Articles tagged with Peptides
Researchers discovered peptides that inhibit metastatic spreading and even lead to regression of existing metastases in pancreatic cancer models. The CD44v6 protein drives the spread of tumor cells, but small segments of the protein can be successfully inhibited by peptides.
Researchers developed a new method that identifies more proteins and peptides in mass spectrometry data, analyzing pairs of overlapping peptide spectra. The method improves performance by up to four-fold, overcoming the bottleneck created by vast amounts of raw data.
Researchers at University of the Pacific have developed a method to significantly extend the lifespan of peptides. By tagging peptides with a compound, they enable it to survive in the bloodstream longer and avoid degradation. This breakthrough technology has the potential to improve peptide therapies for cancer and other diseases.
University of Missouri researchers have created a biodegradable active layer in organic electronics using peptides, enabling full biodegradability. The discovery could significantly reduce electronic waste in landfills and minimize health risks associated with e-waste exposure.
Researchers at Queen Mary University of London developed a method for self-assembling organic molecules into complex tissue-like structures without moulds or 3D printing. This discovery could enable the engineering of tissues like veins, arteries, or the blood-brain barrier, facilitating disease research and implant development.
A recent animal study broadens understanding of the flu virus's impact on the immune system, revealing a more dynamic process that engages multiple biological pathways. This research may lead to the development of more effective vaccines against influenza and other viruses.
Researchers have identified a new protein fragment, amyloid-η, which antagonizes the hyperactive effect of beta-amyloid on nerve cells. This finding has immediate implications for ongoing clinical trials targeting beta-amyloid, suggesting that unanticipated side-effects may occur if eta-amyloid levels increase
Researchers are developing 3D-printed biodegradable polymer scaffolds to accelerate bone growth in head and neck injuries. The technology has the potential to produce mechanically strong replaced bone with minimal inflammation and within a short healing period.
A new peptide drug, TP508, has been shown to significantly increase survival in mice when administered 24 hours after nuclear radiation exposure. The study found that the drug counteracts damage to the gastrointestinal system, delaying mortality and increasing chances of survival.
Researchers found that comet impacts can synthesize peptides, the first building blocks of life, under cold conditions. This suggests that comet impacts played a crucial role in delivering life's seeds to early Earth.
Researchers have developed a new probe that can detect blood clots in any part of the body using positron emission tomography (PET). The probe, called FBP8, contains copper-64 and has shown promise in detecting blood clots in rats, paving the way for future human trials.
Researchers at Toyohashi University of Technology developed new agents to inhibit the production of amyloid-beta peptides, a main cause of Alzheimer's disease. The novel curcumin derivatives were proposed through molecular simulations and shown to bind strongly to amyloid precursor protein.
Researchers have developed a method to increase nitric oxide production in nasal passages, which is linked to chronic sinusitis. The approach involves boosting NO levels using low-molecular-weight peptides that were created from an already-approved drug compound.
University of North Carolina researchers provide evidence that amino acids evolved into proteins, and single cells formed plants and animals. The close linkage between the physical properties of amino acids, genetic code, and protein folding is crucial to life's origins.
Researchers at Princeton University have revealed the structure and biosynthesis of streptide, a peptide involved in bacterial quorum sensing. The study used a combination of chemical and biological approaches to determine the structure of streptide and its mechanism of production.
Scientists at University of California, San Diego School of Medicine demonstrate ability to reprogram large parts of a cell's signaling network by manipulating key hub in communication networks. This approach shows potential to slow or reverse disease progression, including cancer driven by abnormal cell signaling.
A new review of the amyloid-beta peptide, a key component of senile plaques in Alzheimer's disease, has been published in Chemical Reviews. The study combines experimental and theoretical aspects and provides a comprehensive state-of-the-art overview of research on this protein.
Researchers at Tel Aviv University have developed a novel DNA-peptide structure that can be used to produce thin, transparent, and flexible screens. The new material is light, organic, and environmentally friendly, emitting a full range of colors in one pliable pixel layer.
A promising new antivenom derived from opossum serum has shown promise in neutralizing snake venom, with potential for widespread distribution and a single injectable dose. The peptide-based treatment could save thousands of lives worldwide without the side effects of current treatments.
Scientists develop peptide that binds to misshapen α-synuclein protein, stopping toxic fibril formation and brain cell death. The research offers a potential new approach for slowing Parkinson's disease progression.
Researchers at UMBC isolated a peptide that binds strongly to lithium manganese nickel oxide, improving the potential power and stability of electrode materials. The peptides can latch onto nanoscale components, forming a bridge between conductive components and maintaining a connection through multiple charging cycles.
Researchers at Ben Gurion University of the Negev have discovered a promising peptide called humanin that can counteract cell death caused by hypoxia. The peptide's derivatives were tested on neuronal cells and showed successful results, potentially leading to new treatments for necrosis-related diseases.
A team of chemists at IRB Barcelona has developed a shuttle that can cross the blood-brain barrier and transport various substances into the brain, opening up new possibilities for treating diseases such as glioblastoma and Friedreich's Ataxia.
Researchers have identified a peptide called PACAP that reduces food intake and leads to weight loss when administered in the brain's central amygdala. The study suggests PACAP may be a target for medications treating obesity and binge-eating disorders.
Researchers at Oregon Health & Sciences University successfully tested a peptide developed by Case Western Reserve neurosciences professor Jerry Silver, PhD, which showed 100% success in animal models, regenerating nerves into heart attack scar tissue and preventing arrhythmia.
Researchers have developed nanoparticles that can efficiently transport charge-neutral oligonucleotide analogs into cells, enabling them to retain biological activity. This breakthrough delivery approach has the potential to treat various therapeutic targets.
A review on Urotensin II has shown its ability to modulate biologic activities in the cardiovascular system, kidneys, and central nervous system. The peptide can constrict and dilate blood vessels, making it a promising candidate for treating various cardiovascular diseases.
Researchers from North Carolina State University have developed a new technique to bind peptides to gallium nitride surfaces, making them stable even in water and radiation. This breakthrough could lead to the creation of injectable biosensors for detecting specific molecules in biological environments.
In a breakthrough study, researchers at Georgia Institute of Technology have developed a technique to activate biomaterials containing peptide signaling molecules using ultraviolet light. By designing molecular 'hats' that shield the peptides from recognition by cells, they can deliver drugs or particles with their signal in the 'off' ...
Researchers at University of Strathclyde and City University of New York have developed a screening method to accurately predict how peptides can combine to form stable gels. This breakthrough simplifies the discovery of functional gels for various applications, including food, cosmetics, and biomedicine.
Researchers have made breakthroughs in personalized vaccine technology for all types of cancer, using genes expressed in tumors to create tailored vaccines. The approach has shown promise in improving biological responses and disease control.
Researchers have designed peptides to target Ebola's N-trimer protein, allowing for universal inhibition across all known and future strains. This approach enables the selection of effective drugs that block virus entry into cells.
A team of researchers has made a breakthrough in understanding how a powerful antibiotic agent is produced in nature. They found that a special enzyme called dehydratase plays a crucial role in giving the antibiotic its final shape and function.
Researchers discovered that certain peptides undergo a triplet state when exposed to UV light, leading to greater damage than fragmentation. This finding may help develop better UV protection mechanisms.
High-resolution cryo-electron microscopy reveals the structural changes in the bacterial ribosome that result in resistance to erythromycin. The study sheds light on how bacteria acquire resistance genes and how they interact with antibiotics.
Researchers distinguish different types of beta-amyloid aggregates and find that those with 20 to 100 units are most toxic, leading to neuronal death. The study provides evidence for the hypothesis that intermediate aggregates cause neuronal death.
Two new peptide vaccines and two peptide inhibitors targeting HER-3 and IGF-1R receptors have been developed by Ohio State Researchers. The studies show that combining these agents can boost effectiveness and prevent drug resistance, leading to improved response rates and durable remissions for various types of cancer.
Researchers develop a new method called synthetic fermentation to rapidly synthesize large numbers of bioactive molecules using just a few building blocks. The method enables the generation of about 6,000 unnatural peptide-like molecules directly screened for biological activity without purification.
A study published in The FASEB Journal identifies a salamander skin peptide called tylotoin that promotes wound healing by enhancing keratinocyte proliferation and releasing essential growth factors. This discovery could lead to the development of new treatments for human wounds.
Researchers discovered a peptide mimicking high-density lipoprotein (HDL) protein helps reduce oxidized lipids in pulmonary hypertension, improving heart and lung function. The study also found elevated levels of oxidized proteins in rodents with the disease, which can be targeted for treatment development.
Researchers found that apolipoprotein E-derived therapeutic peptide improved synaptic stability and learning and memory performance after diffuse brain injury. The peptide also protected against brain injury by reducing oxidative stress, suppressing the ERK1/2-Bax mitochondrial apoptotic pathway, and decreasing neuronal death.
Researchers have developed a recombinant adenovirus expressing Aβ-ABAD decoy peptide, which increases superoxide dismutase activity and decreases oxidative stress markers in PC12 cells. This study suggests that rAAV/ABAD-DP-6His may be a potential therapeutic strategy for Alzheimer's disease.
A synthesized version of tumor necrosis factor's tip appears to work like a doorstop to keep sodium channels open inside the lungs' air sacs, clearing excess fluid. The TIP peptide may help patients survive pneumonia by targeting bacterial toxins and promoting natural defense mechanisms.
A new method has been developed to produce artificial anti-cancer molecules with properties similar to those of the body's natural defense systems. The molecules have proved effective against colon cancer cells in laboratory tests and show promise for further research.
Researchers identified proteinaceous binding media used in polychrome layers of Qin Shihuang's terracotta army. Natural pigments and binding media were found to be composed of cinnabar, apatite, azurite, and malachite.
The study reveals how hemagglutinin protein reconfigures itself as it infects host cells, providing new insights into the path of the flu virus. This understanding could lead to the development of a universal flu vaccine that lasts a lifetime.
Researchers at Arizona State University have developed a new diagnostic tool called immunosignaturing to identify valley fever, which can be misdiagnosed due to low sensitivity of current methods. This technique uses a microarray platform to produce a detailed profile of immune activity from a small droplet of blood, allowing for accur...
Researchers have developed a innovative technique called immunosignaturing to capture disease complexity, offering a marked improvement in detection over traditional methods. The technique uses a microarray to profile antibodies circulating in blood, demonstrating high accuracy in identifying multiple diseases.
A novel AD vaccine, Plp-Adeno-X-CMV-(Aβ3-10)10-CpG, was administered via nasal mucosal inhalation to AD transgenic mouse models, producing strong T helper 2 humoral immune responses and reducing Aβ1-42-induced cytotoxicity. This approach offers a promising therapeutic strategy for Alzheimer's disease.
Researchers have identified specific neural groups in female fruit flies that regulate their choice to mate, revealing new clues for understanding human sexual behavior. These findings could provide a starting point for exploring the neural mechanisms underlying courtship behaviors in other species.
Researchers analyzed Stanley Miller's old samples and replicated his 1958 experiment, finding peptides formed under basic conditions. This discovery suggests a new path to the formation of proteins and enzymes necessary for life.
Researchers at UW–Madison have built a version of a parathyroid hormone that can stay around longer and at higher concentrations. This breakthrough could lead to better drugs for osteoporosis and diabetes by protecting peptide hormones from degrading enzymes.
Researchers found that apolipoprotein E-derived therapeutic peptide improves synaptic stability and learning memory performance after diffuse brain injury. Apolipoprotein E mimetic peptide also reduces neuronal apoptosis by suppressing the ERK1/2-Bax mitochondrial apoptotic pathway.
Scientists have discovered a potential new target for cancer immunotherapy, peptide antibodies that deplete immune-suppressing MDSCs without harming other vital cells. The treatment showed promising results in preclinical experiments, shrinking tumors and improving outcomes.
Researchers have discovered a common rulebook for the immune system's T cells, enabling faster identification of antigens and potential treatments. This breakthrough could lead to improved understanding of autoimmune diseases like diabetes and multiple sclerosis.
The study found that rAAV/ABAD-DP-6His increases superoxide dismutase activity and decreases malondialdehyde content, reducing oxidative stress-induced injury in PC12 cells. The treatment also maintains mitochondrial membrane potential and reduces apoptosis, indicating its neuroprotective effects.
Researchers developed novel double-stapled peptides that inhibit RSV in cells and mice, and when delivered with nanoparticles, showed significant inhibition of RSV infection. The therapy has potential to prevent and treat RSV infection in high-risk groups such as infants, young children, and the elderly.
Researchers developed a double-stapled peptide that prevents RSV infection by stabilizing its structure, allowing for effective prevention in both cell culture and murine models. Additionally, intranasal and intratracheal delivery methods were found to be effective in preventing nasopulmonary infection.
Researchers at Tel Aviv University have developed a new prototype battery that can fully charge a smartphone in under a minute, using nanodots derived from bio-organic materials. The technology increases electrode capacity and electrolyte performance, making it more efficient and eco-friendly than current battery technologies.
Syracuse University chemists discover enzyme-like activity in seven amino acid peptides, shedding light on the origins of life and potential new catalysts for metabolic reactions. The breakthrough supports the theory that amyloid fibrils may have triggered early forms of life.