Articles tagged with Guanine Nucleotide Exchange Factors
Researchers discovered huperzine A increases resistance to induced seizures in mouse models of genetic epilepsy. The compound has been shown to protect against febrile seizures, a feature of both Dravet syndrome and GEFS+, with complete protection observed in genetically modified mice.
Researchers have discovered a new biomarker, guanine nucleotide exchange factors (GEFs), that triggers hyperactivity in proteins fueling cancer growth and spread. Elevated GEF expression is associated with shorter progression-free survival in patients with metastatic colorectal cancer.
A study of 200 major international water-related projects identified existing and emerging challenges, including insufficient management, urbanization, and climate change. Investing in science and strengthening the science-policy interface can help reduce risks and inform decision-making.
Researchers challenge traditional model of mRNA translation with discovery of EF-G's binding to GDP and its role as a GTP exchange factor. The ribosome plays a dual role in guanine-nucleotide exchange and GTPase-activation, leading to partial translocation of the mRNA.
A novel mutation in the SCN1A gene has been discovered in a family with generalized epilepsy with febrile seizures plus (GEFS+), a condition characterized by unusual brain activity. This finding may lead to improved diagnoses, treatments, and genetic counseling for affected individuals.