Articles tagged with Molecular Targets
Researchers from the University of Bradford and Avant-garde Materials Simulation successfully predicted the crystal structures of five target compounds using computational methods. The ability to predict crystal structures could enable the design of materials with superior properties, such as brighter pigments or more effective pharmac...
PharmaMar is presenting data on its anticancer candidates PM1183 and plitidepsin, showing synergistic effects against breast cancer cell lines and SCLC mouse tumor models. The company's studies also highlight the potential of plitidepsin as a novel therapeutic target in multiple myeloma.
Researchers develop novel approach to target bacterial lipids, labeling and sparing healthy cells. The new strategy exploits covalent chemistry of lipids, enabling selective recognition and labeling of bacterial cells.
Researchers at Keck School of Medicine of USC have identified a crucial molecule in the survival of type 2 innate lymphoid cells, which trigger primary asthma symptoms. Targeting these molecules could lead to a cure for asthma or exacerbations caused by these cells.
Researchers have identified a small molecule capable of interrupting the disease process in cells carrying the C9ORF72 gene, a variant associated with ALS and FTD. The compound selectively targets abnormal RNA molecules, reducing their accumulation and potentially serving as a biomarker for clinical trials.
New targets for drug therapy have been identified in the mast cell system, including enzymes and receptors. These targets include serine proteinases tryptase, chymase, cathepsin G, and proinflammatory cytokines.
A new technology developed by Brown University researchers simplifies biomolecule separation using microfluidics and magnets, increasing accuracy and sensitivity in disease detection. The technique has great applicability for point-of-care platforms and specific applications include testing for HIV and influenza.
Researchers at NYU and USC have developed a synthetic molecule that targets the interaction between two proteins, preventing tumor growth. The approach presents a new frontier in cancer research, offering potential for the treatment of various human diseases.
A team of University of Montreal and McGill researchers has developed a new method to link signaling molecules to target regulators of cell division. This method could provide valuable insights into the processes underlying cell division and potentially reveal new targets for cancer treatment.
Using a device that detects molecules in real-time, researchers can now observe biomolecule interactions in a sample of water. This technology has major implications for medicine, enabling scientists to study proteins, medicines, and cells with unprecedented precision.
A research team developed a new protocol for X-ray single-crystal diffraction analysis that doesn't require crystallisation of the target molecule. This method allows for the analysis of scarce marine natural products and characterises many compounds previously impossible to analyze crystallographically.
A new approach by Yale University scientists offers greater control over the three-dimensional structure of molecular compounds, enabling more effective drugs. This breakthrough can lead to the creation of novel piperidine derivatives with improved binding properties.
Researchers at Scripps Florida have developed a new method to alter RNA function in living cells by designing molecules that recognize and disable disease-associated RNAs. This approach has the potential to treat genetic disorders such as myotonic dystrophy, which can cause muscle wasting and other symptoms.
A new system can identify a single target molecule from millions of water molecules within milliseconds by trapping it on gold nanoparticles. The technology has potential uses in detecting illegal substances and pollutants, offering a compact, reusable, and easy-to-assemble solution.
A new 'lab on a chip' developed by Brigham Young University researchers can detect extremely low concentrations of molecules, allowing for potential disease diagnosis. The device uses capillary action and receptor-lined pipes to measure molecule concentrations, providing an alternative to conventional lab equipment.
A novel 'beads on a string' approach may help reduce cost and development time for agents that neutralize and clear pathogenic molecules. The strategy has been shown to be efficacious against several toxins and may also prove effective in targeting other types of pathogens.
By combining modeling, simulation, analysis, and visualization, researchers can identify potential binding sites on a virus. The work of discovering a breakthrough new drug begins with analyzing the virus, bacteria or mutation that causes the illness, and creating a three-dimensional model to understand its structure and shape.
Researchers have developed a cost-effective method for three-dimensional RNA structure prediction, enabling scientists to understand the functions of RNA molecules that dictate human cell behavior. The technique has the potential to help identify new therapeutic targets for diseases.
Researchers at UCLA have identified dihydromyricetin as a potential treatment for acute alcohol intoxication and withdrawal symptoms. The compound blocks the action of alcohol on the brain's GABAA receptors, reducing voluntary consumption without major side effects.
Researchers have identified Ric-8 as a chaperone that facilitates the transport of G proteins to the cell membrane. Without Ric-8, G proteins are destroyed and their biological processes are disrupted. Understanding the role of Ric-8 in G protein function may lead to more effective treatments for various diseases.
Researchers at MIT have developed a system that visually signals the presence of target chemicals by emitting a fluorescent glow. The approach combines fluorescent molecules with metal-organic frameworks (MOFs) to provide easy visual identification of toxins or pathogens.
Researchers discovered a molecular mechanism allowing signals from target cells to support neuron survival. Activated protein Rac plays a crucial role in long-range signaling and retrograde transport of neuronal survival signals.
Researchers have identified a potential new target for treating obesity by studying the molecular control of appetite in mice. Nutrient intake triggers the secretion of uroguanylin, which is then converted to uroguanylin and binds to GUCY2C receptors, leading to decreased food intake.
Researchers at the University of Illinois have developed a method to use glucose meters for detecting multiple targets in various samples. Functional DNA sensors enable the detection of vital metabolites, contaminants, and disease markers in a simple, low-cost, and portable manner.
The foundation awarded individual grants to six new researchers and funded 18 collaborative grants, totaling over $3.1 million. The grants focus on reprogramming enzymes and genes into therapies to eradicate cancer stem cells.
Researchers create rapid, low-cost imprinting process for nanodevices, enabling production of devices with high sensitivity and precision. The new approach overcomes complexity and expense challenges in processing nanoporous materials.
Researchers have identified multiple molecular targets of the anti-HIV drug nelfinavir, which may explain its effectiveness as a cancer therapy. The study, published in PLOS Computational Biology, suggests that the collective effect of these weak interactions leads to the clinical efficacy of nelfinavir.
Researchers have identified a key role for fibulin-5 in preventing pelvic organ prolapse (POP) by facilitating elastic fiber assembly and inhibiting MMP9 activity. This discovery may lead to nonsurgical treatments targeting elastic fiber-degrading proteins.
Researchers have discovered that ROCK2 protein is involved in regulating the production of IL-17 and IL-21, which are linked to autoimmunity. Administration of a ROCK inhibitor has shown promise in reducing disease symptoms and ameliorating conditions in mice models.
A new NIST prototype method detects and measures elusive hazards such as concealed explosives and toxins using a technique called headspace analysis. The method is sensitive enough to measure amounts of target materials that constitute as little as 0.0000002 percent of a sample.
Scientists discover that quinoline compounds inhibit S100A9's pro-inflammatory effects on white blood cells involved in immune regulation. This new mechanism may provide insights into the early stages of autoimmune disease development.
Researchers developed a two-armed nanorobotic device that can capture and maneuver molecules within DNA structures, enabling the creation of new materials and potential applications in synthetic fibers, encryption, and computer assembly.
Researchers at the University of Rochester Medical Center have identified several compounds that block unwanted RNA coupling, a key step in the disease. The discovery offers hope for developing a drug-like molecule to treat myotonic muscular dystrophy.
A potent bacterial toxin targets human cells expressing Neu5Gc, a sugar incorporated from diet, making humans susceptible to disease. Red meat and dairy products are richest dietary sources of Neu5Gc, increasing the risk of E. coli infection.
Researchers found that eating red meat absorbs human cells with non-human molecules, making them a target for disease-causing bacteria. The study emphasizes the need to eat well-cooked or pasteurized dairy products to avoid food poisoning.
Researchers at DKFZ have developed a new simulation method to predict the molecular targets that control cell behavior. This breakthrough may lead to new treatments against cancer metastasis by targeting specific genetic changes.
Researchers have developed a new MRI technique that combines high temperatures with hyperpolarized xenon to create a supersensitive diagnostic system. The method, called Hyper-CEST MRI, allows for faster and more selective imaging of specific target molecules, such as tumors in human subjects.
In a developing nervous system, peripheral nerve cells compete for NGF availability, with stronger connections surviving while weaker ones die. Target tissues release NGF protein, which changes from a growth cue to a survival factor, ultimately determining cell fate.
Researchers at Purdue University developed a new modeling technique to study and design miniature biosensors. The model explains why certain designs perform better than others and refutes long-held assumptions about sensor performance.
A study published in EMBO reports reveals that AKAP18, a crucial regulator of protein kinase A, may help the heart beat faster in response to adrenaline or noradrenaline. This could lead to improved survival rates for patients with heart failure and heritable heart disease.
Researchers have developed multifunctional nanoparticles that target and image cancer cells by exploiting overexpression of folic acid receptors. These dendrimer-based systems can accumulate in diseased cells and retain bright fluorescence, allowing for easy visualization via confocal microscopy.
Researchers at Virginia Tech have introduced a DNA targeting component in light-activated molecular systems, allowing for more selectivity in attacking cancer cells. The new system uses visible light to signal the synthesized bioactive molecules to cleave DNA, reducing damage to healthy tissue.
The researchers created an inexpensive method to screen for millions of different biomolecules using tiny customizable particles. The technology has the potential to make possible the development of low-cost clinical bedside diagnostics and could be used for disease monitoring, drug discovery, or genetic profiling.
Researchers created dual-modality microbeads to identify disease biomarkers, allowing for faster and more efficient detection of viruses and proteins in human blood and urine. The new technology can analyze very low concentrations of target molecules, enabling diagnosis of diseases like Alzheimer's with high sensitivity.
The NIH is funding a high-throughput screening center network at Scripps Research Institute and Scripps Florida to identify proof-of-concept molecules for studying human health and developing new treatments. The three-year grant aims to accelerate the application of chemical biology to understand physiology and pathophysiology.
Glioblastoma multiforme, the most common and least curable form of brain tumors, may be targeted with new molecular therapies. Researchers identified a protein called Fra-1 that controls malignant features of brain tumor cells and a receptor for interleukin 13 that can be augmented by cytokines to increase treatment accessibility.
Researchers have identified a potential target for preventing HIV transmission through vaginal membranes. A modified chemokine called PSC-RANTES was found to be effective in blocking SHIV transmission in rhesus macaques, offering hope for the development of a topical agent to prevent HIV infection in humans.
The Center of Excellence on Restoration of Function (CERF) at Yale University has received a five-year, $4.5 million grant to study spinal cord repair. The research aims to protect, repair and support the injured nervous system, with potential breakthroughs in treating conditions like multiple sclerosis and spinal cord injuries.
Researchers developed a colorimetric detection capability for Nanosphere's nanoparticle-based molecular detection systems, improving the identification of genomic DNA, RNA, and protein targets. The new technology enables sensitive and specific detection without amplification procedures.
Researchers have discovered a chemical modification of the dopamine transporter that enables amphetamine-induced dopamine release. This finding may lead to the development of treatments for drug addiction by targeting this molecular mechanism.
Scientists have overcome technical difficulties by linking ribozymes to helicases, allowing for efficient inhibition of target RNAs and enabling the development of a method for investigating random RNA functions.
The new process uses a terawatt laser to deliver incredible energies in femtoseconds, sorting isotopes by molecular weight. This breakthrough eliminates the need for huge electro-magnets and cross-contaminated byproducts, making it an efficient alternative to gaseous diffusion.
Hepatitis C virus (HCV) can mimic one of its molecular targets, blocking interferon's ability to kill viruses. This discovery may lead to the development of new therapies by targeting the E2 protein sequence that interferes with PKR phosphorylation.
A team of scientists has made a breakthrough discovery in understanding how the HIV virus attaches to immune system cells, revealing new targets for anti-HIV vaccines and drugs. The study found that the virus uses multiple defenses to evade attack, including shape-shifting projections and carbohydrate molecules.
Scientists have identified a new molecular target that could lead to novel therapies for ischemic cardiovascular disease. The A3 adenosine receptor has been found to exert sustained protection against injury during exposure to ischemia, suggesting potential for drug development.
Researchers at Penn State aim to protect crops by targeting insect taste buds, which are a direct connection between the central nervous system and the outside. By identifying chemicals that stimulate or suppress feeding behavior, scientists hope to develop more effective control methods for corn rootworm pests.
Chemist Benjamin Miller has devised a way to create new drugs by using metal atoms to assemble countless combinations of molecules, then selecting the best candidates through a Darwinian process. This method shifts the burden of tedious drug development work off technicians' shoulders, offering a faster and more efficient approach.
Researchers at Harvard Medical School have identified four human genes critical to cell division, which could lead to more effective cancer treatments. The genes are part of the anaphase-promoting complex (APC) and play a crucial role in regulating mitosis.
Scientists at Indiana University have identified a new potential target for treating parasitic diseases in human cells. The discovery suggests that chloroplast-like plastids, which are found in single-celled parasites, may play an important role in the cell and could be targets for drug therapies.
A study published in Science journal demonstrates the efficacy of vascular targeting agents (VTAs) in treating large solid tumors. VTAs selectively occlude tumor vasculature, causing massive tumor cell death and advanced necrosis within 72 hours. The treatment is well-tolerated and results in complete or partial tumor regressions in mice.