualization of biological structures. This breakthrough enables deeper tissue imaging and could aid in studying disease mechanisms and therapeutic effects.
SourceTechnische Universität Dresden·JournalJournal of the American Chemical Society·DateJun 24, 2026
Researchers developed LiON, a fluorescent reporter that visualizes biologically active iron and oxygen inside living cells. The tool revealed striking differences in iron and oxygen distribution across organs and cells, offering new opportunities to study diseases like cancer, liver disorders, and neurodegenerative conditions.
SourceInstitute of Science Tokyo·JournalCell Reports Methods·TypeExperimental study·DateJun 16, 2026
Researchers have developed a new molecular imaging technology that illuminates proteins inside living cells and animals far more clearly than before. The system uses engineered fluorescent nanobodies to reduce background noise by as much as 100-fold, enabling sharper visualization of protein location and dynamics.
SourceAlbert Einstein College of Medicine·JournalNature Methods·TypeExperimental study·DateApr 22, 2026
A new study co-led by OHSU scientist Catherine Galbraith introduces a series of fluorescent dyes that enable the observation of dynamic biological processes in living cells. These tools allow scientists to study cancer-related processes, such as DNA packaging and gene expression, in real-time.
SourceOregon Health & Science University·JournalNature Methods·DateApr 15, 2026
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Scientists from The University of Osaka have created two new fluorescent markers, Gachapin and Gachapin-C, that can visualize dynamic cell-to-cell contacts and connections within a single neuron's extensions. These indicators allow for the monitoring of complex patterns of connectivity in various cell types, including neurons.
SourceThe University of Osaka·JournalCell Reports Methods·TypeExperimental study·DateJan 28, 2026
Researchers at POSTECH and Korea Brain Research Institute unveil NeuO's mechanism of selective neuron staining through PAK6 kinase phosphorylation. This breakthrough opens path for precise tracking and study of living neurons in brain.
SourcePohang University of Science & Technology (POSTECH)·JournalAngewandte Chemie·DateAug 27, 2025
The CombPlex technology developed at Weizmann Institute allows for the simultaneous imaging and quantification of nearly two dozen proteins within individual cells. This breakthrough enables researchers to measure lots of proteins at the same time, crucial for understanding tissue function and disease processes.
SourceWeizmann Institute of Science·JournalNature Biotechnology·DateApr 7, 2025
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers at FAMU-FSU College of Engineering have developed a method for studying protein degradation within immune cells using engineered microparticles. This approach provides real-time insights into immune system function and dysfunction, offering valuable tools for understanding diseases such as cancer, Alzheimer’s disease, and a...
SourceFlorida State University·JournalACS Applied Materials & Interfaces·DateMar 27, 2025
A team of scientists has created a new method to selectively modify specific proteins in complex biological environments. They achieved this using aptamers and deoxyoxanosine, allowing precise conjugation of desired sites on target proteins. This breakthrough technology has the potential to revolutionize cancer diagnosis and treatment.
SourcePohang University of Science & Technology (POSTECH)·JournalJournal of the American Chemical Society·DateMar 26, 2025
Researchers used novel fluorogen imaging techniques to visualize biomolecular condensates, revealing distinct environmental and structural features. The study provides insights into the dynamic behavior of these condensates, which play a crucial role in various diseases.
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers at Institute of Science Tokyo designed a protein cage system that can control and visualize orientational changes in aromatic side chains through strategic binding of fluorescent ligands. This approach enables precise control over protein dynamics while enhancing fluorescence properties, with potential applications in biomo...
SourceInstitute of Science Tokyo·JournalAdvanced Science·TypeExperimental study·DateFeb 26, 2025
Researchers at POSTECH developed a super-photostable organic dye, PF555, to track proteins in cells over extended periods. This breakthrough enables observation of endocytosis and protein interactions, revealing EGFR's active navigation in its environment.
SourcePohang University of Science & Technology (POSTECH)·JournalNature Methods·DateFeb 26, 2025
A new universal photocage modification strategy based on thioketal enables real-time live cell subcellular imaging. The thioketal-based probe SiR-EDT exhibits improved dark stability and can be specifically activated by UV-visible light.
SourceScience China Press·JournalScience Bulletin·TypeRandomized controlled/clinical trial·DateFeb 25, 2025
This study identified PIBP4, a PRA protein, as a crucial component of the PigmR-mediated immune signaling pathway in rice. The absence of PIBP4 and its interacting partner OsRab5a compromised blast resistance by disrupting PigmR's microdomain localization.
SourceScience China Press·JournalScience Bulletin·DateFeb 21, 2025
Researchers developed a novel microscopy technique to study metabolic changes in individual cancer cells at the single-cell level. They found that radiation treatment caused significant metabolic shifts in head and neck squamous cell carcinoma cells, particularly through the activation of HIF-1α.
SourceSPIE--International Society for Optics and Photonics·JournalBiophotonics Discovery·DateFeb 3, 2025
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at MIT develop CuRVE technology, enabling uniform labeling of proteins across millions of individual cells in intact 3D tissues. This breakthrough allows for unprecedented insights into cellular functions and behaviors, overcoming limitations of existing labeling methods.
SourcePicower Institute at MIT·JournalNature Biotechnology·TypeExperimental study·DateJan 24, 2025
The researchers have developed a groundbreaking method to expand the color palette of bioluminescent protein to 20 distinct colors, enabling advanced simultaneous multi-color imaging. This innovation makes it significantly easier and more cost-effective to monitor multiple targets or track individual cells within a population.
SourceOsaka University·JournalScience Advances·TypeImaging analysis·DateJan 22, 2025
Scientists have developed genetically encoded biosensors to measure the ratio of NADPH to NADP⁺ in real-time, revealing new insights into cellular detoxification and protective function.
SourceUniversity of Münster·JournalNature Communications·TypeExperimental study·DateDec 18, 2024
The signaling molecule (p)ppGpp regulates diverse cellular processes essential for DNA repair and stress response, enabling bacterial adaptation to adverse conditions. It influences nucleotide excision repair, mismatch repair, and recombinational repair pathways, promoting the survival of bacteria under antibiotic pressure.
SourceXia & He Publishing Inc.·JournalGene Expression·DateNov 11, 2024
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study immune cell interactions. The approach reveals that interactions between immune cells in the vicinity of breast cancer or melanoma can predict immune responses and patient outcomes.
SourceJackson Laboratory·JournalCommunications Biology·DateOct 30, 2024
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Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Scientists have developed MINFLUX microscopy to measure distances within biomolecules, down to one nanometer, and with Ångström precision. This allows for the detection of different conformations of individual proteins and the observation of their interactions.
SourceMax-Planck-Gesellschaft·JournalScience·TypeExperimental study·DateOct 14, 2024
Researchers at NIST have developed a new method to measure biomolecules in live cells using infrared light, removing water's obscuring effects. This allows for the determination of key biomolecules like proteins and their amounts in cells, speeding up advances in biomanufacturing and cell therapy development.
SourceNational Institute of Standards and Technology (NIST)·JournalAnalytical Chemistry·DateSep 9, 2024
A study in Current Biology mapped a brain circuit responsible for detecting threats and forming fear memories. The hippocampus and subiculum are key structures involved, with the subiculum transferring information to the hypothalamus.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCurrent Biology·DateAug 22, 2024
A new DNA-powered signal amplification technology called ACE significantly enhances the sensitivity of mass cytometry, enabling the detection of multiple proteins in single cells. This breakthrough allows researchers to investigate complex biological processes and study immune cell functions with unprecedented depth.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalNature Biotechnology·TypeExperimental study·DateJul 30, 2024
Scientists at Kyushu University created QDyeFinder, an AI pipeline that untangles the dense neuronal networks in the brain. The system uses a super-multicolor labeling protocol to tag neurons and then automatically identifies their structure by matching similar color combinations.
SourceKyushu University·JournalNature Communications·TypeExperimental study·DateJun 25, 2024
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers have developed a model to enrich sub-populations of cancer cells with high basal levels of mitophagy, promoting CSC features such as self-renewal, proliferation, and drug-resistance. This study highlights the importance of BNIP3/BNIP3L in maintaining cancer stem cell properties.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateJun 17, 2024
Dr. Alice Walker will investigate the design of fluorescent protein sensors using computer simulations, which may aid in tracking diseases and monitoring treatment effectiveness in living cells and organisms. The five-year $690,816 grant also supports undergraduate research opportunities for WSU students.
SourceWayne State University - Office of the Vice President for Research·DateJun 12, 2024
The UW–Madison team developed a label-free method to observe individual molecules using an optical microresonator, allowing for the detection of molecules with unprecedented sensitivity. This breakthrough has potential applications in drug discovery and advanced materials development.
SourceUniversity of Wisconsin-Madison·JournalNature·TypeExperimental study·DateMay 30, 2024
A team of researchers developed a hybrid nanotube stamp system for intracellular protein delivery, achieving high efficiency and cell viability rates in cancer treatment. The system successfully delivered therapeutic proteins into target cells with precision, showing promising efficacy and safety.
SourceWaseda University·JournalAnalytical Chemistry·TypeExperimental study·DateMay 20, 2024
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DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers at U of T have mapped the movement of proteins encoded by the yeast genome throughout its cell cycle, identifying patterns of emergence and disappearance or movement to specific areas. The study provides a unique dataset that offers a genome-scale view of molecular changes during cell division.
Researchers at CeMM Research Center create 'vpCells' method for simultaneous fluorescent labelling of many proteins, enabling precise tracking and exploration of protein function. The approach opens up new applications in fundamental cell biology and drug discovery.
SourceCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences·JournalNature Cell Biology·TypeImaging analysis·DateApr 19, 2024
Researchers at Kyoto University have discovered a signal protein called ERK that plays an active role in causing growing lung tissue to curve. This finding reveals a previously unknown regulatory system governing the development of intricate branching patterns in mouse lungs.
SourceKyoto University·JournalCurrent Biology·TypeExperimental study·DateMar 27, 2024
Researchers at University of Arizona have developed a novel approach to combat mosquito-borne diseases by targeting the unique alkaline environment of larval mosquito guts. The study uses specially designed chemical compounds to modify proteins, hindering food digestion and growth.
SourceUniversity of Arizona·JournalJournal of the American Chemical Society·TypeExperimental study·DateMar 18, 2024
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Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers from Tohoku University developed a unique chemical reaction to attach two distinct functional molecules to the N-terminus of peptides with a glycine amino acid, achieving site-selective modification and stable carbon-carbon bonds. The method shows potential for labeling diverse peptides and larger proteins for purification,...
SourceTohoku University·JournalAngewandte Chemie International Edition·DateMar 11, 2024
Researchers found that fluorescent proteins function as potent antioxidants, safeguarding cells from oxidative damage in neon-colored sea anemones. The study also revealed a direct genetic link between fluorescence and color variation in these creatures.
SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMar 8, 2024
A new nanocarrier has been developed that can selectively release drugs in cancer cells through controlled endosomal escape. The approach exploits the unique enzymatic activity of cancer cells, allowing for targeted delivery and reduced harm to healthy cells.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateFeb 28, 2024
Researchers have developed a new method to label naïve neurotransmitter receptor proteins in living animal brains without genetic manipulation. This technique, known as ligand-directed acylimidazole chemistry (LDAI chemistry), uses pulse-chase analysis to track the movement and fate of proteins in real-time.
SourceJapan Science and Technology Agency·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 22, 2024
Researchers at Duke University have discovered how stem cells decide their fate by analyzing the activity of two key regulators, short-root and scarecrow, in real-time using light sheet microscopy. This finding has implications for understanding cell development and preventing diseases such as cancer.
SourceDuke University·JournalNature·TypeImaging analysis·DateFeb 9, 2024
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Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers have developed a fluorescent sensor array that can detect Alzheimer's-related proteins, allowing for earlier disease detection. The tool uses an array of sensor molecules that light up amyloids, providing a high level of sensitivity and selectivity in distinguishing between different amyloid-related conditions.
SourceAmerican Chemical Society·JournalACS Sensors·DateFeb 5, 2024
Researchers at Kyoto University have observed a unique phenomenon where talin constantly moves over focal adhesions as a single unit, contradicting prevailing notions. This discovery reveals that talin manages to simultaneously maintain the intercellular connection while transmitting force through dynamic molecular stretching.
SourceKyoto University·JournalNature Communications·TypeExperimental study·DateFeb 1, 2024
Researchers used a novel microscopy technique to image human brain tissue with unprecedented detail, revealing new cells and structures previously invisible. The method could help diagnose tumors, generate more accurate prognoses, and guide treatment decisions.
SourceMassachusetts Institute of Technology·JournalScience Translational Medicine·DateJan 31, 2024
A KAIST research team has developed a technique called SynapShot, which allows for the real-time observation of synapse formation, extinction, and alterations. This breakthrough technique uses fluorescent proteins to track changes in synapses, offering new insights into brain function and potentially revolutionizing neurological research.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalNature Methods·TypeExperimental study·DateJan 18, 2024
Researchers developed a modular flow platform to safely execute SuFEx click chemistry, generating toxic sulfuryl fluoride in a controlled manner. The system facilitates rapid functionalization of small molecules, peptides, and proteins.
SourceUniversiteit van Amsterdam·JournalNature Synthesis·DateDec 6, 2023
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at MIT have developed an alternative method to study molecular signals in cells, allowing them to track up to seven different molecules simultaneously. The technique uses fluorescent proteins that flicker on and off at different rates, enabling the tracking of specific cellular functions over time.
SourceMassachusetts Institute of Technology·JournalCell·DateNov 28, 2023
Researchers have created two new protocols using novel actinometers to quantify photons, providing versatile and precise light intensity measurements. The protocols are faster, more sensitive, and compatible with imaging systems, enabling accurate measurement of light intensity in biological samples.
SourceINsociety·JournalNature Methods·TypeExperimental study·DateNov 23, 2023
Researchers tested AlphaFold2's ability to predict protein structure changes from single point mutations. They found that AlphaFold can accurately predict deformation at the chromophore-binding site, leading to accurate predictions of fluorescence in fluorescent proteins.
SourceInstitute for Basic Science·JournalPhysical Review Letters·TypeMeta-analysis·DateNov 21, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers identify mechanism by which specific protein condensates transition from liquid to solid states, enabling stability and transmission of mechanical forces. MEC-2 proteins' biological function switches with rigidity maturation, facilitating mechanosensation.
SourceICFO-The Institute of Photonic Sciences·JournalNature Cell Biology·DateOct 19, 2023
Researchers at University of California - Riverside uncover COVID's Achilles heel - its dependence on key human proteins. By understanding how the virus interacts with human cells, a new class of antiviral medication may be developed to block replication and treatment.
SourceUniversity of California - Riverside·JournalViruses·DateSep 13, 2023
Scientists have detected over 300 proteins associated with lipoproteins in the central nervous system, far more than previously thought. The most common protein, apolipoprotein E (APOE), plays a key role in delivering nutrient-rich lipids and protein tools to perform tasks such as wound healing and neuron creation.
SourceDOE/Pacific Northwest National Laboratory·JournalScience Advances·TypeImaging analysis·DateSep 12, 2023
Researchers have developed a new method to study the inner workings of cell nuclei during embryonic stem cell differentiation. By using fluorescent proteins, they found that biomaterials become more uniformly distributed as cells mature, resembling oil droplets in water, but with intriguing complexities.
SourceThe Hebrew University of Jerusalem·JournalNature Communications·TypeExperimental study·DateSep 10, 2023
Researchers have identified essential genes for the growth of Patescibacteria, a group of tiny microbes that live on larger bacteria. The study provides insights into their unique biology and potential biotechnology applications.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalCell·DateSep 7, 2023
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers from Max Planck Institute identified mechanisms of deubiquitinating enzymes acting as Fubi proteases, regulating ribosomal protein maturation and modulating immune responses. This discovery expands understanding of post-translational modification systems and their roles in cellular processes.
SourceMax Planck Institute of Molecular Physiology·JournalNature Chemical Biology·TypeExperimental study·DateAug 24, 2023
A new nano-sized force sensor developed by Tampere University researchers allows for the measurement of intracellular forces and mechanical strains. This technology has great potential for studying cancer cells and understanding cellular mechanics.
SourceTampere University·JournalNature Communications·DateAug 21, 2023
Researchers from University of Freiburg and University of Cambridge have observed dynamic molecular aggregates in cells for the first time. These condensates play a crucial role in controlling biochemical processes and are regulated by active biological mechanisms, not just physical forces.
SourceUniversity of Freiburg·JournalNature Communications·DateAug 15, 2023
A research team sheds light on Dmc1 filament assembly mechanisms using single-molecule experiments. Swi5-Sfr1 and Hop2-Mnd1 proteins regulate Dmc1 assembly through distinct mechanisms, promoting efficient strand exchange during homologous recombination.
SourceTokyo Institute of Technology·JournalNucleic Acids Research·TypeExperimental study·DateJul 19, 2023
Scientists at Max Delbrück Center have developed a tool to screen drugs that can help treat viral diseases like COVID-19 by analyzing the immune response of lung epithelial cells. The technology uses synthetic locus control region (sLCR) DNA sequences that glow red when triggered, enabling researchers to identify potential treatments.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalScience Advances·DateJun 22, 2023
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers have developed biomaterials that contain a 'living-like' system, capable of detecting pathogens and monitoring air quality. These materials are designed to interact with air, making them potential sensors for healthy indoor environments.
SourceUniversity of Pennsylvania School of Engineering and Applied Science·JournalFrontiers in Bioengineering and Biotechnology·DateJun 21, 2023
Researchers at Ulsan National Institute of Science and Technology have made a breakthrough in creating ultra-photostable avalanching nanoparticles that can perform unlimited photoswitching. This achievement has significant implications for fields like optical probes, 3D optical memory, and super-resolution microscopy.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalNature·DateMay 31, 2023
Researchers used ancestral sequence reconstruction to study protein interactions in cyanobacteria, finding that they can evolve independently of direct selection pressure. The discovery challenges classical evolutionary theory and suggests that fortuitous compatibility may be the basis for a significant fraction of cellular interactions.
SourceMax-Planck-Gesellschaft·JournalNature Ecology & Evolution·TypeObservational study·DateApr 6, 2023
Scientists at UvA have created a new, highly improved bright red fluorescent protein called mScarlet3. This variant combines maximum brightness with fast and complete folding, making it an ideal tool for researchers studying cellular processes.
SourceUniversiteit van Amsterdam·JournalNature Methods·DateMar 27, 2023
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