Articles tagged with Neuropeptides
Researchers have published a detailed description of neurotensin's interaction with its receptor, suggesting a novel binding mechanism that may activate G-protein coupled receptors. This knowledge could lead to the development of better drugs for conditions such as Parkinson's disease and schizophrenia.
Researchers discovered that underweight babies are more likely to become obese due to a disrupted hypothalamus, which leads to an increased appetite for calories. This results in the child consuming more calories to catch up on lost nutrition in utero, potentially leading to childhood obesity.
Researchers found that male fruit flies drink more alcohol after being rejected by females due to a molecular trigger called neuropeptide F. This discovery may help shed light on the brain mechanisms underlying social interaction and addiction in humans.
A team of Scripps Research scientists found a key biological mechanism underpinning the transition to alcohol dependence. They discovered that neuropeptide Y, a naturally occurring anti-stress agent, plays a crucial role in mediating the transition to alcohol dependence by modulating GABA release in the amygdala.
Researchers studied peptide hormones in planarian flatworms to understand their reproductive output and potential link to parasitic diseases. The study found that disrupting neuropeptide processing in sexually reproducing planaria causes reproductive organs to regress.
ARS scientists have developed a biocontrol agent that uses neuropeptide mimics to kill aphids, potentially reducing pesticide use and environmental harm. The treatment was found to be highly effective in killing 90-100% of aphids within three days, comparable to insecticides on the market.
A new study reveals that serotonin and neuropeptide F regulate aggression in fruit flies, similar to their effects on mammals. The findings suggest that the molecular and neural roots for complex social behavior are of ancient evolutionary origin.
Researchers found that overexpression of RAMP1 protein increases sensitivity and responsiveness to CGRP, a neuropeptide thought to cause migraines. The study suggests people who get migraines may have higher levels of RAMP1 than those who don't.
Researchers at the University of Illinois have identified 36 genes and 100 neuropeptides in the brain of honey bees, revealing new insights into their role in behavior, dance language, and hive defense. The study uses a combination of bioinformatics, mass spectrometry, and other techniques to analyze the honey bee genome.
A Stanford study found that boosting neuropeptide Y levels in the thalamus and hippocampus can reduce seizures. Researchers discovered that valproic acid increases neuropeptide Y production by 50% in these areas, offering a potential new approach to treating epilepsy with fewer side effects.
Researchers discovered that SH2-B, a protein increasing leptin sensitivity, maintains normal energy metabolism and body weight in mice. The absence of SH2-B impairs leptin signal transduction, leading to severe obesity.
Neuropeptide S promotes arousal and anxiolytic-like effects, regulating sleep-wake cycles and anxiety. The discovery may help understand sleep disorders and pathological states of anxiety.
Research finds that leptin controls hypothalamic prohormone convertases 1 and 2, influencing thyrotopin-releasing hormone production. This regulation plays a key role in energy balance and may lead to novel treatments for obesity and thyroid axis disorders.
A study at the University of Illinois Chicago found that a protein in the brain, CREB, controls drinking behavior in laboratory animals. Low levels of active CREB or neuropeptide Y correlated with symptoms of anxiety and excessive alcohol consumption.
Research suggests a genetic polymorphism in neuropeptide Y may decrease risk of Type I and II alcoholism, a surprise finding that challenges previous expectations. The study, published in Alcoholism: Clinical & Experimental Research, found the Pro(7) substitution to be associated with lower rates of alcohol dependence.
Researchers discover orexin-A and orexin-B neuropeptides stimulate food consumption in laboratory rats. The study's findings suggest a new molecular basis for regulating feeding behavior and may lead to the development of medications to inhibit eating habits.