Articles tagged with Molecular Targets
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new Raman spectroscopy method has been developed to capture target molecules in small gaps using nano-capillary pumping, enabling ultrasensitive detection of various substances. This breakthrough allows for real-time monitoring of cell behavior and chemical kinetics, with potential applications in medicine and chemistry.
Researchers have identified four potent antiviral compounds targeting the PF74 binding site, exhibiting improved metabolic stability compared to PF74. One compound, analog 20, shows similar submicromolar potency and significantly longer half-life in human liver microsomes.
The April edition of SLAS Discovery features research on PROTACs, targeting protein degradation, and kinase family profiling. Authors apply the Four Pillars Framework to expedite PROTAC development and inform pharmacokinetic-pharmacodynamic understanding.
UC Santa Barbara researchers develop a method to increase both affinity and cooperativity in aptamer-based biosensors, allowing for fine-tuned regulation of receptor properties. This approach enables precision biosensing applications, such as detecting low concentrations of target molecules like chemotherapy drugs.
Researchers have identified NRXN1, a cell adhesion molecule, as a potential target for antibody-drug conjugate (ADC) therapy in small cell lung cancer. The study found that targeting NRXN1 with ADCs exhibited anti-tumor activity in SCLC cells.
Researchers identified 134 previously unknown activities for 38 approved excipients, demonstrating direct activity against biologically relevant molecules. Several excipients exhibit evidence predictive of tissue-level toxicity, including thimerosal and cetylpyridinium.
Researchers have developed Pillar[n]MaxQ molecules that bind neuromuscular blocking chemicals with high specificity and strength. These new molecular containers show promise for eliminating toxins and malodorous substances in water, outperforming existing macrocyclic agents.
Researchers create novel molecular cage that confines and twists target molecules, activating specific chemical bonds. The twist angle can be precisely controlled using stuffing molecules, enabling accelerated reaction rates.
Researchers at Kyoto University have improved the efficiency of organic solar cells by targeting the molecular backbone of the power-generating layer. The new design approach increased the excited state duration of the electron-accepting component, converting over 70% of light particles into current. Further modifications to the molecu...
Results from 46 patients who received targeted therapies alongside standard chemotherapy showed a 31-month average survival compared to 18 months for those without molecular changes. Targeted therapy has already improved survival for many forms of cancer and could be a game-changer for pancreatic cancer patients with specific alterations.
Researchers at Osaka University have designed and synthesized a new molecular emitter for organic light-emitting diodes (OLEDs), using rational chemical design with U-shaped synthetic building blocks. The efficient macrocyclic OLED emitter could potentially be used in tiny, energy-efficient chemical sensors.
Integral Molecular has developed a panel of fully humanized P2X7 antibodies against autoimmune disorders like atopic dermatitis and glomerulonephritis. The company's MPS Antibody Discovery platform successfully isolated high-affinity antibodies with antagonist or rare agonist activity.
Researchers at Trinity College Dublin engineer molecular sensors based on porphyrin pigments, which can detect and capture pollutants. The novel sensors exploit the shape of porphyrins to mimic a Venus flytrap's opening leaves, enabling selective binding of target molecules.
Researchers at Wyss Institute develop 'eRapid' technology enabling low-cost, handheld electrochemical devices to detect a range of biomarkers with high sensitivity and selectivity. The platform overcomes biofouling problem with simple yet robust design, allowing mass-production of biochemical sensors at low cost.
A new AI system, Generative Tensorial Reinforcement Learning (GENTRL), was used to generate six novel inhibitors of DDR1 kinase target in just 21 days. Four compounds showed activity in biochemical assays, and one lead candidate demonstrated favorable pharmacokinetics in mice.
Scientists at EPFL have found a way to generate over 9,000 macrocyclic molecules below 1 KDa with high structural diversity. The new method enables the discovery of surprisingly efficient macrocyclization reactions, leading to the identification of binders for different disease targets.
Researchers have developed artificial molecules that selectively target abnormal vascular smooth muscle cells without affecting endothelial cells. This could lead to new, safer stent treatments.
Researchers have launched an ultra-large virtual docking library with over 1 billion molecules, expanding the number of 'make-on-demand' compounds for chemical biology and drug discovery. The larger library improves its odds of weeding out inactive decoy molecules.
Researchers at Scripps Research Institute have identified an important intermediate step in how alcohol intoxication occurs. The enzyme phospholipase D2 links ethanol molecules to lipid membranes, triggering a metabolite called phosphatidylethanol that causes nerves to fire more easily, leading to hyperactivity in flies.
Scientists at Harvard University and Brigham and Women's Hospital developed a new immunoassay technique that measures extremely low concentrations of small molecules using single-molecule detection. The method was tested on two important human body molecules, cortisol and PGE2, achieving up to 50 times greater sensitivity than conventi...
Researchers create a concentrator platform with micro- and nano-structured superhydrophilic traps to increase molecule concentration by up to a million times, enabling quick identification of substances in trace amounts. The technology cuts down analysis time from days to hours and potentially achieves single-molecule detection.
Researchers identified a small molecule that activates the antioxidant response, a key mechanism to protect cells from oxidative stress. The discovery targets the glycolysis pathway, opening new strategies for treating diseases involving oxidative stress.
Researchers at the University of Toronto have discovered a way to select the outcome of chemical reactions by manipulating the 'impact parameter', a key factor in reaction dynamics. By directing reagent molecules towards targeted molecules with controlled accuracy, chemists can now control the products of chemical reactions.
Researchers found that targeting IL-1β reduced risk of gout attacks by half, with no change in serum urate levels, suggesting an independent mechanism. The study's findings could lead to new therapeutic avenues for both heart disease and crystal diseases like gout.
A team in Japan developed a new technique to detect and analyze biomolecules with inhomogeneous charge distributions by adjusting the solution. They achieved improved sensor response, allowing researchers to determine the Debye length and map out a molecule's uneven charge distributions.
Researchers at Utah State University have developed a new flavonoid molecule that can release carbon monoxide in a controlled manner, triggering cancer cell death and reducing inflammation. The unique molecules are trackable, targetable, and triggerable using visible light.
The new strategy combines design of a chemical library, virtual screening, automated synthesis, and in vitro study of biological activity. This approach accelerates and automates the process of prototype molecule optimization, increasing chances of finding potential medicinal molecules.
Researchers at UVA School of Medicine have developed a technique to manipulate molecules within cells, enabling precise targeting and minimizing side effects. This breakthrough has significant potential for treating diseases such as cancer, autism, and Alzheimer's.
A novel, affibody-based pretargeted radionuclide therapy for HER2-expressing cancers demonstrated non-toxicity to the kidneys and improved survival in mice. The treatment delivered an absorbed dose to tumors that exceeded the dose to critical organs.
Researchers have developed a novel technique that enables them to visualize biological targets in deep tissues without damaging tissues or labeling with fluorescent molecules. The method, which uses selectively guided light waves, overcomes the limitations of current optical imaging techniques.
Insilico Medicine showcases its use of artificial intelligence to identify disease targets, generate molecular structures, and track interventions for metabesity. The company aims to prevent metabolic-rooted disorders such as diabetes and dementia.
Researchers at Harvard's Wyss Institute create a DNA nanotechnology-based method, called Auto-cycling Proximity Recording (APR), that allows for repeated, non-destructive recording of molecular pairings. This enables the creation of detailed views of molecular structures and observation of different structural states.
Researchers developed an efficient method to produce antibodies that can bind to two different target molecules simultaneously, enhancing cancer immunotherapy. The new approach uses a modified IgG antibody structure with only four key changes, allowing for more versatile formats and improved stability.
A French study of 1,944 patients with advanced cancer found that comprehensive genomic profiling can guide treatment choices and lead to higher survival rates. The study's results suggest that routine genomic testing may not benefit all patients but offers hope for personalized medicine.
Scientists at the University of Alberta have developed synthetic DNA motors that can be used for improved disease detection and drug delivery. The nanomachines demonstrate the potential for early diagnosis and targeted release of drugs within patients, resulting in fewer side effects.
Researchers at the University of Warwick have identified Connexin26, a vital molecule regulating breathing, which detects CO2 levels in the bloodstream. This discovery could lead to targeted treatments for respiratory problems and congenital deafness, improving quality of life for those affected.
Researchers define how anti-cancer molecules work, binding to microtubules and destabilizing cell growth. The study's findings can be used to optimize and develop new, safer drugs.
Researchers from Cincinnati Children's Hospital Medical Center identify novel targets and molecular pathways for IPF, which inflames and scars lung tissues. Analysis of single-cell RNA sequence data reveals genetic markers linked to abnormal cell formation and loss of normal genetic control systems.
Researchers at Nagoya University have identified a novel potential target of the type 2 diabetes drug metformin: the ion exchanger protein NHX-5. In nematode worms and fruit flies, metformin targets NHX-5 to disrupt autophagy and related subcellular processes.
Researchers have identified molecular pathways required for the development of mucormycosis, a fatal infection in patients with weakened immune systems. The study provides new insights into the evolution of Mucorales fungi and offers potential therapeutic targets.
Researchers at Moffitt Cancer Center will investigate prostate cancer metastasis using a multi-disciplinary approach that integrates molecular, cellular and clinical information into mathematical models. The goal is to better understand the key factors driving disease progression and identify new therapeutic targets for prevention.
Research reveals five major ways microRNAs contribute to chemoresistance in epithelial ovarian cancer (EOC). Targeting cell cycle regulation, apoptosis, drug transporters, tumor suppressor roles, and signaling pathways can help reverse resistance. This knowledge highlights the therapeutic potential of miRNAs.
A new antibody, CSL362, specifically targets and depletes plasmacytoid dendritic cells and basophils involved in systemic lupus erythematosus (SLE). This depletion reduces production of type 1 IFN and prevents expansion of antibody-producing cells, showing promise as a potential therapeutic target for SLE treatment.
Researchers aim to develop precision treatment for HCC by targeting genetic abnormalities and chromosomal alterations. Targeted agents such as sorafenib have been developed, but further research is needed to utilize molecular profiles for therapy selection.
Researchers found that molecules use intermittent search patterns to find targets more than 10 times faster than a simple random walk. This behavior can be optimized for applications like DNA biosensors and industrial production.
Researchers at the University of Washington have created a method to accelerate biological assays, which typically take hours or days to complete. By employing cyclic solution draining and replenishing, they were able to reduce reaction times to just seven minutes in one case, using antibodies and nanoparticles to detect specific cellu...
Researchers from the University of Bradford and Avant-garde Materials Simulation successfully predicted the crystal structures of five target compounds using computational methods. The ability to predict crystal structures could enable the design of materials with superior properties, such as brighter pigments or more effective pharmac...
PharmaMar is presenting data on its anticancer candidates PM1183 and plitidepsin, showing synergistic effects against breast cancer cell lines and SCLC mouse tumor models. The company's studies also highlight the potential of plitidepsin as a novel therapeutic target in multiple myeloma.
Researchers develop novel approach to target bacterial lipids, labeling and sparing healthy cells. The new strategy exploits covalent chemistry of lipids, enabling selective recognition and labeling of bacterial cells.
Researchers at Keck School of Medicine of USC have identified a crucial molecule in the survival of type 2 innate lymphoid cells, which trigger primary asthma symptoms. Targeting these molecules could lead to a cure for asthma or exacerbations caused by these cells.
Researchers have identified a small molecule capable of interrupting the disease process in cells carrying the C9ORF72 gene, a variant associated with ALS and FTD. The compound selectively targets abnormal RNA molecules, reducing their accumulation and potentially serving as a biomarker for clinical trials.
New targets for drug therapy have been identified in the mast cell system, including enzymes and receptors. These targets include serine proteinases tryptase, chymase, cathepsin G, and proinflammatory cytokines.
A new technology developed by Brown University researchers simplifies biomolecule separation using microfluidics and magnets, increasing accuracy and sensitivity in disease detection. The technique has great applicability for point-of-care platforms and specific applications include testing for HIV and influenza.
Researchers at NYU and USC have developed a synthetic molecule that targets the interaction between two proteins, preventing tumor growth. The approach presents a new frontier in cancer research, offering potential for the treatment of various human diseases.
A team of University of Montreal and McGill researchers has developed a new method to link signaling molecules to target regulators of cell division. This method could provide valuable insights into the processes underlying cell division and potentially reveal new targets for cancer treatment.
Using a device that detects molecules in real-time, researchers can now observe biomolecule interactions in a sample of water. This technology has major implications for medicine, enabling scientists to study proteins, medicines, and cells with unprecedented precision.
A research team developed a new protocol for X-ray single-crystal diffraction analysis that doesn't require crystallisation of the target molecule. This method allows for the analysis of scarce marine natural products and characterises many compounds previously impossible to analyze crystallographically.
A new approach by Yale University scientists offers greater control over the three-dimensional structure of molecular compounds, enabling more effective drugs. This breakthrough can lead to the creation of novel piperidine derivatives with improved binding properties.
Researchers at Scripps Florida have developed a new method to alter RNA function in living cells by designing molecules that recognize and disable disease-associated RNAs. This approach has the potential to treat genetic disorders such as myotonic dystrophy, which can cause muscle wasting and other symptoms.
A new system can identify a single target molecule from millions of water molecules within milliseconds by trapping it on gold nanoparticles. The technology has potential uses in detecting illegal substances and pollutants, offering a compact, reusable, and easy-to-assemble solution.