Articles tagged with Medicinal Chemistry
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new curriculum developed by Duke University's Pharmacology Education Partnership (PEP) has shown to significantly improve students' understanding of biology and chemistry. The approach uses real-world examples, such as nerve gas and drugs, to make science more relevant and engaging for students.
Computer modeling helps explain experimental results and predict successful reactions, leading to breakthroughs in understanding how new drugs work. Proline, a simple protein building block, was solved using computational methods after decades of uncertainty.
Patrick Harran, associate professor of biochemistry at UT Southwestern Medical Center, has won the AstraZeneca Excellence in Chemistry Award for his discovery of a synthetic alternative to an anticancer compound. His research reveals that the initial structure reported for the natural product was incorrect.
A Wayne State and Virginia chemist has won a national award for his work on developing anti-parasitic compounds by mimicking the structure of sugar molecules. Researchers have learned that these molecules serve as 'ID tags' on cell surfaces, which can be used to identify target tissues and prevent infections.
Researchers developed a 3D biochip with tiny chemical reactor chambers and microfluidic delivery systems for growing cells and delivering chemicals. This technology enables high-throughput screening of hundreds of thousands of molecules while minimizing toxicity testing on animal models.
Dr. K. Barry Sharpless' discovery of chiral catalysts has enabled the production of useful molecules, including therapeutics that improve human health and lives. His work has streamlined the creation of important chemicals, including antibiotics and heart medicines.
John Montgomery, a Wayne State University chemist, has developed a new method to create complex molecules efficiently. He achieves this by making multiple bonds at once, using catalysts based on reactive nickel.
A study published in Clinical Chemistry explores the connection between metabolic abnormalities and SIDS, highlighting a potential standard protocol for medical examiners. MS/MS testing of infant and child deaths may help explain SIDS cases, offering new insights into this leading cause of childhood death.
Purdue University researchers have developed a method to sort and isolate chemical compounds as they are made, identifying the most biologically active compounds among millions of candidates. The new method combines state-of-the-art imaging technology and combinatorial chemistry, reducing screening times by four to 12 times.
Researchers discovered gold compounds emitting fluorescent light for one million times longer than expected. The light is trapped inside the compound, leading to various applications including detecting diseases and producing sensors. Gold's unique properties also make it effective in treating rheumatoid arthritis and cancer.
M. David Francis, an Ohio-based physical biochemist, received a national award from the American Chemical Society for his pioneering work on fluoride additives in toothpaste and pharmaceuticals.
In 1975, medicinal chemists Miguel A. Ondetti and David W. Cushman designed captopril, the first of an innovative class of drugs controlling high blood pressure and heart disease.
Researchers discovered growth hormone inhibitor octreotide, treating acromegaly and gastroenteropancreatic tumors. The drug has also shown promise in preventing eye damage in patients with type I diabetes.
Philip Portoghese, a medicinal chemist at the University of Minnesota, has received the Alfred Burger Award in Medicinal Chemistry from the American Chemical Society for his work on opioid receptors. His research reveals how drugs such as morphine interact with these receptors, enabling the creation of new, more effective drugs.
Chemist William R. Dolbier receives American Chemical Society Award for Creative Work in Fluorine Chemistry for innovative studies of fluorine, which strengthens bonds and makes products like Teflon resistant to high temperatures.
University of Toronto researchers have successfully integrated organic molecules and inorganic materials at the molecular scale, creating a new class of composite materials. These hybrid materials have unique properties that could improve their hardness, thermal and electrical insulation, or light emission and magnetism, paving the way...
The American Association of Pharmaceutical Scientists (AAPS) recognizes outstanding researchers with its annual awards. Joseph R. Robinson receives the Distinguished Pharmaceutical Scientist Award for his work on controlled drug delivery and ocular drug disposition, while Charles Russell Middaugh wins the Research Achievement Award in ...
The American Chemical Society's Southeast Regional Meeting will be held in Knoxville, featuring a variety of topics including environmental and medicinal chemistry. Over 600 scientific papers will be presented during the event.
The American Association of Pharmaceutical Scientists has premiered an online database of the abstracts to be presented at the upcoming annual meeting. The database includes all invited and contributed paper abstracts, with a unique personal itinerary feature allowing attendees to plan their meetings.
Biotechnology graduates need to expand their course load and vary their skills to succeed in careers like regulatory affairs, clinical trials coordination, and bioinformatics. Many biotech companies require employees with degrees in scientific disciplines to transition into management, information technology, and marketing roles.
The use of computers has transformed the field of chemistry, enabling researchers to automate large-scale testing of compounds and speed up drug discovery. Electronic lab notebooks are also being adopted to share information and streamline the process.
Researchers at UNC-CH have synthesized ginkgolide B, a compound isolated from the ginkgo tree, which has been used as herbal medicine for thousands of years. The successful synthesis may lead to new treatments for dementia, multiple sclerosis, and other illnesses.
The American Chemical Society's 32nd Middle Atlantic regional meeting will explore topics such as plastics, environmental protection and medicinal chemistry. More than 700 attendees are expected, with presentations covering the latest research findings.
A new neuroactive chemical, HF-7, isolated from spider venom may block overproduction of neurotransmitters causing brain damage after oxygen deprivation. Theoretical studies suggest HF-7 could stave off severe brain damage during short bouts of oxygen loss.
The American Association of Pharmaceutical Scientists has recognized eight researchers with awards for their outstanding contributions to the field. Sung Wan Kim received the AAPS-Dale E. Wurster Research Award in Pharmaceutics for his work on controlled drug delivery systems, while Vincent H.L. Lee was honored with the Distinguished S...
The University of Pittsburgh has been chosen as one of three pioneer sites for biocombinatorial chemistry research, a revolutionary approach to speed up drug discovery. Researchers will create novel chemical compounds and test them in specific assays to learn whether they can interrupt cellular activities that lead to cancer.
A team of Cornell University researchers discovered that beetle pupae can create hundreds of deterrent compounds using combinatorial chemistry. The pupae secrete these complex chemicals through microscopic body hairs, thwarting most predators and ensuring their survival in the field.
The 216th national meeting of the American Chemical Society will feature over 6,000 technical presentations on various topics including analysis of endocrine disrupters, environmental issues and polymers from renewable resources. Approximately 10,000 registrants are expected to gather for about 609 technical sessions.
Researchers have synthesized the major human metabolite of Taxol, 6-alpha-hydroxypaclitaxel, for the first time in a laboratory setting. This breakthrough will enable easier identification and quantification of the metabolite in complex mixtures, crucial for maximizing the clinical effectiveness of paclitaxel.
A panel of leading research chemists will discuss new ways to fight disease, gene mapping and sequencing's impact on chemistry and medicine, and improving standard living through chemistry. Technologies like buckytube fibers and nanomaterials will also be explored.
Researchers at Yale University are using computer simulations to design more effective pharmaceuticals by optimizing chemical binding to target proteins. This approach has the potential to improve treatment outcomes for diseases such as dementia, diabetes, and spinal cord injuries.
The 215th national meeting of the American Chemical Society will feature over 4,700 papers on various topics including cancer therapy, global warming, and chemistry education. The event will also include a chemistry exposition with over 200 companies showcasing their products and services.
Dr. Paul D. Boyer, a long-time NIH grantee, has won the Nobel Prize in Chemistry for his groundbreaking work on ATP synthesis. His research has provided a deep understanding of the molecular mechanism by which ATP is formed, shedding light on fundamental processes in biology.
Researchers develop tiny coated beads that can release drugs directly onto tumors in response to chemical signals. The beads are designed to remain intact until exposed to sodium-rich blood plasma, at which point they swell and burst explosively, releasing the entrapped drug. This technology has potential for targeted cancer treatment.
University of Delaware researchers use a 'bicyclic lactone' to synthesize five unique compounds derived from red sea algae, making them easier to access for potential pharmaceutical uses. The process allows for efficient synthesis in large quantities, paving the way for further research into the compounds' biological activity.
A breakthrough in basic chemistry developed by University at Buffalo scientists has the potential to expand dramatically the variety and potency of new pharmaceutical compounds. The method uses a chiral catalyst to synthesize biologically important compounds with specific chemical structures.