Articles tagged with Medicinal Chemistry
Researchers at Nanyang Technological University in Singapore have developed a series of chemical-based compounds that could be potential drug candidates for treating pulmonary tuberculosis. The compounds were licensed by US-based Neuro-Horizon Pharma LLC for commercialization.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers from Tokyo University of Science developed novel complex-peptide hybrids that induce programmed cell death in apoptosis-resistant cancer cells through paraptosis. The compounds, syn-6 and anti-6, inhibit cell death by uncoupling mitochondrial calcium uptake and inducing cytoplasmic vacuolization, leading to cell death.
Researchers at Aarhus University have developed an easy and inexpensive method for linking molecules to DNA sequences with desired functions. The method uses sulfonyl azides to introduce various functionalities, avoiding the need for expensive and unstable special phosphoramidites.
Despite advances in biology and medicinal chemistry, research on schistosomiasis and other parasitic worm diseases remains at an early stage. Novel molecular targets and parasite signaling pathways may contribute to the development of new treatments.
Rensselaer researchers will use a five-year grant to develop novel inhibitors of the SARS-CoV-2 virus's CLpro and PLpro proteases. The team aims to create an orally bioavailable drug that can be administered at home, with the potential for improved antiviral activity when combined with other drugs like remdesivir.
Researchers have developed a new therapeutic agent from Brazilian lapacho tree bark that targets acute myeloid leukemia cells while minimizing toxic effects on healthy cells. The compound is attached to an antibody that binds specifically to cancer cells, delivering the drug directly to its target.
A study published in Journal of Pharmaceutical Analysis found that the quality of mistletoe, a traditional Chinese medicine, is affected by its host plant. The researchers used metabolomics to investigate the influence of host plants and environmental factors on mistletoe's medicinal qualities. The results show that both host plants an...
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers developed a deep learning-based model to predict drug-drug interactions using gene expression data. The DeSIDE-DDI model can identify potentially dangerous pairs and act as a drug safety monitoring system, helping establish the correct usage of drugs in the development phase.
Professor Holger Frey's innovative research aims to preserve PEGylation benefits while avoiding immune system recognition. His project RandoPEGMed seeks to create modified polymers for medicinal agents, potentially solving the problem of increasing antibody resistance.
Researchers at Aarhus University have developed improved DNA nanostructures that can assemble biomolecules with multiple functions, increasing the effectiveness of cancer treatment. The new structures are more stable, non-toxic, and immune system-friendly than previous versions.
Researchers at Tokyo University of Science discovered that disulfiram inhibits FROUNT protein and chemokine signaling pathways, reducing anxiety levels in mice. The study suggests a potential breakthrough anti-anxiety medication with safe and effective treatment for elderly patients suffering from anxiety and insomnia.
Recent studies published in the Journal of Pharmaceutical Analysis have found applications of nanotechnology in medicine, drug research, and environmental protection. Researchers developed nanodots made of carbon using natural polysaccharides from mushrooms to detect chromium, and created nanozymes that could be used to detect drug con...
Researchers have developed a method to chart the first-ever map of allosteric sites in two common human proteins, revealing they are abundant and identifiable. This could lead to safer, smarter, and more effective medicines by targeting these 'secret doors'.
A new tool, SPARCLD, speeds up the development of vaccines and pharmaceutical products by accelerating synthesis and analysis on a nano scale. This breakthrough method allows for the creation of 40,000 different molecules in an area smaller than a pinhead, reducing material, energy, and economic costs.
Researchers have developed miniaturized reflectors that enlarge the uses of remote infrared spectroscopy, allowing for field-ready devices with minimal size, weight, and power requirements. The devices utilize Ge-BaF2 thin films for surface micromachined mid-wave and long-wave infrared reflectors.
A team of researchers developed a novel method for producing optically active hydroxy β-lactam derivatives using baker's yeast and microwave irradiation. The process yielded 3:1 ratio of two hydroxyl compounds in 65% yield, with the resulting compounds showing high optical purity.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
Pharmaceutical firms are working towards using machine learning to analyze vast stores of data, developing models that evolve and improve as the data are processed. However, experts agree that a fully functional end-to-end approach is still a ways off due to biology's complexity.
A team of scientists has successfully developed a photo-induced catalytic C-H heteroarylation method for ferrocenes and ruthenocenes, allowing for the creation of new pyridyl and pridonyl metallocenes. This protocol offers mild and concise conditions for functionalization, with significant implications for material science and catalysis.
This issue of Acta Pharmaceutica Sinica B presents several studies on drug-induced liver injury, including the role of p62/SQSTM1 in acetaminophen-induced liver injury and the importance of gut barrier function in pyrrolizidine alkaloid-induced hepatotoxicity. The journal also explores mechanisms of immune checkpoint inhibitor-mediated...
Researchers at NTU Singapore have developed a new method to generate sulphur pharmacophores, which are crucial for drug discovery. The method uses a catalyst called pentanidium and can produce multiple variations of pharmacophores, making the process more efficient and fruitful.
Researchers investigated the effects of insulin aggregation on human health, finding strategies to prevent it. Additionally, a study revealed that amphiphilic membrane environments can regulate enzymatic behaviors in Salmonella proteins.
Researchers have developed a new class of chemical building blocks called TIDA boronates that can form 3D molecules with complex twists and turns. These blocks can be assembled using an automated machine to create complex molecules with specific structures, enabling the easy creation of pharmaceuticals, materials, and diagnostic probes.
Researchers at University of North Carolina at Chapel Hill have developed a method to break down plastics and create stronger, more valuable materials. By modifying carbon-hydrogen bonds, they can expand the life span of single-use plastics into high-value polymers.
Researchers develop a method called Cell Painting that uses morphological profiling to detect side effects of substances on cells, enabling the identification of tubulin-modulating compounds. The study reveals over 1% of tested substances have this effect, including previously unknown reference substances.
Researchers at Université de Montréal have created a nanoantenna to monitor the motions of proteins, offering a new method to study natural and human-designed nanotechnologies. The DNA-based fluorescent nanoantenna can detect protein conformational changes in real-time.
Researchers devised a novel approach to unify quality assessment of generic drugs developed through different processes. The 'population pharmaceutical quality assessment' method uses computational modeling to evaluate process information, providing a scientific tool for objective quality consistency evaluation.
Researchers have mapped the atomic structure of amphotericin B, a powerful but toxic antifungal agent. The detailed structure reveals how the drug kills fungal cells by robbing them of sterol molecules, providing a roadmap for synthesizing less-toxic derivatives.
Researchers at Lawrence Berkeley National Laboratory have developed water-walking liquid robots that can retrieve and deliver precious chemicals autonomously. The robots use chemistry to control buoyancy and do not require electrical energy, making them ideal for applications such as chemical synthesis and drug delivery.
Researchers have created reconstructable uterus-derived materials (RUMs) to aid in the recovery of damaged uteruses. The materials, which can be formed into different states and shapes, prevent intrauterine adhesion and promote angiogenesis, endometrial regeneration, and muscle collagen rebuilding.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers at Tokyo University of Science have developed a novel light-based method for rapidly racemizing chiral sulfoxides, a crucial step in producing desired enantiomers. This breakthrough utilizes photocatalysts to achieve rapid racemization under moderate conditions, bypassing the need for high temperatures previously required.
Scientists at the University of Bath have developed a new method for synthesizing primary amines, used in over half of all pharmaceuticals, significantly reducing energy usage and chemical waste. This breakthrough aims to speed up drug discovery by making it easier to synthesize new chemical structures for testing.
The discovery proposes replacing carbon-hydrogen bonds with nitrogen rings, enabling faster and more efficient production of drug candidates. This breakthrough could lead to rapid creation of potent and effective medication libraries.
Scientists from the University of Nottingham have discovered a new approach for structurally modifying bioactive molecules using visible light, providing a possible sustainable alternative to traditional methods. This method has the potential for extensive application in the design and production of new drugs.
Researchers developed a molecular agent that can target lung and other cancer cells for imaging and treatment, distinguishing between healthy and cancerous cells. The new approach uses a unique chemistry method to tune the reactivity of the molecule, avoiding off-target effects.
A recent study from Penn State and Lawrence Livermore National Laboratory has discovered a natural protein called lanmodulin that can recover and purify radioactive metals like actinium. The protein-based approach simplifies the purification process, reduces costs, and enables the production of higher-purity actinium.
Researchers developed a predictive tool using %V bur (min) to categorize phosphine structures as active or inactive in many experimental datasets. This advancement will facilitate organometallic chemistry and catalysis, enabling easier computation and prediction of phosphine reactivity.
The Danish NMR Center is part of the PANACEA consortium, enabling European researchers to access state-of-the-art solid-state NMR equipment. The project will provide trans-national access to over 30 unique NMR spectrometers and develop new web-based software tools for simplified analysis.
Researchers at TTUHSC have identified novel targets for treating stroke, focusing on enhancing neurolysin activity. The study discovered small molecules that can selectively enhance the activity of neurolysin, which showed promise in reducing damage to the brain after a stroke.
Rice chemist Julian West and graduate student Yen-Chu Lu discovered manganese as a more efficient catalyst for synthesizing fluoroketones, precursor molecules for drugs. The use of manganese reduces material costs and simplifies purification.
Researchers at GlaxoSmithKline and CCDC combined proprietary and published datasets to train machine learning models for predicting stable polymorphs in new drug candidates. The approach leverages the large volume and variety of data in the Cambridge Structural Database, resulting in more confident predictions and improved model accuracy.
The Daylight Award 2022 is now open for nominations, honoring groundbreaking research on the effects of daylight on human health and well-being. The award also recognizes innovative architectural projects showcasing unique uses of daylight, aiming to improve living conditions and environmental impact.
Chronic light exposure disrupts circadian rhythms in rats, leading to memory deficits and amyloid β accumulation similar to Alzheimer's disease. Fluoxetine treatment prevents these effects, suggesting a potential therapeutic strategy.
Recent studies demonstrate the applications of LC-MS in characterizing Traditional Chinese Medicine formulations, real-time drug measurement, and bioactive compounds from Osmanthus fragrans. These techniques offer high sensitivity, robustness, and ease of use for quality assessment and characterization.
Researchers at Ural Federal University developed a simple method to produce fluorine-containing heterocycles, which are promising building blocks for medicinal chemistry and agrochemistry. The new compounds were found to be highly chemically active and selectively entered into various reactions.
Dr. Jitender Mehla has received a National Institutes of Health Grant to study small molecule-based inhibition of multidrug efflux pump in Pseudomonas aeruginosa, a serious threat to hospital-acquired infections. The proposed research aims to develop antibacterials effective against multidrug-resistant Gram-negative pathogens.
A University of Surrey AI model predicts compound properties that promote healthy ageing, identifying flavonoids, fatty acids, and organooxygens as promising candidates. The discovery paves the way for pharmaceutical innovations targeting age-related diseases.
A team of FAU researchers has developed an innovative process for producing asymmetrical hexaarylbenzene (HAB) molecules with six different aromatic rings. The four-step domino reaction allows for the efficient synthesis of large quantities of these complex molecules without toxic metals.
This issue of APSB features studies on protecting against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, as well as investigating alternative strategies to downregulate PD-L1 in gastric cancer cells. The journal also publishes research on a novel injectable micelle-hydrogel hybrid for localized drug delivery and tar...
Researchers discovered novel diarylamides with excellent in vitro UT inhibitory activity, leading to the identification of a promising preclinical candidate. Oral administration of the compound showed a superior diuretic effect in vivo without causing electrolyte imbalance or toxicity.
Researchers discovered a total of 23 new compounds in the endophytic fungus P. dangeardii, including azaphilone monomers, dimers, and trimers with unique structures. The compounds showed significant cytotoxicities, anti-inflammatory, or antioxidant activities.
Insilico Medicine will present its latest results in modern and next-generation AI for generative chemistry at ACS Spring 2021. The company's Chemistry42 platform facilitates the discovery of novel small molecule leads in several therapeutic areas, integrating AI techniques with computational and medicinal chemistry methods.
This issue of APSB features studies on the anticancer effects of berberine, baicalein's potent antivirus ability against HSV-1, and a new class of PDE10A inhibitors for treating PAH. Additionally, several articles explore innovative drug delivery systems and novel targets for cancer therapy.
This special issue of Acta Pharmaceutica Sinica B investigates the impact of tumor microenvironment on drug delivery systems for cancer treatment. Featured papers discuss various strategies to enhance specificity, target tumor-associated macrophages and manipulate immune-vascular crosstalk.
A chemist from RUDN University synthesized analogs of two natural toxins, antofine and septicine, using a universal approach. The new method involves just two steps, the four-component Ugi reaction and cyclization reaction, and can produce compounds with antibacterial, antitumor, and anti-inflammatory properties.
This issue of Acta Pharmaceutica Sinica B features three original research articles exploring novel mechanisms and treatments for various diseases, including cerebral ischemia-reperfusion injury, anti-atherosclerosis, and breast cancer. The articles discuss the potential benefits of IL-4 supplementation, berberine's gut-absorption-enha...
The D3Targets-2019-nCoV webserver uses molecular docking to predict potential drug targets for SARS-CoV-2 and identifies lead compounds via multi-site docking. The server incorporates various features, including correlated conformations and binding sites, making it a valuable tool for medicinal chemists and clinicians combating COVID-19.