Articles tagged with Medicinal Chemistry
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
This issue of Acta Pharmaceutica Sinica B presents several studies on drug-induced liver injury, including the role of p62/SQSTM1 in acetaminophen-induced liver injury and the importance of gut barrier function in pyrrolizidine alkaloid-induced hepatotoxicity. The journal also explores mechanisms of immune checkpoint inhibitor-mediated...
Researchers at NTU Singapore have developed a new method to generate sulphur pharmacophores, which are crucial for drug discovery. The method uses a catalyst called pentanidium and can produce multiple variations of pharmacophores, making the process more efficient and fruitful.
Researchers investigated the effects of insulin aggregation on human health, finding strategies to prevent it. Additionally, a study revealed that amphiphilic membrane environments can regulate enzymatic behaviors in Salmonella proteins.
Researchers have developed a new class of chemical building blocks called TIDA boronates that can form 3D molecules with complex twists and turns. These blocks can be assembled using an automated machine to create complex molecules with specific structures, enabling the easy creation of pharmaceuticals, materials, and diagnostic probes.
Researchers at University of North Carolina at Chapel Hill have developed a method to break down plastics and create stronger, more valuable materials. By modifying carbon-hydrogen bonds, they can expand the life span of single-use plastics into high-value polymers.
Researchers develop a method called Cell Painting that uses morphological profiling to detect side effects of substances on cells, enabling the identification of tubulin-modulating compounds. The study reveals over 1% of tested substances have this effect, including previously unknown reference substances.
Researchers at Université de Montréal have created a nanoantenna to monitor the motions of proteins, offering a new method to study natural and human-designed nanotechnologies. The DNA-based fluorescent nanoantenna can detect protein conformational changes in real-time.
Researchers devised a novel approach to unify quality assessment of generic drugs developed through different processes. The 'population pharmaceutical quality assessment' method uses computational modeling to evaluate process information, providing a scientific tool for objective quality consistency evaluation.
Researchers have mapped the atomic structure of amphotericin B, a powerful but toxic antifungal agent. The detailed structure reveals how the drug kills fungal cells by robbing them of sterol molecules, providing a roadmap for synthesizing less-toxic derivatives.
Researchers at Lawrence Berkeley National Laboratory have developed water-walking liquid robots that can retrieve and deliver precious chemicals autonomously. The robots use chemistry to control buoyancy and do not require electrical energy, making them ideal for applications such as chemical synthesis and drug delivery.
Researchers have created reconstructable uterus-derived materials (RUMs) to aid in the recovery of damaged uteruses. The materials, which can be formed into different states and shapes, prevent intrauterine adhesion and promote angiogenesis, endometrial regeneration, and muscle collagen rebuilding.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers at Tokyo University of Science have developed a novel light-based method for rapidly racemizing chiral sulfoxides, a crucial step in producing desired enantiomers. This breakthrough utilizes photocatalysts to achieve rapid racemization under moderate conditions, bypassing the need for high temperatures previously required.
Scientists at the University of Bath have developed a new method for synthesizing primary amines, used in over half of all pharmaceuticals, significantly reducing energy usage and chemical waste. This breakthrough aims to speed up drug discovery by making it easier to synthesize new chemical structures for testing.
The discovery proposes replacing carbon-hydrogen bonds with nitrogen rings, enabling faster and more efficient production of drug candidates. This breakthrough could lead to rapid creation of potent and effective medication libraries.
Scientists from the University of Nottingham have discovered a new approach for structurally modifying bioactive molecules using visible light, providing a possible sustainable alternative to traditional methods. This method has the potential for extensive application in the design and production of new drugs.
Researchers developed a molecular agent that can target lung and other cancer cells for imaging and treatment, distinguishing between healthy and cancerous cells. The new approach uses a unique chemistry method to tune the reactivity of the molecule, avoiding off-target effects.
A recent study from Penn State and Lawrence Livermore National Laboratory has discovered a natural protein called lanmodulin that can recover and purify radioactive metals like actinium. The protein-based approach simplifies the purification process, reduces costs, and enables the production of higher-purity actinium.
Researchers developed a predictive tool using %V bur (min) to categorize phosphine structures as active or inactive in many experimental datasets. This advancement will facilitate organometallic chemistry and catalysis, enabling easier computation and prediction of phosphine reactivity.
The Danish NMR Center is part of the PANACEA consortium, enabling European researchers to access state-of-the-art solid-state NMR equipment. The project will provide trans-national access to over 30 unique NMR spectrometers and develop new web-based software tools for simplified analysis.
Researchers at TTUHSC have identified novel targets for treating stroke, focusing on enhancing neurolysin activity. The study discovered small molecules that can selectively enhance the activity of neurolysin, which showed promise in reducing damage to the brain after a stroke.
Rice chemist Julian West and graduate student Yen-Chu Lu discovered manganese as a more efficient catalyst for synthesizing fluoroketones, precursor molecules for drugs. The use of manganese reduces material costs and simplifies purification.
Researchers at GlaxoSmithKline and CCDC combined proprietary and published datasets to train machine learning models for predicting stable polymorphs in new drug candidates. The approach leverages the large volume and variety of data in the Cambridge Structural Database, resulting in more confident predictions and improved model accuracy.
The Daylight Award 2022 is now open for nominations, honoring groundbreaking research on the effects of daylight on human health and well-being. The award also recognizes innovative architectural projects showcasing unique uses of daylight, aiming to improve living conditions and environmental impact.
Chronic light exposure disrupts circadian rhythms in rats, leading to memory deficits and amyloid β accumulation similar to Alzheimer's disease. Fluoxetine treatment prevents these effects, suggesting a potential therapeutic strategy.
Recent studies demonstrate the applications of LC-MS in characterizing Traditional Chinese Medicine formulations, real-time drug measurement, and bioactive compounds from Osmanthus fragrans. These techniques offer high sensitivity, robustness, and ease of use for quality assessment and characterization.
Researchers at Ural Federal University developed a simple method to produce fluorine-containing heterocycles, which are promising building blocks for medicinal chemistry and agrochemistry. The new compounds were found to be highly chemically active and selectively entered into various reactions.
Dr. Jitender Mehla has received a National Institutes of Health Grant to study small molecule-based inhibition of multidrug efflux pump in Pseudomonas aeruginosa, a serious threat to hospital-acquired infections. The proposed research aims to develop antibacterials effective against multidrug-resistant Gram-negative pathogens.
A University of Surrey AI model predicts compound properties that promote healthy ageing, identifying flavonoids, fatty acids, and organooxygens as promising candidates. The discovery paves the way for pharmaceutical innovations targeting age-related diseases.
A team of FAU researchers has developed an innovative process for producing asymmetrical hexaarylbenzene (HAB) molecules with six different aromatic rings. The four-step domino reaction allows for the efficient synthesis of large quantities of these complex molecules without toxic metals.
This issue of APSB features studies on protecting against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, as well as investigating alternative strategies to downregulate PD-L1 in gastric cancer cells. The journal also publishes research on a novel injectable micelle-hydrogel hybrid for localized drug delivery and tar...
Researchers discovered novel diarylamides with excellent in vitro UT inhibitory activity, leading to the identification of a promising preclinical candidate. Oral administration of the compound showed a superior diuretic effect in vivo without causing electrolyte imbalance or toxicity.
Researchers discovered a total of 23 new compounds in the endophytic fungus P. dangeardii, including azaphilone monomers, dimers, and trimers with unique structures. The compounds showed significant cytotoxicities, anti-inflammatory, or antioxidant activities.
Insilico Medicine will present its latest results in modern and next-generation AI for generative chemistry at ACS Spring 2021. The company's Chemistry42 platform facilitates the discovery of novel small molecule leads in several therapeutic areas, integrating AI techniques with computational and medicinal chemistry methods.
This issue of APSB features studies on the anticancer effects of berberine, baicalein's potent antivirus ability against HSV-1, and a new class of PDE10A inhibitors for treating PAH. Additionally, several articles explore innovative drug delivery systems and novel targets for cancer therapy.
This special issue of Acta Pharmaceutica Sinica B investigates the impact of tumor microenvironment on drug delivery systems for cancer treatment. Featured papers discuss various strategies to enhance specificity, target tumor-associated macrophages and manipulate immune-vascular crosstalk.
A chemist from RUDN University synthesized analogs of two natural toxins, antofine and septicine, using a universal approach. The new method involves just two steps, the four-component Ugi reaction and cyclization reaction, and can produce compounds with antibacterial, antitumor, and anti-inflammatory properties.
This issue of Acta Pharmaceutica Sinica B features three original research articles exploring novel mechanisms and treatments for various diseases, including cerebral ischemia-reperfusion injury, anti-atherosclerosis, and breast cancer. The articles discuss the potential benefits of IL-4 supplementation, berberine's gut-absorption-enha...
The D3Targets-2019-nCoV webserver uses molecular docking to predict potential drug targets for SARS-CoV-2 and identifies lead compounds via multi-site docking. The server incorporates various features, including correlated conformations and binding sites, making it a valuable tool for medicinal chemists and clinicians combating COVID-19.
Research found that five scientific fields (particle physics, atomic physics, cell biology, neuroscience, and molecular chemistry) account for more than half of Nobel Prizes awarded between 1995 and 2017. Additionally, many papers in these fields received less citation compared to other publications.
Researchers investigated the potential therapeutic effects of dipyridamole on severely ill patients with COVID-19. The study found that dipyridamole supplementation significantly decreased D-dimer concentrations and improved clinical outcomes in comparison to control patients, suggesting its anticoagulation and antiviral effects.
Captisol, developed at KU in 1990, enhances solubility and chemical stability of remdesivir. It was invented by Valentino Stella and Roger Rajewski to address insoluble drugs' limitations.
Chris Vanderwal has made significant contributions to the field of heterocyclic chemistry, particularly in the development of short chemical synthesis strategies for natural products. He is being recognized for his outstanding research on complex, bioactive natural compounds with various therapeutic properties.
The American Chemical Society is celebrating women entrepreneurs in chemistry with a special issue, featuring 20 female pioneers who have founded companies in biotechnology, solar energy, pharmaceuticals, and more. The Trailblazers issue aims to address the gender gap in funding and promote diversity in the entrepreneurial landscape.
Researchers at ICIQ develop a new catalytic reaction that can edit the skeletons of organic molecules, enabling skeletal remodelling and circumventing long-standing challenges in metal-carbyne generation. This breakthrough expands synthetic possibilities for creating new materials or medicines.
Patrick M. Woster, Ph.D., has been inducted into the Medicinal Chemistry Hall of Fame for his significant contributions to the field, including the discovery of novel therapeutics such as antimalarial and antibacterial agents. His work also emphasizes the crucial role of medicinal chemists in the drug discovery pipeline.
An international team of scientists has discovered a potential drug that may prevent neuronal death through glucose metabolism modification. The new drug shows promise in treating conditions such as Amyotrophic lateral sclerosis, Alzheimer's disease, and traumatic brain injury.
Portland State University chemistry professor Dave Stuart has received a three-year $455,000 National Science Foundation grant to study hypervalent iodine reagents. The research aims to design new chemical reactions that can be used to synthesize molecules for pharmaceutical, agriculture, and technology applications.
Researchers discovered that amino acids can stabilize membranes against magnesium ions, enabling the first cells to encode genetic information. The study suggests that amino acids and RNA building blocks co-localized in watery environments, providing a potential mechanism for life's emergence.
Professor Peter Schultz received the 2019 Tetrahedron Prize for his advances in chemical biology and drug discovery. He is credited with developing methods to expand the genetic code of living organisms and discovering catalytic antibodies.
Researchers at Insilico Medicine have developed a new molecular descriptor, MCE-18, which estimates molecular complexity and defines the evolution of small molecules in medicinal chemistry. The study reveals that modern drug development is becoming more qualitative and smarter, with higher degrees of 3D complexity.
The University of Nebraska is leading a $11 million study to develop drug therapies protecting military service members from radiation exposure. The project, in collaboration with the Department of Defense, aims to identify and develop therapeutic candidates that can prevent and counteract radiation effects.
Researchers at Colorado State University have created a new carbon-carbon bond reaction using phosphorus to stitch together molecular rings called pyridines. This reaction could fling open an underexplored wing of biologically relevant chemistry, allowing for the discovery of new drugs.
Researchers have developed new eco-friendly preservatives using guava leaves, while others created fertilizers from fish bones. The top challenge projects showcased sustainable chemistry practices for a greener future.
A female graduate student at FEFU has developed a new synthesis method for marine organic substances related to fascaplysin. The method allows for the production of compounds with higher activity than natural fascaplisin, promising for medicinal applications.
Researchers have discovered a new form of DNA, called the i-motif, which forms in the nuclei of human cells. The i-motif is a four-stranded 'knot' that plays a crucial role in gene expression and cell life cycle.
The KU center will continue to enable researchers to make breakthroughs in cancer, neurodegeneration, cardiovascular disease, and bacterial infections. The $10.8 million grant supports research at KU and regional institutions, including core labs for genomic analysis, lab-on-a-chip devices, and molecular probe synthesis.
Scientists discovered a new binding motif that enables positively charged amino acids to bind with negatively charged terminal groups in peptides or proteins. This discovery may help rationalize why certain peptides easily pass through cell membranes and aid in designing efficient transport of drug molecules.
A special focus issue on immunotherapy has been published in Future Medicinal Chemistry, discussing the discovery and development of novel immunotherapeutic agents for use as anti-inflammatories and cancer treatments. The issue addresses recent scientific advances and challenges in this rapidly evolving field.
The World Health Organization predicts 135.5 million dementia cases by 2050, yet all neurodegenerative diseases are incurable. This Special Focus issue addresses challenges and advancements in therapy.