Articles tagged with Hormones
A large population-based study found that patients on levothyroxine had lower quality of life and more comorbidity than those not taking the hormone. The study also showed that comorbidity had a greater negative impact on the quality of life of LT4 users.
Researchers have discovered that changes in social behavior during adolescence are not triggered by pubertal hormones. Using Siberian hamsters as a model, the team found that behavioral shifts, such as play-fighting to social dominance, occur at the same time regardless of puberty timing.
A phase II clinical trial showed that NGM282 significantly reduced liver fat content in patients with NAFLD and NASH. The treatment, a non-tumorigenic variant of an endocrine gastrointestinal hormone, has no FDA-approved treatments for these conditions.
A retrospective study of patients with laryngeal cancer who underwent radiation treatment found that those with low thyroid hormone levels were more likely to experience fistula formation and prolonged hospital stays. Researchers propose administering a common hormone supplement, levothyroxine, to prevent these complications.
Researchers found that prenatal exposure to androgens had no significant association with girls' time spent with either boys or girls. However, girls with classical CAH spent more time in male-typical activities and less time in female-typical activities. This study suggests that gender development is a complex process influenced by bo...
Researchers at the University of Edinburgh identified a hormone called DHEA that can prime cells for implantation and increase active hormones. This discovery could lead to new treatments for infertility in women over 40.
Researchers found changes in gene activity in the pituitary gland of foxes selectively bred for tameness, which may explain why tame foxes are less stressed. The study suggests that domestication alters animals' reactivity to stress by modifying the way their brain centers communicate about hormone release.
The study reveals how fibroblast growth factor 23 (FGF23) signals to cells through its receptor and alpha-Klotho, reversing previous conjecture on alpha-Klotho's anti-aging role. The findings also shed light on kidney disease leading to heart hypertrophy.
A study published in PNAS found that constant noise from oil and gas operations can cause physiological stress in birds, leading to reduced egg hatching rates and stunted chick growth. The research also showed that species previously thought to be tolerant of noise were actually most affected.
Researchers have found a potential new treatment for fetal growth restriction, a condition where the fetus doesn't grow at a normal rate during pregnancy. The treatment involves injecting a growth factor into sheep fetuses, which increased their growth without increasing stillbirths or deaths.
A recent study by UNC Lineberger Comprehensive Cancer Center researchers found that black women with hormone-receptor positive, HER2-negative breast cancer had a higher risk of recurrence compared to white women. The biological features of patients' tumors partially explained this difference, but not completely.
A recent study published in Women and Birth found that consuming placenta capsules has limited benefits for new moms, including no significant impact on postpartum mood or maternal bonding. However, the study did show detectable changes in hormone concentrations in mothers taking placenta capsules.
A recent study found a link between genetic variants and lower GLP-1 levels, which may predict increased cardiovascular mortality risks in type 2 diabetes patients. The research could lead to personalized patient care by testing genetic risk markers and tailoring treatments accordingly.
Researchers from RUDN University have developed a three-stage synthesis method for producing steroid analogs, including hormones and terpenes. The process takes 2-3 days at room temperature, significantly reducing the time required compared to previous methods.
A team of researchers at the Broad Institute has created a high-resolution census of the small intestine's cellular composition, revealing new insights into gut biology and its connection to diseases such as inflammatory bowel disease and food allergies. The atlas uses single-cell RNA sequencing and provides a reference for studying th...
A study on chicken embryos reveals that thyroid hormone transporter MCT8 plays a vital role in brain development. The research found that MCT8-deficient cells failed to migrate and proliferate, leading to disrupted brain formation. This suggests that brain lesions associated with a rare neurological disorder may originate before birth.
Researchers at Aarhus University have found a hormonal link to unexplained seizures in women, revealing a biological cause for the previously psychologically attributed condition. The study measured hormone levels in patients with psychogenic non-epileptic seizures (PNES) and found lower neuropeptide Y levels, associated with stress re...
A new study found that high levels of thyroid hormone FT4 are associated with an increased risk of artery disease and death. Researchers analyzed data from 9,420 participants and discovered a significant link between thyroid function and atherosclerosis.
Researchers at UC find that certain spadefoot toad species regulate hormone production to adapt to environmental changes, speeding up development and shortening larval periods. This process enables them to survive in warmer and drier climates.
Research finds individuals with higher thyroid hormone levels, even within normal range, are more likely to develop irregular heartbeat. The study analyzed data from 30,085 individuals and found a significant increase in risk associated with moderate increases in FT4 levels.
A study published in JAMA found that biomarkers indicating diminished ovarian reserve were not associated with reduced fertility in women aged 30-44 attempting natural conception. Low AMH or high FSH levels were not linked to lower fecundability or cumulative probability of conceiving.
A new study found that women exposed to Agent Orange during the Vietnam War had higher levels of hormones in their breast milk, which were then transferred to their babies. The research revealed a nearly three-fold increase in DHEA in babies from dioxin hotspots compared to non-contaminated regions.
Researchers found that signalling by prolactin to its receptors is essential for mothers to show vital maternal nurturing behaviour towards their young. This discovery may explain why some animal species abandon their young and highlights the importance of prolactin in establishing a bond between mother and baby.
A newly-discovered reflex arc disrupts hormone secretion by adrenal glands, leading to increased bacterial infections. Trauma-induced spinal cord injuries weaken the immune system, resulting in severe infections and hindering nervous tissue regeneration.
A UC Riverside-led study identified two hormones (ecdysis triggering hormone and juvenile hormone) and a neurotransmitter (dopamine) that regulate courtship memories in males. The study found that these molecules are critical to maintaining aversive memories of failed courtship attempts, influencing future behaviors.
Kimera Biotecnologia's biotech eCG has proven as effective as conventional eCG, reducing production costs by 30-50% and eliminating animal blood use. The hormone is produced in the lab, hastening puberty, inducing superovulation, and increasing fecundity.
Scientists have discovered the key trigger molecule that helps mature red blood cells. By removing a hydrophobic molecule from serum using charcoal filters, researchers found that adding back just thyroid hormone triggers red blood cell maturation.
Developed by a team of researchers, the biosensor uses antibody fragments and polyethylene glycol molecules to detect target compounds in serum. The device can diagnose many conditions and illnesses at sub-picomolar concentrations, making it inexpensive and easy to use.
Researchers found that obese people have fewer enteroendocrine cells in the gut, reducing satiety hormones and altering appetite. Surgical weight-loss procedures can repair this disorder by restoring cell numbers and normalizing hormone release.
A study led by Columbia University Medical Center researchers found that boosting blood levels of osteocalcin reverses age-related memory loss in mice. Osteocalcin binds to a receptor called Gpr158 in the brain's memory center, and restoring youthful levels of the hormone improves cognitive function.
Researchers found that largemouth bass stressed by air exposure are less likely to be caught by angling, suggesting a potential link between cortisol levels and fishing vulnerability. The study's findings have implications for fisheries management and the selection of fish populations for recreational fishing.
A study by UC San Francisco scientists found that administering klotho to young, aging or impaired mice rapidly improves their cognitive and physical performance. The treatment also showed benefits for aged mice and those with Parkinson's disease-like symptoms, suggesting a potential therapeutic application.
New research from Northwestern University suggests that children who live in neighborhoods with high rates of violent crime struggle more in school due to sleep disruption and increased stress hormone cortisol. The study found that violent crimes alter sleep patterns, leading to a negative impact on academic performance.
A new study found that violent crime can disrupt sleep patterns and increase stress hormones in youth, leading to decreased academic performance. The study, conducted on 82 youth aged 11-18, showed that sleep and cortisol levels changed after a violent crime occurred nearby, with the largest effects seen for homicides.
A study found that hemodialysis patients with hypothyroidism exhibit impairments in health-related quality of life, including physical function and pain. The findings suggest a potential link between thyroid hormone levels and patient outcomes.
A recent study found that consuming foods high in polyunsaturated fats, such as walnuts and salmon, can favorably change appetite hormones in young adults. The study participants experienced a decrease in fasting ghrelin and an increase in peptide YY, leading to better appetite control.
Naoki Yamanaka, the first researcher at UC Riverside to receive a Pew scholarship, will pursue foundational research using state-of-the-art techniques. His research focuses on identifying chemicals that interrupt steroid hormone entry into cells, which could lead to novel means of manipulating steroid-related processes.
Scientists at Imperial College London discovered a way to target specific receptors controlling appetite in mouse brains without causing side effects. This breakthrough could lead to the development of a new type of anti-obesity medication that activates thyroid hormone receptors in the hypothalamus.
Early childhood exposure to specific phthalates was associated with depressed thyroid function in girls at age 3. Lower levels of active thyroid hormone free thyroxin (FT4) were linked to metabolites of certain phthalate chemicals.
Researchers identified VEGF-A as a key player in thyroid-vascular coordination, producing excess hormones and dense capillaries in hyperthyroidism. Blocking VEGFR2 could inhibit thyroid enlargement and remodeling.
Researchers have developed a laboratory model for Allan-Herndon-Dudley syndrome, a rare psychomotor disease that affects brain development. The study uses induced pluripotent stem cell technology to replicate the patient's blood-brain barrier, providing new insights into the disease and potential therapies.
A steroid hormone called ecdysone has been identified as a crucial trigger for brain development in fruit flies. The hormone is similar to human thyroid hormone and its activity timing may hold clues to maternal hypothyroidism, a condition that can cause severe neurological defects and fetal brain damage.
New research finds that suppressing thyroid hormone receptor activity locally in the retina protects cone photoreceptor cells, slowing cell death and prolonging their life span. The study suggests a therapeutic strategy for treating retinal degeneration using topical medications or eyedrops.
The emerging field of conservation endocrinology explores the effects of environmental change on species and ecosystems through hormone analysis. Researchers are developing new techniques to monitor ecological responses and plan future conservation efforts.
A study published in Cell Metabolism found that a liver hormone called FGF21 may play a role in determining who has a sweet tooth. The researchers discovered two variants of the FGF21 gene associated with increased intake of sweets and candies.
Researchers using endocrine markers can monitor ecological responses to climate change and plan conservation efforts. This emerging field aims to improve conservation biology by studying the impact of environmental stressors on species health.
Researchers at the University of Birmingham have discovered a new cause of high blood pressure, known as Connshing syndrome, which is characterized by the overproduction of both aldosterone and cortisol. This condition can lead to increased risk of heart attack and stroke, and may require additional treatment beyond current medications.
Researchers discovered a separate mechanism in the brain that deals only with chronic stress, involving a small group of nerve cells in the paraventricular nucleus. The CRFR1 system is thought to play a role in regulating cortisol levels and may be involved in depression, with patients having more of this receptor than average.
A new study found that higher levels of vitamin D, insulin-like growth factor-1, and dehydroepiandrosterone sulfate are associated with a lower risk of worsening frailty in men. These findings suggest that targeting these hormones may help prevent frailty development in aging men.
Research reveals that consuming cow's milk with levothyroxine supplement can lead to reduced absorption of the medication, potentially resulting in inadequate thyroid hormone levels. The study advises patients on managing hypothyroidism or taking levothyroxine to avoid consuming dairy products simultaneously.
Researchers have found that a hormone called hepcidin helps fight off bacterial pneumonia by limiting the spread of bacteria in the blood. Stimulating hepcidin production could be lifesaving for vulnerable patients, including those with iron overload or liver disease.
When parent little auks were stressed, they reduced feeding and spent more time searching for food, impacting their offspring's nutrition. Despite this, the birds still displayed a care response to their chicks' begging behaviour.
Thyroid hormones are essential for brain cell development and signalling, but impaired transporters can lead to severe mental retardation. Researchers found that a genetic mutation deactivates an important transporter, MCT8, in patients with Allan-Herndon-Dudley syndrome.
Crossing chickpeas is challenging due to self-pollination and inbreeding. Researchers found that emasculation and hormone treatment do not increase cross-pollination rates, instead lowering success rates. Studying environmental factors like light, temperature, and humidity may improve breeding efficiency.
Researchers at TSRI identified a brain hormone called FLP-7 that stimulates fat metabolism without affecting food intake. By studying roundworms and visualizing the hormone in living animals, they found a direct link between serotonin levels in the brain and FLP-7 production, which triggers fat burning in the gut.
A recent study found that kisspeptin stimulates the release of reproductive hormones and boosts brain activity linked to sexual arousal and romance. The researchers believe this may help treat psychosexual disorders and improve conception rates for infertile couples.
Researchers have turned to frog models to study the impact of early stressors on adult diseases, finding that a specific gene USH1g is highly expressed in response to stress. This study sheds light on the mechanisms behind fetal stress hormone effects on adult chronic diseases.
Researchers developed a portable sensor using engineered E. coli bacteria to detect environmentally relevant concentrations of endocrine disrupting chemicals (EDCs). The device can determine concentrations of known EDCs individually and overall mixtures in minutes, offering a cost-effective solution for detecting hormone disruptors.
A new study published in the Journal of Bone Joint Surgery has found that treatment with teriparatide accelerates bone healing and improves recovery after hip fractures. Patients who received teriparatide showed significant improvements in mobility and reduced pain compared to those treated with a different medication.
Researchers at German Resilience Center found that corticotrophs rapidly influence avoidance behavior after stress onset, contradicting previous slow effects of hormones. This breakthrough suggests new treatments for acute stress-induced reactions and alleviating conditions.