Articles tagged with Peptides
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Scientists have discovered stapled peptides that can target proteins involved in colon cancer and asthma. These peptides, which are not small molecules, inhibit activity of key proteins in the body, offering a new frontier in medicine.
Researchers developed two peptide inhibitors targeting HER-2 and VEGF pathways, showing additive benefits in reducing tumor burdens with minimal side effects. The strategy aims to overcome acquired resistance and provide clinical benefit in several types of cancer.
Researchers at UCLA and the Veterans Administration may have accidentally discovered a solution to regrow hair by blocking a stress-related hormone, according to an article published in PLoS One. The compound, astressin-B, induced long-term hair growth in chronically stressed mutant mice through a short-duration treatment.
Scientists at TUM have developed a novel method to observe hydrogen bond formation in protein binding processes. Their model system showed that protein recognition takes place via hydrophobic interaction of the S-protein with two spatially clearly defined areas of the unstructured S-peptide.
Researchers at the University at Buffalo have developed two new ways to staple peptide helices, which could help speed the development of peptide-based drugs against diseases like cancer. The techniques simplify existing methods and offer new targets for therapies.
Researchers at Princeton University used mathematical concepts to discover new drugs for HIV and other diseases by calculating physical properties of biological molecules. The technique identified several potential new drugs that were effective against strains of HIV, offering a promising alternative to existing treatments.
Scientists at UC San Diego have developed injectable fluorescent peptides that cause hard-to-see peripheral nerves to glow, alerting surgeons to their location. The discovery could revolutionize nerve preservation in surgery, especially in cases where nerves are damaged or distorted.
A targeted delivery combination has been developed to selectively cross the blood-brain barrier and bind to brain tumors, enabling imaging and treatment. The approach uses a peptide that mimics iron, binding agent glides through the blood-brain barrier to target glioblastoma tumors.
Researchers at Arizona State University have developed synthetic antibodies that can be used for diagnostic tools. By optimizing binding affinity using random peptide sequences, these synbodies show promise in detecting diseases early on.
Researchers used fruit flies to investigate the function of intestinal neurons, finding that they regulate appetite and adjust water balance during reproduction. Intestinal changes triggered by reproductive hormones may provide a benefit in terms of nutrient absorption but could come at a cost: shorter lifespan.
A Canadian researcher has identified a small peptide, 15-1, which blocks fragments of the ubiquitous sugar molecule hyaluronan and promotes robust healing and less scarring in deep wounds. The study found that this peptide effectively reduced wound contraction, collagen deposits, inflammation, and growth of unwanted new blood vessels.
Researchers at Tufts University discovered bioactive peptides that stimulate the healing process by promoting angiogenesis and epithelialization. The peptides, synthesized from collagenase treatment of extracellular matrix, show promise in treating acute and chronic wound healing.
Researchers at Centre for Addiction and Mental Health have developed a protein peptide that disrupts coupling between dopamine receptors, potentially treating depression. The peptide showed marked improvement in depression-related behaviors in animal models, comparable to traditional anti-depressant medications.
A new study reveals that APP695 is the primary source of amyloid-beta peptide, a toxic compound contributing to Alzheimer's disease. This discovery enables researchers to target their work more precisely, potentially leading to a better understanding and treatment of the disease.
A study found that a peptide being tested to treat atherosclerosis significantly inhibited the growth of ovarian cancer in human cell lines and mouse models. The peptide, an apoA-I mimetic, was shown to be effective when administered via injection or ingestion, with minimal side effects.
Researchers at ASU's Biodesign Institute have developed new technologies to create a potential therapeutic that can protect soldiers against an unknown pathogen in just 7 days, significantly reducing the time needed for production. The project aims to utilize synthetic antibodies or synbodies to rapidly construct a custom-tailored ther...
Researchers have synthesized hundreds of new compounds that can specifically reduce A-beta 42 levels in the brain, a primary component of Alzheimer's disease. The compounds, called gamma-secretase modulators, were tested in mouse models and showed promising results, reducing neuritic plaques and A-beta 42 levels.
A new antibacterial peptide has shown great effectiveness against multidrug-resistant Acinetobacter baumannii and Escherichia coli infections in burn wounds. The peptide A3-APO is less toxic than current antibiotics and offers a promising alternative for treating these common infections in soldiers.
Researchers developed new 'stapled peptides' to block key cancer proteins, showing promise for treating cancer, diabetes, and other diseases. The advances could lead to a new generation of medicines, overcoming the shortcomings of previous drugs.
Researchers found that transforming growth factor-β1 contributes to kidney disease by inducing fibrosis and nephron degeneration. Meanwhile, a new diagnostic criteria for T-cell lymphoma was discovered using mast cells and Th17 cells. Additionally, a novel peptide ASARM may implicate in impaired dentin mineralization in rickets.
Researchers at MIT discovered a link between SIRT1 gene and amyloid plaques in Alzheimer's patients, finding that SIRT1 controls production of devastating protein fragments. Overproduction of SIRT1 in mice with Alzheimer's symptoms improved learning and memory deficits, while deletion exacerbated them.
Researchers have identified three protein fragments in gluten that trigger an immune response in people with coeliac disease, leading to small intestine damage. This discovery could pave the way for a new generation of diagnostic tools, treatments, and prevention strategies.
A team of Vanderbilt chemists has developed a novel method for synthesizing peptides that incorporates non-natural amino acids. The technique streamlines the process, making it easier to create diverse peptides and proteins, which have highly specific biological activity associated with low toxicity.
A study by Rensselaer Polytechnic Institute professor Peter M. Tessier has found that an organic compound in red wine, resveratrol, can neutralize the toxic effects of proteins linked to Alzheimer's disease. The research provides insights into the structural differences between toxic and benign peptide arrangements.
Researchers at National Jewish Health and the University of Colorado Anschutz Medical Campus have identified a precise protein fragment that can trigger diabetes in mice. The finding contradicts conventional wisdom and suggests that poorly presented peptides may cause autoimmune diseases, including type 1 diabetes.
Researchers at Arizona State University have developed a method to create synthetic antibodies that can bind with human proteins with high affinity and specificity. This technique, called synbody construction, involves combining random amino acid sequences to form a binding molecule that can target specific proteins.
Researchers developed a new approach to harness and modulate enzyme activity, allowing for the design of industrial catalysts and healthcare diagnostics. The technique uses polyvinyl alcohol to limit molecule diffusion, enabling simultaneous monitoring of enzyme- peptide interactions.
Researchers at Emory University have discovered that simple peptides can organize into bi-layer membranes, a 'missing link' between pre-biotic Earth's chemical inventory and the scaffolding essential to life. This finding may also shed light on protein assemblies related to Alzheimer's disease, Type 2 diabetes, and other serious ailments.
Researchers propose a new theory on the cause of autoimmunity in diabetes, suggesting that unusual protein fragments can trigger an immune response. This discovery could lead to a new strategy for preventing type 1 diabetes.
Scientists aim to prevent insects from spreading deadly diseases like Chagas' by manipulating physiology to stop the transmission of the illness. Researchers have identified genes controlling diuresis in kissing bugs and hope to create a peptide agonist to prevent waste and parasites from being left on wounds.
Researchers have gained new insight into protein fiber assembly, providing a potential route to temporal control of fibers with future applications in biotechnology and nanoscale science and medicine. By manipulating conditions, they were able to demonstrate the ability to manipulate fibrous structures with some precision.
Researchers found a molecular link between genetic mutations and type 1 diabetes, identifying a critical new target for intervention. The study's findings suggest a way to break 'tolerance' in the immune system, potentially leading to novel antibody or small molecule therapies.
Researchers found truncated peptides form active ion channels causing cell death and memory loss, contradicting previous effective treatments. A new approach aims to control these ion channels for an effective treatment.
Researchers have discovered a type of soy protein that inhibits fat accumulation and reduces inflammation. Soybeans with high levels of beta-conglycinins are found to limit lipid accumulation in fat cells by suppressing an enzyme called fatty acid synthase.
Researchers discovered NG peptides in marine animals, similar to the mutant gene causing diabetes insipidus, providing new understanding of a rare form of diabetes. The discovery could help explain symptoms and treatment for around 10,000 people in the UK.
Researchers have developed two potential drug candidates that block cancer-promoting pathways in novel ways. The peptides offer a new approach to interfere with the epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) pathways.
A computer simulation of protein malfunction related to Alzheimer's disease was created by researchers at Universitat Autonoma de Barcelona and University of Stockholm. The model shows that ApoE4 loses its functional structure in the presence of Amyloid beta, but not ApoE2 and ApoE3 forms.
A new tool called PEG-POD significantly increases gene delivery to retinal cells, outperforming existing carriers and DNA alone. This breakthrough may help develop therapies for conditions like retinitis pigmentosa and age-related macular degeneration.
Researchers used a special peptide to modify laboratory mice's immune systems, reducing characteristic features of Alzheimer's disease. Anti-inflammatory cells were recruited, dampening the local inflammatory response and boosting plaque-degrading enzyme action.
Researchers have identified a peptide called iRGD that specifically targets and penetrates cancerous tumors, delivering diagnostic particles and medicines. This breakthrough could improve cancer treatment and reduce side effects.
A breakthrough in assembling peptides at the nano-scale level could lead to self-cleaning coatings for windows and solar panels. The material can also boost electric battery capacity, potentially solving limitations like thrust.
Researchers at the University of Illinois have discovered that soy peptide lunasin may help fight leukemia by activating a protein called caspase-3. Lunasin also showed anti-inflammatory properties by blocking the activation of NF-kappa-B and reducing interleukin-1 and interleukin-6 levels.
Researchers produced single-molecule resolution images of peptide-mineral interaction, revealing mechanisms that molecules use to bind to surfaces. Peptides slow down or speed up crystal growth depending on conditions, offering potential solutions for pathological mineralization and kidney stone treatment.
Scientists at the University of Michigan have determined the atomic-level structure of a SEVI precursor and found it damages cell membranes to make them more vulnerable to HIV infection. The study provides insights into how SEVI interacts with cell membranes, which may help in developing new treatments for AIDS.
A recent study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that eating quickly can lead to overeating by curbing the release of hormones that signal fullness. Researchers discovered that subjects who took their time consuming a meal had higher concentrations of appetite-regulating hormones,...
Researchers at NIST have developed a method to quantify extremely low levels of C-reactive protein (CRP), a molecule that indicates cardiovascular disease risk. The new certified reference material will improve the accuracy of clinical laboratory tests for CRP, enabling more precise detection of individuals at high risk of heart attack.
Researchers propose a new hypothesis for Alzheimer's disease: the myelin model. This theory suggests that degenerative diseases like Alzheimer's begin with normal brain maintenance and repair processes. The model suggests targeting earlier stages of myelination, potentially reducing dementia's burden.
Einstein scientists have identified two small protein fragments that could be developed into an anthrax vaccine, potentially causing fewer side effects than the current vaccine. The research focuses on the protein toxin used in the current vaccine, looking for peptides that can trigger protective antibodies when injected into animals.
Assoc Prof Lam has won a S$20,000 fellowship to support her research on self-assembling biomolecules for sensing applications. The award recognizes her contributions to the advancement of science and research in Singapore, building on her expertise in understanding and designing materials.
Biophysicists at TUM develop a new technique to observe calmodulin in action, allowing them to study its binding sequences and regulate its target proteins. The results reveal new insights into the protein's hierarchy of folding and unbinding events.
A study by researchers at Albert Einstein College of Medicine has identified a peptide called humanin that improves insulin action and lowers blood glucose levels in diabetic rodents. Humanin also protects nerve cells from death associated with Alzheimer's and other brain diseases.
A team of researchers has identified a protein that breaks down an appetite-suppressing peptide, leading to reduced food intake in mice. Mice lacking the protein were leaner and less likely to become obese on high-fat diets.
Researchers have developed computational tools to decode and rapidly determine whether natural compounds are new or patented. These advances will speed the discovery process, enabling scientists to characterize ring-shaped nonribosomal peptides and accelerate the timeline for bringing new therapies into clinical application.
A rapid and inexpensive drug-screening method developed by Whitehead Institute scientists uses baker's yeast to synthesize and screen molecules, cutting testing time to weeks. The technique targets protein-protein interactions found in cellular processes, offering new potential for treating diseases like Parkinson's.
Researchers create highly stable chemical compounds that can bind to proteins with high affinity and selectivity, replacing traditional antibodies used in medical diagnostic tests. The technique involves a stepwise approach using in situ click chemistry, allowing for the creation of complex molecules in a relatively simple process.
Researchers at Stanford University School of Medicine have identified a wide range of antibodies in healthy people and Alzheimer's patients that target protein aggregates, including those found in plaques. These findings suggest that these antibodies may play a role in slowing or preventing the progression of Alzheimer's disease.
A Scripps Research team has created a chemical system that assembles and disassembles itself without enzymes, mimicking DNA. The system uses peptides and nucleobases, potentially shedding light on the emergence of life on Earth.
Researchers have detected a peptide in cerebrospinal fluid that can indicate the onset of Alzheimer's disease, potentially allowing for earlier diagnosis and treatment. This discovery raises new opportunities for combating the disease, which currently requires treatments to be started after significant brain damage has occurred.
Researchers at UC Santa Barbara and the Burnham Institute for Medical Research have created a nanoparticle that can detect and attack plaque in arteries, a leading cause of cardiovascular disease. The treatment shows promise for developing therapies to prevent heart attacks and strokes.
The NPs-NPR-B/pGC-cGMP signal pathway is up-regulated in diabetic rats, leading to potentiated relaxation and increased cGMP production in gastric smooth muscle. This suggests a potential role of the CNP-(NPR-B)-pGC-cGMP pathway in the pathogenesis of diabetic gastroparesis.