Peptide Substrates

Penn engineers develop AI tool to design peptides that turn signals on or off

Researchers at the University of Pennsylvania and Chinese University of Hong Kong created TD3B, an AI framework guiding peptide generation toward candidates predicted to have a desired effect. The tool predicts binding likelihood and determines activation or deactivation of associated cellular machinery.

SourceUniversity of Pennsylvania School of Engineering and Applied Science·TypeComputational simulation/modeling·DateJul 9, 2026

New study reveals simple peptides can mimic nature’s protein protection strategy

Researchers at CUNY ASRC discover that simple tripeptides can encapsulate proteins and protect them from stress, opening up possibilities for protein preservation without refrigeration. This breakthrough could lead to innovative vaccine distribution methods and smart materials.

SourceAdvanced Science Research Center, GC/CUNY·JournalNature Materials·TypeExperimental study·DateAug 5, 2025

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New study reveals simple peptides can mimic nature’s protein protection strategy

Researchers at CUNY ASRC Nanoscience reveal that extremely simple peptides can mimic a biological process that protects sensitive proteins from environmental stress. The findings offer a promising new approach to stabilizing biomolecules like vaccines and therapeutic proteins without refrigeration.

SourceAdvanced Science Research Center, GC/CUNY·JournalNature Materials·TypeExperimental study·DateAug 5, 2025

Ribosome hooks a 'ring' onto proteins after billions of years

A research team led by Professor Joongoo Lee successfully expanded ribosome range to produce ring-shaped backbones in proteins. This breakthrough could open doors to novel therapeutics and advanced biomaterials.

SourcePohang University of Science & Technology (POSTECH)·JournalNature Communications·DateJul 8, 2025

Elucidating the complex structure of the blood vessel contraction factor endothelin, its receptor protein, and G protein

The study uses cryo-electron microscopy to observe the ETB receptor-G protein complex, revealing a strong binding interaction between G protein and ETB receptor. This finding may deepen understanding of endothelin signaling mechanisms and inform the development of new drugs.

SourceUniversity of Tsukuba·JournalCommunications Biology·DateOct 24, 2024

Exploring peptide clumping for improved drug and material solutions

Researchers investigated peptide clumping behavior using molecular dynamics simulations and AI techniques. They discovered that aromatic amino acids enhance aggregation, while hydrophilic ones inhibit it, offering insights into peptide structure and function.

SourceXi'an Jiaotong-Liverpool University·JournalJACS Au·TypeComputational simulation/modeling·DateSep 3, 2024

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