Articles tagged with Medicinal Chemistry
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers successfully synthesized Zika virus from a viral sequence detected in infected tissue, allowing them to induce microcephaly in pregnant mice and study its transmission by mosquitoes. This breakthrough helps advance research into the mysterious emergence of Zika virus, which causes devastating foetal brain infections.
A team of scientists from Kyoto University has developed a simpler approach to drug discovery using decision trees, achieving high predictive ability with reduced data sets. The new method could lead to significant cost savings in the drug development process.
Researchers have developed a chemical-biological strategy for microRNA target identification using photo-clickable miRNAs. This approach enables the identification of target genes associated with miRNAs without disrupting their function, revealing new insights into miRNA-involved cellular regulation pathways.
A new review of scientific literature on curcumin finds limited evidence to support its therapeutic benefits for cancer and Alzheimer's disease. The compound is unstable under physiological conditions and not readily absorbed by the body, making it a poor therapeutic candidate.
A Japanese research team has found that 2-aminobutyric acid (2-AB) can effectively increase glutathione levels in the body, a major antioxidant component. The study suggests that 2-AB could be used as a biomarker for early detection of oxidative stress and potentially treat conditions such as Alzheimer's disease and heart failure.
Researchers at the University of Bonn present a new scaffold concept that combines structural key compounds and reaction criteria for a more consistent definition. The analog series-based scaffolds (ASB) framework provides a unique insight into compound diversity and structure-activity relationships.
A recent study published in Nature Neuroscience has made significant progress in understanding the role of proteins in synaptic transmission. The researchers identified two variations of a protein called Unc13 that work separately to regulate synaptic function, paving the way for new diagnostic and therapeutic approaches.
Researchers have discovered a new class of antimicrobial materials that use carbon nanodots to kill drug-resistant bacteria. The materials, which include molecules such as PAMAM, exhibit greater efficacy against certain strains of E. coli and Klebsiella pneumoniae, and may also enhance the effectiveness of existing antibiotics.
Scientists have designed a new vaccine that increases anti-nicotine antibodies, delaying nicotine's effects in mice. This approach shows promise for reducing cravings and aiding smokers in quitting
Scientists at Nagoya University have made a breakthrough in synthesizing cyanohydrins, useful molecules that are precursors to carboxylic acids and amino acids. The new method uses a chiral catalyst to produce optically active cyanohydrins with high yield and efficiency.
Researchers identify five chemicals that trigger rice plants to fend off white-backed planthoppers, reducing the need for pesticides. The chemicals, phenoxyalkanoic acid derivatives, have shown potential in controlling insect pests and protecting ecosystems.
A special issue of Future Medicinal Chemistry explores the diverse field of chemical biology, highlighting its expanding scope and sub-disciplines. The issue features reviews, opinion pieces, and primary research papers on topics such as protein-protein interactions, epigenetic modulators, and tissue regeneration.
A themed issue of Future Medicinal Chemistry highlights academia's role in drug discovery, discussing industry-academia alliances and novel models. The issue features expert commentaries on bridging the translational research gap and implementing open innovation platforms.
Matthew Disney, a professor at Scripps Research Institute, has won the Tetrahedron Young Investigator Award for his exceptional creativity and dedication to organic synthesis and bioorganic and medicinal chemistry. The award recognizes his lab's work on tackling difficult problems in biomedical science.
Researchers will investigate three projects: one on menopausal symptoms, another on biological activity of botanicals, and a third on interactions with prescription drugs. The goal is to determine the safety and efficacy of botanical dietary supplements as alternatives to hormone therapy.
Foreign chemical and pharmaceutical companies face challenges in China due to economic downturn, overcapacity, and tightening regulations. Despite uncertainty, company heads remain confident in their long-term success in the country, which represents 50% of the Asian chemical market.
Researchers discuss emerging antischistosomal drug candidates and address clinical resistance concerns. Praziquantel, the current 'wonder drug,' is being reevaluated due to its drawbacks and potential for clinical resistance.
The Mainau Declaration 2015 on Climate Change states that nations must limit future global emissions and approve a new international agreement. The declaration warns of the consequences of unchecked climate change, which will overwhelm the Earth's ability to satisfy humanity's needs, leading to wholesale human tragedy.
Scientists design a peptide that binds to ghrelin and Y2 receptors, reducing appetite in obese mice. The compound shows promise as an obesity treatment targeting the complex system of hormones regulating appetite.
Researchers identified 422 structural clusters of naturally-derived fragments with diverse properties, suitable for chemical biology and drug discovery. These fragments could serve as the starting point for a highly diverse library with minimal structural complexity.
Revolution Medicines has developed a unified 'building blocks' approach for synthesizing multiple classes of complex natural chemicals that could be valuable backbones for new medicines. The company's technology can produce a broad range of molecules, including those with diverse types of chemical bonds and highly complex cyclic struct...
Haibo Ge, a chemist at IUPUI, has received a $600,000 NSF award to support his research on efficient methods for preparing organic molecules with potential impact on medicinal and agricultural chemistries. The grant also supports the development of an interdisciplinary course linking organic and medicinal chemistry.
Understanding the structure and movement within molecular factories in microorganisms enables researchers to design and engineer systems for producing novel drugs. The discovery provides a blueprint for redesigning microbial assembly lines, holding promise for developing new medicines.
The study found that average waiting times for Nobel prizes are increasing exponentially, with average age at which laureates receive the award also rising. This trend threatens to undermine the prestigious award, as the predicted average age among prizewinners could even exceed life expectancy by the end of this century.
The pharmaceutical industry is turning its attention to hearing loss, a condition affecting 36 million Americans. Researchers are developing potential therapies targeting the inner ear and central nervous system, with several drug candidates already advancing through clinical testing.
Five chemists from Indonesia, Jamaica, Nigeria, Uzbekistan and Yemen are being honored with Elsevier Foundation Awards for Early Career Women Scientists in the Developing World. The winners were selected for their impressive accomplishments in applying chemistry to pharmaceutical science.
Researchers have developed a novel compound that protects mice against developing movement problems associated with Parkinson's disease. The compound, known as '12g', effectively prevented motor deficits linked to PD and showed promise as a potential new therapy.
The 2014 Congressional agenda will shape public health, energy, and pharmaceutical research through key legislation. Modernization of the Toxic Substances Control Act and new energy bills are expected to have significant implications.
Chi-Huey Wong, a professor of chemistry at The Scripps Research Institute, has been awarded the 2014 Wolf Prize in Chemistry for his groundbreaking work on synthesizing complex carbohydrates and glycoproteins. His research methods have led to breakthroughs in understanding cancer progression and developing vaccines and therapeutics.
Researchers have found that bisphenol A impairs the function of vital proteins in cells, suggesting a potential health risk. The study also discovered alternative compounds with promising applications in cancer treatment.
Researchers at Cardiff University have created a peptide linked to a light-responsive dye that triggers cell death in cancerous cells. The new pathway activation technology, called transient photoactivation, enables scientists to precisely define the area where peptides should act, leading to more effective treatment strategies.
The American Chemical Society has inducted scientists from DuPont, Merck & Co., Inc., Pfizer, and Vertex into its Heroes of Chemistry program. These innovators have developed groundbreaking products that protect the global food supply, treat HIV-1 infection, and provide personalized medicine for lung cancer and cystic fibrosis patients.
Researchers have identified a group of compounds that work against human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71, blocking the ability of these viruses to multiply. These broad-spectrum antiviral drugs hold promise for treating infections like asthma and chronic obstructive pulmonary disease.
The GHIT Fund will screen Japanese pharmaceutical companies' and research institutes' compound libraries for new treatments of malaria, tuberculosis, and neglected diseases like leishmaniasis and sleeping sickness.
Scientists have developed a new method to study mechanochemical synthesis, allowing for the observation of complex chemical transformations in real-time. This breakthrough could lead to more environmentally friendly chemical production and optimize processes in various industries.
A lack of access to clean water and sanitation affects 2.6 billion people, causing preventable illnesses and deaths. Women in developing countries can play a key role in addressing this issue if given the chance.
Many pharmaceutical companies are making progress in embracing green chemistry principles, reducing waste generation and operating more environmentally friendly ways. The American Chemical Society's Green Chemistry Institute is helping its members share best practices and compare progress.
The ACS Presidential Sessions emphasize communicating science to the public, with speakers including Roger Tsien, Laura Kiessling, Samuel Stupp, J. Craig Venter, Carolyn Bertozzi, and Paul Raeburn. The sessions also explore innovative chemistry applications, such as producing fuels directly from sunlight.
Researchers at Harvard University and BASF are working on creating nanoscale particles of drugs to overcome hydrophobic drug compounds. The symposium aims to discuss efficient creation and delivery of these tiny particles for targeted treatment, addressing major challenges in modern medicine.
University of Houston students Nicholas Eastham and Thomas Markovich have been named Barry M. Goldwater Scholars, while Mason Biamonte and Abdulrahman Ibrahim received honorable mentions for their outstanding research work. The scholarships recognize academic merit and provide funding for further research and education.
Dr. A.K. Ganguly, a renowned pharmaceutical researcher, received the Topliss Award Lecture at the University of Michigan for his lifetime contributions to medicinal chemistry. His lecture discussed lessons learned in drug discovery, highlighting approaches taken at Schering-Plough and ongoing work at Stevens.
Researchers have discovered a promising new treatment for prion diseases, a group of untreatable brain disorders. The compound, derived from aminothiazoles, has shown to reduce abnormal prion protein in laboratory mice and cell cultures.
A national research team led by UC San Diego scientists created the first lipidome of human plasma, discovering hundreds more fats than previously known. The findings reveal lipids' diverse roles beyond energy storage and cell membrane building, including signaling molecules that may play a role in diseases like diabetes and cancer.
Researchers at NYU have developed a method to prevent the growth of crystals that form cystine kidney stones by using a synthetic inhibitor. This breakthrough may lead to a new approach to preventing cystine stones and offers hope for individuals affected by this disease.
Researchers at UC San Diego identified misfolding of neuroligin-3 due to gene mutations, leading to trafficking deficiencies and abnormal neuron communications. The findings advance understanding of autism causes and may offer new drug therapies.
Researchers have synthesized hundreds of new compounds that can specifically reduce A-beta 42 levels in the brain, a primary component of Alzheimer's disease. The compounds, called gamma-secretase modulators, were tested in mouse models and showed promising results, reducing neuritic plaques and A-beta 42 levels.
The Reaxys PhD Prize awarded Thomas Maimone, Hiroyuki Miyamura, and Robert Phipps for their groundbreaking research. The winners were selected from over 300 submissions based on originality, innovation, and publication quality.
The American Society for Biochemistry and Molecular Biology will present 10 scientists with various awards for their outstanding contributions to the field. This year's awardees include Phillip Sharp, Sarah Keller, David Russell, James Wells, John Tesmer, Lisa Gentile, Susan S. Taylor, Douglas Rees, and Ruedi Aebersold.
Researchers have developed 'filters' that can be used to weed out compounds likely to show up as false positives during high-throughput chemical screening. This will reduce the time spent on medicinal chemistry and optimize the compound selection process for drug development.
James A. Wells, a UCSF professor and director of the small molecule discovery center, has made groundbreaking contributions to protein engineering and discovery. He integrates multiple disciplines to design molecules that selectively activate or inhibit cellular processes.
The University of Arizona College of Pharmacy and the Translational Genomics Research Institute have been awarded a $7.5 million grant to establish a comprehensive center for drug discovery and development. The center aims to assemble a team capable of designing and selecting drug candidates to respond quickly to unmet medical needs.
Marine biomedicine researchers have deciphered the structure of a naturally produced ocean-based compound hoiamide A, which offers a novel template for drug development. The findings suggest that hoiamide A may interact with neurons in different ways, potentially leading to therapeutic effects for diseases such as epilepsy and neurodeg...
A new international public-private partnership aims to develop small molecule inhibitors for 25 proteins involved in epigenetic signalling. The project, led by the Structural Genomics Consortium, involves major pharmaceutical companies and academia.
Feldmann and Maini discovered tumor necrosis factor-alpha as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions. Their research led to the development of several anti-TNF drugs, transforming treatment for people diagnosed with chronic inflammatory conditions.
Researchers at UIC aim to develop a compound blocking mania associated with bipolar disorder, improving on dated 'mood stabilizers' like lithium and valproic acid. The goal is to create safer, more effective treatments for the mental illness affecting over 2 million Americans.
The American Chemical Society has awarded a national recognition to a prominent chemist for their groundbreaking work in medicinal chemistry. Anderson has made significant contributions to the development of statins and HIV treatments, including Zocor and Crixivan.
The Dr. Paul Janssen Award for Biomedical Research aims to recognize and reward innovative contributions to human health, as identified by a six-member international selection committee. The first Award will be presented in September 2006, with a $100,000 prize and global recognition for the recipient.
Researchers have found a way to increase the potency of Khellinone, a naturally occurring substance with anti-inflammatory properties. By disrupting rogue T cell potassium channels, the compound reduces myelin damage and may help tackle multiple sclerosis.
Researchers develop new chemical reaction to simplify indole synthesis, reducing the number of steps from six to three and minimizing toxic by-products. The technique could lead to significant cost savings and reduced environmental impact in pharmaceutical manufacturing.
NIST's new reference material, calibrated microspheres coated with fluorescent dye, provides an authoritative national fluorescence measurement scale. This improvement enables more accurate measurements of signal intensity, reflecting numbers of target molecules in samples.