Articles tagged with Medicinal Chemistry
Researchers have synthesized hundreds of new compounds that can specifically reduce A-beta 42 levels in the brain, a primary component of Alzheimer's disease. The compounds, called gamma-secretase modulators, were tested in mouse models and showed promising results, reducing neuritic plaques and A-beta 42 levels.
The Reaxys PhD Prize awarded Thomas Maimone, Hiroyuki Miyamura, and Robert Phipps for their groundbreaking research. The winners were selected from over 300 submissions based on originality, innovation, and publication quality.
The American Society for Biochemistry and Molecular Biology will present 10 scientists with various awards for their outstanding contributions to the field. This year's awardees include Phillip Sharp, Sarah Keller, David Russell, James Wells, John Tesmer, Lisa Gentile, Susan S. Taylor, Douglas Rees, and Ruedi Aebersold.
Researchers have developed 'filters' that can be used to weed out compounds likely to show up as false positives during high-throughput chemical screening. This will reduce the time spent on medicinal chemistry and optimize the compound selection process for drug development.
James A. Wells, a UCSF professor and director of the small molecule discovery center, has made groundbreaking contributions to protein engineering and discovery. He integrates multiple disciplines to design molecules that selectively activate or inhibit cellular processes.
The University of Arizona College of Pharmacy and the Translational Genomics Research Institute have been awarded a $7.5 million grant to establish a comprehensive center for drug discovery and development. The center aims to assemble a team capable of designing and selecting drug candidates to respond quickly to unmet medical needs.
Marine biomedicine researchers have deciphered the structure of a naturally produced ocean-based compound hoiamide A, which offers a novel template for drug development. The findings suggest that hoiamide A may interact with neurons in different ways, potentially leading to therapeutic effects for diseases such as epilepsy and neurodeg...
A new international public-private partnership aims to develop small molecule inhibitors for 25 proteins involved in epigenetic signalling. The project, led by the Structural Genomics Consortium, involves major pharmaceutical companies and academia.
Feldmann and Maini discovered tumor necrosis factor-alpha as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions. Their research led to the development of several anti-TNF drugs, transforming treatment for people diagnosed with chronic inflammatory conditions.
Researchers at UIC aim to develop a compound blocking mania associated with bipolar disorder, improving on dated 'mood stabilizers' like lithium and valproic acid. The goal is to create safer, more effective treatments for the mental illness affecting over 2 million Americans.
The American Chemical Society has awarded a national recognition to a prominent chemist for their groundbreaking work in medicinal chemistry. Anderson has made significant contributions to the development of statins and HIV treatments, including Zocor and Crixivan.
The Dr. Paul Janssen Award for Biomedical Research aims to recognize and reward innovative contributions to human health, as identified by a six-member international selection committee. The first Award will be presented in September 2006, with a $100,000 prize and global recognition for the recipient.
Researchers have found a way to increase the potency of Khellinone, a naturally occurring substance with anti-inflammatory properties. By disrupting rogue T cell potassium channels, the compound reduces myelin damage and may help tackle multiple sclerosis.
Researchers develop new chemical reaction to simplify indole synthesis, reducing the number of steps from six to three and minimizing toxic by-products. The technique could lead to significant cost savings and reduced environmental impact in pharmaceutical manufacturing.
NIST's new reference material, calibrated microspheres coated with fluorescent dye, provides an authoritative national fluorescence measurement scale. This improvement enables more accurate measurements of signal intensity, reflecting numbers of target molecules in samples.
A new curriculum developed by Duke University's Pharmacology Education Partnership (PEP) has shown to significantly improve students' understanding of biology and chemistry. The approach uses real-world examples, such as nerve gas and drugs, to make science more relevant and engaging for students.
Computer modeling helps explain experimental results and predict successful reactions, leading to breakthroughs in understanding how new drugs work. Proline, a simple protein building block, was solved using computational methods after decades of uncertainty.
Patrick Harran, associate professor of biochemistry at UT Southwestern Medical Center, has won the AstraZeneca Excellence in Chemistry Award for his discovery of a synthetic alternative to an anticancer compound. His research reveals that the initial structure reported for the natural product was incorrect.
A Wayne State and Virginia chemist has won a national award for his work on developing anti-parasitic compounds by mimicking the structure of sugar molecules. Researchers have learned that these molecules serve as 'ID tags' on cell surfaces, which can be used to identify target tissues and prevent infections.
Researchers developed a 3D biochip with tiny chemical reactor chambers and microfluidic delivery systems for growing cells and delivering chemicals. This technology enables high-throughput screening of hundreds of thousands of molecules while minimizing toxicity testing on animal models.
Dr. K. Barry Sharpless' discovery of chiral catalysts has enabled the production of useful molecules, including therapeutics that improve human health and lives. His work has streamlined the creation of important chemicals, including antibiotics and heart medicines.
John Montgomery, a Wayne State University chemist, has developed a new method to create complex molecules efficiently. He achieves this by making multiple bonds at once, using catalysts based on reactive nickel.
A study published in Clinical Chemistry explores the connection between metabolic abnormalities and SIDS, highlighting a potential standard protocol for medical examiners. MS/MS testing of infant and child deaths may help explain SIDS cases, offering new insights into this leading cause of childhood death.
Purdue University researchers have developed a method to sort and isolate chemical compounds as they are made, identifying the most biologically active compounds among millions of candidates. The new method combines state-of-the-art imaging technology and combinatorial chemistry, reducing screening times by four to 12 times.
Researchers discovered gold compounds emitting fluorescent light for one million times longer than expected. The light is trapped inside the compound, leading to various applications including detecting diseases and producing sensors. Gold's unique properties also make it effective in treating rheumatoid arthritis and cancer.
Researchers discovered growth hormone inhibitor octreotide, treating acromegaly and gastroenteropancreatic tumors. The drug has also shown promise in preventing eye damage in patients with type I diabetes.
M. David Francis, an Ohio-based physical biochemist, received a national award from the American Chemical Society for his pioneering work on fluoride additives in toothpaste and pharmaceuticals.
In 1975, medicinal chemists Miguel A. Ondetti and David W. Cushman designed captopril, the first of an innovative class of drugs controlling high blood pressure and heart disease.
Philip Portoghese, a medicinal chemist at the University of Minnesota, has received the Alfred Burger Award in Medicinal Chemistry from the American Chemical Society for his work on opioid receptors. His research reveals how drugs such as morphine interact with these receptors, enabling the creation of new, more effective drugs.
Chemist William R. Dolbier receives American Chemical Society Award for Creative Work in Fluorine Chemistry for innovative studies of fluorine, which strengthens bonds and makes products like Teflon resistant to high temperatures.
University of Toronto researchers have successfully integrated organic molecules and inorganic materials at the molecular scale, creating a new class of composite materials. These hybrid materials have unique properties that could improve their hardness, thermal and electrical insulation, or light emission and magnetism, paving the way...
The American Association of Pharmaceutical Scientists (AAPS) recognizes outstanding researchers with its annual awards. Joseph R. Robinson receives the Distinguished Pharmaceutical Scientist Award for his work on controlled drug delivery and ocular drug disposition, while Charles Russell Middaugh wins the Research Achievement Award in ...
The American Chemical Society's Southeast Regional Meeting will be held in Knoxville, featuring a variety of topics including environmental and medicinal chemistry. Over 600 scientific papers will be presented during the event.
The American Association of Pharmaceutical Scientists has premiered an online database of the abstracts to be presented at the upcoming annual meeting. The database includes all invited and contributed paper abstracts, with a unique personal itinerary feature allowing attendees to plan their meetings.
Biotechnology graduates need to expand their course load and vary their skills to succeed in careers like regulatory affairs, clinical trials coordination, and bioinformatics. Many biotech companies require employees with degrees in scientific disciplines to transition into management, information technology, and marketing roles.
The use of computers has transformed the field of chemistry, enabling researchers to automate large-scale testing of compounds and speed up drug discovery. Electronic lab notebooks are also being adopted to share information and streamline the process.
Researchers at UNC-CH have synthesized ginkgolide B, a compound isolated from the ginkgo tree, which has been used as herbal medicine for thousands of years. The successful synthesis may lead to new treatments for dementia, multiple sclerosis, and other illnesses.
The American Chemical Society's 32nd Middle Atlantic regional meeting will explore topics such as plastics, environmental protection and medicinal chemistry. More than 700 attendees are expected, with presentations covering the latest research findings.
A new neuroactive chemical, HF-7, isolated from spider venom may block overproduction of neurotransmitters causing brain damage after oxygen deprivation. Theoretical studies suggest HF-7 could stave off severe brain damage during short bouts of oxygen loss.
The American Association of Pharmaceutical Scientists has recognized eight researchers with awards for their outstanding contributions to the field. Sung Wan Kim received the AAPS-Dale E. Wurster Research Award in Pharmaceutics for his work on controlled drug delivery systems, while Vincent H.L. Lee was honored with the Distinguished S...
The University of Pittsburgh has been chosen as one of three pioneer sites for biocombinatorial chemistry research, a revolutionary approach to speed up drug discovery. Researchers will create novel chemical compounds and test them in specific assays to learn whether they can interrupt cellular activities that lead to cancer.
A team of Cornell University researchers discovered that beetle pupae can create hundreds of deterrent compounds using combinatorial chemistry. The pupae secrete these complex chemicals through microscopic body hairs, thwarting most predators and ensuring their survival in the field.
The 216th national meeting of the American Chemical Society will feature over 6,000 technical presentations on various topics including analysis of endocrine disrupters, environmental issues and polymers from renewable resources. Approximately 10,000 registrants are expected to gather for about 609 technical sessions.
Researchers have synthesized the major human metabolite of Taxol, 6-alpha-hydroxypaclitaxel, for the first time in a laboratory setting. This breakthrough will enable easier identification and quantification of the metabolite in complex mixtures, crucial for maximizing the clinical effectiveness of paclitaxel.
A panel of leading research chemists will discuss new ways to fight disease, gene mapping and sequencing's impact on chemistry and medicine, and improving standard living through chemistry. Technologies like buckytube fibers and nanomaterials will also be explored.
Researchers at Yale University are using computer simulations to design more effective pharmaceuticals by optimizing chemical binding to target proteins. This approach has the potential to improve treatment outcomes for diseases such as dementia, diabetes, and spinal cord injuries.
The 215th national meeting of the American Chemical Society will feature over 4,700 papers on various topics including cancer therapy, global warming, and chemistry education. The event will also include a chemistry exposition with over 200 companies showcasing their products and services.
Dr. Paul D. Boyer, a long-time NIH grantee, has won the Nobel Prize in Chemistry for his groundbreaking work on ATP synthesis. His research has provided a deep understanding of the molecular mechanism by which ATP is formed, shedding light on fundamental processes in biology.
Researchers develop tiny coated beads that can release drugs directly onto tumors in response to chemical signals. The beads are designed to remain intact until exposed to sodium-rich blood plasma, at which point they swell and burst explosively, releasing the entrapped drug. This technology has potential for targeted cancer treatment.
University of Delaware researchers use a 'bicyclic lactone' to synthesize five unique compounds derived from red sea algae, making them easier to access for potential pharmaceutical uses. The process allows for efficient synthesis in large quantities, paving the way for further research into the compounds' biological activity.
A breakthrough in basic chemistry developed by University at Buffalo scientists has the potential to expand dramatically the variety and potency of new pharmaceutical compounds. The method uses a chiral catalyst to synthesize biologically important compounds with specific chemical structures.