Articles tagged with Peptides
Researchers at Institut de recherches cliniques de Montreal (IRCM) have discovered therapeutic peptides affecting mitochondria. These compounds target cell mitochondria to treat various acute and chronic diseases, including ischemia reperfusion injury and neurodegenerative conditions.
Researchers have identified two peptides that target an enzyme in cancerous cells, leading to a rise in tumor suppressor protein p53 levels and cell death. The discovery shows promise for new cancer treatments.
Researchers at North Carolina State University and Purdue University have shown that gallium nitride (GaN) is non-toxic and biocompatible, making it a promising material for biomedical implants. The material was found to be stable in environments mimicking the human body and bonded effectively with cells when coated with peptides.
Researchers discovered that A-beta oligomers form calcium-permeable pores in the plasma membrane, inducing excess calcium influx into cells. This influx disrupts synaptic signaling and stimulates cell death, contributing to neurodegeneration associated with Alzheimer's disease.
Biodesign researchers are developing a state-of-the-art pipeline to generate synthetic affinity reagents called 'DNA synbodies' to study protein function and disease. The goal is to create low-cost, high-quality reagents for the entire human proteome, revolutionizing molecular medicine.
A new study found that genetic factors beyond major histocompatibility complex (MHC) molecules play a crucial role in determining the effectiveness of an Alzheimer's vaccine. The findings suggest that vaccines could be designed to prevent neuroinflammatory reactions, improving treatment outcomes for patients.
Scientists at Sanford-Burnham and Salk Institute developed a method to combine peptides and nanoparticles to eliminate glioblastoma in previously untreatable mouse models. The nanosystem proved effective in treating two different mouse models, curing most tumors and significantly delaying tumor development.
Dr. Andrei Yudin's innovative process makes linear peptides circular, increasing their stability and ability to enter cells effectively. A library of macrocycles will be built to test properties and identify potential therapeutic compounds.
Researchers at Northwestern University have discovered a new protein called P21, which acts as a protective barrier against hyperactive immune cells in people with rheumatoid arthritis. By inhibiting the immune cells' destructive rampage, the bouncer molecule halts the disease process, offering a promising new avenue for future therapies.
Masaaki Tamura's team creates a targeted therapy to combat lung cancer by delivering a receptor gene to cancer cells via nanoparticles, stimulating the immune system to prevent tumor growth. The therapy uses a cationic peptide to guide the gene to cancerous cells, offering a non-invasive treatment option for lung cancer patients.
Researchers at Arizona State University have developed a new method for producing antibody-like binding agents, called DNA synbodies, which can be rapidly optimized for high affinity. The technique uses pre-existing ligands to create artificial antibodies capable of detecting diseases, offering a promising alternative to traditional mo...
Researchers found that seaweed proteins can reduce blood pressure like ACE inhibitor drugs, and the macroalgae have potential to be used in functional foods. The variety of species and ease of cultivation make them a relatively untapped source of new bioactive compounds.
Researchers at Penn Vet found a cancer drug that shrinks dog tumors and may lead to human treatment. The study discovered the same aberrant activation of a critical pathway in dogs with lymphoma as humans.
A previously understudied amyloid peptide, A-beta-43, is more abundant and neurotoxic than previously studied peptides in promoting Alzheimer's disease. The findings suggest a potential role for A-beta-43 as a biomarker for diagnosis and a new approach for preventing AD-causing amyloidosis.
A new near-infrared fluorescence agent has been developed to detect deep vein thrombosis, a potentially deadly cardiovascular disease. The agent uses a biomarker that targets fibrin, a protein involved in blood clot formation, and has shown high-resolution imaging capabilities in phase II clinical trials.
Researchers at Indiana University School of Medicine have discovered a peptide, CBD3, that short circuits a pathway for chronic pain without debilitating side effects. The peptide has been shown to block pain signals by interfering with calcium channels, making it potentially safer than addictive opioids or cone snail toxin.
Researchers at Scripps Research Institute found a way to disrupt a critical enzyme interaction that prevents cell death, potentially leading to new treatments for heart attack and stroke. The discovery could provide a new therapeutic target against conditions including neurodegenerative diseases like Parkinson's.
The FASEB MARC Program has awarded 3 travel grants totaling $4,950 to support underrepresented minority students and postdoctorates at the 22nd American Peptide Symposium. The program aims to increase diversity in biomedical research by promoting participation of young scientists from underrepresented groups.
Researchers at the Ragon Institute identified variations in peptide stability that alter targeting of infected cells by CD8 T cells. The study found that specific mutations can reduce peptide stability, impairing immune response and increasing HIV resistance.
Researchers at the University of Strathclyde have developed a new technique that can detect Alzheimer's disease earlier than current methods. This approach uses fluorescence signals to identify clusters of peptide associated with the disease, allowing for potential treatment development and screening patients without needles or wires.
Researchers at Arizona State University have developed a superior method for immobilizing enzymes on surfaces, enabling precise control over their orientation. This technique uses high-affinity peptides to covalently bind enzymes, increasing efficiency and stability.
Scientists have discovered stapled peptides that can target proteins involved in colon cancer and asthma. These peptides, which are not small molecules, inhibit activity of key proteins in the body, offering a new frontier in medicine.
Researchers developed two peptide inhibitors targeting HER-2 and VEGF pathways, showing additive benefits in reducing tumor burdens with minimal side effects. The strategy aims to overcome acquired resistance and provide clinical benefit in several types of cancer.
Researchers at UCLA and the Veterans Administration may have accidentally discovered a solution to regrow hair by blocking a stress-related hormone, according to an article published in PLoS One. The compound, astressin-B, induced long-term hair growth in chronically stressed mutant mice through a short-duration treatment.
Scientists at TUM have developed a novel method to observe hydrogen bond formation in protein binding processes. Their model system showed that protein recognition takes place via hydrophobic interaction of the S-protein with two spatially clearly defined areas of the unstructured S-peptide.
Researchers at the University at Buffalo have developed two new ways to staple peptide helices, which could help speed the development of peptide-based drugs against diseases like cancer. The techniques simplify existing methods and offer new targets for therapies.
Researchers at Princeton University used mathematical concepts to discover new drugs for HIV and other diseases by calculating physical properties of biological molecules. The technique identified several potential new drugs that were effective against strains of HIV, offering a promising alternative to existing treatments.
Scientists at UC San Diego have developed injectable fluorescent peptides that cause hard-to-see peripheral nerves to glow, alerting surgeons to their location. The discovery could revolutionize nerve preservation in surgery, especially in cases where nerves are damaged or distorted.
A targeted delivery combination has been developed to selectively cross the blood-brain barrier and bind to brain tumors, enabling imaging and treatment. The approach uses a peptide that mimics iron, binding agent glides through the blood-brain barrier to target glioblastoma tumors.
Researchers at Arizona State University have developed synthetic antibodies that can be used for diagnostic tools. By optimizing binding affinity using random peptide sequences, these synbodies show promise in detecting diseases early on.
Researchers used fruit flies to investigate the function of intestinal neurons, finding that they regulate appetite and adjust water balance during reproduction. Intestinal changes triggered by reproductive hormones may provide a benefit in terms of nutrient absorption but could come at a cost: shorter lifespan.
A Canadian researcher has identified a small peptide, 15-1, which blocks fragments of the ubiquitous sugar molecule hyaluronan and promotes robust healing and less scarring in deep wounds. The study found that this peptide effectively reduced wound contraction, collagen deposits, inflammation, and growth of unwanted new blood vessels.
Researchers at Tufts University discovered bioactive peptides that stimulate the healing process by promoting angiogenesis and epithelialization. The peptides, synthesized from collagenase treatment of extracellular matrix, show promise in treating acute and chronic wound healing.
Researchers at Centre for Addiction and Mental Health have developed a protein peptide that disrupts coupling between dopamine receptors, potentially treating depression. The peptide showed marked improvement in depression-related behaviors in animal models, comparable to traditional anti-depressant medications.
A new study reveals that APP695 is the primary source of amyloid-beta peptide, a toxic compound contributing to Alzheimer's disease. This discovery enables researchers to target their work more precisely, potentially leading to a better understanding and treatment of the disease.
A study found that a peptide being tested to treat atherosclerosis significantly inhibited the growth of ovarian cancer in human cell lines and mouse models. The peptide, an apoA-I mimetic, was shown to be effective when administered via injection or ingestion, with minimal side effects.
Researchers at ASU's Biodesign Institute have developed new technologies to create a potential therapeutic that can protect soldiers against an unknown pathogen in just 7 days, significantly reducing the time needed for production. The project aims to utilize synthetic antibodies or synbodies to rapidly construct a custom-tailored ther...
Researchers have synthesized hundreds of new compounds that can specifically reduce A-beta 42 levels in the brain, a primary component of Alzheimer's disease. The compounds, called gamma-secretase modulators, were tested in mouse models and showed promising results, reducing neuritic plaques and A-beta 42 levels.
A new antibacterial peptide has shown great effectiveness against multidrug-resistant Acinetobacter baumannii and Escherichia coli infections in burn wounds. The peptide A3-APO is less toxic than current antibiotics and offers a promising alternative for treating these common infections in soldiers.
Researchers developed new 'stapled peptides' to block key cancer proteins, showing promise for treating cancer, diabetes, and other diseases. The advances could lead to a new generation of medicines, overcoming the shortcomings of previous drugs.
Researchers found that transforming growth factor-β1 contributes to kidney disease by inducing fibrosis and nephron degeneration. Meanwhile, a new diagnostic criteria for T-cell lymphoma was discovered using mast cells and Th17 cells. Additionally, a novel peptide ASARM may implicate in impaired dentin mineralization in rickets.
Researchers at MIT discovered a link between SIRT1 gene and amyloid plaques in Alzheimer's patients, finding that SIRT1 controls production of devastating protein fragments. Overproduction of SIRT1 in mice with Alzheimer's symptoms improved learning and memory deficits, while deletion exacerbated them.
Researchers have identified three protein fragments in gluten that trigger an immune response in people with coeliac disease, leading to small intestine damage. This discovery could pave the way for a new generation of diagnostic tools, treatments, and prevention strategies.
A team of Vanderbilt chemists has developed a novel method for synthesizing peptides that incorporates non-natural amino acids. The technique streamlines the process, making it easier to create diverse peptides and proteins, which have highly specific biological activity associated with low toxicity.
A study by Rensselaer Polytechnic Institute professor Peter M. Tessier has found that an organic compound in red wine, resveratrol, can neutralize the toxic effects of proteins linked to Alzheimer's disease. The research provides insights into the structural differences between toxic and benign peptide arrangements.
Researchers at National Jewish Health and the University of Colorado Anschutz Medical Campus have identified a precise protein fragment that can trigger diabetes in mice. The finding contradicts conventional wisdom and suggests that poorly presented peptides may cause autoimmune diseases, including type 1 diabetes.
Researchers at Arizona State University have developed a method to create synthetic antibodies that can bind with human proteins with high affinity and specificity. This technique, called synbody construction, involves combining random amino acid sequences to form a binding molecule that can target specific proteins.
Researchers developed a new approach to harness and modulate enzyme activity, allowing for the design of industrial catalysts and healthcare diagnostics. The technique uses polyvinyl alcohol to limit molecule diffusion, enabling simultaneous monitoring of enzyme- peptide interactions.
Researchers at Emory University have discovered that simple peptides can organize into bi-layer membranes, a 'missing link' between pre-biotic Earth's chemical inventory and the scaffolding essential to life. This finding may also shed light on protein assemblies related to Alzheimer's disease, Type 2 diabetes, and other serious ailments.
Researchers propose a new theory on the cause of autoimmunity in diabetes, suggesting that unusual protein fragments can trigger an immune response. This discovery could lead to a new strategy for preventing type 1 diabetes.
Scientists aim to prevent insects from spreading deadly diseases like Chagas' by manipulating physiology to stop the transmission of the illness. Researchers have identified genes controlling diuresis in kissing bugs and hope to create a peptide agonist to prevent waste and parasites from being left on wounds.
Researchers have gained new insight into protein fiber assembly, providing a potential route to temporal control of fibers with future applications in biotechnology and nanoscale science and medicine. By manipulating conditions, they were able to demonstrate the ability to manipulate fibrous structures with some precision.
Researchers found a molecular link between genetic mutations and type 1 diabetes, identifying a critical new target for intervention. The study's findings suggest a way to break 'tolerance' in the immune system, potentially leading to novel antibody or small molecule therapies.
Researchers found truncated peptides form active ion channels causing cell death and memory loss, contradicting previous effective treatments. A new approach aims to control these ion channels for an effective treatment.
Researchers have discovered a type of soy protein that inhibits fat accumulation and reduces inflammation. Soybeans with high levels of beta-conglycinins are found to limit lipid accumulation in fat cells by suppressing an enzyme called fatty acid synthase.
Researchers discovered NG peptides in marine animals, similar to the mutant gene causing diabetes insipidus, providing new understanding of a rare form of diabetes. The discovery could help explain symptoms and treatment for around 10,000 people in the UK.
Researchers have developed two potential drug candidates that block cancer-promoting pathways in novel ways. The peptides offer a new approach to interfere with the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) pathways.
A computer simulation of protein malfunction related to Alzheimer's disease was created by researchers at Universitat Autonoma de Barcelona and University of Stockholm. The model shows that ApoE4 loses its functional structure in the presence of Amyloid beta, but not ApoE2 and ApoE3 forms.
A new tool called PEG-POD significantly increases gene delivery to retinal cells, outperforming existing carriers and DNA alone. This breakthrough may help develop therapies for conditions like retinitis pigmentosa and age-related macular degeneration.
Researchers used a special peptide to modify laboratory mice's immune systems, reducing characteristic features of Alzheimer's disease. Anti-inflammatory cells were recruited, dampening the local inflammatory response and boosting plaque-degrading enzyme action.