Articles tagged with Metabolism
A study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism found that undertreatment with thyroid hormone replacement can lead to longer hospital stays and higher readmission rates. Patients with high TSH levels before hospitalization had a 49% higher risk of 30-day readmission.
Researchers have identified a new type of programmed cell death, erebosis, that takes place in the intestines of fruit flies, contradicting the long-held theory of apoptosis. The process involves gradual cell death without nuclear membranes, mitochondria, and cytoskeletons, and is thought to play a role in gut metabolism.
A recent study published in Microbiome found that a calorie-reduced diet can alter the gut microbiome, improving metabolism and delaying immune senescence. Researchers used a low-calorie diet to investigate its effects on the gut microbiome and its impact on metabolism and the immune system.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism found that people with type 2 diabetes and cognitive impairment have a higher risk of heart attack and stroke. Cognitive function may predict a person's future risk of heart disease, according to researchers.
A study published in the American Journal of Cardiology found that measuring intramuscular fat in thigh muscles can predict cardiovascular health outcomes in heart failure patients. Patients with lower intramuscular fat had higher grip strength and were less likely to be hospitalized.
The ESMO Breast Cancer Congress 2022 event will present more than 200 studies on various aspects of breast cancer, including new treatments and innovative clinical practices. The congress will be held onsite in Berlin, Germany, and online, offering a platform for breast cancer specialists to share knowledge and improve patient outcomes.
Researchers at NTU Singapore's Lee Kong Chian School of Medicine found that saturated fatty acids degrade protein FIT2, leading to insulin-producing cells' loss of function and death. This impairs the body's ability to secrete enough insulin, resulting in diabetes.
Researchers at Institut Pasteur have found that hypothalamic neurons can directly detect variations in bacterial activity, adapting appetite and body temperature accordingly. This discovery could lead to new treatments for diabetes and obesity.
A study from the University of Pittsburgh found that methionine restriction can slow down the growth of difficult-to-treat brain tumors in children, known as diffuse midline gliomas. The researchers discovered that these tumors are uniquely dependent on methionine, an amino acid, and that depleting it can repress cancer cell growth.
Yale scientists have discovered a protein called augmentor-alpha that regulates body weight in mice, offering insights into potential new treatments for metabolic disorders. The protein is found in the hypothalamus region of the brain and plays a role in energy conservation during fasting.
A study published in the Journal of Cachexia, Sarcopenia and Muscle found that BAM15 improves health outcomes for aged mice with obesity by preventing muscle loss and increasing energy expenditure. The compound helped mice lose fat, gain strength and increase physical activity.
A team from Goethe University has identified the spatial structure of the mannitol-synthesizing enzyme MtlD in Acinetobacter baumannii, which is crucial for its survival. This discovery could lead to the development of customized substances to inhibit the enzyme and combat this hospital pathogen.
Researchers have identified avocado meal as a safe and palatable fiber source for dogs, rivaling industry standards in digestibility and energy intake. The study found that persin levels were undetectable in processed meal, contradicting long-held concerns about avocado toxicity in pets.
The IOF Skeletal Rare Diseases Academy has awarded grants to six young researchers for their outstanding work on rare skeletal disorders. The awards recognize the importance of advancing knowledge and diagnosis for these conditions.
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
A study found that excessive sugar consumption can promote inflammation and autoimmune diseases, such as Crohn's disease and type 1 diabetes. Researchers identified GLUT3, a glucose transporter, as a key player in this process, and proposed blocking its activity to mitigate inflammatory responses.
A new study published in JAMA Network Open reveals that the first-pass metabolism of alcohol occurs in the stomach, not the liver. This finding explains why some patients experience increased sensitivity to alcohol after bariatric surgery, leading to higher risks of alcohol-related disorders.
Researchers at the University of Bergen found that genes linked to extreme obesity, appetite, and energy consumption regulate child growth. The study, published in Nature Metabolism, provides insight into mechanisms controlling appetite and energy metabolism early in life, potentially leading to better treatment for obesity.
Scientists have generated an atlas of cell types in white adipose tissue, identifying novel subpopulations linked to increased risk of metabolic disease. The study provides a comprehensive resource for translational research into human metabolic diseases.
A team of scientists successfully investigated the electronic structure of tautomeric mixtures using inelastic X-ray scattering (RIXS) at BESSY II. They can now experimentally separate the signal of each individual molecule, providing detailed insight into their functionality and chemical properties.
Autophagy is induced when ER-bound ribosomes are stalled, rescuing them from cellular harm. The ERC grant aims to decipher the role of Autophagy in rescuing stalled ER-bound ribosomes.
Intermittent fasting produces mild to moderate weight loss and improves cardiometabolic risk factors, comparable to traditional calorie-restricted diets. The review also dispels myths about intermittent fasting, including the misconception that it leads to weakness and decreased concentration.
A study by Osaka University investigated the relationship between autophagy and metabolism during fasting. Autophagy was found to play a key role in promoting fat loss during fasting, particularly through the upregulation of adipogenic genes. The findings may have important implications for understanding metabolism during aging.
The study found that superlinear scaling occurs in aquatic ecosystems of larger watersheds, releasing carbon back into the atmosphere. Smaller watersheds are less effective at filtering pollutants and mitigating nonpoint source pollution.
Researchers found that yellow-bellied marmot's biological aging stalls during hibernation, with epigenetic changes playing a key role. The study suggests that hibernation may be a natural way to slow aging and promote longevity in other mammals.
A new study published in Menopause reveals that lifestyle interventions targeting metabolic changes are most valuable during perimenopause. The study found unfavorable body composition and metabolic characteristics beginning before the menopause transition, making it an opportune window for intervention.
A study published in Cell Metabolism shows that nicotinamide riboside supplementation significantly increases NAD levels in the human brain and improves Parkinson's disease symptoms, suggesting a potential new treatment approach.
A recent study by ITQB NOVA scientists uncovered the crucial role of a small marker protein, DsrD, in increasing metabolic activity for sulfate respiration. The findings suggest that DsrD acts as an allosteric activator of the DsrAB dissimilatory sulfite reductase, enhancing energy efficiency in microbial metabolism.
A new University of Copenhagen study reveals that well-functioning fat tissue is crucial for overall health and may help prevent diseases such as type 2 diabetes, cancer, and obesity. High levels of lifelong exercise have been shown to improve mitochondrial function in fat cells, reducing oxidative stress and damage.
Researchers have developed an AI-based method to analyze cryo-electron microscopy data, enabling the simultaneous examination of multiple protein complexes in cells. This breakthrough can lead to a better understanding of protein functions and potentially create new treatments for diseases like Alzheimer's and cancer.
Scientists have found a new energy metabolism in lactic acid bacteria that combines features of respiration with fermentation. This hybrid metabolism enables the bacteria to thrive better and faster, potentially improving gut health by manipulating its growth.
Researchers at Lancaster University have identified a genetic change that impacts insulin signaling and glucose metabolism in the brain, which may lead to effective drug treatments for autism. The study found that individuals with a specific DNA deletion are more likely to develop neurodevelopmental disorders, including autism.
A new study found that calorie restriction improves metabolic and immune responses, generating more T cells to fight off infections and improve energy efficiency. This could lead to a potential treatment to reduce age-related inflammation and improve metabolic health.
Researchers at Helmholtz Munich have discovered a crucial link between the immune system and metabolic response to fasting. By examining liver cells and immune cells, they found that immune cells can directly influence the effect of fasting on metabolism through a key molecule called the glucocorticoid receptor.
A study of 14 high-risk children found that convalescent plasma provided expected antibody levels without safety concerns. The therapy's effectiveness declined over time, highlighting the need for early administration.
Researchers discovered multiple levels of torpor in hummingbirds, including shallow and deep states, as well as a transition stage between normal sleep and torpor. This flexible control allows hummingbirds to conserve energy while minimizing potential costs, such as increased vulnerability to disease or predation.
Researchers discovered that microbes capable of extracellular electron transfer (EET) are spread through horizontal gene transfer and exist in various environments worldwide. The genes, which enable EET, were found in a wide range of organisms, from deep-sea microbes to human gut bacteria.
A study by Michigan Medicine researchers found that people with diabetes have more macrophages in their fat tissue, particularly the anti-inflammatory CD206+ subtype. This subtype is unique in terms of gene expression and may play a role in the development of diabetes.
Research found that over 55,000 chemicals in everyday plastic products can reprogram precursor cells to become fat cells, leading to increased fat accumulation. The study suggests that previously unknown plastic chemicals may be contributing to overweight and obesity.
The Nutrition for Precision Health study will use data from 10,000 participants to develop algorithms predicting individual responses to food and dietary routines. The goal is to create more personalized nutrition recommendations and reduce health disparities.
Researchers used optical imaging to study the metabolic interactions between pancreatic cancer cells and surrounding non-cancer cells. They found that cancer cells can hijack the metabolic activity of these non-cancer cells to fuel tumor growth. This discovery could lead to new therapies targeting the tumor microenvironment.
A recent study published in Scientific Reports found that chewing food thoroughly increases energy expenditure through diet-induced thermogenesis (DIT), which helps prevent obesity. The study involved participants who chewed liquid food for varying durations, revealing that prolonged chewing and tasting increased DIT, gas exchange, pro...
Researchers at Salk Institute have discovered a new molecular pathway that controls blood glucose levels independent of insulin, offering new avenues for treating diabetes and metabolic disorders. The hormone FGF1 suppresses lipolysis and regulates glucose production in the liver.
Researchers found that SGLT2 inhibitor empagliflozin can improve insulin sensitivity in the brain, leading to better glucose control and reduced liver fat content. This breakthrough discovery positions SGLT2 inhibitors as a potential treatment for insulin resistance in the brain.
A study in mice suggests that transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack by dampening gene activation linked to negative effects. The transplantation method could help researchers understand the mechanisms behind this protective effect and potentially lead to therapeutic applications.
New research suggests that cannabis use can lead to harmful drug-drug interactions by interfering with two families of enzymes that metabolize a wide range of drugs. This could result in unintended side effects such as toxicity or accidental overdose, particularly for older individuals using medications.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
A bile acid derivative, TUDCA, reduced food intake and increased energy expenditure in mice with an Alzheimer's-like disorder. The treatment improved quality of life by mitigating metabolic abnormalities associated with the disease.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
Researchers at University of California - Riverside are studying the keto and intermittent fasting diets on a molecular level, finding that women may metabolize fat differently than men. The study aims to understand why keto diet may not be effective for women and how it affects their overall health.
Researchers discovered that wound macrophages undergo different metabolic programs to coordinate tissue repair, including the use of reactive oxygen radicals for blood vessel growth. Macrophages also utilize a different type of mitochondrial exchange for anti-inflammatory and reparative functions in late-stage wound healing.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
A study by the Technical University of Munich discovered that pungent substances from chili, ginger, and pepper are transferred to breast milk after consumption. These substances can be detectable in breast milk for several hours, with maximum concentrations being 70- to 350-fold below the taste perception threshold of an adult.
The Zinc Status Index is a new evaluation method developed by Cornell food scientists that uses biomarkers to calculate the physiological status of a subject. It aims to provide a comprehensive assessment tool for zinc deficiency, which affects over 1 billion people worldwide.
Researchers discovered that ants pass proteins through mouth-to-mouth exchanges to share metabolic labor and adapt to colony needs. This discovery sheds light on how ants divide tasks between individuals and the colony's life cycle.
A new review in the Journal of Dairy Science explores the relationship between serotonin and calcium metabolism in dairy cows, highlighting its importance in maintaining calcium balance. Research shows that mammary serotonin drives hormone production that modulates mammary calcium transport.
A study found that D-glyceric acid treatment improved metabolism, blood parameters, and reduced low-grade inflammation in healthy volunteers aged 50-60 years. The compound's activation of mitochondrial metabolism may help interrupt the spiral of persistent systemic inflammation and improve liver function.
A study published in Nature Communications identified C-terminal binding protein 2 (CtBP2) as a global regulator of metabolism that balances sugar and fat levels in the liver. CtBP2 is crucial for controlling glucose and lipid balance, making it a promising drug target for treating symptoms associated with obesity.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
A new study from University of Wisconsin-Madison researchers reveals that fasting is essential for mice to derive full benefit from calorie restriction. Fasting alone improves insulin sensitivity and reprograms metabolism, reducing frailty in old age and extending lifespan.